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Tytuł :
Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis.
Autorzy :
Lu P; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA. .
Yamaguchi Y; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Fulton WB; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Wang S; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Zhou Q; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Jia H; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Kovler ML; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Salazar AG; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Sampah M; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Prindle T Jr; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Wipf P; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.
Sodhi CP; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Hackam DJ; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 15; Vol. 12 (1), pp. 1042. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*genetics
Enterocolitis, Necrotizing/*genetics
Indoles/*administration & dosage
Milk, Human/*physiology
Receptors, Aryl Hydrocarbon/*genetics
Toll-Like Receptor 4/*genetics
Animals ; Animals, Newborn ; Basic Helix-Loop-Helix Transcription Factors/agonists ; Basic Helix-Loop-Helix Transcription Factors/immunology ; Cytochrome P-450 CYP1A1/genetics ; Cytochrome P-450 CYP1A1/immunology ; Diet/methods ; Disease Models, Animal ; Enterocolitis, Necrotizing/immunology ; Enterocolitis, Necrotizing/pathology ; Enterocolitis, Necrotizing/prevention & control ; Female ; Gene Expression Regulation ; Humans ; Infant, Newborn ; Infant, Premature ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Ligands ; Maternal Exposure ; Mice ; Pregnancy ; Receptors, Aryl Hydrocarbon/agonists ; Receptors, Aryl Hydrocarbon/immunology ; Signal Transduction ; Swine ; Toll-Like Receptor 4/immunology
Czasopismo naukowe
Tytuł :
Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma.
Autorzy :
Zhang B; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390-9072, USA.
Chen Y; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390-9072, USA.
Shi X; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Zhou M; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390-9072, USA.
Bao L; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390-9072, USA.
Hatanpaa KJ; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390-9072, USA.
Patel T; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
DeBerardinis RJ; Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Wang Y; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390-9072, USA. .; Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, 75390, USA. .
Luo W; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390-9072, USA. .; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX, 75390, USA. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Jan; Vol. 78 (1), pp. 195-206. Date of Electronic Publication: 2020 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acids, Branched-Chain/*metabolism
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Basic Helix-Loop-Helix Transcription Factors/deficiency ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; CRISPR-Cas Systems/genetics ; Cell Hypoxia ; Cell Proliferation ; Cells, Cultured ; Gene Expression Regulation, Neoplastic ; Gene Knockout Techniques ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Glutamic Acid/metabolism ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/deficiency ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Large Neutral Amino Acid-Transporter 1/genetics ; Large Neutral Amino Acid-Transporter 1/metabolism ; Protein Binding ; Transaminases/antagonists & inhibitors ; Transaminases/genetics ; Transaminases/metabolism
Czasopismo naukowe
Tytuł :
Mechanisms Leading to Differential Hypoxia-Inducible Factor Signaling in the Diabetic Kidney: Modulation by SGLT2 Inhibitors and Hypoxia Mimetics.
Autorzy :
Packer M; Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX; Imperial College, London, United Kingdom. Electronic address: .
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Źródło :
American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 2021 Feb; Vol. 77 (2), pp. 280-286. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*drug effects
Diabetes Mellitus, Type 2/*metabolism
Diabetic Nephropathies/*metabolism
Hypoxia/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*drug effects
Kidney/*drug effects
Sodium-Glucose Transporter 2 Inhibitors/*pharmacology
Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cobalt/pharmacology ; Diabetes Mellitus, Type 2/drug therapy ; Diabetic Nephropathies/drug therapy ; Endoplasmic Reticulum Stress/drug effects ; Erythropoiesis/drug effects ; Fibrosis ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Inflammation ; Kidney/metabolism ; Oxidative Stress/drug effects ; Signal Transduction/drug effects ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł :
VHL gene methylation contributes to excessive erythrocytosis in chronic mountain sickness rat model by upregulating the HIF-2α/EPO pathway.
Autorzy :
Yang M; Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province, Xining 810001, China.
Zhu M; Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province, Xining 810001, China; Affiliated Hospital of Qinghai University, Xining 810001, China.
Song K; Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province, Xining 810001, China; Qinghai Provincial People's Hospital, Xining 810001, China.
Wuren T; Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province, Xining 810001, China.
Yan J; Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province, Xining 810001, China.
Ge RL; Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province, Xining 810001, China.
Ji L; Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province, Xining 810001, China; Huadu District People's Hospital of Guangzhou, Guangzhou 510800, China. Electronic address: .
Cui S; Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province, Xining 810001, China; Affiliated Hospital of Qinghai University, Xining 810001, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118873. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*
Altitude Sickness/*physiopathology
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Erythropoietin/*metabolism
Hypoxia/*physiopathology
Polycythemia/*pathology
Von Hippel-Lindau Tumor Suppressor Protein/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Chronic Disease ; Disease Models, Animal ; Erythropoietin/genetics ; Gene Expression Regulation ; Male ; Polycythemia/genetics ; Polycythemia/metabolism ; Rats ; Rats, Sprague-Dawley ; Von Hippel-Lindau Tumor Suppressor Protein/genetics
Czasopismo naukowe
Tytuł :
Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress.
Autorzy :
Rudloff S; Department of Nephrology and Hypertension, Bern University Hospital, Freiburgstrasse 15, 3010, Bern, Switzerland.; Department of Biomedical Research, University of Bern, Freiburgstrasse 15, 3010, Bern, Switzerland.
Janot M; Department of Nephrology and Hypertension, Bern University Hospital, Freiburgstrasse 15, 3010, Bern, Switzerland.; Department of Biomedical Research, University of Bern, Freiburgstrasse 15, 3010, Bern, Switzerland.
Rodriguez S; Department of Nephrology and Hypertension, Bern University Hospital, Freiburgstrasse 15, 3010, Bern, Switzerland.; Department of Biomedical Research, University of Bern, Freiburgstrasse 15, 3010, Bern, Switzerland.; Department of Onco-haematology, Geneva Medical University, Geneva, Switzerland.
Dessalle K; Department of Nephrology and Hypertension, Bern University Hospital, Freiburgstrasse 15, 3010, Bern, Switzerland.; Department of Biomedical Research, University of Bern, Freiburgstrasse 15, 3010, Bern, Switzerland.
Jahnen-Dechent W; Helmholtz-Institute for Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University Medical Faculty, Pauwelsstrasse 30, 52074, Aachen, Germany.
Huynh-Do U; Department of Nephrology and Hypertension, Bern University Hospital, Freiburgstrasse 15, 3010, Bern, Switzerland. .; Department of Biomedical Research, University of Bern, Freiburgstrasse 15, 3010, Bern, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 22; Vol. 12 (1), pp. 549. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Fetal Growth Retardation/*metabolism
Kidney/*metabolism
Reperfusion Injury/*physiopathology
alpha-2-HS-Glycoprotein/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Calcinosis/genetics ; Calcinosis/metabolism ; Disease Models, Animal ; Female ; Fetal Growth Retardation/genetics ; Fibrosis ; Hypoxia ; Inflammation/genetics ; Inflammation/metabolism ; Kidney/pathology ; Macrophage Activation/genetics ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; alpha-2-HS-Glycoprotein/genetics
Czasopismo naukowe
Tytuł :
SARS-CoV-2-induced lung pathology: AHR as a candidate therapeutic target.
Autorzy :
Giovannoni F; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Quintana FJ; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. .; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .
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Źródło :
Cell research [Cell Res] 2021 Jan; Vol. 31 (1), pp. 1-2.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*/drug therapy
COVID-19*/metabolism
COVID-19*/pathology
Drug Delivery Systems*
Antiviral Agents/*therapeutic use
Basic Helix-Loop-Helix Transcription Factors/*antagonists & inhibitors
Receptors, Aryl Hydrocarbon/*antagonists & inhibitors
SARS-CoV-2/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Humans ; Lung/metabolism ; Lung/pathology ; Lung/virology ; Receptors, Aryl Hydrocarbon/metabolism
Czasopismo naukowe
Tytuł :
A bHLH gene NnTT8 of Nelumbo nucifera regulates anthocyanin biosynthesis.
Autorzy :
Deng J; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, 430062, China; Research Center of Buckwheat Industry Technology, Guizhou Normal University, Guiyang, 550001, China. Electronic address: .
Li J; Hubei Province Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, College of Life Science and Technology, Hubei Engineering University, Xiaogan, Hubei, 432000, China. Electronic address: .
Su M; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, 430062, China. Electronic address: .
Lin Z; Institute of Oceanography, Minjiang University, Fuzhou, 350108, China. Electronic address: .
Chen L; Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, PR China. Electronic address: .
Yang P; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, 430062, China. Electronic address: .
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Źródło :
Plant physiology and biochemistry : PPB [Plant Physiol Biochem] 2021 Jan; Vol. 158, pp. 518-523. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article
MeSH Terms :
Nelumbo*/genetics
Nelumbo*/metabolism
Anthocyanins/*biosynthesis
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Plant Proteins/*metabolism
Basic Helix-Loop-Helix Transcription Factors/genetics ; Flowers ; Gene Expression Regulation, Plant ; Plant Proteins/genetics
Czasopismo naukowe
Tytuł :
E2A regulates neural ectoderm fate specification in human embryonic stem cells.
Autorzy :
Yi S; Department of Periodontology, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, Peking University, Beijing 100191, China.
Huang X; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, Peking University, Beijing 100191, China.
Zhou S; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, Peking University, Beijing 100191, China.
Zhou Y; Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Anderson MK; Department of Immunology, University of Toronto, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada.
Zúñiga-Pflücker JC; Department of Immunology, University of Toronto, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada.
Luan Q; Department of Periodontology, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China .
Li Y; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, Peking University, Beijing 100191, China .
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Źródło :
Development (Cambridge, England) [Development] 2020 Dec 13; Vol. 147 (23). Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*genetics
GPI-Linked Proteins/*genetics
Human Embryonic Stem Cells/*cytology
Intercellular Signaling Peptides and Proteins/*genetics
Neoplasm Proteins/*genetics
Nodal Protein/*genetics
Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors ; Cell Differentiation/genetics ; Cell Lineage/genetics ; Ectoderm/growth & development ; Ectoderm/metabolism ; Epigenesis, Genetic/genetics ; Gene Expression Regulation, Developmental/genetics ; Genome, Human/genetics ; Human Embryonic Stem Cells/metabolism ; Humans ; Neural Stem Cells/cytology ; Nodal Protein/antagonists & inhibitors ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
PCP4/PEP19 downregulates neurite outgrowth via transcriptional regulation of Ascl1 and NeuroD1 expression in human neuroblastoma M17 cells.
Autorzy :
Kitazono I; Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Hamada T; Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Yoshimura T; Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Kirishima M; Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Yokoyama S; Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Akahane T; Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Tanimoto A; Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. .
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Źródło :
Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2020 Dec; Vol. 100 (12), pp. 1551-1563. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
Nerve Tissue Proteins*/genetics
Nerve Tissue Proteins*/metabolism
Nerve Tissue Proteins*/pharmacology
Neuronal Outgrowth*/drug effects
Neuronal Outgrowth*/genetics
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Neuroblastoma/*metabolism
Adult ; Aged ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Child ; Child, Preschool ; Down-Regulation/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Recombinant Fusion Proteins/pharmacology
Czasopismo naukowe
Tytuł :
Biochemical properties of human full-length aryl hydrocarbon receptor (AhR).
Autorzy :
Uemura S; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Nakajima Y; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Yoshida Y; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Furuya M; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Matsutani S; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Kawate S; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Ikeda SI; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Tsuji N; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Grave E; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Wakui H; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Itoh H; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
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Źródło :
Journal of biochemistry [J Biochem] 2020 Sep 01; Vol. 168 (3), pp. 285-294.
Typ publikacji :
Journal Article
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*chemistry
Basic Helix-Loop-Helix Transcription Factors/*metabolism
HSP90 Heat-Shock Proteins/*metabolism
Nuclear Proteins/*metabolism
Prostaglandin-E Synthases/*metabolism
Receptors, Aryl Hydrocarbon/*chemistry
Receptors, Aryl Hydrocarbon/*metabolism
Trans-Activators/*metabolism
Antibodies/immunology ; Basic Helix-Loop-Helix Transcription Factors/immunology ; Basic Helix-Loop-Helix Transcription Factors/isolation & purification ; Escherichia coli/genetics ; Escherichia coli/metabolism ; HSP90 Heat-Shock Proteins/immunology ; HeLa Cells ; Humans ; Ligands ; Nuclear Proteins/immunology ; Prostaglandin-E Synthases/immunology ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Receptors, Aryl Hydrocarbon/immunology ; Receptors, Aryl Hydrocarbon/isolation & purification ; Trans-Activators/immunology
Czasopismo naukowe
Tytuł :
HLH-11 modulates lipid metabolism in response to nutrient availability.
Autorzy :
Li Y; State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking University, 100871, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, China.; Academy for Advanced Interdisciplinary Studies, Peking University, 100871, Beijing, China.
Ding W; Laboratory of Bioinformatics and Genomic Medicine, Institute of Molecular Medicine, Peking University, 100871, Beijing, China.
Li CY; Laboratory of Bioinformatics and Genomic Medicine, Institute of Molecular Medicine, Peking University, 100871, Beijing, China.
Liu Y; State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking University, 100871, Beijing, China. .; Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, China. .; Beijing Advanced Innovation Center for Genomics, Peking University, 100871, Beijing, China. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 24; Vol. 11 (1), pp. 5959. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors*/genetics
Basic Helix-Loop-Helix Transcription Factors*/metabolism
Caenorhabditis elegans*/genetics
Caenorhabditis elegans*/metabolism
Lipid Metabolism/*genetics
Animals ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Gene Expression Regulation ; RNA Interference ; Starvation/metabolism
Czasopismo naukowe
Tytuł :
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR.
Autorzy :
Smith AK; Emory University, Department of Gynecology and Obstetrics, Atlanta, GA, USA. .; Emory University, Department of Psychiatry & Behavioral Sciences, Atlanta, GA, USA. .
Ratanatharathorn A; Columbia University, Department of Epidemiology, New York, NY, USA.
Maihofer AX; University of California San Diego, Department of Psychiatry, La Jolla, CA, USA.
Naviaux RK; University of California, The Mitochondrial and Metabolic Disease Center, Departments of Medicine, Pediatrics, and Pathology, San Diego, CA, USA.
Aiello AE; University of North Carolina, Gillings School of Global Public Health, Department of Epidemiology, Chapel Hill, NC, USA.
Amstadter AB; Virginia Commonwealth University, Department of Psychiatry, Richmond, VA, USA.
Ashley-Koch AE; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Baker DG; University of California San Diego, Department of Psychiatry, La Jolla, CA, USA.; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; Veterans Affairs Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Beckham JC; VA Mid-Atlantic, Mental Illness Research, Education, and Clinical Center, Durham, NC, USA.; Veterans Affairs Durham Healthcare System, Durham, NC, USA.; Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA.
Boks MP; University Medical Center Utrecht, Brain Center Rudolf Magnus, Utrecht, The Netherlands.
Bromet E; State University of New York at Stony Brook, Epidemiology Research Group, Stony Brook, NY, USA.
Dennis M; VA Mid-Atlantic, Mental Illness Research, Education, and Clinical Center, Durham, NC, USA.; Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA.
Galea S; Boston University, School of Public Health, Boston, MA, USA.
Garrett ME; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Geuze E; University Medical Center Utrecht, Brain Center Rudolf Magnus, Utrecht, The Netherlands.; Netherlands Ministry of Defence, Brain Research and Innovation Centre, Utrecht, The Netherlands.
Guffanti G; McLean Hospital, Division of Depression and Anxiety, Belmont, MA, USA.; Harvard Medical School, Boston, MA, USA.
Hauser MA; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.; Duke University, Department of Medicine, Durham, NC, USA.
Katrinli S; Emory University, Department of Gynecology and Obstetrics, Atlanta, GA, USA.
Kilaru V; Emory University, Department of Gynecology and Obstetrics, Atlanta, GA, USA.
Kessler RC; Harvard Medical School, Boston, MA, USA.
Kimbrel NA; VA Mid-Atlantic, Mental Illness Research, Education, and Clinical Center, Durham, NC, USA.; Veterans Affairs Durham Healthcare System, Durham, NC, USA.; Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA.
Koenen KC; Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.; Massachusetts General Hospital, Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Department of Psychiatry, Boston, MA, USA.; Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Kuan PF; State University of New York at Stony Brook, Department of Applied Mathematics and Statistics, Stony Brook, NY, USA.
Li K; University of California, The Mitochondrial and Metabolic Disease Center, Department of Medicine, San Diego, CA, USA.
Logue MW; National Center for PTSD, Behavioral Science Division at VA Boston Healthcare System, Boston, MA, USA.; Boston University School of Medicine, Department of Psychiatry, Boston, MA, USA.; Boston University School of Medicine, Department of Medicine (Biomedical Genetics), Boston, MA, USA.; Boston University School of Public Health, Department of Biostatistics, Boston, MA, USA.
Lori A; Emory University, Department of Psychiatry & Behavioral Sciences, Atlanta, GA, USA.
Luft BJ; State University of New York at Stony Brook, Department of Medicine, Stony Brook, NY, USA.
Miller MW; National Center for PTSD, Behavioral Science Division at VA Boston Healthcare System, Boston, MA, USA.; Boston University School of Medicine, Department of Psychiatry, Boston, MA, USA.
Naviaux JC; University of California, The Mitochondrial and Metabolic Disease Center, Department of Neuroscience, San Diego, CA, USA.
Nugent NR; Brown University, Psychiatry and Human Behavior, Department of Pediatric Research, Providence, RI, USA.
Qin X; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Ressler KJ; Emory University, Department of Psychiatry & Behavioral Sciences, Atlanta, GA, USA.; McLean Hospital, Division of Depression and Anxiety, Belmont, MA, USA.; Harvard Medical School, Boston, MA, USA.
Risbrough VB; University of California San Diego, Department of Psychiatry, La Jolla, CA, USA.; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; Veterans Affairs Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Rutten BPF; Maastricht University Medical Centre, School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht, The Netherlands.
Stein MB; University of California San Diego, Department of Psychiatry, La Jolla, CA, USA.; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; University of California San Diego, Department of Family Medicine and Public Health, La Jolla, CA, USA.
Ursano RJ; Uniformed Services University School of Medicine, Center for the Study of Traumatic Stress, Bethesda, MD, USA.
Vermetten E; University Medical Center Utrecht, Brain Center Rudolf Magnus, Utrecht, The Netherlands.; Uniformed Services University School of Medicine, Center for the Study of Traumatic Stress, Bethesda, MD, USA.; Leiden University Medical Center, Department of Psychiatry, Leiden, The Netherlands.; Netherlands Defense Department, Research Center, Utrecht, UT, The Netherlands.; Arq Psychotrauma Expert Group, Diemen, The Netherlands.
Vinkers CH; Amsterdam UMC (location VUmc), Department of Psychiatry, Amsterdam, The Netherlands.; Amsterdam UMC (location VUmc), Department of Anatomy and Neurosciences, Amsterdam, The Netherlands.
Wang L; University of California, The Mitochondrial and Metabolic Disease Center, Department of Medicine, San Diego, CA, USA.
Youssef NA; Medical College of Georgia at Augusta University, Department of Psychiatry and Human Behavior and Office of Academic Affairs, Augusta, GA, USA.
Uddin M; University of South Florida, College of Public Health, Tampa, FL, USA.
Nievergelt CM; University of California San Diego, Department of Psychiatry, La Jolla, CA, USA.; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; Veterans Affairs Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
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Corporate Authors :
INTRuST Clinical Consortium
VA Mid-Atlantic MIRECC Workgroup
PGC PTSD Epigenetics Workgroup
Źródło :
Nature communications [Nat Commun] 2020 Nov 24; Vol. 11 (1), pp. 5965. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors*/blood
Basic Helix-Loop-Helix Transcription Factors*/genetics
DNA Methylation*
Repressor Proteins*/blood
Repressor Proteins*/genetics
Stress Disorders, Post-Traumatic*/genetics
Stress Disorders, Post-Traumatic*/metabolism
Case-Control Studies ; Cohort Studies ; Epigenesis, Genetic ; Epigenome ; Female ; Humans ; Kynurenine/metabolism ; Male ; Military Personnel ; Wounds and Injuries/genetics ; Wounds and Injuries/metabolism
Czasopismo naukowe
Tytuł :
Hypoxia-inducible factor signaling in pulmonary hypertension.
Autorzy :
Pullamsetti SS; Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research (DZL), member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany.; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center, member of the DZL and CPI, Justus Liebig University, Giessen, Germany.
Mamazhakypov A; Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research (DZL), member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany.
Weissmann N; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center, member of the DZL and CPI, Justus Liebig University, Giessen, Germany.
Seeger W; Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research (DZL), member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany.; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center, member of the DZL and CPI, Justus Liebig University, Giessen, Germany.; Institute for Lung Health (ILH), Justus Liebig University, Giessen, Germany.
Savai R; Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, member of the German Center for Lung Research (DZL), member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany.; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center, member of the DZL and CPI, Justus Liebig University, Giessen, Germany.; Institute for Lung Health (ILH), Justus Liebig University, Giessen, Germany.; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Nov 02; Vol. 130 (11), pp. 5638-5651.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Hypertension, Pulmonary*/genetics
Hypertension, Pulmonary*/metabolism
Hypertension, Pulmonary*/therapy
Signal Transduction*
Vascular Remodeling*
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Pulmonary Artery/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Heart Failure/genetics ; Heart Failure/metabolism ; Heart Failure/therapy ; Humans ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression.
Autorzy :
Kim H; Center for RNA Research, Institute for Basic Science, 08826, Seoul, South Korea.; Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826, Seoul, South Korea.
Cho Y; Center for RNA Research, Institute for Basic Science, 08826, Seoul, South Korea.; Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826, Seoul, South Korea.
Kim HS; Center for RNA Research, Institute for Basic Science, 08826, Seoul, South Korea.; Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826, Seoul, South Korea.
Kang D; Center for RNA Research, Institute for Basic Science, 08826, Seoul, South Korea.; Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826, Seoul, South Korea.
Cheon D; Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826, Seoul, South Korea.
Kim YJ; Department of Radiation Oncology, Ewha Womans University College of Medicine, 07985, Seoul, South Korea.
Chang MJ; Department of Orthopaedic Surgery, Seoul National University College of Medicine, Boramae Hospital, 07061, Seoul, South Korea.
Lee KM; Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, 13620, Seongnam, South Korea.
Chang CB; Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, 13620, Seongnam, South Korea.
Kang SB; Department of Orthopaedic Surgery, Seoul National University College of Medicine, Boramae Hospital, 07061, Seoul, South Korea.
Kang HG; Orthopedic Oncology Clinic, Specific Organs Cancer Branch, Research Institute and Hospital, National Cancer Center, 10408, Goyang, South Korea.
Kim JH; Center for RNA Research, Institute for Basic Science, 08826, Seoul, South Korea. .; Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826, Seoul, South Korea. .; Interdisciplinary Program in Bioinformatics, Seoul National University, 08826, Seoul, South Korea. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 06; Vol. 11 (1), pp. 5023. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*genetics
Bone Neoplasms/*drug therapy
Bone Neoplasms/*pathology
Chondrosarcoma/*drug therapy
Chondrosarcoma/*pathology
Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Benzimidazoles/administration & dosage ; Bone Neoplasms/genetics ; Cell Line, Tumor ; Chondrosarcoma/genetics ; Cisplatin/administration & dosage ; Female ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Isocitrate Dehydrogenase/genetics ; Mice, Nude ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
EPAS1 regulates proliferation of erythroblasts in chronic mountain sickness.
Autorzy :
Liu H; Research Center for High Altitude Medicine, Qinghai University, Xining, China; Qinghai Key Laboratory of Science and Technology for High Altitude Medicine, Xining, China; Qinghai-Utah Joint Research Key Lab for High Altitude Medicine, Xining, China; Department of Rheumatology, Affiliated Hospital of Qinghai University, Xining, China.
Tang F; Research Center for High Altitude Medicine, Qinghai University, Xining, China; Qinghai Key Laboratory of Science and Technology for High Altitude Medicine, Xining, China; Qinghai-Utah Joint Research Key Lab for High Altitude Medicine, Xining, China.
Su J; Department of Rheumatology, Affiliated Hospital of Qinghai University, Xining, China.
Ma J; Department of Hematology, Affiliated Hospital of Qinghai University, Xining, China.
Qin Y; Department of Rheumatology, Affiliated Hospital of Qinghai University, Xining, China.
Ji L; Department of Hematology, Affiliated Hospital of Qinghai University, Xining, China.
Geng H; Department of Rheumatology, Affiliated Hospital of Qinghai University, Xining, China.
Wang S; Research Center for High Altitude Medicine, Qinghai University, Xining, China; Qinghai Key Laboratory of Science and Technology for High Altitude Medicine, Xining, China; Qinghai-Utah Joint Research Key Lab for High Altitude Medicine, Xining, China.
Zhang P; Research Center for High Altitude Medicine, Qinghai University, Xining, China; Qinghai Key Laboratory of Science and Technology for High Altitude Medicine, Xining, China; Qinghai-Utah Joint Research Key Lab for High Altitude Medicine, Xining, China.
Liu J; Research Center for High Altitude Medicine, Qinghai University, Xining, China; Qinghai Key Laboratory of Science and Technology for High Altitude Medicine, Xining, China; Qinghai-Utah Joint Research Key Lab for High Altitude Medicine, Xining, China.
Cui S; Department of Hematology, Affiliated Hospital of Qinghai University, Xining, China.
Ge RL; Research Center for High Altitude Medicine, Qinghai University, Xining, China; Qinghai Key Laboratory of Science and Technology for High Altitude Medicine, Xining, China; Qinghai-Utah Joint Research Key Lab for High Altitude Medicine, Xining, China.
Li Z; Department of Rheumatology, Affiliated Hospital of Qinghai University, Xining, China. Electronic address: .
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Źródło :
Blood cells, molecules & diseases [Blood Cells Mol Dis] 2020 Sep; Vol. 84, pp. 102446. Date of Electronic Publication: 2020 May 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Altitude Sickness/*metabolism
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Erythroblasts/*pathology
Adult ; Altitude Sickness/genetics ; Altitude Sickness/pathology ; Basic Helix-Loop-Helix Transcription Factors/analysis ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Cycle ; Cell Line ; Cell Proliferation ; Chronic Disease ; Erythroblasts/cytology ; Erythroblasts/metabolism ; Humans ; Middle Aged ; Transcriptome ; Up-Regulation
Czasopismo naukowe
Tytuł :
Dissecting Hes-centred transcriptional networks in neural stem cell maintenance and tumorigenesis in Drosophila .
Autorzy :
Magadi SS; Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology Hellas, 70013 Heraklion, Crete, Greece.; Department of Biology, University of Crete, 70013 Heraklion, Crete, Greece.
Voutyraki C; Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology Hellas, 70013 Heraklion, Crete, Greece.; Department of Biology, University of Crete, 70013 Heraklion, Crete, Greece.
Anagnostopoulos G; Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology Hellas, 70013 Heraklion, Crete, Greece.; Department of Biology, University of Crete, 70013 Heraklion, Crete, Greece.
Zacharioudaki E; Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology Hellas, 70013 Heraklion, Crete, Greece.
Poutakidou IK; Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology Hellas, 70013 Heraklion, Crete, Greece.; Department of Biology, University of Crete, 70013 Heraklion, Crete, Greece.
Efraimoglou C; Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology Hellas, 70013 Heraklion, Crete, Greece.; Department of Biology, University of Crete, 70013 Heraklion, Crete, Greece.
Stapountzi M; Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology Hellas, 70013 Heraklion, Crete, Greece.
Theodorou V; Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology Hellas, 70013 Heraklion, Crete, Greece.
Nikolaou C; Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology Hellas, 70013 Heraklion, Crete, Greece.; Department of Biology, University of Crete, 70013 Heraklion, Crete, Greece.
Koumbanakis KA; Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology Hellas, 70013 Heraklion, Crete, Greece.; Department of Biology, University of Crete, 70013 Heraklion, Crete, Greece.
Fullard JF; Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology Hellas, 70013 Heraklion, Crete, Greece.
Delidakis C; Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology Hellas, 70013 Heraklion, Crete, Greece .; Department of Biology, University of Crete, 70013 Heraklion, Crete, Greece.
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Źródło :
Development (Cambridge, England) [Development] 2020 Nov 23; Vol. 147 (22). Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Regulatory Networks*
Signal Transduction*
Transcription, Genetic*
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Carcinogenesis/*metabolism
DNA-Binding Proteins/*metabolism
Drosophila Proteins/*metabolism
Neural Stem Cells/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Carcinogenesis/genetics ; DNA-Binding Proteins/genetics ; Drosophila Proteins/genetics ; Drosophila melanogaster ; Receptors, Notch/genetics ; Receptors, Notch/metabolism
Czasopismo naukowe
Tytuł :
SIRT2 modulates VEGFD-associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer.
Autorzy :
Hu A; Department of Otolaryngology-Head and Neck Surgery, Gongli Hospital, Second Military Medical University, Shanghai, China.
Yang LY; Department of Otolaryngology-Head and Neck Surgery, Gongli Hospital, Second Military Medical University, Shanghai, China.
Liang J; Department of Otolaryngology-Head and Neck Surgery, Gongli Hospital, Second Military Medical University, Shanghai, China.
Lu D; Department of Otolaryngology-Head and Neck Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang JL; Department of Otolaryngology, Jinqiao Community Health Service Center, Shanghai, China.
Cao FF; Department of Sino-French Cooperative Central Lab, Gongli Hospital, Second Military Medical University, Shanghai, China.
Fu JY; Department of Otolaryngology-Head and Neck Surgery, Gongli Hospital, Second Military Medical University, Shanghai, China.
Dai WJ; Department of Otolaryngology-Head and Neck Surgery, Gongli Hospital, Second Military Medical University, Shanghai, China.
Zhang JF; Department of Otolaryngology-Head and Neck Surgery, Gongli Hospital, Second Military Medical University, Shanghai, China.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2020 Nov; Vol. 59 (11), pp. 1280-1291. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Lymphangiogenesis*
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Biomarkers, Tumor/*metabolism
Head and Neck Neoplasms/*pathology
Sirtuin 2/*metabolism
Vascular Endothelial Growth Factor D/*metabolism
Acetylation ; Animals ; Apoptosis ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Biomarkers, Tumor/genetics ; Cell Proliferation ; Female ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Humans ; Lymphatic Metastasis ; Mice ; Mice, Nude ; Neoplasm Invasiveness ; Sirtuin 2/genetics ; Tumor Cells, Cultured ; Vascular Endothelial Growth Factor D/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
HIF-2α is indispensable for regulatory T cell function.
Autorzy :
Hsu TS; Institute of Molecular Biology, Academia Sinica, 11529, Taipei, Taiwan.
Lin YL; Institute of Molecular Biology, Academia Sinica, 11529, Taipei, Taiwan.
Wang YA; Institute of Molecular Biology, Academia Sinica, 11529, Taipei, Taiwan.
Mo ST; Institute of Molecular Biology, Academia Sinica, 11529, Taipei, Taiwan.
Chi PY; Institute of Biomedical Sciences, Academia Sinica, 11529, Taipei, Taiwan.
Lai AC; Institute of Biomedical Sciences, Academia Sinica, 11529, Taipei, Taiwan.
Pan HY; Institute of Molecular Biology, Academia Sinica, 11529, Taipei, Taiwan.
Chang YJ; Institute of Biomedical Sciences, Academia Sinica, 11529, Taipei, Taiwan.
Lai MZ; Institute of Molecular Biology, Academia Sinica, 11529, Taipei, Taiwan. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 06; Vol. 11 (1), pp. 5005. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*metabolism
T-Lymphocytes, Regulatory/*physiology
Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Bronchial Hyperreactivity/genetics ; CD4-Positive T-Lymphocytes/cytology ; Cell Differentiation ; Cellular Reprogramming ; Colitis/etiology ; Colitis/pathology ; Colonic Neoplasms/genetics ; Colonic Neoplasms/pathology ; Female ; Forkhead Transcription Factors/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Interleukin-17/metabolism ; Male ; Melanoma/genetics ; Melanoma/pathology ; Mice, Knockout ; T-Lymphocytes, Regulatory/metabolism
Czasopismo naukowe
Tytuł :
Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury.
Autorzy :
Lissner MM; Department of Microbiology and Immunology, Stanford University, Stanford, United States.
Cumnock K; Department of Microbiology and Immunology, Stanford University, Stanford, United States.
Davis NM; Department of Microbiology and Immunology, Stanford University, Stanford, United States.
Vilches-Moure JG; Department of Comparative Medicine, Stanford University, Stanford, United States.
Basak P; Department of Microbiology and Immunology, Stanford University, Stanford, United States.
Navarrete DJ; Department of Microbiology and Immunology, Stanford University, Stanford, United States.
Allen JA; Division of Health, Mathematics and Science, Columbia College, Columbia, United States.
Schneider D; Department of Microbiology and Immunology, Stanford University, Stanford, United States.
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Źródło :
ELife [Elife] 2020 Oct 06; Vol. 9. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Acute Kidney Injury/*genetics
Basic Helix-Loop-Helix Transcription Factors/*genetics
Malaria, Falciparum/*metabolism
Receptors, Aryl Hydrocarbon/*genetics
Acute Kidney Injury/metabolism ; Acute Kidney Injury/parasitology ; Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Female ; Malaria, Falciparum/complications ; Male ; Metabolome ; Mice ; Mice, Inbred C57BL ; Plasmodium falciparum/physiology ; Receptors, Aryl Hydrocarbon/metabolism
Czasopismo naukowe
Tytuł :
Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks.
Autorzy :
Elliott KH; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.; Division of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.; Graduate Program in Molecular and Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, United States.
Chen X; Center for Autoimmune Genomics and Etiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Salomone J; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.; Graduate Program in Molecular and Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, United States.; Medical-Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, United States.
Chaturvedi P; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Schultz PA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.; Division of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Balchand SK; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.; Division of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Servetas JD; Jackson Laboratory, Bar Harbor, United States.
Zuniga A; Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
Zeller R; Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
Gebelein B; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Weirauch MT; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.; Center for Autoimmune Genomics and Etiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Peterson KA; Jackson Laboratory, Bar Harbor, United States.
Brugmann SA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.; Division of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.; Shriners Children's Hospital, Cincinnati, United States.
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Źródło :
ELife [Elife] 2020 Oct 02; Vol. 9. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Maxillofacial Development*/genetics
Basic Helix-Loop-Helix Transcription Factors/*genetics
Mice/*genetics
Nerve Tissue Proteins/*genetics
Skull/*growth & development
Zinc Finger Protein Gli3/*genetics
Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Female ; Male ; Mice/metabolism ; Models, Animal ; Nerve Tissue Proteins/metabolism ; Skull/metabolism ; Zinc Finger Protein Gli3/metabolism
Czasopismo naukowe

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