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Wyszukujesz frazę ""Benzbromarone"" wg kryterium: Temat


Tytuł :
Randomized, Open-Label, Cross-Over Comparison of the Effects of Benzbromarone and Febuxostat on Endothelial Function in Patients with Hyperuricemia.
Autorzy :
Nakata T; Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences.; Department of Cardiology, Saiseikai Nagasaki Hospital.
Ikeda S; Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences.
Koga S; Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences.
Yonekura T; Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences.
Tsuneto A; Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences.
Doi Y; Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences.
Fukae S; Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences.
Minami T; Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences.
Kawano H; Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences.
Maemura K; Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences.
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Źródło :
International heart journal [Int Heart J] 2020 Sep 29; Vol. 61 (5), pp. 984-992. Date of Electronic Publication: 2020 Sep 12.
Typ publikacji :
Comparative Study; Journal Article; Randomized Controlled Trial
MeSH Terms :
Benzbromarone/*therapeutic use
Endothelium, Vascular/*physiopathology
Febuxostat/*therapeutic use
Hyperemia/*physiopathology
Hyperuricemia/*drug therapy
Uricosuric Agents/*therapeutic use
Adiponectin/blood ; Aged ; Arginine/analogs & derivatives ; Arginine/blood ; Cross-Over Studies ; Female ; Gout Suppressants/therapeutic use ; Humans ; Hyperuricemia/physiopathology ; Male ; Middle Aged ; Organic Anion Transporters/antagonists & inhibitors ; Organic Cation Transport Proteins/antagonists & inhibitors ; Treatment Outcome ; Uric Acid/blood ; Xanthine Oxidase/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Glutathione Conjugation and Protein Adduction Derived from Oxidative Debromination of Benzbromarone in Mice.
Autorzy :
Wang H; State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People's Republic of China (J.Z.); and Wuya College of Innovation (H.W., Y.F., Y.P., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering (W.W., B.G., Z.W., W.Z., S.W.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People's Republic of China.
Wang W; State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People's Republic of China (J.Z.); and Wuya College of Innovation (H.W., Y.F., Y.P., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering (W.W., B.G., Z.W., W.Z., S.W.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People's Republic of China.
Gong B; State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People's Republic of China (J.Z.); and Wuya College of Innovation (H.W., Y.F., Y.P., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering (W.W., B.G., Z.W., W.Z., S.W.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People's Republic of China.
Wang Z; State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People's Republic of China (J.Z.); and Wuya College of Innovation (H.W., Y.F., Y.P., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering (W.W., B.G., Z.W., W.Z., S.W.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People's Republic of China.
Feng Y; State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People's Republic of China (J.Z.); and Wuya College of Innovation (H.W., Y.F., Y.P., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering (W.W., B.G., Z.W., W.Z., S.W.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People's Republic of China.
Zhang W; State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People's Republic of China (J.Z.); and Wuya College of Innovation (H.W., Y.F., Y.P., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering (W.W., B.G., Z.W., W.Z., S.W.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People's Republic of China.
Wang S; State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People's Republic of China (J.Z.); and Wuya College of Innovation (H.W., Y.F., Y.P., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering (W.W., B.G., Z.W., W.Z., S.W.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People's Republic of China.
Peng Y; State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People's Republic of China (J.Z.); and Wuya College of Innovation (H.W., Y.F., Y.P., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering (W.W., B.G., Z.W., W.Z., S.W.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People's Republic of China. .
Zheng J; State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People's Republic of China (J.Z.); and Wuya College of Innovation (H.W., Y.F., Y.P., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering (W.W., B.G., Z.W., W.Z., S.W.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People's Republic of China. .
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Źródło :
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2019 Nov; Vol. 47 (11), pp. 1281-1290. Date of Electronic Publication: 2019 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzbromarone/*metabolism
Glutathione/*metabolism
Proteins/*chemistry
Acetylcysteine/metabolism ; Animals ; Benzbromarone/toxicity ; Chemical and Drug Induced Liver Injury/etiology ; Halogenation ; Liver/metabolism ; Male ; Mice ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Benzbromarone in the treatment of gout.
Autorzy :
Azevedo VF; Universidade Federal do Paraná, Rua General Carneiro 181, Centro, Curitiba, Paraná, Brazil. .; Edumed Educação em Saúde, Rua Bispo Dom José, 2495, Curitiba, Paraná, Brazil. .
Kos IA; Edumed Educação em Saúde, Rua Bispo Dom José, 2495, Curitiba, Paraná, Brazil.
Vargas-Santos AB; Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Brazil.
da Rocha Castelar Pinheiro G; Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Brazil.
Dos Santos Paiva E; Universidade Federal do Paraná, Rua General Carneiro 181, Centro, Curitiba, Paraná, Brazil.
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Źródło :
Advances in rheumatology (London, England) [Adv Rheumatol] 2019 Aug 07; Vol. 59 (1), pp. 37. Date of Electronic Publication: 2019 Aug 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Benzbromarone/*therapeutic use
Gout/*drug therapy
Uricosuric Agents/*therapeutic use
Benzbromarone/adverse effects ; Benzbromarone/metabolism ; Cytochrome P-450 CYP2C9/metabolism ; Humans ; In Vitro Techniques ; Liver/drug effects ; Liver/metabolism ; Mitochondria, Liver/drug effects ; Models, Animal ; Organic Anion Transporters/antagonists & inhibitors ; Organic Cation Transport Proteins/antagonists & inhibitors ; Safety-Based Drug Withdrawals ; Symptom Flare Up ; Uricosuric Agents/adverse effects ; Uricosuric Agents/metabolism
Czasopismo naukowe
Tytuł :
Repurposing benzbromarone for pulmonary arterial hypertension: can channelling the past deliver the therapy of the future?
Autorzy :
Theilmann AL; Queen's University, Depts of Biomedical and Molecular Sciences, Medicine and Surgery, Kingston, ON, Canada.
Ormiston ML; Queen's University, Depts of Biomedical and Molecular Sciences, Medicine and Surgery, Kingston, ON, Canada.
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Źródło :
The European respiratory journal [Eur Respir J] 2019 Jun 05; Vol. 53 (6). Date of Electronic Publication: 2019 Jun 05 (Print Publication: 2019).
Typ publikacji :
Editorial; Comment
MeSH Terms :
Benzbromarone*
Hypertension, Pulmonary*
Familial Primary Pulmonary Hypertension ; Humans ; Vasoconstriction
Opinia redakcyjna
Tytuł :
Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation.
Autorzy :
Ohe T; Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan. Electronic address: .
Umezawa R; Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan.
Kitagawara Y; Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan.
Yasuda D; Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan.
Takahashi K; Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan.
Nakamura S; Department of Chemistry, Nippon Medical School, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo, Japan.
Abe A; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
Sekine S; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
Ito K; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
Okunushi K; Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba, Japan.
Morio H; Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba, Japan.
Furihata T; Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba, Japan.
Anzai N; Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba, Japan.
Mashino T; Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Dec 15; Vol. 28 (23-24), pp. 3708-3711. Date of Electronic Publication: 2018 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzbromarone/*analogs & derivatives
Benzbromarone/*metabolism
Organic Anion Transporters/*antagonists & inhibitors
Organic Cation Transport Proteins/*antagonists & inhibitors
Uricosuric Agents/*chemistry
Uricosuric Agents/*metabolism
Activation, Metabolic ; Animals ; Benzbromarone/pharmacology ; Benzbromarone/toxicity ; Chemistry Techniques, Synthetic ; HEK293 Cells ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Humans ; Mice ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Mitochondria/drug effects ; Mitochondria/metabolism ; Organic Anion Transporters/metabolism ; Organic Cation Transport Proteins/metabolism ; Rats ; Uric Acid/metabolism ; Uricosuric Agents/pharmacology ; Uricosuric Agents/toxicity
Czasopismo naukowe
Tytuł :
Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo.
Autorzy :
Cabrita I; Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Kraus A; Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Scholz JK; Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Skoczynski K; Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Schreiber R; Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Kunzelmann K; Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany. .
Buchholz B; Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
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Źródło :
Nature communications [Nat Commun] 2020 Aug 28; Vol. 11 (1), pp. 4320. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anoctamin-1/*genetics
Anoctamin-1/*metabolism
Cysts/*metabolism
Polycystic Kidney, Autosomal Dominant/*metabolism
TRPP Cation Channels/*genetics
TRPP Cation Channels/*metabolism
Animals ; Anoctamin-1/drug effects ; Benzbromarone/pharmacology ; Calcium Channels ; Cell Proliferation ; Chlorides/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator ; Cysts/drug therapy ; Cysts/genetics ; Disease Models, Animal ; Dogs ; Epithelial Cells/metabolism ; Humans ; Kidney/metabolism ; Kidney/pathology ; Madin Darby Canine Kidney Cells ; Mice ; Mice, Knockout ; Nephrons/metabolism ; Niclosamide/pharmacology ; Polycystic Kidney, Autosomal Dominant/drug therapy ; Polycystic Kidney, Autosomal Dominant/genetics
Czasopismo naukowe
Tytuł :
Benzbromarone as a possible cause of acute kidney injury in patients with urolithiasis: Two case reports.
Autorzy :
Ye X; Department of Pharmacy, Zhejiang Provincial People's Hospital.; Department of Pharmacy, People's Hospital of Hangzhou Medical College, Hangzhou.; Department of Pharmacy, China-Japan Friendship Hospital, Beijing.
Wu J; Laboratory Medicine, The First People's Hospital of Yancheng City, Yancheng, Jiangsu.
Tang K; Department of Pharmacy, China-Japan Friendship Hospital, Beijing.
Li W; Department of Nephrology, China-Japan Friendship Hospital, Beijing.
Xiong C; College of Pharmacy, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu, China.
Zhuo L; Department of Nephrology, China-Japan Friendship Hospital, Beijing.
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Źródło :
Medicine [Medicine (Baltimore)] 2019 Apr; Vol. 98 (15), pp. e15214.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Acute Kidney Injury/*etiology
Benzbromarone/*adverse effects
Hyperuricemia/*drug therapy
Uricosuric Agents/*adverse effects
Urolithiasis/*drug therapy
Acute Kidney Injury/pathology ; Adolescent ; Benzbromarone/therapeutic use ; Humans ; Hyperuricemia/complications ; Kidney/drug effects ; Kidney/pathology ; Male ; Middle Aged ; Self Medication/adverse effects ; Uricosuric Agents/therapeutic use ; Urolithiasis/complications
Czasopismo naukowe
Tytuł :
Safety and Efficacy of Benzbromarone and Febuxostat in Hyperuricemia Patients with Chronic Kidney Disease: A Prospective Pilot Study.
Autorzy :
Yu H; Department of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Liu X; Department of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Song Y; Department of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Cheng J; Department of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Bao H; Department of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Qin L; Department of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Zhou X; Department of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Wang L; Department of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China. .
Peng A; Department of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China. .
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Źródło :
Clinical and experimental nephrology [Clin Exp Nephrol] 2018 Dec; Vol. 22 (6), pp. 1324-1330. Date of Electronic Publication: 2018 May 14.
Typ publikacji :
Comparative Study; Journal Article; Randomized Controlled Trial
MeSH Terms :
Benzbromarone/*therapeutic use
Febuxostat/*therapeutic use
Hyperuricemia/*drug therapy
Uricosuric Agents/*therapeutic use
Aged ; Alpha-Globulins/urine ; Benzbromarone/adverse effects ; Febuxostat/adverse effects ; Female ; Glomerular Filtration Rate ; Hemoglobins/metabolism ; Humans ; Hyperuricemia/blood ; Hyperuricemia/complications ; Kidney Calculi/chemically induced ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/physiopathology ; Uric Acid/blood ; Uric Acid/urine
Czasopismo naukowe
Tytuł :
Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation.
Autorzy :
Kimura Y; From the Department of Internal Medicine, Faculty of Medicine (Y.K., T.Y., A.O., D.T., H.K.), Teikyo University, Tokyo, Japan.
Yanagida T; From the Department of Internal Medicine, Faculty of Medicine (Y.K., T.Y., A.O., D.T., H.K.), Teikyo University, Tokyo, Japan.
Onda A; From the Department of Internal Medicine, Faculty of Medicine (Y.K., T.Y., A.O., D.T., H.K.), Teikyo University, Tokyo, Japan.
Tsukui D; From the Department of Internal Medicine, Faculty of Medicine (Y.K., T.Y., A.O., D.T., H.K.), Teikyo University, Tokyo, Japan.
Hosoyamada M; Department of Human Physiology and Pathology, Faculty of Pharma-Sciences (M.H.), Teikyo University, Tokyo, Japan.
Kono H; From the Department of Internal Medicine, Faculty of Medicine (Y.K., T.Y., A.O., D.T., H.K.), Teikyo University, Tokyo, Japan.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Mar; Vol. 40 (3), pp. 570-582. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
AMP-Activated Protein Kinases/*metabolism
Atherosclerosis/*enzymology
Inflammation/*enzymology
Leukocytes, Mononuclear/*enzymology
Uric Acid/*blood
Adult ; Animals ; Atherosclerosis/blood ; Atherosclerosis/pathology ; Atherosclerosis/prevention & control ; Benzbromarone/administration & dosage ; Biomarkers/blood ; Disease Models, Animal ; Enzyme Inhibitors/pharmacology ; Female ; HEK293 Cells ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Inflammasomes/genetics ; Inflammasomes/metabolism ; Inflammation/blood ; Inflammation/pathology ; Inflammation/prevention & control ; Inflammation Mediators/blood ; Interleukin-18/blood ; Interleukin-1beta/blood ; Interleukin-1beta/genetics ; Leukocytes, Mononuclear/drug effects ; Male ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; Middle Aged ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Nuclear Factor 45 Protein/blood ; Plaque, Atherosclerotic ; Reactive Oxygen Species/metabolism ; Receptors, LDL/deficiency ; Receptors, LDL/genetics ; Urate Oxidase/genetics ; Urate Oxidase/metabolism ; Uricosuric Agents/administration & dosage ; Xanthine Oxidase/antagonists & inhibitors ; Xanthine Oxidase/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Verinurad combined with febuxostat in Japanese adults with gout or asymptomatic hyperuricaemia: a phase 2a, open-label study.
Autorzy :
Shiramoto M; SOUSEIKAI PS Clinic, Fukuoka, Japan.
Liu S; Ardea Biosciences, Inc., San Diego, CA, USA.
Shen Z; Ardea Biosciences, Inc., San Diego, CA, USA.
Yan X; Ardea Biosciences, Inc., San Diego, CA, USA.
Yamamoto A; Ardea Biosciences, Inc., San Diego, CA, USA.
Gillen M; AstraZeneca LP, Gaithersburg, MD, USA.
Ito Y; AstraZeneca K.K., Osaka, Japan.
Hall J; Ardea Biosciences, Inc., San Diego, CA, USA.
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Źródło :
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2018 Sep 01; Vol. 57 (9), pp. 1602-1610.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzbromarone/*administration & dosage
Febuxostat/*administration & dosage
Gout/*drug therapy
Hyperuricemia/*drug therapy
Thioglycolates/*administration & dosage
Triazoles/*administration & dosage
Administration, Oral ; Adult ; Aged ; Benzbromarone/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Febuxostat/pharmacokinetics ; Female ; Follow-Up Studies ; Gout/blood ; Gout/epidemiology ; Gout Suppressants/administration & dosage ; Gout Suppressants/pharmacokinetics ; Humans ; Hyperuricemia/blood ; Hyperuricemia/epidemiology ; Male ; Middle Aged ; Organic Anion Transporters/antagonists & inhibitors ; Organic Cation Transport Proteins/antagonists & inhibitors ; Thioglycolates/pharmacokinetics ; Time Factors ; Treatment Outcome ; Triazoles/pharmacokinetics ; Uric Acid/blood ; Uricosuric Agents/administration & dosage ; Uricosuric Agents/pharmacokinetics ; Young Adult
Czasopismo naukowe
Tytuł :
Benzbromarone aggravates hepatic steatosis in obese individuals.
Autorzy :
Sun P; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China.
Zhu JJ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Wang T; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Huang Q; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Zhou YR; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Yu BW; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Jiang HL; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Wang HY; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2018 Jun; Vol. 1864 (6 Pt A), pp. 2067-2077. Date of Electronic Publication: 2018 Mar 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzbromarone/*pharmacology
Lipid Metabolism/*drug effects
Liver/*drug effects
Non-alcoholic Fatty Liver Disease/*drug therapy
Uricosuric Agents/*pharmacology
Adult ; Aged ; Animals ; Apoptosis/drug effects ; Benzbromarone/therapeutic use ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/pathology ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Fatty Acids, Nonesterified/metabolism ; Female ; Hep G2 Cells ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Humans ; Hyperuricemia/blood ; Hyperuricemia/drug therapy ; Liver/cytology ; Liver/metabolism ; Liver/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Middle Aged ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Obesity/blood ; Obesity/complications ; Obesity/genetics ; Obesity/metabolism ; Oxidative Stress/drug effects ; Transaminases/blood ; Uricosuric Agents/therapeutic use ; Young Adult
Czasopismo naukowe
Tytuł :
Benzbromarone mitigates cisplatin nephrotoxicity involving enhanced peroxisome proliferator-activated receptor-alpha (PPAR-α) expression.
Autorzy :
Abdel-Razek EA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address: .
Abo-Youssef AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address: .
Azouz AA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Feb 15; Vol. 243, pp. 117272. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
Benzbromarone/*pharmacology
Cisplatin/*toxicity
Kidney/*drug effects
PPAR gamma/*metabolism
Animals ; Antioxidants/pharmacology ; Blood Urea Nitrogen ; Creatinine/blood ; Inflammation/chemically induced ; Kidney/metabolism ; Kidney/pathology ; Kidney Function Tests ; Male ; Oxidative Stress/drug effects ; PPAR gamma/physiology ; RNA, Messenger/genetics ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Comparative study on the interaction between 3 CYP2C9 allelic isoforms and benzbromarone by using LC-MS/MS method.
Autorzy :
He L; Department of Industrial Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Li C; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China.
Liu X; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China.
Yang Q; Department of Pharmacology, Tianjin Medical University, Tianjin 300070, China.
Zhang H; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. Electronic address: .
Xu W; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. Electronic address: .
Zhang L; Department of Industrial Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: .
Liu C; Tianjin Center for New Drug Evaluation and Research, State Key Laboratory of Drug Delivery Technology and Pharmaceutics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China.
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Źródło :
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2017 Dec 01; Vol. 1070, pp. 97-103.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Benzbromarone/*analysis
Benzbromarone/*metabolism
Chromatography, Liquid/*methods
Cytochrome P-450 CYP2C9/*metabolism
Tandem Mass Spectrometry/*methods
Benzbromarone/chemistry ; Cytochrome P-450 CYP2C9/chemistry ; Humans ; Limit of Detection ; Linear Models ; Protein Isoforms ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Effects of Conventional Uric Acid-Lowering Therapy on Monosodium Urate Crystal Deposits.
Autorzy :
Ellmann H; Friedrich-Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Bayat S; Friedrich-Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Araujo E; Friedrich-Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Manger B; Friedrich-Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Kleyer A; Friedrich-Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Cavallaro A; Friedrich-Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Lell M; Klinikum Nuremberg, Radiologie Nuremberg, Nuremberg, Germany.
Schenker H; Friedrich-Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Simon D; Friedrich-Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Tascilar K; Friedrich-Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Baraf HSB; Klinikum Nuremberg, Radiologie Nuremberg, Nuremberg, Germany, the Center for Rheumatology and Bone Research, Wheaton, Maryland, and The George Washington University, Washington, DC.
Schett G; Friedrich-Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Rech J; Friedrich-Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
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Źródło :
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2020 Jan; Vol. 72 (1), pp. 150-156. Date of Electronic Publication: 2019 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Diet Therapy*
Foot Joints/*diagnostic imaging
Gout/*therapy
Gout Suppressants/*therapeutic use
Uric Acid/*blood
Aged ; Alcohol Drinking ; Allopurinol/therapeutic use ; Benzbromarone/therapeutic use ; Febuxostat/therapeutic use ; Female ; Fructose ; Gout/diagnostic imaging ; Humans ; Male ; Meat ; Middle Aged ; Prospective Studies ; Purines ; Shellfish ; Tomography, X-Ray Computed ; Uricosuric Agents/therapeutic use
Czasopismo naukowe
Tytuł :
Metabolic Epoxidation Is a Critical Step for the Development of Benzbromarone-Induced Hepatotoxicity.
Autorzy :
Wang H; Wuya College of Innovation (H.W., Y.P., H.Z., Y.Z., X.W., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education) (W.W., S.W.), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China; School of Pharmacy, China Medical University, Shenyang, Liaoning, P.R. China (T.Z.); Guangdong Provincial Key Laboratory of Drug Screening and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, P.R. China (Q.L., J.P.); and State Key Laboratory of Functions and Applications of Medicinal Plants and Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, P.R. China (J.Z.).
Peng Y; Wuya College of Innovation (H.W., Y.P., H.Z., Y.Z., X.W., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education) (W.W., S.W.), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China; School of Pharmacy, China Medical University, Shenyang, Liaoning, P.R. China (T.Z.); Guangdong Provincial Key Laboratory of Drug Screening and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, P.R. China (Q.L., J.P.); and State Key Laboratory of Functions and Applications of Medicinal Plants and Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, P.R. China (J.Z.).
Zhang T; Wuya College of Innovation (H.W., Y.P., H.Z., Y.Z., X.W., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education) (W.W., S.W.), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China; School of Pharmacy, China Medical University, Shenyang, Liaoning, P.R. China (T.Z.); Guangdong Provincial Key Laboratory of Drug Screening and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, P.R. China (Q.L., J.P.); and State Key Laboratory of Functions and Applications of Medicinal Plants and Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, P.R. China (J.Z.).
Lan Q; Wuya College of Innovation (H.W., Y.P., H.Z., Y.Z., X.W., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education) (W.W., S.W.), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China; School of Pharmacy, China Medical University, Shenyang, Liaoning, P.R. China (T.Z.); Guangdong Provincial Key Laboratory of Drug Screening and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, P.R. China (Q.L., J.P.); and State Key Laboratory of Functions and Applications of Medicinal Plants and Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, P.R. China (J.Z.).
Zhao H; Wuya College of Innovation (H.W., Y.P., H.Z., Y.Z., X.W., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education) (W.W., S.W.), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China; School of Pharmacy, China Medical University, Shenyang, Liaoning, P.R. China (T.Z.); Guangdong Provincial Key Laboratory of Drug Screening and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, P.R. China (Q.L., J.P.); and State Key Laboratory of Functions and Applications of Medicinal Plants and Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, P.R. China (J.Z.).
Wang W; Wuya College of Innovation (H.W., Y.P., H.Z., Y.Z., X.W., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education) (W.W., S.W.), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China; School of Pharmacy, China Medical University, Shenyang, Liaoning, P.R. China (T.Z.); Guangdong Provincial Key Laboratory of Drug Screening and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, P.R. China (Q.L., J.P.); and State Key Laboratory of Functions and Applications of Medicinal Plants and Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, P.R. China (J.Z.).
Zhao Y; Wuya College of Innovation (H.W., Y.P., H.Z., Y.Z., X.W., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education) (W.W., S.W.), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China; School of Pharmacy, China Medical University, Shenyang, Liaoning, P.R. China (T.Z.); Guangdong Provincial Key Laboratory of Drug Screening and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, P.R. China (Q.L., J.P.); and State Key Laboratory of Functions and Applications of Medicinal Plants and Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, P.R. China (J.Z.).
Wang X; Wuya College of Innovation (H.W., Y.P., H.Z., Y.Z., X.W., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education) (W.W., S.W.), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China; School of Pharmacy, China Medical University, Shenyang, Liaoning, P.R. China (T.Z.); Guangdong Provincial Key Laboratory of Drug Screening and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, P.R. China (Q.L., J.P.); and State Key Laboratory of Functions and Applications of Medicinal Plants and Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, P.R. China (J.Z.).
Pang J; Wuya College of Innovation (H.W., Y.P., H.Z., Y.Z., X.W., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education) (W.W., S.W.), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China; School of Pharmacy, China Medical University, Shenyang, Liaoning, P.R. China (T.Z.); Guangdong Provincial Key Laboratory of Drug Screening and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, P.R. China (Q.L., J.P.); and State Key Laboratory of Functions and Applications of Medicinal Plants and Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, P.R. China (J.Z.) .
Wang S; Wuya College of Innovation (H.W., Y.P., H.Z., Y.Z., X.W., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education) (W.W., S.W.), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China; School of Pharmacy, China Medical University, Shenyang, Liaoning, P.R. China (T.Z.); Guangdong Provincial Key Laboratory of Drug Screening and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, P.R. China (Q.L., J.P.); and State Key Laboratory of Functions and Applications of Medicinal Plants and Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, P.R. China (J.Z.) .
Zheng J; Wuya College of Innovation (H.W., Y.P., H.Z., Y.Z., X.W., J.Z.) and Key Laboratory of Structure-Based Drug Design and Discovery (Ministry of Education) (W.W., S.W.), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China; School of Pharmacy, China Medical University, Shenyang, Liaoning, P.R. China (T.Z.); Guangdong Provincial Key Laboratory of Drug Screening and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, P.R. China (Q.L., J.P.); and State Key Laboratory of Functions and Applications of Medicinal Plants and Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, P.R. China (J.Z.) .
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Źródło :
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2017 Dec; Vol. 45 (12), pp. 1354-1363. Date of Electronic Publication: 2017 Oct 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzbromarone/*toxicity
Chemical and Drug Induced Liver Injury/*etiology
Cytochrome P-450 CYP3A/*metabolism
Gout/*drug therapy
Uricosuric Agents/*toxicity
Activation, Metabolic ; Animals ; Benzbromarone/analogs & derivatives ; Benzbromarone/metabolism ; Benzbromarone/therapeutic use ; Chemical and Drug Induced Liver Injury/metabolism ; Disease Models, Animal ; Dogs ; Epoxy Compounds/metabolism ; Gout/chemically induced ; Humans ; Liver/cytology ; Liver/drug effects ; Madin Darby Canine Kidney Cells ; Male ; Mice ; Microsomes, Liver/drug effects ; Organic Anion Transporters/antagonists & inhibitors ; Organic Cation Transport Proteins/antagonists & inhibitors ; Oxonic Acid/toxicity ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Treatment Outcome ; Uricosuric Agents/chemistry ; Uricosuric Agents/metabolism ; Uricosuric Agents/therapeutic use
Czasopismo naukowe
Tytuł :
Nephrolithiasis in gout: prevalence and characteristics of Brazilian patients.
Autorzy :
Hoff LS; Division of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), Av. Dr. Arnaldo 455, sala 3131, Sao Paulo, 01246-903, Brazil. .
Goldenstein-Schainberg C; Division of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), Av. Dr. Arnaldo 455, sala 3131, Sao Paulo, 01246-903, Brazil.
Fuller R; Division of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), Av. Dr. Arnaldo 455, sala 3131, Sao Paulo, 01246-903, Brazil.
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Źródło :
Advances in rheumatology (London, England) [Adv Rheumatol] 2019 Dec 31; Vol. 60 (1), pp. 2. Date of Electronic Publication: 2019 Dec 31.
Typ publikacji :
Journal Article
MeSH Terms :
Gout/*complications
Kidney Calculi/*epidemiology
Adult ; Asymptomatic Diseases/epidemiology ; Benzbromarone/therapeutic use ; Brazil/epidemiology ; Cross-Sectional Studies ; Diabetes Mellitus/drug therapy ; Diuretics/therapeutic use ; Dyslipidemias/drug therapy ; Female ; Gout/drug therapy ; Humans ; Hypoglycemic Agents/therapeutic use ; Kidney Calculi/chemically induced ; Kidney Calculi/chemistry ; Kidney Calculi/diagnostic imaging ; Male ; Middle Aged ; Potassium Citrate/therapeutic use ; Prevalence ; Sex Factors ; Ultrasonography ; Uricosuric Agents/therapeutic use
Czasopismo naukowe
Tytuł :
Human MRP2 exports MC-LR but not the glutathione conjugate.
Autorzy :
Kaur G; Human and Environmental Toxicology, University of Konstanz, 78457, Konstanz, Germany; School of Pharmaceutical Sciences, Shoolini University, Solan, 173212, India. Electronic address: .
Fahrner R; Department of Chemistry, University of Konstanz, 78457, Konstanz, Germany. Electronic address: .
Wittmann V; Department of Chemistry, University of Konstanz, 78457, Konstanz, Germany. Electronic address: .
Stieger B; Department of Clinical Pharmacology and Toxicology, University Hospital, 8091, Zurich, Switzerland. Electronic address: .
Dietrich DR; Human and Environmental Toxicology, University of Konstanz, 78457, Konstanz, Germany. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2019 Sep 25; Vol. 311, pp. 108761. Date of Electronic Publication: 2019 Jul 23.
Typ publikacji :
Journal Article
MeSH Terms :
Glutathione/*chemistry
Microcystins/*metabolism
Multidrug Resistance-Associated Proteins/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Benzbromarone/chemistry ; Benzbromarone/metabolism ; Chromatography, High Pressure Liquid ; HEK293 Cells ; Hepatocytes/cytology ; Hepatocytes/metabolism ; Humans ; Microcystins/analysis ; Multidrug Resistance-Associated Proteins/antagonists & inhibitors ; Organic Anion Transporters/genetics ; Organic Anion Transporters/metabolism ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension.
Autorzy :
Wang Y; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Pandey RN; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
York AJ; Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Mallela J; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Nichols WC; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Hu YC; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Molkentin JD; Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Wikenheiser-Brokamp KA; Division of Pathology & Laboratory Medicine and Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Hegde RS; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA. .
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Źródło :
Nature communications [Nat Commun] 2019 Sep 12; Vol. 10 (1), pp. 4143. Date of Electronic Publication: 2019 Sep 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Vascular Remodeling*/drug effects
DNA-Binding Proteins/*metabolism
Pulmonary Arterial Hypertension/*enzymology
Pulmonary Arterial Hypertension/*physiopathology
Animals ; Apoptosis/drug effects ; Benzbromarone/analogs & derivatives ; Benzbromarone/pharmacology ; Cardiomegaly/complications ; Cardiomegaly/pathology ; Cardiomegaly/physiopathology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; DNA Damage ; DNA Repair/drug effects ; DNA-Binding Proteins/antagonists & inhibitors ; Heart Ventricles/drug effects ; Heart Ventricles/pathology ; Hypoxia/complications ; Hypoxia/physiopathology ; Male ; Mice, Transgenic ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Pulmonary Arterial Hypertension/complications ; Pulmonary Artery/pathology ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Baseline urate level and renal function predict outcomes of urate-lowering therapy using low doses of febuxostat and benzbromarone: a prospective, randomized controlled study in a Chinese primary gout cohort.
Autorzy :
Liang N; The Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, China.; Qingdao University, Qingdao, China.; Shandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, the Affiliated Hospital of Qingdao University, Qingdao, China.
Sun M; Department of Rheumatology and Clinical Immunology, the Affiliated Hospital of Qingdao University, Qingdao, China.
Sun R; The Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, China.
Xu T; Department of Geratology, the 971th Hospital of PLA, Qingdao, China.
Cui L; Shandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, the Affiliated Hospital of Qingdao University, Qingdao, China.
Wang C; Shandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, the Affiliated Hospital of Qingdao University, Qingdao, China.
Ma L; The Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, China.
Cheng X; The Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, China.
Xue X; The Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, China.; Qingdao University, Qingdao, China.; Shandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, the Affiliated Hospital of Qingdao University, Qingdao, China.
Sun W; Institute of Metabolic Diseases, Qingdao University, Qingdao, China.
Yuan X; Institute of Metabolic Diseases, Qingdao University, Qingdao, China.
Zhang H; Institute of Metabolic Diseases, Qingdao University, Qingdao, China.
Li H; Institute of Metabolic Diseases, Qingdao University, Qingdao, China.
He Y; Shandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, the Affiliated Hospital of Qingdao University, Qingdao, China.; Institute of Metabolic Diseases, Qingdao University, Qingdao, China.
Ji A; Shandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, the Affiliated Hospital of Qingdao University, Qingdao, China.; Institute of Metabolic Diseases, Qingdao University, Qingdao, China.
Wu X; Institute of Metabolic Diseases, Qingdao University, Qingdao, China. .
Li C; The Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, China. .; Shandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, the Affiliated Hospital of Qingdao University, Qingdao, China. .; Institute of Metabolic Diseases, Qingdao University, Qingdao, China. .
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Źródło :
Arthritis research & therapy [Arthritis Res Ther] 2019 Sep 02; Vol. 21 (1), pp. 200. Date of Electronic Publication: 2019 Sep 02.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzbromarone/*administration & dosage
Febuxostat/*administration & dosage
Glomerular Filtration Rate/*physiology
Gout/*drug therapy
Kidney/*physiopathology
Uric Acid/*metabolism
Biomarkers/metabolism ; China ; Dose-Response Relationship, Drug ; Follow-Up Studies ; Gout/metabolism ; Gout/physiopathology ; Gout Suppressants/administration & dosage ; Humans ; Male ; Middle Aged ; Prospective Studies ; Treatment Outcome ; Uricosuric Agents/administration & dosage
Czasopismo naukowe
Tytuł :
Identification of novel glutathione adducts of benzbromarone in human liver microsomes.
Autorzy :
Cho N; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
Kobayashi K; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan. Electronic address: .
Yoshida M; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
Kogure N; Department of Bio-functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
Takayama H; Department of Bio-functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
Chiba K; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
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Źródło :
Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2017 Feb; Vol. 32 (1), pp. 46-52. Date of Electronic Publication: 2016 Oct 27.
Typ publikacji :
Journal Article
MeSH Terms :
Benzbromarone/*analogs & derivatives
Benzbromarone/*metabolism
Glutathione/*metabolism
Microsomes, Liver/*metabolism
Benzbromarone/adverse effects ; Benzbromarone/chemistry ; Glutathione/chemistry ; Humans ; Inactivation, Metabolic ; Molecular Structure
Czasopismo naukowe

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