Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements.
Autorzy:
Snouwaert JN; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America. Jania LA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America. Nguyen T; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America. Martinez DR; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Schäfer A; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Catanzaro NJ; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Gully KL; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. BaricRS; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Heise M; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Ferris MT; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Anderson E; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Pressey K; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Dillard JA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Taft-Benz S; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Baxter VK; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Ting JP; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Center for Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Koller BH; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2023 Feb 22; Vol. 19 (2), pp. e1011168. Date of Electronic Publication: 2023 Feb 22 (Print Publication: 2023).
Dynamics of SARS-CoV-2 VOC Neutralization and Novel mAb Reveal Protection against Omicron.
Autorzy:
Hao L; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.; Center for Emerging & Re-Emerging Infectious Diseases, University of Washington, Seattle, WA 98109, USA. Hsiang TY; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.; Center for Emerging & Re-Emerging Infectious Diseases, University of Washington, Seattle, WA 98109, USA. Dalmat RR; International Clinical Research Center, Department of Global Health, Schools of Medicine and Public Health, University of Washington, Seattle, WA 98104, USA.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA. Ireton R; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.; Center for Emerging & Re-Emerging Infectious Diseases, University of Washington, Seattle, WA 98109, USA. Morton JF; International Clinical Research Center, Department of Global Health, Schools of Medicine and Public Health, University of Washington, Seattle, WA 98104, USA.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA. Stokes C; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.; Center for Emerging & Re-Emerging Infectious Diseases, University of Washington, Seattle, WA 98109, USA.; Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA 98195, USA. Netland J; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA. Hale M; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA. Thouvenel C; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA. Wald A; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA.; Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA.; Allergy and Infectious Diseases Division, Laboratory Medicine & Pathology, & Epidemiology, University of Washington, Seattle, WA 98195, USA.; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. Franko NM; Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA. Huden K; Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA. Chu HY; Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA. Sigal A; Africa Health Research Institute, Durban 4001, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Mayville 4058, South Africa.; Centre for the AIDS Program of Research in South Africa, Congella 4013, South Africa. Greninger AL; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA. Tilles S; Center for Emerging & Re-Emerging Infectious Diseases, University of Washington, Seattle, WA 98109, USA.; Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA. Barrett LK; Center for Emerging & Re-Emerging Infectious Diseases, University of Washington, Seattle, WA 98109, USA.; Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA. Van Voorhis WC; Center for Emerging & Re-Emerging Infectious Diseases, University of Washington, Seattle, WA 98109, USA.; Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA. Munt J; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27695, USA. Scobey T; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27695, USA. BaricRS; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27695, USA. Rawlings DJ; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA. Pepper M; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA. Drain PK; International Clinical Research Center, Department of Global Health, Schools of Medicine and Public Health, University of Washington, Seattle, WA 98104, USA.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA.; Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA. Gale M Jr; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.; Center for Emerging & Re-Emerging Infectious Diseases, University of Washington, Seattle, WA 98109, USA.
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Źródło:
Viruses [Viruses] 2023 Feb 14; Vol. 15 (2). Date of Electronic Publication: 2023 Feb 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Mahita J; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Ha B; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Gambiez A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Schendel SL; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Li H; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Hastie KM; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Dennison SM; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA. Li K; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA. Kuzmina N; Department of Pathology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555-0609, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555-1019, USA. Periasamy S; Department of Pathology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555-0609, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555-1019, USA. Bukreyev A; Department of Pathology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555-0609, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555-1019, USA.; Galveston National Laboratory, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77550, USA. Munt JE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 135 Dauer Drive, 2101 McGavran-Greenberg Hall,CB #7435, Chapel Hill, NC 27599-7435, USA. Osei-Twum M; Nexelis, a Q2 Solutions Company, 525 Boulevard Cartier Ouest, Laval, Quebec H7V 3S8, Canada. Atyeo C; Ragon Institute of MGH, MIT and Harvard, 400 Technology Square, Cambrige, MA 02139-3583, USA. Overton JA; Knocean Inc., 107 Quebec Ave. Toronto, Ontario, M6P 2T3, Canada. Vita R; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Guzman-Orozco H; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Mendes M; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Kojima M; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Halfmann PJ; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, WI 53711, USA. Kawaoka Y; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, WI 53711, USA.; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo 162-8655, Japan. Alter G; Ragon Institute of MGH, MIT and Harvard, 400 Technology Square, Cambrige, MA 02139-3583, USA. Gagnon L; Nexelis, a Q2 Solutions Company, 525 Boulevard Cartier Ouest, Laval, Quebec H7V 3S8, Canada. BaricRS; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 135 Dauer Drive, 2101 McGavran-Greenberg Hall,CB #7435, Chapel Hill, NC 27599-7435, USA.; Department of Microbiology and Immunology, School of Medicine, 125 Marson Farm Road, Chapel Hill, NC 27599-7290, USA. Tomaras GD; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA. Germann T; Carterra Inc., 825 N. 300 W.Ste, C309, Salt Lake City, UT 84103, USA. Bedinger D; Carterra Inc., 825 N. 300 W.Ste, C309, Salt Lake City, UT 84103, USA. Greenbaum JA; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Saphire EO; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, 9500 Gilman Drive MC 0507, La Jolla 92093-0507, California. Peters B; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, 9500 Gilman Drive MC 0507, La Jolla 92093-0507, California.
Mouse Adapted SARS-CoV-2 (MA10) Viral Infection Induces Neuroinflammation in Standard Laboratory Mice.
Autorzy:
Amruta N; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA. Ismael S; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA. Leist SR; Department of Epidemiology, Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Gressett TE; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA.; Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA. Srivastava A; Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA. Dinnon KH 3rd; Department of Epidemiology, Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Engler-Chiurazzi EB; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA.; Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA.; Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, USA. Maness NJ; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.; Tulane National Primate Research Center, Covington, LA 70433, USA. Qin X; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.; Tulane National Primate Research Center, Covington, LA 70433, USA. Kolls JK; Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA. BaricRS; Department of Epidemiology, Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Bix G; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA.; Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA.; Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, USA.; Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70122, USA.
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Źródło:
Viruses [Viruses] 2022 Dec 30; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children.
Autorzy:
Becker-Dreps S; Department of Family Medicine, University of North Carolina at Chapel Hill (UNC-Chapel Hill), Chapel Hill, North Carolina, USA.; Department of Epidemiology, UNC-Chapel Hill, Chapel Hill, North Carolina, USA. Brewer-Jensen PD; Department of Epidemiology, UNC-Chapel Hill, Chapel Hill, North Carolina, USA. González F; Department of Microbiology, National Autonomous University of Nicaragua, León (UNAN-León), León, Nicaragua. Reyes Y; Department of Microbiology, National Autonomous University of Nicaragua, León (UNAN-León), León, Nicaragua.; Division of Viral Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA. Mallory ML; Department of Epidemiology, UNC-Chapel Hill, Chapel Hill, North Carolina, USA. Gutiérrez L; Department of Microbiology, National Autonomous University of Nicaragua, León (UNAN-León), León, Nicaragua.; Division of Viral Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA. Vielot NA; Department of Family Medicine, University of North Carolina at Chapel Hill (UNC-Chapel Hill), Chapel Hill, North Carolina, USA. Diez-Valcarce M; Division of Viral Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA. Vinjé J; Division of Viral Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA. BaricRS; Department of Epidemiology, UNC-Chapel Hill, Chapel Hill, North Carolina, USA. Lindesmith LC; Department of Epidemiology, UNC-Chapel Hill, Chapel Hill, North Carolina, USA. Bucardo F; Department of Microbiology, National Autonomous University of Nicaragua, León (UNAN-León), León, Nicaragua.
Breadth and Dynamics of Human Norovirus-Specific Antibodies in the First Year of Life.
Autorzy:
Vielot NA; Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Brinkman A; Takeda Vaccines, Inc., Cambridge, Massachusetts, USA. DeMaso C; Takeda Vaccines, Inc., Cambridge, Massachusetts, USA. Vilchez S; Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León, León, Nicaragua. Lindesmith LC; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Bucardo F; Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León, León, Nicaragua. Reyes Y; Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León, León, Nicaragua. BaricRS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Ryan EP; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA. Braun R; Takeda Vaccines, Inc., Cambridge, Massachusetts, USA. Becker-Dreps S; Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
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