- Tytuł:
- Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington's disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number.
- Autorzy:
- Źródło:
- Stem cell research & therapy [Stem Cell Res Ther] 2015 Feb 19; Vol. 6, pp. 9. Date of Electronic Publication: 2015 Feb 19.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Mesenchymal Stem Cell Transplantation*
Bone Marrow Cells/*cytology
Huntington Disease/*therapy
Mesenchymal Stem Cells/*cytology
Animals ; Behavior, Animal ; Brain/metabolism ; Brain/pathology ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Cells, Cultured ; Disease Models, Animal ; Female ; Humans ; Huntingtin Protein ; Male ; Mesenchymal Stem Cells/metabolism ; Mice ; Mice, Transgenic ; Motor Activity ; Nerve Growth Factor/genetics ; Nerve Growth Factor/metabolism ; Nerve Tissue Proteins/genetics ; Receptor, trkB/genetics ; Receptor, trkB/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe