McGaunn J; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. BaurJA; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Jun 09; Vol. 380 (6649), pp. 1010-1011. Date of Electronic Publication: 2023 Jun 08.
Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes.
Autorzy:
Chandramouleeswaran PM; Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Guha M; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, United States of America. Shimonosono M; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, United States of America. Whelan KA; Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, United States of America. Maekawa H; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, United States of America. Sachdeva UM; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, United States of America.; Division of Thoracic Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America. Ruthel G; Department of Biomedical Sciences, Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Mukherjee S; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Engel N; Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Gonzalez MV; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America. Garifallou J; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America. Ohashi S; Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan. Klein-Szanto AJ; Histopathology Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America. Mesaros CA; Translational Biomarkers Core, Center of Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Blair IA; Translational Biomarkers Core, Center of Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Pellegrino da Silva R; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America. Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America. Noguchi E; Department of Biochemistry and Molecular Biology, College of Medicine, Drexel University, Philadelphia, Pennsylvania, United States of America. BaurJA; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Nakagawa H; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, United States of America.
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Źródło:
PloS one [PLoS One] 2020 Sep 23; Vol. 15 (9), pp. e0239625. Date of Electronic Publication: 2020 Sep 23 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Tissue metabolic profiling shows that saccharopine accumulates during renal ischemic-reperfusion injury, while kynurenine and itaconate accumulate in renal allograft rejection.
Autorzy:
Beier UH; Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Hartung EA; Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Concors S; Department of Transplant Surgery, Penn Transplant Institute, Perelman School of Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, 3400 Spruce Street, 2 Ravdin Courtyard, Philadelphia, PA, 19104, USA. Hernandez PT; Department of Transplant Surgery, Penn Transplant Institute, Perelman School of Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, 3400 Spruce Street, 2 Ravdin Courtyard, Philadelphia, PA, 19104, USA. Wang Z; Department of Transplant Surgery, Penn Transplant Institute, Perelman School of Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, 3400 Spruce Street, 2 Ravdin Courtyard, Philadelphia, PA, 19104, USA. Perry C; Department of Physiology and Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA, 19104, USA. BaurJA; Department of Physiology and Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA, 19104, USA. Denburg MR; Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Hancock WW; Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Biesecker Center for Pediatric Liver Disease, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, 19104, USA. Gade TP; Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA. Levine MH; Department of Transplant Surgery, Penn Transplant Institute, Perelman School of Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, 3400 Spruce Street, 2 Ravdin Courtyard, Philadelphia, PA, 19104, USA. .
Hypothalamic mTORC2 is essential for metabolic health and longevity.
Autorzy:
Chellappa K; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Brinkman JA; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. Mukherjee S; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Morrison M; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. Alotaibi MI; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Endocrinology and Reproductive Physiology Graduate Training Program, University of Wisconsin-Madison, Madison, WI, USA. Carbajal KA; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. Alhadeff AL; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA. Perron IJ; Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Yao R; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Purdy CS; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. DeFelice DM; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Wakai MH; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. Tomasiewicz J; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA. Lin A; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Department of Dairy Science, University of Wisconsin-Madison, Madison, WI, USA. Meyer E; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Department of Dairy Science, University of Wisconsin-Madison, Madison, WI, USA. Peng Y; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA. Arriola Apelo SI; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Department of Dairy Science, University of Wisconsin-Madison, Madison, WI, USA. Puglielli L; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA. Betley JN; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA. Paschos GK; Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; The Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. BaurJA; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Lamming DW; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Endocrinology and Reproductive Physiology Graduate Training Program, University of Wisconsin-Madison, Madison, WI, USA.
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Źródło:
Aging cell [Aging Cell] 2019 Oct; Vol. 18 (5), pp. e13014. Date of Electronic Publication: 2019 Aug 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms.
Autorzy:
Chellappa K; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Perron IJ; Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Naidoo N; Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. BaurJA; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
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Źródło:
Aging cell [Aging Cell] 2019 Jun; Vol. 18 (3), pp. e12874. Date of Electronic Publication: 2019 Mar 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Supplemental arginine vasopressin during the resuscitation of severe hemorrhagic shock preserves renal mitochondrial function.
Autorzy:
Sims CA; The Trauma Center at the University of Pennsylvania, Department of Surgery, Perelman School of Medicine, Philadelphia, PA, United States of America.; Penn Acute Research Collaboration (PARC), University of Pennsylvania, Philadelphia, PA, United States of America. Yuxia G; The Trauma Center at the University of Pennsylvania, Department of Surgery, Perelman School of Medicine, Philadelphia, PA, United States of America. Singh K; The Trauma Center at the University of Pennsylvania, Department of Surgery, Perelman School of Medicine, Philadelphia, PA, United States of America. Werlin EC; Department of Surgery, University of California, San Francisco, San Francisco, CA, United States of America. Reilly PM; The Trauma Center at the University of Pennsylvania, Department of Surgery, Perelman School of Medicine, Philadelphia, PA, United States of America. BaurJA; Penn Acute Research Collaboration (PARC), University of Pennsylvania, Philadelphia, PA, United States of America.; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
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Źródło:
PloS one [PLoS One] 2017 Oct 24; Vol. 12 (10), pp. e0186339. Date of Electronic Publication: 2017 Oct 24 (Print Publication: 2017).
The grapes and wrath: using resveratrol to treat the pathophysiology of hemorrhagic shock.
Autorzy:
Sims CA; The Trauma Center at the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania. BaurJA; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.
Autorzy:
Côté CD; 1] Toronto General Research Institute and Department of Medicine, University Health Network, Toronto, Ontario, Canada. [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. Rasmussen BA; 1] Toronto General Research Institute and Department of Medicine, University Health Network, Toronto, Ontario, Canada. [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. Duca FA; Toronto General Research Institute and Department of Medicine, University Health Network, Toronto, Ontario, Canada. Zadeh-Tahmasebi M; 1] Toronto General Research Institute and Department of Medicine, University Health Network, Toronto, Ontario, Canada. [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. BaurJA; Department of Physiology, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Daljeet M; Toronto General Research Institute and Department of Medicine, University Health Network, Toronto, Ontario, Canada. Breen DM; Toronto General Research Institute and Department of Medicine, University Health Network, Toronto, Ontario, Canada. Filippi BM; Toronto General Research Institute and Department of Medicine, University Health Network, Toronto, Ontario, Canada. Lam TK; 1] Toronto General Research Institute and Department of Medicine, University Health Network, Toronto, Ontario, Canada. [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. [3] Department of Medicine, University of Toronto, Toronto, Ontario, Canada. [4] Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada.
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Źródło:
Nature medicine [Nat Med] 2015 May; Vol. 21 (5), pp. 498-505. Date of Electronic Publication: 2015 Apr 06.
Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism.
Autorzy:
Naidoo N; Division of Sleep Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Davis JG Zhu J Yabumoto M Singletary K Brown M Galante R Agarwal B BaurJA
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Źródło:
Aging cell [Aging Cell] 2014 Feb; Vol. 13 (1), pp. 131-41. Date of Electronic Publication: 2013 Nov 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Are sirtuins viable targets for improving healthspan and lifespan?
Autorzy:
BaurJA; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. baur@mail.med.upenn.edu Ungvari Z Minor RK Le Couteur DG de Cabo R
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Źródło:
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2012 Jun 01; Vol. 11 (6), pp. 443-61. Date of Electronic Publication: 2012 Jun 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review
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