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Tytuł:
Tecovirimat Resistance in Mpox Patients, United States, 2022-2023.
Autorzy:
Smith TG
Gigante CM
Wynn NT
Matheny A
Davidson W
Yang Y
Condori RE
O'Connell K
Kovar L
Williams TL
Yu YC
Petersen BW
Baird N
Lowe D
Li Y
Satheshkumar PS
Hutson CL
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Źródło:
Emerging infectious diseases [Emerg Infect Dis] 2023 Dec; Vol. 29 (12), pp. 2426-2432. Date of Electronic Publication: 2023 Oct 19.
Typ publikacji:
Journal Article
MeSH Terms:
Mpox (monkeypox)*
Humans ; United States/epidemiology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Benzamides/therapeutic use ; Biological Assay ; Monkeypox virus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Discovery of 3-((3-amino- 1H -indazol-4-yl)ethynyl)- N -(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutant.
Autorzy:
El-Damasy AK; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Kim HJ; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Park JW; Supercomputing Application Center, Div. of National Supercomputing, Korea Institute of Science and Technology Information, Daejeon, Republic of Korea.
Nam Y; Medicinal Materials Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Hur W; Medicinal Materials Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Bang EK; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Keum G; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul, Republic of Korea.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2228515.
Typ publikacji:
Journal Article
MeSH Terms:
Indazoles*/pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/metabolism
Humans ; Drug Resistance, Neoplasm ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Fusion Proteins, bcr-abl/genetics ; Fusion Proteins, bcr-abl/metabolism ; Benzamides/pharmacology ; Cell Line, Tumor ; Mutation ; Cell Proliferation ; Apoptosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Treatment of Mpox with Suspected Tecovirimat Resistance in Immunocompromised Patient, United States, 2022.
Autorzy:
Contag CA
Mische L
Fong I
Karan A
Vaidya A
McCormick DW
Bower W
Hacker JK
Johnson K
SanJuan P
Crebbin L
Temmins C
Sahni H
Bogler Y
Cooper JD
Narasimhan S
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Źródło:
Emerging infectious diseases [Emerg Infect Dis] 2023 Dec; Vol. 29 (12), pp. 2520-2523. Date of Electronic Publication: 2023 Oct 19.
Typ publikacji:
Journal Article
MeSH Terms:
Mpox (monkeypox)*
Humans ; United States ; Immunocompromised Host ; Benzamides ; Disease Outbreaks
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Synthesis, kinetic studies and in-silico investigations of novel quinolinyl-iminothiazolines as alkaline phosphatase inhibitors.
Autorzy:
Mustafa MN; Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.
Channar PA; Department of Basic sciences and Humanities, Dawood University of Engineering and Technology, Karachi, Pakistan.
Sarfraz M; College of Pharmacy, Al Ain Campus, Al Ain University, Al Ain, United Arab Emirates.
Saeed A; Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.
Ejaz SA; Department of Pharmaceutical Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Aziz M; Department of Pharmaceutical Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Alasmary FA; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Alsoqair HY; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Raza H; Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, Republic of Korea.
Kim SJ; Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, Republic of Korea.
Hamad A; Faculty of Pharmacy, Grand Asian University Sialkot, Sialkot, Pakistan.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2163394.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaline Phosphatase*/metabolism
Enzyme Inhibitors*/chemistry
Molecular Docking Simulation ; Kinetics ; Benzamides/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Overcoming the imatinib-resistant BCR-ABL mutants with new ureidobenzothiazole chemotypes endowed with potent and broad-spectrum anticancer activity.
Autorzy:
El-Damasy AK; Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Jin H; Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Park JW; Center for Supercomputing Applications, Div. of National Supercomputing R&D, Korea Institute of Science and Technology Information, Daejeon, Republic of Korea.
Kim HJ; Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Khojah H; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Seo SH; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Lee JH; Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Bang EK; Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Keum G; Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul, Republic of Korea.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2189097.
Typ publikacji:
Journal Article
MeSH Terms:
Fusion Proteins, bcr-abl*/genetics
Pyrimidines*/pharmacology
Imatinib Mesylate/pharmacology ; Piperazines/pharmacology ; Benzamides/pharmacology ; Apoptosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Are off-target effects of imatinib the key to improving beta-cell function in diabetes?
Autorzy:
Welsh N; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
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Źródło:
Upsala journal of medical sciences [Ups J Med Sci] 2022 Sep 14; Vol. 127. Date of Electronic Publication: 2022 Sep 14 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review
MeSH Terms:
Benzamides*
Diabetes Mellitus, Type 2*/drug therapy
Humans ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; Piperazines/pharmacology ; Protein-Tyrosine Kinases ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Oxidation of p -[ At]Astatobenzoic Acid Derivatives and Evaluation In Vivo.
Autorzy:
Li Y; Radiochemistry Division, Department of Radiation Oncology, University of Washington, Seattle, WA 98105, USA.
Chyan MK; Radiochemistry Division, Department of Radiation Oncology, University of Washington, Seattle, WA 98105, USA.
Hamlin DK; Radiochemistry Division, Department of Radiation Oncology, University of Washington, Seattle, WA 98105, USA.
Nguyen H; GU Cancer Research Lab, Department of Urology, University of Washington, Seattle, WA 98195, USA.
Corey E; GU Cancer Research Lab, Department of Urology, University of Washington, Seattle, WA 98195, USA.
Wilbur DS; Radiochemistry Division, Department of Radiation Oncology, University of Washington, Seattle, WA 98105, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 13; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 13.
Typ publikacji:
Journal Article
MeSH Terms:
Benzamides*
Iodine Radioisotopes*/chemistry
Amino Acids ; Animals ; Esters ; Isotope Labeling/methods ; Mice ; Tissue Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Application of Parallel Reaction Monitoring to the Development and Validation of a Quantitative Assay for ST-246 in Human Plasma.
Autorzy:
Chernonosov AA; Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
Oleinik GA; Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
Koval VV; Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.; Department of Natural Sciences, Novosibirsk State University, Pirogova Str. 2, 630090 Novosibirsk, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 21; Vol. 23 (14). Date of Electronic Publication: 2022 Jul 21.
Typ publikacji:
Journal Article; Validation Study
MeSH Terms:
Benzamides*/blood
Biological Assay*
Isoindoles*/blood
Chromatography, Liquid ; Humans ; Mass Spectrometry ; Plasma ; Reproducibility of Results
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats.
Autorzy:
Zubrzycki M; Department of Cardiac Surgery and Transplantology, The Cardinal Stefan Wyszynski Institute of Cardiology, Alpejska 42, 04-628 Warsaw, Poland.
Zubrzycka M; Department of Clinical Physiology, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.
Wysiadecki G; Department of Normal and Clinical Anatomy, Chair of Anatomy and Histology, Medical University of Lodz, Żeligowskiego 7/9, 90-752 Lodz, Poland.
Szemraj J; Department of Medical Biochemistry, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.
Jerczynska H; Central Scientific Laboratory (CoreLab), Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.
Stasiolek M; Department of Neurology, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Apr 23; Vol. 23 (9). Date of Electronic Publication: 2022 Apr 23.
Typ publikacji:
Journal Article
MeSH Terms:
Benzamides*/pharmacology
Benzamides*/therapeutic use
Calcitonin Gene-Related Peptide*
Carbamates*/pharmacology
Carbamates*/therapeutic use
Pain Perception*/drug effects
Amidohydrolases/genetics ; Animals ; Endocannabinoids/metabolism ; Facial Pain/drug therapy ; Polyunsaturated Alkamides/metabolism ; RNA, Messenger ; Rats ; Receptor, Cannabinoid, CB1/drug effects ; Receptors, Cannabinoid/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Causal inferences and real-world evidence: A comparative effectiveness evaluation of abiraterone acetate against enzalutamide.
Autorzy:
Johansson P; Department of Statistics, Uppsala University, Uppsala, Sweden.; Centre for Health-Economic Research, Uppsala University, Uppsala, Sweden.; Institute for Evaluation of Labour Market and Education Policy, Uppsala University, Uppsala, Sweden.; Tsinghua University, Beijing, China.
Jonéus P; Department of Statistics, Uppsala University, Uppsala, Sweden.
Langenskiöld S; Centre for Health-Economic Research, Uppsala University, Uppsala, Sweden.; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
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Źródło:
PloS one [PLoS One] 2023 Oct 26; Vol. 18 (10), pp. e0293000. Date of Electronic Publication: 2023 Oct 26 (Print Publication: 2023).
Typ publikacji:
Observational Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/therapeutic use
Prostatic Neoplasms, Castration-Resistant*/drug therapy
Male ; Humans ; Abiraterone Acetate/therapeutic use ; Phenylthiohydantoin/therapeutic use ; Benzamides/therapeutic use ; Nitriles/therapeutic use ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An Ultrafast UPLC-MS/MS Method for Characterizing the In Vitro Metabolic Stability of Acalabrutinib.
Autorzy:
Attwa MW; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Bakheit AH; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Abdelhameed AS; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Kadi AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Oct 23; Vol. 28 (20). Date of Electronic Publication: 2023 Oct 23.
Typ publikacji:
Journal Article
MeSH Terms:
Tandem Mass Spectrometry*/methods
Leukemia, Lymphocytic, Chronic, B-Cell*
Humans ; Chromatography, Liquid ; Benzamides ; Pyrazines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Theobromine Derivative with Anticancer Properties Targeting VEGFR-2: Semisynthesis, in silico and in vitro Studies.
Autorzy:
Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.
Yousef RG; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.
Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.
Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, 13713, Saudi Arabia.
Alsfouk AA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
Husein DZ; Chemistry Department, Faculty of Science, New Valley University, El-Kharja, 72511, Egypt.
Ibrahim IM; Biophysics Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Radwan MM; National Center for Natural Products Research, University of Mississippi, Mississippi, MS 38677, USA.; Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Metwaly AM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.; Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt.
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Źródło:
ChemistryOpen [ChemistryOpen] 2023 Oct; Vol. 12 (10), pp. e202300066.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Theobromine*
Vascular Endothelial Growth Factor Receptor-2*/chemistry
Vascular Endothelial Growth Factor Receptor-2*/metabolism
Humans ; Molecular Structure ; Structure-Activity Relationship ; Molecular Docking Simulation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/metabolism ; MCF-7 Cells ; Benzamides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CSE1L is a negative regulator of the RB-DREAM pathway in p53 wild-type NSCLC and can be targeted using an HDAC1/2 inhibitor.
Autorzy:
Duan L; Department of Anatomy and Cell Biology, Rush University Medical Center, 600 S. Paulina Street, AcFac 507, Chicago, IL, 60612, USA.
Tadi MJ; Department of Anatomy and Cell Biology, Rush University Medical Center, 600 S. Paulina Street, AcFac 507, Chicago, IL, 60612, USA.
Maki CG; Department of Anatomy and Cell Biology, Rush University Medical Center, 600 S. Paulina Street, AcFac 507, Chicago, IL, 60612, USA. Carl_.
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 27; Vol. 13 (1), pp. 16271. Date of Electronic Publication: 2023 Sep 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Humans ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Benzamides ; Retinoblastoma Protein/metabolism ; Histone Deacetylase 1/genetics ; Histone Deacetylase 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Lateral Metalation of Isoxazolo[3,4- d ]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors.
Autorzy:
Gates CA; Department of Biomedical and Pharmaceutical Sciences, University of Montana, 32 Campus Drive, Missoula, MT 59812, USA.
Backos DS; Skaggs School of Pharmacy and Pharmaceutical Sciences, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, USA.
Reigan P; Skaggs School of Pharmacy and Pharmaceutical Sciences, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, USA.
Natale NR; Department of Biomedical and Pharmaceutical Sciences, University of Montana, 32 Campus Drive, Missoula, MT 59812, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Sep 25; Vol. 28 (19). Date of Electronic Publication: 2023 Sep 25.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Dynamics Simulation*
Models, Chemical*
Allosteric Regulation ; Benzamides ; Isoxazoles/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A 40-Year-Old Man with Anemia, Proctitis, Rectal Bleeding, and a Perianal Rash Due to Mpox (Monkeypox) Infection.
Autorzy:
Moore C; Department of General Surgery, University of Florida School of Medicine, Jacksonville, FL, USA.
Marcucci V; Department of Surgery, Jersey Shore University Medical Center, Neptune, NJ, USA.
Torres P; Department of Surgery, Jersey Shore University Medical Center, Neptune, NJ, USA.
Liu E; Department of Medicine, St. George's University, St. George, Grenada.
Parker GS; Department of Surgery, Jersey Shore University Medical Center, Neptune, NJ, USA.; Department of Medicine, St. George's University, St. George, Grenada.
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Źródło:
The American journal of case reports [Am J Case Rep] 2023 Sep 03; Vol. 24, pp. e940177. Date of Electronic Publication: 2023 Sep 03.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Mpox (monkeypox)*
Proctitis*/diagnosis
Proctitis*/drug therapy
Dermatitis*
Anemia*/etiology
Exanthema*
Male ; Humans ; Adult ; Gastrointestinal Hemorrhage/etiology ; Benzamides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Non-chemotherapy adjuvant agents in TP53 mutant Ewing sarcoma.
Autorzy:
Kim JA; Children's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA. .
Crawford KA; Children's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA.
Spada PA; Children's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA.
Martin LR; Children's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA.
Zhang J; Children's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA.
Wong R; Children's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA.
Reid JM; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA.
Stewart CF; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, 38105-2794, USA.
Frank TM; Children's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA.
Liu Q; Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, TX, 78229, USA.
Michalek JE; Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, TX, 78229, USA.
Keller C; Children's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 01; Vol. 13 (1), pp. 14360. Date of Electronic Publication: 2023 Sep 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Sarcoma, Ewing*/drug therapy
Neuroectodermal Tumors, Primitive, Peripheral*
Humans ; Animals ; Mice ; Enoxacin ; Benzamides ; Adjuvants, Immunologic ; Adjuvants, Pharmaceutic ; Disease Models, Animal ; Tumor Suppressor Protein p53
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Different Size Formulations of Fluopyram: Preparation, Antifungal Activity, and Accumulation in the Fungal Pathogen Botrytis cinerea .
Autorzy:
Wang Y; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.; Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University, Beijing 100193, China.; State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Zhang S; State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Xu Y; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.; Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University, Beijing 100193, China.
Li H; State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Zhang R; State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Chen D; State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Xu J; State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Wu X; Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.; Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University, Beijing 100193, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Aug 17; Vol. 28 (16). Date of Electronic Publication: 2023 Aug 17.
Typ publikacji:
Journal Article
MeSH Terms:
Antifungal Agents*/pharmacology
Pesticides*
Benzamides
SCR Organism:
Botrytis cinerea
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Real-world burden of adverse events for apalutamide- or enzalutamide-treated non-metastatic castration-resistant prostate cancer patients in the United States.
Autorzy:
Hussain A; University of Maryland Greenebaum Comprehensive Cancer Center, 22 S Greene St, Baltimore, MD, 21201, USA.
Jiang S; Bayer Healthcare Pharmaceuticals, 100 Bayer Blvd, Whippany, NJ, 07981, USA.
Varghese D; OPEN Health, 4350 East-West Highway, Suite 1100, Bethesda, MD, 20184, USA.
Appukkuttan S; Bayer Healthcare Pharmaceuticals, 100 Bayer Blvd, Whippany, NJ, 07981, USA.
Kebede N; OPEN Health, 4350 East-West Highway, Suite 1100, Bethesda, MD, 20184, USA.
Gnanasakthy K; RTI Health Solutions, 5 Sylvan Way, Parsippany, NJ, 07054, USA.
Macahilig C; RTI Health Solutions, 5 Sylvan Way, Parsippany, NJ, 07054, USA.
Waldeck R; Bayer Healthcare Pharmaceuticals, 100 Bayer Blvd, Whippany, NJ, 07981, USA.
Corman S; OPEN Health, 4350 East-West Highway, Suite 1100, Bethesda, MD, 20184, USA. .
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Źródło:
BMC cancer [BMC Cancer] 2022 Mar 22; Vol. 22 (1), pp. 304. Date of Electronic Publication: 2022 Mar 22.
Typ publikacji:
Journal Article; Multicenter Study
MeSH Terms:
Androgen Receptor Antagonists/*adverse effects
Antineoplastic Agents, Hormonal/*adverse effects
Benzamides/*adverse effects
Nitriles/*adverse effects
Phenylthiohydantoin/*adverse effects
Prostatic Neoplasms, Castration-Resistant/*drug therapy
Thiohydantoins/*adverse effects
Aged ; Androgen Receptor Antagonists/therapeutic use ; Antineoplastic Agents, Hormonal/therapeutic use ; Arthralgia/chemically induced ; Asthenia/chemically induced ; Benzamides/therapeutic use ; Fatigue/chemically induced ; Flushing/chemically induced ; Hospitalization ; Humans ; Male ; Nitriles/therapeutic use ; Phenylthiohydantoin/therapeutic use ; Retrospective Studies ; Thiohydantoins/therapeutic use ; United States
Czasopismo naukowe
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Tytuł:
HDAC class I inhibitor domatinostat sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation.
Autorzy:
Roca MS; Experimental Pharmacology Unit-Laboratory of Naples and Mercogliano (AV), Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy.
Moccia T; Experimental Pharmacology Unit-Laboratory of Naples and Mercogliano (AV), Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy.
Iannelli F; Experimental Pharmacology Unit-Laboratory of Naples and Mercogliano (AV), Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy.
Testa C; Experimental Pharmacology Unit-Laboratory of Naples and Mercogliano (AV), Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy.
Vitagliano C; Experimental Pharmacology Unit-Laboratory of Naples and Mercogliano (AV), Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy.
Minopoli M; Neoplastic Progression Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy.
Camerlingo R; Cell Biology and Biotherapy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy.
De Riso G; Department of molecular medicine and medical biotechnology, University of Naples 'Federico II', Naples, Italy.
De Cecio R; Pathology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy.
Bruzzese F; Animal Facility, Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy.
Conte M; Department of Precision Medicine, Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy.
Altucci L; Department of Precision Medicine, Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy.; BIOGEM, (AV), Naples, Italy.
Di Gennaro E; Experimental Pharmacology Unit-Laboratory of Naples and Mercogliano (AV), Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy.
Avallone A; Experimental Clinical Abdominal Oncology; Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy.
Leone A; Experimental Pharmacology Unit-Laboratory of Naples and Mercogliano (AV), Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy.
Budillon A; Experimental Pharmacology Unit-Laboratory of Naples and Mercogliano (AV), Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2022 Mar 03; Vol. 41 (1), pp. 83. Date of Electronic Publication: 2022 Mar 03.
Typ publikacji:
Journal Article
MeSH Terms:
Benzamides*/pharmacology
Carcinoma, Pancreatic Ductal*/drug therapy
Carcinoma, Pancreatic Ductal*/genetics
Carcinoma, Pancreatic Ductal*/metabolism
Pancreatic Neoplasms*/drug therapy
Pancreatic Neoplasms*/genetics
Pancreatic Neoplasms*/metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation ; Forkhead Box Protein M1/genetics ; Forkhead Box Protein M1/metabolism ; Gene Expression Regulation, Neoplastic ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Mice ; Neoplastic Stem Cells/metabolism
Czasopismo naukowe
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Tytuł:
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia.
Autorzy:
Bora V; Department of Pharmacology, Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad, Gujarat 382481, India.
Patel D; Department of Pharmacology, Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad, Gujarat 382481, India.
Johar K; Department of Zoology, BMTC, Human Genetics, USSC, Gujarat University, Ahmedabad, Gujarat, 380009, India.
Goyal RK; Delhi Pharmaceutical Sciences Research University, Delhi, 110017, India.
Patel BM; Department of Pharmacology, Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad, Gujarat 382481, India.
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Źródło:
Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2022 Mar; Vol. 100 (3), pp. 240-251. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji:
Journal Article
MeSH Terms:
Benzamides/*therapeutic use
Cachexia/*drug therapy
Cachexia/*etiology
Heart Diseases/*drug therapy
Heart Diseases/*etiology
Histone Deacetylase Inhibitors/*therapeutic use
Neoplasms/*complications
Pyridines/*therapeutic use
Animals ; Benzamides/pharmacology ; Butyric Acid ; Cell Line, Tumor ; Disease Models, Animal ; Disease Progression ; Female ; Histone Deacetylase Inhibitors/pharmacology ; Hydroxamic Acids/adverse effects ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Pyridines/pharmacology ; Pyrroles/adverse effects ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 41-60 z 5131

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