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Tytuł:
4.5 Defective phosphorylation of the interleukin 18 receptor beta-chain causes impaired NK cell function in systemic onset Juvenile Idiopathic Arthritis
Autorzy:
de Jager W
Vastert SJ
Beekman JM
Wulffraat NM
Kuis W
Coffer PJ
Prakken BJ
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Temat:
Pediatrics
RJ1-570
Diseases of the musculoskeletal system
RC925-935
Źródło:
Pediatric Rheumatology Online Journal, Vol 6, Iss Suppl 1, p S9 (2008)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/1546-0096
Dostęp URL:
https://doaj.org/article/a56f22dcf227407eb86d7f998cbf45df  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
OrgaSegment: deep-learning based organoid segmentation to quantify CFTR dependent fluid secretion.
Autorzy:
Lefferts JW; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.
Kroes S; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.
Smith MB; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.; Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, 3584 CB, Utrecht, The Netherlands.
Niemöller PJ; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.
Nieuwenhuijze NDA; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.; Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, 3584 CB, Utrecht, The Netherlands.
Sonneveld van Kooten HN; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.; Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, 3584 CB, Utrecht, The Netherlands.
van der Ent CK; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.
Beekman JM; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands. j.beekman@umcutrecht.nl.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands. j.beekman@umcutrecht.nl.; Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, 3584 CB, Utrecht, The Netherlands. j.beekman@umcutrecht.nl.
van Beuningen SFB; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands. .; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands. .; Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, 3584 CB, Utrecht, The Netherlands. .
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Źródło:
Communications biology [Commun Biol] 2024 Mar 13; Vol. 7 (1), pp. 319. Date of Electronic Publication: 2024 Mar 13.
Typ publikacji:
Journal Article
MeSH Terms:
Deep Learning*
Cystic Fibrosis*/genetics
Humans ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Intestines ; Organoids
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Exploring intrinsic variability between cultured nasal and bronchial epithelia in cystic fibrosis.
Autorzy:
Rodenburg LW; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA, Utrecht, The Netherlands. .; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT, Utrecht, The Netherlands. .
Metzemaekers M; Department of Pulmonary Medicine, Erasmus University Medical Center, 3015 CE, Rotterdam, The Netherlands.; Department of Cell Biology, Erasmus University Medical Center, 3015 CE, Rotterdam, The Netherlands.
van der Windt IS; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT, Utrecht, The Netherlands.
Smits SMA; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT, Utrecht, The Netherlands.
den Hertog-Oosterhoff LA; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT, Utrecht, The Netherlands.
Kruisselbrink E; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT, Utrecht, The Netherlands.
Brunsveld JE; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT, Utrecht, The Netherlands.
Michel S; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA, Utrecht, The Netherlands.
de Winter-de Groot KM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA, Utrecht, The Netherlands.
van der Ent CK; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA, Utrecht, The Netherlands.
Stadhouders R; Department of Pulmonary Medicine, Erasmus University Medical Center, 3015 CE, Rotterdam, The Netherlands.; Department of Cell Biology, Erasmus University Medical Center, 3015 CE, Rotterdam, The Netherlands.
Beekman JM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT, Utrecht, The Netherlands.; Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, 3584 CB, Utrecht, The Netherlands.
Amatngalim GD; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT, Utrecht, The Netherlands.
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 30; Vol. 13 (1), pp. 18573. Date of Electronic Publication: 2023 Oct 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cystic Fibrosis*/genetics
Cystic Fibrosis*/metabolism
Humans ; Cells, Cultured ; Respiratory Mucosa/metabolism ; Nose ; Epithelial Cells/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CFTR Function Restoration upon Elexacaftor/Tezacaftor/Ivacaftor Treatment in Patient-Derived Intestinal Organoids with Rare CFTR Genotypes.
Autorzy:
Lefferts JW; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, The Netherlands.
Bierlaagh MC; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, The Netherlands.
Kroes S; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, The Netherlands.
Nieuwenhuijze NDA; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, The Netherlands.; Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, 3584 CB Utrecht, The Netherlands.
Sonneveld van Kooten HN; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, The Netherlands.; Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, 3584 CB Utrecht, The Netherlands.
Niemöller PJ; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, The Netherlands.
Verburg TF; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, The Netherlands.
Janssens HM; Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus Medical Center-Sophia Children's Hospital, University Hospital Rotterdam, 3015 CN Rotterdam, The Netherlands.
Muilwijk D; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, The Netherlands.
van Beuningen SFB; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, The Netherlands.; Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, 3584 CB Utrecht, The Netherlands.
van der Ent CK; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, The Netherlands.
Beekman JM; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, The Netherlands.; Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, 3584 CB Utrecht, The Netherlands.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 26; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 26.
Typ publikacji:
Journal Article
MeSH Terms:
Benzodioxoles*/pharmacology
Benzodioxoles*/therapeutic use
Cystic Fibrosis*/drug therapy
Cystic Fibrosis*/genetics
Cystic Fibrosis Transmembrane Conductance Regulator*/genetics
Humans ; Genotype ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids.
Autorzy:
Rodenburg LW; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT Utrecht, The Netherlands.
Delpiano L; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Railean V; BioISI-Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, 1749-016 Lisboa, Portugal.
Centeio R; Physiological Institute, University of Regensburg, D-93053 Regensburg, Germany.
Pinto MC; BioISI-Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, 1749-016 Lisboa, Portugal.
Smits SMA; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT Utrecht, The Netherlands.
van der Windt IS; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT Utrecht, The Netherlands.
van Hugten CFJ; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT Utrecht, The Netherlands.
van Beuningen SFB; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT Utrecht, The Netherlands.; Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, 3584 CB Utrecht, The Netherlands.
Rodenburg RNP; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT Utrecht, The Netherlands.
van der Ent CK; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA Utrecht, The Netherlands.
Amaral MD; BioISI-Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, 1749-016 Lisboa, Portugal.
Kunzelmann K; Physiological Institute, University of Regensburg, D-93053 Regensburg, Germany.
Gray MA; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Beekman JM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT Utrecht, The Netherlands.; Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, 3584 CB Utrecht, The Netherlands.
Amatngalim GD; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, 3584 EA Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, 3584 CT Utrecht, The Netherlands.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Oct 21; Vol. 23 (20). Date of Electronic Publication: 2022 Oct 21.
Typ publikacji:
Journal Article
MeSH Terms:
Cystic Fibrosis Transmembrane Conductance Regulator*/genetics
Cystic Fibrosis Transmembrane Conductance Regulator*/metabolism
Cystic Fibrosis*/drug therapy
Cystic Fibrosis*/genetics
Cystic Fibrosis*/metabolism
Humans ; Organoids/metabolism ; Chlorides/metabolism ; Drug Repositioning ; Epithelial Cells/metabolism ; Adrenergic Agonists/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center.
Autorzy:
Rümke LW; Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Groenveld FC; Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
van Os YMG; Occupational Health Office, Department of Human Resources, University Medical Center Utrecht, Utrecht, the Netherlands.
Praest P; Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Tanja AAN; Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
de Jong DTCM; Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Symons J; Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Schuurman R; Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Reinders T; Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Hofstra LM; Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Nierkens S; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.
Thijsen SFT; Department of Medical Microbiology & Immunology, Utrecht, the Netherlands.
Heron M; Department of Medical Microbiology & Immunology, Utrecht, the Netherlands.
Lebbink RJ; Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Beekman JM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, the Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht, the Netherlands.
Nijhuis M; Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Wensing AMJ; Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
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Źródło:
Open forum infectious diseases [Open Forum Infect Dis] 2021 Nov 06; Vol. 9 (1), pp. ofab553. Date of Electronic Publication: 2021 Nov 06 (Print Publication: 2022).
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A new era for people with cystic fibrosis.
Autorzy:
Bierlaagh MC; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Muilwijk D; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Beekman JM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
van der Ent CK; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands. .
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Źródło:
European journal of pediatrics [Eur J Pediatr] 2021 Sep; Vol. 180 (9), pp. 2731-2739. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cystic Fibrosis*/diagnosis
Cystic Fibrosis*/drug therapy
Quinolones*/therapeutic use
Aminophenols/therapeutic use ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Humans ; Mutation ; Quality of Life
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Modulation of the maladaptive stress response to manage diseases of protein folding.
Autorzy:
Roth DM; Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Hutt DM; Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Tong J; Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Bouchecareilh M; Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Wang N; Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America.
Seeley T; Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Dekkers JF; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands; Laboratory of Translational Immunology, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands.
Beekman JM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands; Laboratory of Translational Immunology, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands.
Garza D; Proteostasis Therapeutics Inc., Cambridge, Massachusetts, United States of America.
Drew L; Proteostasis Therapeutics Inc., Cambridge, Massachusetts, United States of America.
Masliah E; Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America.
Morimoto RI; Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America.
Balch WE; Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America; The Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, California, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2014 Nov 18; Vol. 12 (11), pp. e1001998. Date of Electronic Publication: 2014 Nov 18 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cystic Fibrosis/*etiology
Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism
DNA-Binding Proteins/*genetics
Proteostasis Deficiencies/*genetics
Transcription Factors/*genetics
Animals ; Antineoplastic Agents, Alkylating/therapeutic use ; Caenorhabditis elegans ; Cell Line ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/metabolism ; DNA-Binding Proteins/metabolism ; Diterpenes/therapeutic use ; Drug Evaluation, Preclinical ; Epoxy Compounds/therapeutic use ; Gene Silencing ; Heat Shock Transcription Factors ; Humans ; Intramolecular Oxidoreductases/genetics ; Intramolecular Oxidoreductases/metabolism ; Mice, Transgenic ; Organoids ; Phenanthrenes/therapeutic use ; Prostaglandin-E Synthases ; Protein Folding ; Respiratory Mucosa/metabolism ; Stress, Physiological ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effect of long-term voluntary exercise wheel running on susceptibility to bacterial pulmonary infections in a mouse model.
Autorzy:
van de Weert-van Leeuwen PB; Department of Pediatric Pulmonology, University Medical Centre Utrecht, Utrecht, The Netherlands ; Department of Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands ; Centre for Molecular and Cellular Intervention, University Medical Centre Utrecht, Utrecht, The Netherlands.
de Vrankrijker AM; Department of Pediatric Pulmonology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Fentz J; Department of Nutrition, Exercise and Sports, Section of Molecular Physiology, University of Copenhagen, Copenhagen, Denmark.
Ciofu O; Department of International Health, Immunology and Microbiology, Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Wojtaszewski JF; Department of Nutrition, Exercise and Sports, Section of Molecular Physiology, University of Copenhagen, Copenhagen, Denmark.
Arets HG; Department of Pediatric Pulmonology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Hulzebos HJ; Child Development & Exercise Centre, University Medical Centre Utrecht, Utrecht, The Netherlands.
van der Ent CK; Department of Pediatric Pulmonology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Beekman JM; Department of Pediatric Pulmonology, University Medical Centre Utrecht, Utrecht, The Netherlands ; Department of Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands ; Centre for Molecular and Cellular Intervention, University Medical Centre Utrecht, Utrecht, The Netherlands.
Johansen HK; Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
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Źródło:
PloS one [PLoS One] 2013 Dec 23; Vol. 8 (12), pp. e82869. Date of Electronic Publication: 2013 Dec 23 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Monocytes/*immunology
Neutrophils/*immunology
Physical Conditioning, Animal/*adverse effects
Pseudomonas Infections/*immunology
Respiratory Tract Infections/*immunology
Spleen/*immunology
Animals ; Bacterial Load ; Disease Susceptibility ; Female ; Mice ; Mice, Inbred C57BL ; Monocytes/microbiology ; Monocytes/pathology ; Neutrophils/microbiology ; Neutrophils/pathology ; Phagocytosis ; Pseudomonas Infections/etiology ; Pseudomonas Infections/microbiology ; Pseudomonas Infections/pathology ; Pseudomonas aeruginosa/pathogenicity ; Pseudomonas aeruginosa/physiology ; Respiratory Tract Infections/etiology ; Respiratory Tract Infections/microbiology ; Respiratory Tract Infections/pathology ; Severity of Illness Index ; Spleen/microbiology ; Spleen/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Mechanism-based corrector combination restores ΔF508-CFTR folding and function.
Autorzy:
Okiyoneda T; Department of Physiology, McGill University, Montréal, Quebec, Canada.
Veit G
Dekkers JF
Bagdany M
Soya N
Xu H
Roldan A
Verkman AS
Kurth M
Simon A
Hegedus T
Beekman JM
Lukacs GL
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Źródło:
Nature chemical biology [Nat Chem Biol] 2013 Jul; Vol. 9 (7), pp. 444-54. Date of Electronic Publication: 2013 May 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Aminopyridines/*pharmacology
Benzodioxoles/*pharmacology
Cystic Fibrosis Transmembrane Conductance Regulator/*physiology
Animals ; Binding Sites ; Bronchi/cytology ; Cell Membrane/metabolism ; Cricetinae ; Cystic Fibrosis/genetics ; Cystic Fibrosis/therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/chemistry ; Endoplasmic Reticulum/metabolism ; Epithelial Cells/metabolism ; Glycosylation ; Humans ; Mutation ; Nucleotides/chemistry ; Protein Folding ; Protein Structure, Tertiary ; Recombinant Proteins/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Infection, inflammation and exercise in cystic fibrosis.
Autorzy:
van de Weert-van Leeuwen PB; Department of Paediatric Pulmonology, Cystic Fibrosis Centre, University Medical Centre Utrecht, Utrecht, the Netherlands. />Arets HG
van der Ent CK
Beekman JM
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Źródło:
Respiratory research [Respir Res] 2013 Mar 06; Vol. 14, pp. 32. Date of Electronic Publication: 2013 Mar 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Cystic Fibrosis/*pathology
Cystic Fibrosis/*physiopathology
Exercise/*physiology
Respiratory Tract Infections/*physiopathology
Animals ; Cystic Fibrosis/immunology ; Humans ; Immune Tolerance/physiology ; Inflammation/immunology ; Inflammation/pathology ; Inflammation/physiopathology ; Physical Fitness/physiology ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Apical CFTR expression in human nasal epithelium correlates with lung disease in cystic fibrosis.
Autorzy:
van Meegen MA; Department of Pediatric Pulmonology, University Medical Center Utrecht, Utrecht, The Netherlands.
Terheggen-Lagro SW
Koymans KJ
van der Ent CK
Beekman JM
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Źródło:
PloS one [PLoS One] 2013; Vol. 8 (3), pp. e57617. Date of Electronic Publication: 2013 Mar 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Polarity*
Cystic Fibrosis/*metabolism
Cystic Fibrosis/*pathology
Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism
Nasal Mucosa/*metabolism
Nasal Mucosa/*pathology
Adolescent ; Case-Control Studies ; Child ; Cystic Fibrosis/physiopathology ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Female ; Humans ; Male ; Microscopy, Confocal ; Mutation/genetics ; Protein Transport ; Reproducibility of Results ; Respiratory Function Tests
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Syntenin-mediated regulation of Sox4 proteasomal degradation modulates transcriptional output.
Autorzy:
Beekman JM; Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Vervoort SJ
Dekkers F
van Vessem ME
Vendelbosch S
Brugulat-Panès A
van Loosdregt J
Braat AK
Coffer PJ
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Źródło:
Oncogene [Oncogene] 2012 May 24; Vol. 31 (21), pp. 2668-79. Date of Electronic Publication: 2011 Oct 10.
Typ publikacji:
Journal Article
MeSH Terms:
Proteasome Endopeptidase Complex/*metabolism
SOXC Transcription Factors/*metabolism
Syntenins/*metabolism
Amino Acid Motifs ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Half-Life ; Humans ; RNA Processing, Post-Transcriptional ; Transcriptional Activation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass.
Autorzy:
de Jong PR; Department of Pediatric Intensive Care, University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht, The Netherlands.
Schadenberg AW
van den Broek T
Beekman JM
van Wijk F
Coffer PJ
Prakken BJ
Jansen NJ
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (4), pp. e35070. Date of Electronic Publication: 2012 Apr 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cardiopulmonary Bypass/*adverse effects
Inflammation/*immunology
Monocytes/*immunology
STAT3 Transcription Factor/*immunology
Tumor Necrosis Factor-alpha/*biosynthesis
Child ; Female ; Humans ; I-kappa B Kinase/immunology ; I-kappa B Kinase/metabolism ; Immunity, Innate/immunology ; Inflammation/blood ; Inflammation/etiology ; Interleukin-10/immunology ; Interleukin-10/metabolism ; Interleukin-6/immunology ; Interleukin-6/metabolism ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Lipopolysaccharides/pharmacology ; Male ; Monocytes/drug effects ; Monocytes/metabolism ; NF-kappa B/immunology ; NF-kappa B/metabolism ; STAT3 Transcription Factor/blood ; Signal Transduction ; Thoracic Surgery/methods ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/immunology ; p38 Mitogen-Activated Protein Kinases/immunology ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 30

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