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Tytuł :
Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect.
Autorzy :
Bachireddy P; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Ennis C; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
Nguyen VN; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
Gohil SH; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Academic Haematology, University College London, London WC1E 6BT, UK.
Clement K; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA.
Shukla SA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Forman J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Barkas N; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Freeman S; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Bavli N; Division of Hematology and Oncology, UT Southwestern, Dallas, TX 75390, USA.
Elagina L; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Leshchiner I; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Mohammad AW; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Mathewson ND; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Keskin DB; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Rassenti LZ; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92037, USA.
Kipps TJ; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92037, USA.
Brown JR; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Getz G; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
Ho VT; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Gnirke A; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Neuberg D; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Soiffer RJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Ritz J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Alyea EP; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Kharchenko PV; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. .; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
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Źródło :
Science translational medicine [Sci Transl Med] 2020 Sep 16; Vol. 12 (561).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing.
Autorzy :
Amante SM; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Montibus B; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Cowley M; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Barkas N; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Setiadi J; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Saadeh H; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Giemza J; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Contreras-Castillo S; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Fleischanderl K; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Schulz R; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Oakey RJ; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 04; Vol. 48 (15), pp. 8349-8359.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Transcription, Genetic*
Protein Processing, Post-Translational/*genetics
RNA Precursors/*genetics
Animals ; Cell Differentiation/genetics ; Chromatin/genetics ; CpG Islands/genetics ; DNA Methylation/genetics ; Genome/genetics ; Histone Code/genetics ; Humans ; Promoter Regions, Genetic ; Pseudogenes/genetics ; RNA Precursors/metabolism
Czasopismo naukowe
Tytuł :
Spliceosome mutations are common in persons with myeloproliferative neoplasm-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to pomalidomide.
Autorzy :
Chowdhury O; NIHR Biomedical Research Centre and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
O'Sullivan J; NIHR Biomedical Research Centre and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Barkas N; NIHR Biomedical Research Centre and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Wang G; NIHR Biomedical Research Centre and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Buck G; NIHR Biomedical Research Centre and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Hamblin A; NIHR Biomedical Research Centre and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Tefferi A; Mayo Clinic, Rochester, MN, USA.
Al-Ali HK; University Hospital Halle, Halle, Germany.
Barosi G; Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.
Devos T; Department of Hematology, University Hospitals Leuven and Department of Microbiology and Immunology, Laboratory of Molecular Immunology (Rega Institute), Leuven, Belgium.
Gisslinger H; Medizinische Universität Wien, Vienna, Austria.
Jiang Q; Peking University, People's Hospital, Beijing, China.
Kiladjian JJ; Hôpital Saint-Louis, Paris, France.
Mesa R; Mays Cancer Center at UT Health San Antonio MD Anderson, San Antonio, TX, USA.
Passamonti F; University of Insubria, Varese, Italy.
Ribrag V; Cancer Campus, 11 Gustave Roussy, Villejuif, France.
Schiller G; Division of Hematology and Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Vannucchi AM; Center for Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Zhou D; Peking Union Medical College Hospital, Beijing, China.
McMullin MF; Queens University Belfast, Belfast, UK.
Zhong J; Bristol-Myers Squibb, New Brunswick, NJ, USA.
Gale RP; Haematology Research Centre, Imperial College London, London, UK.
Mead AJ; NIHR Biomedical Research Centre and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. .
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Corporate Authors :
RESUME trialists
Źródło :
Leukemia [Leukemia] 2020 Aug 07. Date of Electronic Publication: 2020 Aug 07.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Joint analysis of heterogeneous single-cell RNA-seq dataset collections.
Autorzy :
Barkas N; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Petukhov V; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Nikolaeva D; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Lozinsky Y; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Demharter S; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Khodosevich K; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kharchenko PV; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. .; Harvard Stem Cell Institute, Cambridge, MA, USA. .
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Źródło :
Nature methods [Nat Methods] 2019 Aug; Vol. 16 (8), pp. 695-698. Date of Electronic Publication: 2019 Jul 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Databases, Genetic*
Gene Expression Profiling*
Bone Marrow/*metabolism
Computational Biology/*methods
High-Throughput Nucleotide Sequencing/*methods
Single-Cell Analysis/*methods
Humans
Czasopismo naukowe
Tytuł :
Myocardial differentiation is dependent upon endocardial signaling during early cardiogenesis in vitro .
Autorzy :
Saint-Jean L; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
Barkas N; Department of Medical & Molecular Genetics, King's College London, London, SE1 9RT, UK.
Harmelink C; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Tompkins KL; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Oakey RJ; Department of Medical & Molecular Genetics, King's College London, London, SE1 9RT, UK.
Baldwin HS; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA .; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
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Źródło :
Development (Cambridge, England) [Development] 2019 May 08; Vol. 146 (9). Date of Electronic Publication: 2019 May 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation/*physiology
Endocardium/*cytology
Endocardium/*metabolism
Myocardium/*cytology
Myocardium/*metabolism
Animals ; Cell Differentiation/genetics ; Female ; Flow Cytometry ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Fluorescence ; NFATC Transcription Factors/genetics ; NFATC Transcription Factors/metabolism ; Organogenesis/genetics ; Organogenesis/physiology ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction
Czasopismo naukowe
Tytuł :
Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing.
Autorzy :
Rodriguez-Meira A; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Buck G; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Clark SA; Flow Cytometry Facility, Medical Research Council, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Povinelli BJ; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Alcolea V; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Louka E; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
McGowan S; Medical Research Council Centre for Computational Biology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Hamblin A; National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, UK.
Sousos N; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Barkas N; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Giustacchini A; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Psaila B; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, UK.
Jacobsen SEW; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Department of Cell and Molecular Biology, Wallenberg Institute for Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden; Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Thongjuea S; Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Centre for Computational Biology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Mead AJ; Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, UK. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2019 Mar 21; Vol. 73 (6), pp. 1292-1305.e8. Date of Electronic Publication: 2019 Feb 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Heterogeneity*
High-Throughput Nucleotide Sequencing*
Mutation*
Sequence Analysis, RNA*
Single-Cell Analysis*
Biomarkers, Tumor/*genetics
DNA Mutational Analysis/*methods
Leukemia/*genetics
Humans ; Jurkat Cells ; K562 Cells ; Reproducibility of Results ; Schizosaccharomyces/genetics
Czasopismo naukowe
Tytuł :
Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq data.
Autorzy :
Fan J; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Lee HO; Samsung Genome Institute, Samsung Medical Center/Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
Lee S; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Ryu DE; Samsung Genome Institute, Samsung Medical Center/Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
Lee S; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Xue C; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Kim SJ; Division of Hematology-Oncology, Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, 06351, Korea.
Kim K; Division of Hematology-Oncology, Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, 06351, Korea.
Barkas N; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Park WY; Samsung Genome Institute, Samsung Medical Center/Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
Kharchenko PV; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.
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Źródło :
Genome research [Genome Res] 2018 Aug; Vol. 28 (8), pp. 1217-1227. Date of Electronic Publication: 2018 Jun 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genetic Heterogeneity*
Transcription, Genetic*
Multiple Myeloma/*genetics
Neoplasms/*genetics
Alleles ; Computational Biology ; High-Throughput Nucleotide Sequencing ; Humans ; Multiple Myeloma/pathology ; Mutation ; Neoplasms/pathology ; Polymorphism, Single Nucleotide ; Single-Cell Analysis/methods
Czasopismo naukowe
Tytuł :
Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.
Autorzy :
Booth CAG; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Barkas N; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Neo WH; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Boukarabila H; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Soilleux EJ; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK.
Giotopoulos G; Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge, UK; Department of Haematology, University of Cambridge, Cambridge, UK; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
Farnoud N; Center for Molecular Oncology, Center for Heme Malignancies and Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Giustacchini A; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
Ashley N; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Carrelha J; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Jamieson L; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Atkinson D; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Bouriez-Jones T; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Prinjha RK; Epigenetics DPU, Oncology and Immuno-Inflammation Therapy Area Units, GlaxoSmithKline, Stevenage, UK.
Milne TA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Teachey DT; Division of Oncology, Children's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Papaemmanuil E; Center for Molecular Oncology, Center for Heme Malignancies and Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Huntly BJP; Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge, UK; Department of Haematology, University of Cambridge, Cambridge, UK; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
Jacobsen SEW; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, SE-141 86 Stockholm, Sweden; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address: .
Mead AJ; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LE, UK. Electronic address: .
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Źródło :
Cancer cell [Cancer Cell] 2018 Feb 12; Vol. 33 (2), pp. 274-291.e8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Core Binding Factor Alpha 2 Subunit/*genetics
Enhancer of Zeste Homolog 2 Protein/*genetics
Leukemia, Myeloid, Acute/*genetics
Mutation/*genetics
Animals ; Gene Expression Regulation, Leukemic ; Mice, Knockout ; Myeloid Cells/metabolism ; Signal Transduction/genetics ; Stem Cells
Czasopismo naukowe

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