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Tytuł :
Treating amblyopia with liquid crystal glasses: a pilot study.
Autorzy :
Spierer A; Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. />Raz J
Benezra O
Herzog R
Cohen E
Karshai I
Benezra D
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2010 Jul; Vol. 51 (7), pp. 3395-8. Date of Electronic Publication: 2010 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eyeglasses*
Liquid Crystals*
Amblyopia/*therapy
Visual Acuity/*physiology
Amblyopia/etiology ; Amblyopia/physiopathology ; Anisometropia/complications ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Male ; Patient Compliance ; Pilot Projects ; Prospective Studies ; Strabismus/complications ; Time Factors ; Vision, Binocular/physiology
Czasopismo naukowe
Tytuł :
Effects of ciliary muscle plasmid electrotransfer of TNF-alpha soluble receptor variants in experimental uveitis.
Autorzy :
Touchard E; INSERM, U872 Physiopathology of Ocular Diseases: Therapeutic Innovations, 15 rue de l'Ecole de Médecine, Paris, France.
Bloquel C
Bigey P
Kowalczuk L
Jonet L
Thillaye-Goldenberg B
Naud MC
Scherman D
de Kozak Y
Benezra D
Behar-Cohen F
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Źródło :
Gene therapy [Gene Ther] 2009 Jul; Vol. 16 (7), pp. 862-73. Date of Electronic Publication: 2009 May 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ciliary Body/*metabolism
Genetic Therapy/*methods
Muscle, Smooth/*metabolism
Receptors, Tumor Necrosis Factor, Type I/*biosynthesis
Recombinant Fusion Proteins/*biosynthesis
Tumor Necrosis Factor Decoy Receptors/*biosynthesis
Uveitis/*therapy
Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Electroporation/methods ; Endotoxins/adverse effects ; Eye/metabolism ; Female ; Gene Transfer Techniques ; Genes, Reporter ; Humans ; Immunomodulation ; Interleukin-10/metabolism ; Interleukin-6/metabolism ; Lac Operon/genetics ; Leukocyte Rolling ; Microscopy, Confocal ; Nitric Oxide Synthase Type II/metabolism ; Plasmids ; Rats ; Rats, Inbred Lew ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Recombinant Fusion Proteins/metabolism ; Recombinant Fusion Proteins/pharmacology ; Reverse Transcriptase Polymerase Chain Reaction ; Transfection/methods ; Tumor Necrosis Factor Decoy Receptors/metabolism ; Tumor Necrosis Factor-alpha/adverse effects ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Local ocular immunomodulation resulting from electrotransfer of plasmid encoding soluble TNF receptors in the ciliary muscle.
Autorzy :
Kowalczuk L; INSERM UMRS 872 Team17, Centre de Recherches des Cordeliers, Université Pierre et Marie Curie, Université Paris Descartes, Paris, France.
Touchard E
Camelo S
Naud MC
Castaneda B
Brunel N
Besson-Lescure B
Thillaye-Goldenberg B
Bigey P
BenEzra D
de Kozak Y
Behar-Cohen F
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2009 Apr; Vol. 50 (4), pp. 1761-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoimmune Diseases/*therapy
Ciliary Body/*metabolism
Genetic Therapy/*methods
Muscle, Smooth/*metabolism
Plasmids/*genetics
Receptors, Tumor Necrosis Factor, Type I/*genetics
Tumor Necrosis Factor Decoy Receptors/*genetics
Uveitis, Posterior/*therapy
Animals ; Arrestin ; Autoimmune Diseases/metabolism ; Chemokines/metabolism ; Disease Models, Animal ; Electroporation/methods ; Fluorescent Antibody Technique, Indirect ; Gene Expression ; Male ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Rats ; Rats, Inbred Lew ; Reverse Transcriptase Polymerase Chain Reaction ; Uveitis, Posterior/metabolism
Czasopismo naukowe
Tytuł :
Evaluation of the new photosensitizer Stakel (WST-11) for photodynamic choroidal vessel occlusion in rabbit and rat eyes.
Autorzy :
Berdugo M; Centre de Recherche des Cordeliers, Physiopathology of Ocular Diseases: Therapeutic Innovations, UMR S 872, Université Paris Descartes, Paris, France.
Bejjani RA
Valamanesh F
Savoldelli M
Jeanny JC
Blanc D
Ficheux H
Scherz A
Salomon Y
BenEzra D
Behar-Cohen F
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2008 Apr; Vol. 49 (4), pp. 1633-44.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Photochemotherapy*
Bacteriochlorophylls/*therapeutic use
Choroidal Neovascularization/*drug therapy
Photosensitizing Agents/*therapeutic use
Animals ; Bacteriochlorophylls/pharmacokinetics ; Bacteriochlorophylls/toxicity ; Choroid/drug effects ; Choroidal Neovascularization/etiology ; Choroidal Neovascularization/pathology ; Drug Evaluation, Preclinical ; Fluorescein Angiography ; Laser Coagulation ; Photosensitizing Agents/pharmacokinetics ; Photosensitizing Agents/toxicity ; Pigment Epithelium of Eye/drug effects ; Pigment Epithelium of Eye/ultrastructure ; Porphyrins/therapeutic use ; Rabbits ; Rats ; Rats, Inbred BN ; Retina/drug effects ; Retina/ultrastructure ; Verteporfin
Czasopismo naukowe
Tytuł :
Population history and infrequent mutations: how old is a rare mutation? GUCY2D as a worked example.
Autorzy :
Hanein S; Unité de Recherches sur les Handicaps Génétiques de l'Enfant. Hôpital Necker - Enfants Malades, Paris, France.
Perrault I
Gerber S
Delphin N
Benezra D
Shalev S
Carmi R
Feingold J
Dufier JL
Munnich A
Kaplan J
Rozet JM
Jeanpierre M
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Źródło :
European journal of human genetics : EJHG [Eur J Hum Genet] 2008 Jan; Vol. 16 (1), pp. 115-23. Date of Electronic Publication: 2007 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Genetics, Population*
Models, Genetic*
Mutation*
Guanylate Cyclase/*genetics
Receptors, Cell Surface/*genetics
Africa, Northern/ethnology ; Bayes Theorem ; DNA Primers/genetics ; Female ; Founder Effect ; France ; Haplotypes ; Humans ; Linkage Disequilibrium ; Male ; Models, Statistical ; Optic Atrophy, Hereditary, Leber/genetics ; Polymorphism, Single Nucleotide ; Portugal/ethnology ; Sequence Deletion ; Time Factors
Czasopismo naukowe
Tytuł :
Glucocorticoids induce retinal toxicity through mechanisms mainly associated with paraptosis.
Autorzy :
Valamanesh F; INSERM, Physiopathology of ocular diseases: Therapeutic innovations, Institut des Cordeliers, Université René Descartes, Paris, France.
Torriglia A
Savoldelli M
Gandolphe C
Jeanny JC
BenEzra D
Behar-Cohen F
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Źródło :
Molecular vision [Mol Vis] 2007 Sep 19; Vol. 13, pp. 1746-57. Date of Electronic Publication: 2007 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Adrenal Cortex Hormones/*poisoning
Retina/*drug effects
Retina/*pathology
Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/chemistry ; Animals ; Apoptosis ; Autophagy ; Cell Death ; Cell Survival/drug effects ; Cells, Cultured ; Cytoplasm/pathology ; Dose-Response Relationship, Drug ; Humans ; Injections ; Microscopy, Electron ; Necrosis ; Neuroglia/drug effects ; Pigment Epithelium of Eye/drug effects ; Pigment Epithelium of Eye/pathology ; Polysorbates/poisoning ; Rats ; Rats, Inbred Lew ; Retina/physiopathology ; Solubility ; Triamcinolone Acetonide/poisoning ; Vacuoles/pathology ; Vitreous Body ; Water
Czasopismo naukowe
Tytuł :
Nitrosative stress and corneal transplant endothelial cell death during acute graft rejection.
Autorzy :
Bourges JL; INSERM, UMRS, Team 17, Physiopathology of Ocular Diseases, Therapeutic Innovations, Paris, France.
Torriglia A
Valamanesh F
Benezra D
Renard G
Behar-Cohen FF
Pokaż więcej
Źródło :
Transplantation [Transplantation] 2007 Aug 15; Vol. 84 (3), pp. 415-23.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*physiology
Corneal Transplantation/*pathology
Endothelium, Corneal/*pathology
Graft Rejection/*pathology
Peroxynitrous Acid/*physiology
Animals ; Apoptosis/drug effects ; Cell Survival/drug effects ; Cell Survival/physiology ; Corneal Transplantation/physiology ; Endothelium, Corneal/cytology ; Endothelium, Corneal/drug effects ; Graft Rejection/physiopathology ; Humans ; Imines/pharmacology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/antagonists & inhibitors ; Nitrosation ; Peroxynitrous Acid/pharmacology ; Rats ; Rats, Inbred BN ; Rats, Inbred Lew
Czasopismo naukowe
Tytuł :
Influence of triamcinolone intravitreal injection on retinochoroidal healing processes.
Autorzy :
Dot C; U598 INSERM, Physiopathologie des Maladies Oculaires, Innovations Thérapeutiques, Institut Biomédical des Cordeliers, 15 Rue de l'Ecole de Médecine, 75270 Paris Cedex 06, France.
Behar-Cohen F
BenEzra D
Doat M
Jonet L
May F
Jeanny JC
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Źródło :
Experimental eye research [Exp Eye Res] 2007 Jun; Vol. 84 (6), pp. 1081-9. Date of Electronic Publication: 2007 Feb 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Choroidal Neovascularization/*prevention & control
Glucocorticoids/*therapeutic use
Triamcinolone Acetonide/*therapeutic use
Wound Healing/*drug effects
Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Choroidal Neovascularization/etiology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Female ; Glucocorticoids/pharmacology ; In Situ Nick-End Labeling ; Laser Coagulation ; Mice ; Mice, Inbred C57BL ; Triamcinolone Acetonide/pharmacology
Czasopismo naukowe
Tytuł :
Liquid crystal glasses: feasibility and safety of a new modality for treating amblyopia.
Autorzy :
BenEzra O
Herzog R
Cohen E
Karshai I
BenEzra D
Pokaż więcej
Źródło :
Archives of ophthalmology (Chicago, Ill. : 1960) [Arch Ophthalmol] 2007 Apr; Vol. 125 (4), pp. 580-1.
Typ publikacji :
Letter
MeSH Terms :
Eyeglasses*
Liquid Crystals*
Amblyopia/*therapy
Child ; Equipment Safety ; Feasibility Studies ; Humans ; Sensory Deprivation
Opinia redakcyjna
Tytuł :
Electrically assisted ocular gene therapy.
Autorzy :
Bejjani RA; Unit INSERM U598, René Descartes Paris 5 University, Paris, France.
Andrieu C
Bloquel C
Berdugo M
BenEzra D
Behar-Cohen F
Pokaż więcej
Źródło :
Survey of ophthalmology [Surv Ophthalmol] 2007 Mar-Apr; Vol. 52 (2), pp. 196-208.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Gene Transfer Techniques*
Electroporation/*methods
Eye Diseases/*therapy
Genetic Therapy/*methods
Iontophoresis/*methods
Animals ; Humans
Czasopismo naukowe
Tytuł :
Placental growth factor-1 and epithelial haemato-retinal barrier breakdown: potential implication in the pathogenesis of diabetic retinopathy.
Autorzy :
Miyamoto N; INSERM U598, Physiopathology of Ocular Diseases, Therapeutic Innovations, Biomedical Institute des Cordeliers, 15 rue de l'Ecole de médecine, 75006, Paris, France.
de Kozak Y
Jeanny JC
Glotin A
Mascarelli F
Massin P
BenEzra D
Behar-Cohen F
Pokaż więcej
Źródło :
Diabetologia [Diabetologia] 2007 Feb; Vol. 50 (2), pp. 461-70. Date of Electronic Publication: 2006 Dec 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetic Retinopathy/*physiopathology
Pigment Epithelium of Eye/*physiology
Pregnancy Proteins/*physiology
Retinal Vessels/*physiology
Cell Culture Techniques ; Electrophysiology ; Epithelial Cells/physiology ; Homeostasis ; Humans ; Macular Edema/physiopathology ; Placenta Growth Factor ; Vascular Endothelial Growth Factor A/physiology
Czasopismo naukowe
Tytuł :
Non-viral ocular gene therapy: potential ocular therapeutic avenues.
Autorzy :
Bloquel C; INSERM U598, Physiopathology of Ocular Diseases, Therapeutic innovations, René Descartes University, Paris 5, 15 Rue de l'Ecole de Médecine 75006 Paris, France.
Bourges JL
Touchard E
Berdugo M
BenEzra D
Behar-Cohen F
Pokaż więcej
Źródło :
Advanced drug delivery reviews [Adv Drug Deliv Rev] 2006 Nov 15; Vol. 58 (11), pp. 1224-42. Date of Electronic Publication: 2006 Sep 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene Targeting*
Genetic Vectors*
Eye Diseases/*therapy
Genetic Therapy/*methods
Animals ; Drug Administration Routes ; Gene Transfer Techniques ; Humans
Czasopismo naukowe
Tytuł :
Intraocular implants for extended drug delivery: therapeutic applications.
Autorzy :
Bourges JL; INSERM, U598, Physiopathology of Ocular Diseases, Therapeutic Innovations, 15 Rue de l'Ecole de Médecine 75006 Paris, France.
Bloquel C
Thomas A
Froussart F
Bochot A
Azan F
Gurny R
BenEzra D
Behar-Cohen F
Pokaż więcej
Źródło :
Advanced drug delivery reviews [Adv Drug Deliv Rev] 2006 Nov 15; Vol. 58 (11), pp. 1182-202. Date of Electronic Publication: 2006 Sep 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Delivery Systems*
Drug Implants*
Eye Diseases/*drug therapy
Pharmaceutical Preparations/*administration & dosage
Animals ; Humans ; Polymers/chemistry
Czasopismo naukowe
Tytuł :
Ocular gene therapy: a review of nonviral strategies.
Autorzy :
Andrieu-Soler C; INSERM, U598, Paris, France.
Bejjani RA
de Bizemont T
Normand N
BenEzra D
Behar-Cohen F
Pokaż więcej
Źródło :
Molecular vision [Mol Vis] 2006 Oct 30; Vol. 12, pp. 1334-47. Date of Electronic Publication: 2006 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Eye Diseases/*therapy
Genetic Therapy/*methods
Animals ; Humans
Czasopismo naukowe
Tytuł :
Enhanced oligonucleotide delivery to mouse retinal cells using iontophoresis.
Autorzy :
Andrieu-Soler C; INSERM, U598, Paris, France.
Doat M
Halhal M
Keller N
Jonet L
BenEzra D
Behar-Cohen F
Pokaż więcej
Źródło :
Molecular vision [Mol Vis] 2006 Sep 26; Vol. 12, pp. 1098-107. Date of Electronic Publication: 2006 Sep 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oligonucleotides/*administration & dosage
Retina/*metabolism
Retinal Degeneration/*metabolism
Animals ; Animals, Newborn ; Injections ; Iontophoresis ; Mice ; Mice, Inbred C3H ; Microscopy, Electron ; Oligonucleotides/pharmacokinetics ; Photoreceptor Cells ; Retina/pathology ; Retinal Degeneration/genetics ; Retinal Degeneration/pathology ; Tissue Distribution ; Vitreous Body
Czasopismo naukowe

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