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Tytuł :
FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma.
Autorzy :
Milewski D; Division of Pulmonary Biology, The Perinatal Institute of Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Genetics Branch, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Shukla S; Division of Pulmonary Biology, The Perinatal Institute of Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Gryder BE; Genetics Branch, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Pradhan A; Division of Pulmonary Biology, The Perinatal Institute of Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Donovan J; Division of Pulmonary Biology, The Perinatal Institute of Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Sudha P; Division of Pulmonary Biology, The Perinatal Institute of Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Vallabh S; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Pyros A; Division of Pulmonary Biology, The Perinatal Institute of Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Xu Y; Division of Pulmonary Biology, The Perinatal Institute of Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Barski A; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Szabo S; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Turpin B; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Pressey JG; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Millay DP; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Khan J; Genetics Branch, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Kalinichenko VV; Division of Pulmonary Biology, The Perinatal Institute of Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Center for Lung Regenerative Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Kalin TV; Division of Pulmonary Biology, The Perinatal Institute of Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. .; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. .
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Źródło :
Oncogene [Oncogene] 2021 Feb 24. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition.
Autorzy :
Maezawa S; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. .; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. .; Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan. .; Faculty of Science and Technology, Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba, Japan. .
Sakashita A; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan.
Yukawa M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Allergy and Immunology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Chen X; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Takahashi K; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Alavattam KG; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Nakata I; Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.
Weirauch MT; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Barski A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Allergy and Immunology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Namekawa SH; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. .; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. .; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Oct; Vol. 27 (10), pp. 978-988. Date of Electronic Publication: 2020 Sep 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Enhancer Elements, Genetic*
Meiosis/*genetics
Mitosis/*genetics
Polycomb-Group Proteins/*genetics
Proto-Oncogene Proteins c-myb/*genetics
Spermatogenesis/*genetics
Trans-Activators/*genetics
Animals ; Cell Differentiation ; Gene Expression Regulation ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutation ; Polycomb-Group Proteins/metabolism ; Proto-Oncogene Proteins c-myb/metabolism ; Spermatogonia/cytology ; Spermatogonia/physiology ; Trans-Activators/metabolism ; X Chromosome/genetics
Czasopismo naukowe
Tytuł :
Endogenous retroviruses drive species-specific germline transcriptomes in mammals.
Autorzy :
Sakashita A; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan.
Maezawa S; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.; Faculty of Science and Technology, Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba, Japan.
Takahashi K; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Alavattam KG; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Yukawa M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Allergy and Immunology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Hu YC; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Kojima S; Genome Immunobiology RIKEN Hakubi Research Team, RIKEN Center for Integrative Medical Sciences and RIKEN Cluster for Pioneering Research, Yokohama, Japan.
Parrish NF; Genome Immunobiology RIKEN Hakubi Research Team, RIKEN Center for Integrative Medical Sciences and RIKEN Cluster for Pioneering Research, Yokohama, Japan.
Barski A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Allergy and Immunology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Pavlicev M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Center for Prevention of Preterm Birth, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department for Theoretical Biology, University of Vienna, Vienna, Austria.
Namekawa SH; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. .; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. .; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Oct; Vol. 27 (10), pp. 967-977. Date of Electronic Publication: 2020 Sep 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endogenous Retroviruses/*genetics
Spermatogenesis/*genetics
Spermatozoa/*physiology
Animals ; Chromatin/genetics ; Chromatin/virology ; Enhancer Elements, Genetic ; Gene Expression Regulation, Viral ; Humans ; Long Interspersed Nucleotide Elements ; Male ; Mammals/genetics ; Mammals/virology ; Meiosis ; Mice, Inbred C57BL ; Mice, Transgenic ; Mitosis ; Mutation ; Proto-Oncogene Proteins c-myb/genetics ; Repetitive Sequences, Nucleic Acid ; Rodentia/genetics ; Rodentia/virology ; Spermatozoa/virology ; Trans-Activators/genetics ; Transcriptome
Czasopismo naukowe
Tytuł :
Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome.
Autorzy :
Pilarowski GO; Predoctoral Program in Human Genetics, Johns Hopkins School of Medicine, Baltimore, Md; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Md.
Cazares T; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Zhang L; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Md.
Benjamin JS; Predoctoral Program in Human Genetics, Johns Hopkins School of Medicine, Baltimore, Md; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Md.
Liu K; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Jagannathan S; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Mousa N; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Kasten J; Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Barski A; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Lindsley AW; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address: .
Bjornsson HT; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Md; Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Md; Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Department of Genetics and Molecular Biology, Landspitali University Hospital, Reykjavik, Iceland.
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2020 Mar; Vol. 145 (3), pp. 982-992. Date of Electronic Publication: 2019 Dec 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Abnormalities, Multiple/*immunology
Abnormalities, Multiple/*pathology
B-Lymphocytes/*pathology
Face/*abnormalities
Hematologic Diseases/*immunology
Hematologic Diseases/*pathology
Peyer's Patches/*pathology
Vestibular Diseases/*immunology
Vestibular Diseases/*pathology
Animals ; B-Lymphocytes/immunology ; Cell Differentiation/immunology ; Cell Movement/immunology ; DNA-Binding Proteins/genetics ; Face/pathology ; Histone-Lysine N-Methyltransferase/genetics ; Humans ; IgA Deficiency/genetics ; IgA Deficiency/immunology ; Integrin beta Chains/metabolism ; Intestines/immunology ; Mice ; Mutation ; Myeloid-Lymphoid Leukemia Protein/genetics ; Neoplasm Proteins/genetics ; Peyer's Patches/immunology
SCR Disease Name :
Kabuki syndrome
Czasopismo naukowe
Tytuł :
KMT2C/D COMPASS complex-associated diseases [K CD COM-ADs]: an emerging class of congenital regulopathies.
Autorzy :
Lavery WJ; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center (CCHMC), 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA.
Barski A; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center (CCHMC), 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA.; Division of Human Genetics, CCHMC, Cincinnati, OH, USA.
Wiley S; Division of Developmental and Behavioral Pediatrics, CCHMC, Cincinnati, OH, USA.
Schorry EK; Division of Human Genetics, CCHMC, Cincinnati, OH, USA.
Lindsley AW; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center (CCHMC), 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA. .
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Źródło :
Clinical epigenetics [Clin Epigenetics] 2020 Jan 10; Vol. 12 (1), pp. 10. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation.
Autorzy :
Yukawa M; Division of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Jagannathan S; Division of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Vallabh S; Division of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Kartashov AV; Division of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Chen X; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Weirauch MT; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Barski A; Division of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2020 Jan 06; Vol. 217 (1).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin/*metabolism
Lymphocyte Activation/*immunology
T-Lymphocytes/*immunology
Transcription Factor AP-1/*immunology
Binding Sites/immunology ; Cells, Cultured ; Chromatin Assembly and Disassembly/immunology ; Gene Expression Regulation/immunology ; Humans ; Hypersensitivity/immunology ; Inflammatory Bowel Diseases/immunology ; Multiple Sclerosis/immunology
Czasopismo naukowe
Tytuł :
Identification of anoctamin 1 (ANO1) as a key driver of esophageal epithelial proliferation in eosinophilic esophagitis.
Autorzy :
Vanoni S; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; PharmGenetix Gmbh, Niederalm-Anif, Austria.
Zeng C; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Marella S; Mary H Weiser Food Allergy Center and Department of Pathology, Ann Arbor, Mich.
Uddin J; Mary H Weiser Food Allergy Center and Department of Pathology, Ann Arbor, Mich.
Wu D; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Arora K; Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Ptaschinski C; Mary H Weiser Food Allergy Center and Department of Pathology, Ann Arbor, Mich.
Que J; Department of Medicine, Columbia University Medical Center, New York, NY.
Noah T; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Mary H Weiser Food Allergy Center and Department of Pathology, Ann Arbor, Mich.
Waggoner L; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Barski A; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Kartashov A; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Rochman M; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Wen T; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Martin L; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Spence J; Departments of Biomedical Engineering, Internal Medicine and Cell and Developmental Biology, University of Michigan, Ann Arbor, Mich.
Collins M; Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Mukkada V; Division of Gastroenterology, Nutrition and Hepatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Putnam P; Division of Gastroenterology, Nutrition and Hepatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Naren A; Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Chehade M; Mount Sinai Center for Eosinophilic Disorders, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Rothenberg ME; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Hogan SP; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Mary H Weiser Food Allergy Center and Department of Pathology, Ann Arbor, Mich. Electronic address: .
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2020 Jan; Vol. 145 (1), pp. 239-254.e2. Date of Electronic Publication: 2019 Oct 21.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Anoctamin-1/*immunology
Eosinophilic Esophagitis/*immunology
Epithelial Cells/*immunology
Esophagus/*immunology
Neoplasm Proteins/*immunology
Animals ; Cell Line ; Disease Models, Animal ; Eosinophilic Esophagitis/pathology ; Epithelial Cells/pathology ; Esophagus/pathology ; Female ; Humans ; Male ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł :
CWL-Airflow: a lightweight pipeline manager supporting Common Workflow Language.
Autorzy :
Kotliar M; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Kartashov AV; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Barski A; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
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Źródło :
GigaScience [Gigascience] 2019 Jul 01; Vol. 8 (7).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Software*
Workflow*
Chromatin Immunoprecipitation Sequencing/*methods
Genomics/*methods
Animals ; Big Data ; Humans
Czasopismo naukowe
Tytuł :
Genetic, Inflammatory, and Epithelial Cell Differentiation Factors Control Expression of Human Calpain-14.
Autorzy :
Miller DE; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Forney C; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Rochman M; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Cranert S; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Habel J; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Rymer J; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Lynch A; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Schroeder C; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Lee J; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Sauder A; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Smith Q; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Chawla M; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Trimarchi MP; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Lu X; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Fjellman E; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Brusilovsky M; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Barski A; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.; Department of Pediatrics, University of Cincinnati, College of Medicine, Ohio 45229.
Waggoner S; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.; Department of Pediatrics, University of Cincinnati, College of Medicine, Ohio 45229.
Weirauch MT; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.; Department of Pediatrics, University of Cincinnati, College of Medicine, Ohio 45229.; Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Rothenberg ME; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.; Department of Pediatrics, University of Cincinnati, College of Medicine, Ohio 45229.
Kottyan LC; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229 .; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.; Department of Pediatrics, University of Cincinnati, College of Medicine, Ohio 45229.
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Źródło :
G3 (Bethesda, Md.) [G3 (Bethesda)] 2019 Mar 07; Vol. 9 (3), pp. 729-736. Date of Electronic Publication: 2019 Mar 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Polymorphism, Single Nucleotide*
Calpain/*genetics
Eosinophilic Esophagitis/*genetics
Epithelial Cells/*enzymology
Interleukin-13/*metabolism
STAT6 Transcription Factor/*metabolism
Cell Line ; Eosinophilic Esophagitis/metabolism ; Genetic Predisposition to Disease ; Humans ; Inflammation ; Interleukin-4/metabolism ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł :
Attenuated chromatin compartmentalization in meiosis and its maturation in sperm development.
Autorzy :
Alavattam KG; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Maezawa S; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.
Sakashita A; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Khoury H; Department of Physiology, Biophysics & Systems Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Barski A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Allergy and Immunology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Kaplan N; Department of Physiology, Biophysics & Systems Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel. .
Namekawa SH; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. .; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2019 Mar; Vol. 26 (3), pp. 175-184. Date of Electronic Publication: 2019 Feb 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin Assembly and Disassembly/*physiology
Meiosis/*physiology
Spermatids/*growth & development
Spermatocytes/*growth & development
Spermatogenesis/*physiology
Animals ; Chromatin/metabolism ; Chromosomes/metabolism ; Interphase/physiology ; Male ; Meiotic Prophase I/physiology ; Mice ; Mice, Inbred C57BL ; Protein Domains/physiology
Czasopismo naukowe
Tytuł :
A rapidly evolved domain, the SCML2 DNA-binding repeats, contributes to chromatin binding of mouse SCML2†.
Autorzy :
Maezawa S; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.
Alavattam KG; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Tatara M; Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.
Nagai R; Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.
Barski A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Allergy and Immunology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Namekawa SH; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
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Źródło :
Biology of reproduction [Biol Reprod] 2019 Feb 01; Vol. 100 (2), pp. 409-419.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Evolution, Molecular*
Polycomb-Group Proteins/*genetics
Animals ; Cell Line ; Chromatin ; DNA-Binding Proteins ; Gene Expression Regulation ; Histones/genetics ; Histones/metabolism ; Mice ; Mice, Knockout ; Phylogeny ; Protein Binding ; Protein Domains ; Recombinant Proteins
Czasopismo naukowe
Tytuł :
Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease.
Autorzy :
Kelly D; Division of Immunobiology, Center for Inflammation and Tolerance.; Division of Gastroenterology, Hepatology, and Nutrition.
Kotliar M; Divisions of Allergy and Immunology and Human Genetics, and.
Woo V; Division of Immunobiology, Center for Inflammation and Tolerance.
Jagannathan S; Divisions of Allergy and Immunology and Human Genetics, and.
Whitt J; Division of Immunobiology, Center for Inflammation and Tolerance.
Moncivaiz J; Division of Immunobiology, Center for Inflammation and Tolerance.
Aronow BJ; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center (CCHMC) and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Dubinsky MC; Department of Pediatrics, Mount Sinai Hospital, New York, New York, USA.
Hyams JS; Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut, USA.
Markowitz JF; Department of Pediatrics, Northwell Health, New York, New York, USA.
Baldassano RN; Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Stephens MC; Department of Pediatric Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA.
Walters TD; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
Kugathasan S; Division of Pediatric Gastroenterology, Emory University School of Medicine, Atlanta, Georgia, USA.
Haberman Y; Division of Gastroenterology, Hepatology, and Nutrition.; Sheba Medical Center, Tel Hashomer, affiliated with the Tel-Aviv University, Israel.
Sundaram N; Division of Pediatric General and Thoracic Surgery, CCHMC and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Rosen MJ; Division of Gastroenterology, Hepatology, and Nutrition.
Helmrath M; Division of Pediatric General and Thoracic Surgery, CCHMC and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Karns R; Division of Gastroenterology, Hepatology, and Nutrition.
Barski A; Divisions of Allergy and Immunology and Human Genetics, and.
Denson LA; Division of Gastroenterology, Hepatology, and Nutrition.
Alenghat T; Division of Immunobiology, Center for Inflammation and Tolerance.
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Źródło :
JCI insight [JCI Insight] 2018 Sep 20; Vol. 3 (18). Date of Electronic Publication: 2018 Sep 20 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Inflammation*
Crohn Disease/*metabolism
Gastrointestinal Microbiome/*physiology
Adolescent ; Animals ; Child ; Epithelial Cells/metabolism ; Female ; Histones/metabolism ; Humans ; Ileum ; Male ; Methylation ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
SCML2 promotes heterochromatin organization in late spermatogenesis.
Autorzy :
Maezawa S; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA .; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 49267, USA.; Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan.
Hasegawa K; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 49267, USA.
Alavattam KG; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 49267, USA.
Funakoshi M; Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan.
Sato T; Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan.
Barski A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 49267, USA.; Division of Allergy and Immunology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Namekawa SH; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA .; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 49267, USA.
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Źródło :
Journal of cell science [J Cell Sci] 2018 Sep 03; Vol. 131 (17). Date of Electronic Publication: 2018 Sep 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Spermatogenesis*
Heterochromatin/*metabolism
Polycomb-Group Proteins/*metabolism
Spermatids/*metabolism
Animals ; Gene Expression Regulation, Developmental ; Heterochromatin/genetics ; Histones/genetics ; Histones/metabolism ; Male ; Meiosis ; Mice, Inbred C57BL ; Mice, Knockout ; Polycomb Repressive Complex 1/genetics ; Polycomb Repressive Complex 1/metabolism ; Polycomb-Group Proteins/genetics ; Spermatids/cytology
Czasopismo naukowe
Tytuł :
Reuse of public, genome-wide, murine eosinophil expression data for hypotheses development.
Autorzy :
Grace JO; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Malik A; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Reichman H; Department of Clinical Microbiology and Immunology, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
Munitz A; Department of Clinical Microbiology and Immunology, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
Barski A; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Fulkerson PC; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2018 Jul; Vol. 104 (1), pp. 185-193. Date of Electronic Publication: 2018 May 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Databases, Genetic*
Eosinophils*
Genome-Wide Association Study*
Animals ; Mice ; Research Design
Czasopismo naukowe
Tytuł :
Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline.
Autorzy :
Maezawa S; Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229.
Hasegawa K; Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229.
Yukawa M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229.; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Kubo N; Division of Epigenomics and Development, Medical Institute of Bioregulation, and Epigenome Network Research Center, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Sakashita A; Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229.
Alavattam KG; Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229.
Sin HS; Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229.
Kartashov AV; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229.; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Sasaki H; Division of Epigenomics and Development, Medical Institute of Bioregulation, and Epigenome Network Research Center, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Barski A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229.; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Namekawa SH; Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229; .; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 May 08; Vol. 115 (19), pp. 4957-4962. Date of Electronic Publication: 2018 Apr 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Promoter Regions, Genetic*
Histones/*metabolism
Polycomb-Group Proteins/*metabolism
Spermatogenesis/*physiology
Spermatogonia/*metabolism
Animals ; Embryonic Development ; Gene Expression Regulation, Developmental ; Histones/genetics ; Male ; Mice ; Mice, Knockout ; Polycomb-Group Proteins/genetics ; Spermatogonia/cytology
Czasopismo naukowe
Tytuł :
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity.
Autorzy :
Harley JB; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. .; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. .; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. .; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. .; US Department of Veterans Affairs Medical Center, Cincinnati, OH, USA. .
Chen X; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Pujato M; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Miller D; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Maddox A; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Forney C; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Magnusen AF; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Lynch A; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Chetal K; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Yukawa M; Division of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Barski A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Salomonis N; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Kaufman KM; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; US Department of Veterans Affairs Medical Center, Cincinnati, OH, USA.
Kottyan LC; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. .; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. .
Weirauch MT; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. .; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. .; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. .; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. .
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Źródło :
Nature genetics [Nat Genet] 2018 May; Vol. 50 (5), pp. 699-707. Date of Electronic Publication: 2018 Apr 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Epstein-Barr Virus Nuclear Antigens/*genetics
Epstein-Barr Virus Nuclear Antigens/*immunology
Transcription Factors/*genetics
Viral Proteins/*genetics
Viral Proteins/*immunology
Autoimmunity/genetics ; Cell Line ; Cell Line, Tumor ; DNA-Binding Proteins/genetics ; Herpesvirus 4, Human/genetics ; Humans ; Lupus Erythematosus, Systemic/genetics ; Maximum Tolerated Dose ; Neoplasms/genetics ; Phenotype ; Protein Binding ; Regulatory Sequences, Nucleic Acid
Czasopismo naukowe
Tytuł :
TSLP signaling in CD4 T cells programs a pathogenic T helper 2 cell state.
Autorzy :
Rochman Y; Division of Immunobiology and the Center for Systems Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. .; Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
Dienger-Stambaugh K; Division of Immunobiology and the Center for Systems Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Richgels PK; Division of Immunobiology and the Center for Systems Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Lewkowich IP; Division of Immunobiology and the Center for Systems Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Kartashov AV; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Barski A; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Khurana Hershey GK; Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Leonard WJ; Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
Singh H; Division of Immunobiology and the Center for Systems Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. .
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Źródło :
Science signaling [Sci Signal] 2018 Mar 13; Vol. 11 (521). Date of Electronic Publication: 2018 Mar 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
Cytokines/*immunology
Signal Transduction/*immunology
Th2 Cells/*immunology
Adoptive Transfer ; Animals ; Asthma/genetics ; Asthma/immunology ; Asthma/therapy ; CD4-Positive T-Lymphocytes/metabolism ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Cells, Cultured ; Cytokines/genetics ; Cytokines/metabolism ; Female ; Gene Expression Regulation/immunology ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Signal Transduction/genetics ; Th2 Cells/metabolism
Czasopismo naukowe
Tytuł :
RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes.
Autorzy :
Adams SR; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.; Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
Maezawa S; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
Alavattam KG; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
Abe H; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
Sakashita A; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
Shroder M; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
Broering TJ; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
Sroga Rios J; Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
Thomas MA; Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
Lin X; State Key Laboratory of Genetic Engineering, Institute of Genetics, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Price CM; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
Barski A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.; Division of Allergy and Immunology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.
Andreassen PR; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.
Namekawa SH; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
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Źródło :
PLoS genetics [PLoS Genet] 2018 Feb 20; Vol. 14 (2), pp. e1007233. Date of Electronic Publication: 2018 Feb 20 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Histones/*metabolism
Polycomb-Group Proteins/*physiology
Sex Chromosomes/*genetics
Transcriptional Activation/*genetics
Ubiquitin-Protein Ligases/*physiology
Ubiquitination/*genetics
Acetylation ; Animals ; Female ; Male ; Meiosis/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Sex Chromosomes/metabolism ; Spermatids/physiology ; Spermatogenesis/genetics
Czasopismo naukowe
Tytuł :
Dynamic reorganization of open chromatin underlies diverse transcriptomes during spermatogenesis.
Autorzy :
Maezawa S; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 49267, USA.
Yukawa M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 49267, USA.; Division of Allergy and Immunology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Alavattam KG; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 49267, USA.
Barski A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 49267, USA.; Division of Allergy and Immunology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Namekawa SH; Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 49267, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2018 Jan 25; Vol. 46 (2), pp. 593-608.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin/*genetics
Spermatogenesis/*genetics
Spermatozoa/*metabolism
Transcriptome/*genetics
Animals ; Chromatin/metabolism ; Gene Expression Regulation, Developmental ; Histones/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Mitosis/genetics ; Polycomb-Group Proteins/genetics ; Polycomb-Group Proteins/metabolism ; Sex Chromosomes ; Spermatogonia/cytology ; Spermatogonia/metabolism ; Spermatozoa/cytology
Czasopismo naukowe
Tytuł :
Chromatin Preparation from Murine Eosinophils for Genome-Wide Analyses.
Autorzy :
Bouffi C; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Barski A; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Fulkerson PC; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2018; Vol. 1799, pp. 265-274.
Typ publikacji :
Journal Article
MeSH Terms :
Genome-Wide Association Study*
Chromatin/*genetics
Chromatin/*metabolism
Eosinophils/*immunology
Eosinophils/*metabolism
Animals ; Cell Separation/methods ; Chromatin Immunoprecipitation ; Epigenesis, Genetic ; Flow Cytometry ; Gene Expression Regulation ; Mice
Czasopismo naukowe

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