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    Tytuł:
    Improvement of functional outcome for patients with newly diagnosed grade 2 or 3 gliomas with co-deletion of 1p/19q - IMPROVE CODEL: the NOA-18 trial.
    Autorzy:
    Wick A; Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany.
    Sander A; Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
    Koch M; Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany.
    Bendszus M; Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany.
    Combs S; Department of Radiation Oncology at the Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.
    Haut T; Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany.
    Dormann A; Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany.
    Walter S; Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany.
    Pertz M; Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany.
    Merkle-Lock J; Coordination Centre for Clinical Trials (KKS), Medical Faculty & University Hospital Heidelberg, Heidelberg, Germany.
    Selkrig N; Coordination Centre for Clinical Trials (KKS), Medical Faculty & University Hospital Heidelberg, Heidelberg, Germany.
    Limprecht R; Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
    Baumann L; Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
    Kieser M; Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
    Sahm F; Department of Neuropathology, University Hospital Heidelberg, DKTK and CCU Neuropathology, DKFZ, Heidelberg, Germany.
    Schlegel U; Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany.
    Winkler F; Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany.; German Cancer Consortium (DKTK), Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Platten M; DKTK, Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, DKFZ, Heidelberg, Germany.; Department of Neurology, Medical faculty, MCTN, University of Heidelberg, Mannheim, Germany.
    Wick W; Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany. .; German Cancer Consortium (DKTK), Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. .; Neurology Clinic, University of Heidelberg & CCU Neurooncology, DKFZ, Im Neuenheimer Feld 400, D-69120, Heidelberg, Germany. .
    Kessler T; Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany.; German Cancer Consortium (DKTK), Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
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    Źródło:
    BMC cancer [BMC Cancer] 2022 Jun 13; Vol. 22 (1), pp. 645. Date of Electronic Publication: 2022 Jun 13.
    Typ publikacji:
    Journal Article; Randomized Controlled Trial
    MeSH Terms:
    Brain Neoplasms*/drug therapy
    Brain Neoplasms*/genetics
    Brain Neoplasms*/pathology
    Oligodendroglioma*/drug therapy
    Oligodendroglioma*/genetics
    Oligodendroglioma*/pathology
    Adult ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Humans ; Lomustine/therapeutic use ; Neoplasm Grading ; Procarbazine/therapeutic use ; Quality of Life ; Treatment Outcome ; Vincristine/therapeutic use
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Methylome analyses of three glioblastoma cohorts reveal chemotherapy sensitivity markers within DDR genes.
    Autorzy:
    Kessler T; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology and Neurooncology Program of the National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
    Berberich A; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology and Neurooncology Program of the National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
    Sadik A; Brain Tumor Metabolism, DKTK, DKFZ, Heidelberg, Germany.
    Sahm F; Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, DKTK, DKFZ, Heidelberg, Germany.
    Gorlia T; European Organization for Research and Treatment of Cancer Headquarters, Brussels, Belgium.
    Meisner C; Institute for Clinical Epidemiology and Biometry, Tübingen, Germany.
    Hoffmann DC; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology and Neurooncology Program of the National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
    Wick A; Department of Neurology and Neurooncology Program of the National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
    Kickingereder P; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
    Rübmann P; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Bendszus M; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
    Opitz C; Brain Tumor Metabolism, DKTK, DKFZ, Heidelberg, Germany.
    Weller M; Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
    van den Bent M; The Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
    Stupp R; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
    Winkler F; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology and Neurooncology Program of the National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
    Brandes A; Department of Medical Oncology, Azienda USL-IRCCS Institute of Neurological Sciences, Bologna, Italy.
    von Deimling A; Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, DKTK, DKFZ, Heidelberg, Germany.
    Platten M; Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, DKTK, DKFZ, Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Mannheim, Germany.
    Wick W; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology and Neurooncology Program of the National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
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    Źródło:
    Cancer medicine [Cancer Med] 2020 Nov; Vol. 9 (22), pp. 8373-8385. Date of Electronic Publication: 2020 Sep 29.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    CpG Islands*
    DNA Methylation*
    DNA Repair*
    Epigenome*
    Brain Neoplasms/*genetics
    Glioblastoma/*genetics
    Antineoplastic Agents/therapeutic use ; Brain Neoplasms/drug therapy ; Brain Neoplasms/mortality ; Cell Line, Tumor ; DNA Modification Methylases/genetics ; DNA Repair Enzymes/genetics ; Databases, Genetic ; Drug Resistance, Neoplasm/genetics ; Glioblastoma/drug therapy ; Glioblastoma/mortality ; Humans ; Nuclear Proteins/genetics ; Progression-Free Survival ; Promoter Regions, Genetic ; RNA Splicing Factors/genetics ; Risk Assessment ; Risk Factors ; Telomerase/genetics ; Time Factors ; Tumor Protein p73/genetics ; Tumor Suppressor Proteins/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Glioblastoma multiforme restructures the topological connectivity of cerebrovascular networks.
    Autorzy:
    Hahn A; Heidelberg University Hospital, Department of Neuroradiology, Heidelberg, 69120, Germany.; University of Heidelberg, Department of Physics and Astronomy, Heidelberg, 69120, Germany.
    Bode J; University of Heidelberg and German Cancer Research Center (DKFZ), Schaller Research Group, Molecular Mechanisms of Tumor Invasion, Heidelberg, 69120, Germany.
    Krüwel T; University of Heidelberg and German Cancer Research Center (DKFZ), Schaller Research Group, Molecular Mechanisms of Tumor Invasion, Heidelberg, 69120, Germany.
    Solecki G; Heidelberg University Hospital, Neurology Clinic and National Center for Tumor Diseases, Heidelberg, 69120, Germany.; German Cancer Consortium (DKTK), Clinical Cooperation Unit Neurooncology, Heidelberg, 69120, Germany.
    Heiland S; Heidelberg University Hospital, Department of Neuroradiology, Heidelberg, 69120, Germany.
    Bendszus M; Heidelberg University Hospital, Department of Neuroradiology, Heidelberg, 69120, Germany.
    Tews B; University of Heidelberg and German Cancer Research Center (DKFZ), Schaller Research Group, Molecular Mechanisms of Tumor Invasion, Heidelberg, 69120, Germany.
    Winkler F; Heidelberg University Hospital, Neurology Clinic and National Center for Tumor Diseases, Heidelberg, 69120, Germany.; German Cancer Consortium (DKTK), Clinical Cooperation Unit Neurooncology, Heidelberg, 69120, Germany.
    Breckwoldt MO; Heidelberg University Hospital, Department of Neuroradiology, Heidelberg, 69120, Germany.; German Cancer Research Center (DKFZ), Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, Heidelberg, 69120, Germany.
    Kurz FT; Heidelberg University Hospital, Department of Neuroradiology, Heidelberg, 69120, Germany. .
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    Źródło:
    Scientific reports [Sci Rep] 2019 Aug 13; Vol. 9 (1), pp. 11757. Date of Electronic Publication: 2019 Aug 13.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cerebrovascular Circulation*
    Connectome*
    Brain Neoplasms/*pathology
    Glioblastoma/*pathology
    Animals ; Brain Neoplasms/blood supply ; Female ; Glioblastoma/blood supply ; Heterografts ; Humans ; Male ; Mice
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Impact of F-FET PET on Target Volume Definition and Tumor Progression of Recurrent High Grade Glioma Treated with Carbon-Ion Radiotherapy.
    Autorzy:
    Debus C; German Cancer Consortium (DKTK), Heidelberg, Germany. .; Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany. .; Division of Molecular and Translational Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany. .; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany. .
    Waltenberger M; German Cancer Consortium (DKTK), Heidelberg, Germany.; Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
    Floca R; Division of Molecular and Translational Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; Division of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Afshar-Oromieh A; Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.
    Bougatf N; Division of Molecular and Translational Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
    Adeberg S; Division of Molecular and Translational Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
    Heiland S; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
    Bendszus M; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
    Wick W; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Neurology, Heidelberg University Hospital and Clinical Cooperation Unit Neurooncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Rieken S; Division of Molecular and Translational Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
    Haberkorn U; Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Debus J; German Cancer Consortium (DKTK), Heidelberg, Germany.; Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
    Knoll M; German Cancer Consortium (DKTK), Heidelberg, Germany.; Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
    Abdollahi A; German Cancer Consortium (DKTK), Heidelberg, Germany. .; Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany. .; Division of Molecular and Translational Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany. .; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany. .
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    Źródło:
    Scientific reports [Sci Rep] 2018 May 08; Vol. 8 (1), pp. 7201. Date of Electronic Publication: 2018 May 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Heavy Ion Radiotherapy*
    Brain Neoplasms/*diagnostic imaging
    Glioma/*diagnostic imaging
    Neoplasm Recurrence, Local/*diagnostic imaging
    Adult ; Aged ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Disease Progression ; Female ; Fluorodeoxyglucose F18/administration & dosage ; Glioma/mortality ; Glioma/pathology ; Glioma/therapy ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/therapy ; Positron-Emission Tomography ; Prognosis ; Radiotherapy, Computer-Assisted/methods ; Retrospective Studies ; Sensitivity and Specificity ; Survival Analysis ; Tumor Burden/radiation effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Sensitivity of different MRI sequences in the early detection of melanoma brain metastases.
    Autorzy:
    Deike-Hofmann K; Department of Radiology, German Cancer Research Center, DKFZ, Heidelberg, Germany.
    Thünemann D; Department of Radiology, German Cancer Research Center, DKFZ, Heidelberg, Germany.
    Breckwoldt MO; Department of Radiology, German Cancer Research Center, DKFZ, Heidelberg, Germany.; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Schwarz D; Department of Radiology, German Cancer Research Center, DKFZ, Heidelberg, Germany.; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Radbruch A; Department of Radiology, German Cancer Research Center, DKFZ, Heidelberg, Germany.
    Enk A; Department of Dermatology, National Center for Tumor Diseases, NCT, University of Heidelberg Medical Center Heidelberg, Germany.
    Bendszus M; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Hassel J; Department of Dermatology, National Center for Tumor Diseases, NCT, University of Heidelberg Medical Center Heidelberg, Germany.
    Schlemmer HP; Department of Radiology, German Cancer Research Center, DKFZ, Heidelberg, Germany.
    Bäumer P; Department of Radiology, German Cancer Research Center, DKFZ, Heidelberg, Germany.
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    Źródło:
    PloS one [PLoS One] 2018 Mar 29; Vol. 13 (3), pp. e0193946. Date of Electronic Publication: 2018 Mar 29 (Print Publication: 2018).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Brain Neoplasms/*diagnosis
    Brain Neoplasms/*pathology
    Melanoma/*pathology
    Contrast Media/metabolism ; Diffusion Magnetic Resonance Imaging/methods ; Early Diagnosis ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Differentiation of pseudoprogression and real progression in glioblastoma using ADC parametric response maps.
    Autorzy:
    Reimer C; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Deike K; Department of Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Graf M; Department of Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Reimer P; Institute of Diagnostic and Interventional Radiology, Klinikum Karlsruhe, Academic Teaching Hospital of the University of Freiburg, Karlsruhe, Germany.
    Wiestler B; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.; Department of Neuroradiology, Technical University Munich, Munich, Germany.; Department of Neurology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Floca RO; Department of Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Kickingereder P; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Schlemmer HP; Department of Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Wick W; Department of Neurology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Bendszus M; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Radbruch A; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.; Department of Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
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    Źródło:
    PloS one [PLoS One] 2017 Apr 06; Vol. 12 (4), pp. e0174620. Date of Electronic Publication: 2017 Apr 06 (Print Publication: 2017).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Brain Mapping/*methods
    Brain Neoplasms/*pathology
    Glioblastoma/*pathology
    Aged ; Diffusion Magnetic Resonance Imaging ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Tumor Infiltration in Enhancing and Non-Enhancing Parts of Glioblastoma: A Correlation with Histopathology.
    Autorzy:
    Eidel O; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.; Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Radiology, Heidelberg, Germany.
    Burth S; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.; Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Radiology, Heidelberg, Germany.
    Neumann JO; Department of Neurosurgery, Division Stereotactic Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany.
    Kieslich PJ; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
    Sahm F; Department of Neuropathology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Jungk C; Department of Neurosurgery, Division Stereotactic Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany.
    Kickingereder P; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Bickelhaupt S; Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Mundiyanapurath S; Department of Neurology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Bäumer P; Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Wick W; Department of Neurology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Schlemmer HP; Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Kiening K; Department of Neurosurgery, Division Stereotactic Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany.
    Unterberg A; Department of Neurosurgery, Division Stereotactic Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany.
    Bendszus M; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Radbruch A; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.; Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Radiology, Heidelberg, Germany.
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    Źródło:
    PloS one [PLoS One] 2017 Jan 19; Vol. 12 (1), pp. e0169292. Date of Electronic Publication: 2017 Jan 19 (Print Publication: 2017).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Brain Neoplasms/*diagnostic imaging
    Brain Neoplasms/*pathology
    Glioblastoma/*diagnostic imaging
    Glioblastoma/*pathology
    Aged ; Cell Count ; Female ; Humans ; Image-Guided Biopsy ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Necrosis ; Neoplasm Invasiveness/diagnostic imaging ; Neoplasm Invasiveness/pathology ; Neuroimaging/methods ; Retrospective Studies ; Stereotaxic Techniques
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Automatic Analysis of Cellularity in Glioblastoma and Correlation with ADC Using Trajectory Analysis and Automatic Nuclei Counting.
    Autorzy:
    Eidel O; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Neumann JO; Department of Neurosurgery, Division Stereotactic Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany.
    Burth S; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Kieslich PJ; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
    Jungk C; Department of Neurosurgery, Division Stereotactic Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany.
    Sahm F; Department of Neuropathology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Kickingereder P; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Kiening K; Department of Neurosurgery, Division Stereotactic Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany.
    Unterberg A; Department of Neurosurgery, Division Stereotactic Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany.
    Wick W; Neurology Clinic, University of Heidelberg Medical Center, Heidelberg, Germany.
    Schlemmer HP; Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Bendszus M; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Radbruch A; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.; Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.
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    Źródło:
    PloS one [PLoS One] 2016 Jul 28; Vol. 11 (7), pp. e0160250. Date of Electronic Publication: 2016 Jul 28 (Print Publication: 2016).
    Typ publikacji:
    Comparative Study; Journal Article
    MeSH Terms:
    Automation*
    Brain Neoplasms/*pathology
    Cell Nucleus/*pathology
    Glioblastoma/*pathology
    Biopsy ; Brain Neoplasms/diagnostic imaging ; Glioblastoma/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Retrospective Studies
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    IDH mutation status is associated with a distinct hypoxia/angiogenesis transcriptome signature which is non-invasively predictable with rCBV imaging in human glioma.
    Autorzy:
    Kickingereder P; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Sahm F; Department of Neuropathology, University of Heidelberg Medical Center, Heidelberg, Germany.; German Cancer Consortium (DKTK), Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Radbruch A; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.; DKFZ, Department of Radiology, Heidelberg, Germany.
    Wick W; Neurology Clinic, University of Heidelberg Medical Center, Heidelberg, Germany.; DKTK, Clinical Cooperation Unit Neurooncology, DKFZ, Heidelberg, Germany.
    Heiland S; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Deimling Av; Department of Neuropathology, University of Heidelberg Medical Center, Heidelberg, Germany.; German Cancer Consortium (DKTK), Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Bendszus M; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Wiestler B; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.; Neurology Clinic, University of Heidelberg Medical Center, Heidelberg, Germany.; DKTK, Clinical Cooperation Unit Neurooncology, DKFZ, Heidelberg, Germany.
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    Źródło:
    Scientific reports [Sci Rep] 2015 Nov 05; Vol. 5, pp. 16238. Date of Electronic Publication: 2015 Nov 05.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Brain Neoplasms/*genetics
    Glioma/*genetics
    Hypoxia/*genetics
    Isocitrate Dehydrogenase/*genetics
    Mutation/*genetics
    Neovascularization, Pathologic/*genetics
    Transcriptome/*genetics
    Adolescent ; Adult ; Aged ; Biomarkers, Tumor/genetics ; Brain/pathology ; Brain Neoplasms/pathology ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Female ; Glioma/pathology ; Humans ; Hypoxia/pathology ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neovascularization, Pathologic/pathology ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Nuclear Overhauser Enhancement imaging of glioblastoma at 7 Tesla: region specific correlation with apparent diffusion coefficient and histology.
    Autorzy:
    Paech D; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany; Neurooncologic Imaging, Department of Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Burth S; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany; Neurooncologic Imaging, Department of Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Windschuh J; Department of Medical Physics in Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Meissner JE; Neurooncologic Imaging, Department of Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany; Department of Medical Physics in Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Zaiss M; Department of Medical Physics in Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Eidel O; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Kickingereder P; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Nowosielski M; Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
    Wiestler B; Department of Neurology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Sahm F; Department of Neuropathology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Floca RO; Department of Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Neumann JO; Department of Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany.
    Wick W; Department of Neurology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Heiland S; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Bendszus M; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.
    Schlemmer HP; Department of Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Ladd ME; Department of Medical Physics in Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Bachert P; Department of Medical Physics in Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Radbruch A; Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany; Neurooncologic Imaging, Department of Radiology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2015 Mar 19; Vol. 10 (3), pp. e0121220. Date of Electronic Publication: 2015 Mar 19 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Diffusion Magnetic Resonance Imaging*
    Brain Neoplasms/*diagnosis
    Brain Neoplasms/*pathology
    Glioblastoma/*diagnosis
    Glioblastoma/*pathology
    Brain Neoplasms/complications ; Diffusion ; Edema/complications ; Female ; Glioblastoma/complications ; Humans ; Male ; Middle Aged ; Stereotaxic Techniques
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Quantification of tumor vessels in glioblastoma patients using time-of-flight angiography at 7 Tesla: a feasibility study.
    Autorzy:
    Radbruch A; Dept. of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Baden-Württemberg, Germany; Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany.
    Eidel O; Dept. of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Baden-Württemberg, Germany.
    Wiestler B; Department of Neurology, University of Heidelberg Medical Center, Heidelberg, Baden-Württemberg, Germany.
    Paech D; Dept. of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Baden-Württemberg, Germany.
    Burth S; Dept. of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Baden-Württemberg, Germany.
    Kickingereder P; Dept. of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Baden-Württemberg, Germany.
    Nowosielski M; Dept. of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Baden-Württemberg, Germany; Department of Neurology, University of Innsbruck, Innsbruck, Austria.
    Bäumer P; Dept. of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Baden-Württemberg, Germany.
    Wick W; Department of Neurology, University of Heidelberg Medical Center, Heidelberg, Baden-Württemberg, Germany.
    Schlemmer HP; Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany.
    Bendszus M; Dept. of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Baden-Württemberg, Germany.
    Ladd M; Dept. of Medical Physics, German Cancer Research Center (DKFZ), German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany.
    Nagel AM; Dept. of Medical Physics, German Cancer Research Center (DKFZ), German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany.
    Heiland S; Dept. of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Baden-Württemberg, Germany.
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2014 Nov 21; Vol. 9 (11), pp. e110727. Date of Electronic Publication: 2014 Nov 21 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Magnetic Resonance Angiography*
    Brain Neoplasms/*blood supply
    Glioblastoma/*blood supply
    Feasibility Studies ; Humans ; Prospective Studies
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Quantitative susceptibility mapping differentiates between blood depositions and calcifications in patients with glioblastoma.
    Autorzy:
    Deistung A; Medical Physics Group, Institute of Diagnostic and Interventional Radiology I, Jena University Hospital - Friedrich Schiller University Jena, Philosophenweg 3, Jena, Germany.
    Schweser F
    Wiestler B
    Abello M
    Roethke M
    Sahm F
    Wick W
    Nagel AM
    Heiland S
    Schlemmer HP
    Bendszus M
    Reichenbach JR
    Radbruch A
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2013; Vol. 8 (3), pp. e57924. Date of Electronic Publication: 2013 Mar 21.
    Typ publikacji:
    Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Brain Neoplasms*/blood supply
    Brain Neoplasms*/diagnostic imaging
    Brain Neoplasms*/metabolism
    Brain Neoplasms*/therapy
    Calcinosis*/diagnostic imaging
    Calcinosis*/metabolism
    Calcinosis*/therapy
    Glioblastoma*/blood supply
    Glioblastoma*/diagnostic imaging
    Glioblastoma*/metabolism
    Glioblastoma*/therapy
    Magnetic Resonance Imaging*
    Adult ; Aged ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Oligodendroglia/diagnostic imaging ; Oligodendroglia/metabolism ; Radiography
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Does age matter? - A MRI study on peritumoral edema in newly diagnosed primary glioblastoma.
    Autorzy:
    Seidel C; Department of Neurooncology University Clinic Heidelberg, Germany.
    Dörner N
    Osswald M
    Wick A
    Platten M
    Bendszus M
    Wick W
    Pokaż więcej
    Źródło:
    BMC cancer [BMC Cancer] 2011 Apr 12; Vol. 11, pp. 127. Date of Electronic Publication: 2011 Apr 12.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Edema*
    Brain/*metabolism
    Brain Neoplasms/*diagnosis
    Brain Neoplasms/*physiopathology
    Glioblastoma/*diagnosis
    Glioblastoma/*physiopathology
    Adult ; Age Factors ; Aged ; Brain/diagnostic imaging ; Brain/pathology ; Brain Neoplasms/epidemiology ; Brain Neoplasms/pathology ; Female ; Glioblastoma/epidemiology ; Glioblastoma/pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Necrosis ; Neovascularization, Pathologic ; Prognosis ; Radiography ; Retrospective Studies ; Risk Factors ; Vascular Endothelial Growth Factor A/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-14 z 14

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