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Wyszukujesz frazę ""Benzyl Alcohols"" wg kryterium: Temat


Tytuł :
Mechanistic study of the biosynthesis of R-phenylcarbinol by acetohydroxyacid synthase enzyme using hybrid quantum mechanics/molecular mechanics simulations.
Autorzy :
Alvarado O; Departamento de Físico-Química, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción, Chile; Departamento de Química, Facultad de Ciencias, Universidad del Bío-Bío, Avenida Collao 1202, Concepción, Chile.
García-Meseguer R; School of Mathematics, University of Bristol, Bristol, United Kingdom; Department of Physical Chemistry, Universitat de Valencia, 46100, Burjassot, Spain.
Ruiz-Pernía JJ; Department of Physical Chemistry, Universitat de Valencia, 46100, Burjassot, Spain.
Tuñon I; Department of Physical Chemistry, Universitat de Valencia, 46100, Burjassot, Spain.
Delgado EJ; Departamento de Físico-Química, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción, Chile. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Apr 15; Vol. 701, pp. 108807. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Dynamics Simulation*
Acetolactate Synthase/*chemistry
Benzyl Alcohols/*chemical synthesis
Benzyl Alcohols/chemistry ; Quantum Theory
Czasopismo naukowe
Tytuł :
Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial.
Autorzy :
Lee LA; GlaxoSmithKline (GSK), Collegeville, PA, USA.
Bailes Z; GSK, Stockley Park West, Uxbridge, Middlesex, UK.
Barnes N; GSK, Brentford, Middlesex, UK; Barts and the London School of Medicine and Dentistry, London, UK.
Boulet LP; Laval University, Quebec, QC, Canada.
Edwards D; GSK, Stockley Park West, Uxbridge, Middlesex, UK.
Fowler A; GSK, Stockley Park West, Uxbridge, Middlesex, UK.
Hanania NA; Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA.
Kerstjens HAM; University of Groningen and University Medical Center Groningen, and Groningen Research Institute for Asthma and COPD, Groningen, Netherlands.
Kerwin E; Crisor, Clinical Research Institute, Medford, OR, USA.
Nathan R; Asthma & Allergy Associates, PC and Research Center, Colorado Springs, CO, USA.
Oppenheimer J; Rutgers New Jersey Medical School, Newark, NJ, USA.
Papi A; University of Ferrara, Ferrara, Italy.
Pascoe S; GlaxoSmithKline (GSK), Collegeville, PA, USA.
Brusselle G; Ghent University Hospital, Ghent, Belgium.
Peachey G; GSK, Stockley Park West, Uxbridge, Middlesex, UK.
Sule N; GlaxoSmithKline (GSK), Collegeville, PA, USA.
Tabberer M; GSK, Stockley Park West, Uxbridge, Middlesex, UK.
Pavord ID; Nuffield Department of Medicine and Oxford Respiratory NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. Electronic address: .
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Źródło :
The Lancet. Respiratory medicine [Lancet Respir Med] 2021 Jan; Vol. 9 (1), pp. 69-84. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Androstadienes/*administration & dosage
Anti-Asthmatic Agents/*administration & dosage
Asthma/*drug therapy
Benzyl Alcohols/*administration & dosage
Chlorobenzenes/*administration & dosage
Quinuclidines/*administration & dosage
Administration, Inhalation ; Androstadienes/therapeutic use ; Anti-Asthmatic Agents/therapeutic use ; Benzyl Alcohols/therapeutic use ; Chlorobenzenes/therapeutic use ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Humans ; Male ; Middle Aged ; Nebulizers and Vaporizers ; Quinuclidines/therapeutic use
Czasopismo naukowe
Tytuł :
The improvement effect of gastrodin on LPS/GalN-induced fulminant hepatitis via inhibiting inflammation and apoptosis and restoring autophagy.
Autorzy :
Lv H; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, Heilongjiang Bayi, China.
Liu Y; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, Heilongjiang Bayi, China.
Zhang B; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, Heilongjiang Bayi, China.
Zheng Y; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, Heilongjiang Bayi, China.
Ji H; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, Heilongjiang Bayi, China.
Li S; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, Heilongjiang Bayi, China. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2020 Aug; Vol. 85, pp. 106627. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Benzyl Alcohols/*pharmacology
Glucosides/*pharmacology
Massive Hepatic Necrosis/*drug therapy
Acetyl-CoA Carboxylase/metabolism ; Alanine Transaminase/blood ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Apoptosis/drug effects ; Aspartate Aminotransferases/blood ; Autophagy/drug effects ; Benzyl Alcohols/chemistry ; Benzyl Alcohols/therapeutic use ; Cytokines/metabolism ; Galactosamine/toxicity ; Glucosides/chemistry ; Glucosides/therapeutic use ; Hep G2 Cells ; Humans ; Inflammasomes/drug effects ; Inflammation/drug therapy ; Inflammation/metabolism ; Lipopolysaccharides/toxicity ; Male ; Massive Hepatic Necrosis/chemically induced ; Mice, Inbred C57BL ; NF-kappa B p50 Subunit/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Protein Kinases/metabolism ; Survival Rate
Czasopismo naukowe
Tytuł :
The antidepressant effect of 4-hydroxybenzyl alcohol 2-naphthoate through monoaminergic, GABAergic system and BDNF signaling pathway.
Autorzy :
Zhang D; Department of traditional Chinese medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Zhu HY; Department of traditional Chinese medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Bian XB; Department of traditional Chinese medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Zhao Y; Department of traditional Chinese medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Zang P; Department of traditional Chinese medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Gao YG; Department of traditional Chinese medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Zhang LX; Department of traditional Chinese medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
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Źródło :
Natural product research [Nat Prod Res] 2020 Aug; Vol. 34 (16), pp. 2328-2331. Date of Electronic Publication: 2018 Dec 23.
Typ publikacji :
Journal Article
MeSH Terms :
Antidepressive Agents/*pharmacology
Benzyl Alcohols/*pharmacology
Brain/*metabolism
Brain-Derived Neurotrophic Factor/*metabolism
Signal Transduction/*drug effects
Animals ; Antidepressive Agents/chemistry ; Benzyl Alcohols/chemistry ; Biogenic Monoamines/metabolism ; Gastrodia/chemistry ; Hindlimb Suspension ; Mice ; Swimming ; gamma-Aminobutyric Acid/metabolism
Czasopismo naukowe
Tytuł :
RIFM fragrance ingredient safety assessment, p-isopropylbenzyl alcohol, CAS Registry Number 536-60-7.
Autorzy :
Api AM; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Belsito D; Member Expert Panel, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.
Biserta S; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Botelho D; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Bruze M; Member Expert Panel, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo, SE, 20502, Sweden.
Burton GA Jr; Member Expert Panel, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI, 58109, USA.
Buschmann J; Member Expert Panel, Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, 30625, Hannover, Germany.
Cancellieri MA; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Dagli ML; Member Expert Panel, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo CEP, 05508-900, Brazil.
Date M; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Dekant W; Member Expert Panel, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078, Würzburg, Germany.
Deodhar C; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Fryer AD; Member Expert Panel, Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.
Gadhia S; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Jones L; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Joshi K; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Lapczynski A; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Lavelle M; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Liebler DC; Member Expert Panel, Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN, 37232-0146, USA.
Na M; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
O'Brien D; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Patel A; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Penning TM; Member of Expert Panel, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA.
Ritacco G; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Rodriguez-Ropero F; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Romine J; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Sadekar N; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Salvito D; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Schultz TW; Member Expert Panel, The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN, 37996- 4500, USA.
Siddiqi F; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Sipes IG; Member Expert Panel, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ, 85724-5050, USA.
Sullivan G; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. Electronic address: .
Thakkar Y; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Tokura Y; Member Expert Panel, The Journal of Dermatological Science (JDS), Editor-in-Chief, Professor and Chairman, Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.
Tsang S; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2020 Jul 15; Vol. 141 Suppl 1, pp. 111338. Date of Electronic Publication: 2020 Apr 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Benzyl Alcohols/*toxicity
Perfume/*chemistry
Animals ; Benzyl Alcohols/metabolism ; Humans ; Mutagenicity Tests ; Odorants ; Toxicity Tests
Czasopismo naukowe
Tytuł :
The effects of gastrodin injection on hypertension: A systematic review and meta-analysis.
Autorzy :
Qian L; Affiliated Hospital of Nanjing University of Chinese Medicine.; Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Yan S; Affiliated Hospital of Nanjing University of Chinese Medicine.
Li Y; Affiliated Hospital of Nanjing University of Chinese Medicine.; Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Wu L; Affiliated Hospital of Nanjing University of Chinese Medicine.; Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Zheng Y; Affiliated Hospital of Nanjing University of Chinese Medicine.; Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Wang Y; Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Fang Z; Affiliated Hospital of Nanjing University of Chinese Medicine.; Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Jul 02; Vol. 99 (27), pp. e20936.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Benzyl Alcohols/*therapeutic use
Glucosides/*therapeutic use
Hypertension/*drug therapy
Benzyl Alcohols/administration & dosage ; Blood Pressure ; Glucosides/administration & dosage ; Humans ; Injections
Czasopismo naukowe
Tytuł :
Enantioselective Hydroxylation of Benzylic C(sp )-H Bonds by an Artificial Iron Hydroxylase Based on the Biotin-Streptavidin Technology.
Autorzy :
Serrano-Plana J; Department of Chemistry, University of Basel, BPR1096, Mattenstrasse 24a, CH-4058 Basel, Switzerland.
Rumo C; Department of Chemistry, University of Basel, BPR1096, Mattenstrasse 24a, CH-4058 Basel, Switzerland.
Rebelein JG; Department of Chemistry, University of Basel, BPR1096, Mattenstrasse 24a, CH-4058 Basel, Switzerland.
Peterson RL; Department of Chemistry, University of Basel, BPR1096, Mattenstrasse 24a, CH-4058 Basel, Switzerland.; Department of Chemistry and Biochemistry, Texas State University, 78666 Texas, United States.
Barnet M; Department of Chemistry, University of Basel, BPR1096, Mattenstrasse 24a, CH-4058 Basel, Switzerland.
Ward TR; Department of Chemistry, University of Basel, BPR1096, Mattenstrasse 24a, CH-4058 Basel, Switzerland.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2020 Jun 17; Vol. 142 (24), pp. 10617-10623. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzyl Alcohols/*metabolism
Biotin/*metabolism
Iron/*metabolism
Mixed Function Oxygenases/*metabolism
Streptavidin/*metabolism
Benzyl Alcohols/chemistry ; Biotin/chemistry ; Hydroxylation ; Iron/chemistry ; Mixed Function Oxygenases/chemistry ; Models, Molecular ; Molecular Structure ; Stereoisomerism ; Streptavidin/chemistry
Czasopismo naukowe
Tytuł :
Single-inhaler triple therapy fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol and umeclidinium/vilanterol in patients with COPD: results on cardiovascular safety from the IMPACT trial.
Autorzy :
Day NC; GlaxoSmithKline, Stockley Park West, 1-3 Ironbridge Road, Uxbridge, Middlesex, UB11 1BT, UK. .
Kumar S; GlaxoSmithKline, Stockley Park West, 1-3 Ironbridge Road, Uxbridge, Middlesex, UB11 1BT, UK.
Criner G; Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Dransfield M; Division of Pulmonary, Allergy, and Critical Care Medicine, Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Halpin DMG; University of Exeter Medical School, College of Medicine and Health, Exeter, UK.
Han MK; University of Michigan, Pulmonary & Critical Care, Ann Arbor, MI, USA.
Jones CE; GlaxoSmithKline, Research Triangle Park, NC, USA.
Kaisermann MC; GlaxoSmithKline, Collegeville, PA, USA.
Kilbride S; GlaxoSmithKline, Stockley Park West, 1-3 Ironbridge Road, Uxbridge, Middlesex, UB11 1BT, UK.
Lange P; Department of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, Denmark.; Medical Department, Herlev and Gentofte Hospital, Herlev, Denmark.
Lomas DA; UCL Respiratory, University College London, London, UK.
Martin N; GlaxoSmithKline, Brentford, UK.; University of Leicester, Leicester, UK.
Martinez FJ; New York-Presbyterian Weill Cornell Medical Center, New York, NY, USA.
Singh D; University of Manchester, Manchester University NHS Foundation Trust, Manchester, UK.
Wise R; Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medicine, Baltimore, MD, USA.
Lipson DA; GlaxoSmithKline, Collegeville, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
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Źródło :
Respiratory research [Respir Res] 2020 Jun 05; Vol. 21 (1), pp. 139. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Androstadienes/*administration & dosage
Benzyl Alcohols/*administration & dosage
Chlorobenzenes/*administration & dosage
Nebulizers and Vaporizers/*trends
Pulmonary Disease, Chronic Obstructive/*diagnosis
Pulmonary Disease, Chronic Obstructive/*drug therapy
Quinuclidines/*administration & dosage
Aged ; Androstadienes/adverse effects ; Benzyl Alcohols/adverse effects ; Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/diagnosis ; Chlorobenzenes/adverse effects ; Double-Blind Method ; Drug Combinations ; Female ; Humans ; Male ; Middle Aged ; Quinuclidines/adverse effects
Czasopismo naukowe
Tytuł :
Reply to López-Campos et al. : Triple-Therapy Trials for Chronic Obstructive Pulmonary Disease: Methodological Considerations in the Mortality Effect.
Autorzy :
Lipson DA; GlaxoSmithKline Collegeville, Pennsylvania.
Han MK; University of Pennsylvania Philadelphia, Pennsylvania.
Wise R; University of Michigan Ann Arbor, Michigan.
Martinez FJ; Johns Hopkins University Baltimore, Maryland and.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2021 Apr 01; Vol. 203 (7), pp. 928-929.
Typ publikacji :
Letter; Comment
MeSH Terms :
Chlorobenzenes*
Pulmonary Disease, Chronic Obstructive*/drug therapy
Androstadienes ; Benzyl Alcohols ; Humans ; Quinuclidines
Opinia redakcyjna
Tytuł :
The Infuence of Salicin on Rheological and Film-Forming Properties of Collagen.
Autorzy :
Adamiak K; Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarin 7 Street, 87-100 Torun, Poland.; WellU sp.z.o.o, Wielkopolska 280, 81-531 Gdynia, Poland.
Lewandowska K; Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarin 7 Street, 87-100 Torun, Poland.
Sionkowska A; Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarin 7 Street, 87-100 Torun, Poland.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Mar 16; Vol. 26 (6). Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article
MeSH Terms :
Benzyl Alcohols/*chemistry
Collagen/*chemistry
Glucosides/*chemistry
Animals ; Fishes/metabolism ; Microscopy, Atomic Force/methods ; Rheology ; Surface Properties
Czasopismo naukowe
Tytuł :
Clinical therapeutic effects of gastrodin in combination with betahistine on vertigo: A protocol for systematic review and meta-analysis.
Autorzy :
Qiao YL; Department of Neurology, Hanyang Hospital of Wuhan.
Xiang WQ; Department of Neurology, the Fourth Hospital of Wuhan.
Liu F; Department of Respiratory Medicine, Hubei NO.3 People's Hospital of Jianghan University.
Jin S; Nephrology Department of Integrated Traditional Chinese and Western Medicine, Hubei NO.3 People's Hospital of Jianghan University, Wuhan, Hubei, China.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Mar 12; Vol. 100 (10), pp. e23825.
Typ publikacji :
Journal Article
MeSH Terms :
Benzyl Alcohols/*therapeutic use
Betahistine/*therapeutic use
Glucosides/*therapeutic use
Vertigo/*drug therapy
China ; Drug Therapy, Combination/methods ; Humans ; Meta-Analysis as Topic ; Randomized Controlled Trials as Topic ; Systematic Reviews as Topic ; Treatment Outcome
Czasopismo naukowe
Tytuł :
The effect of exacerbation history on outcomes in the IMPACT trial.
Autorzy :
Halpin DMG; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK .
Dransfield MT; Division of Pulmonary, Allergy, and Critical Care Medicine, Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Han MK; University of Michigan, Pulmonary & Critical Care, Ann Arbor, MI, USA.
Jones CE; GlaxoSmithKline, Research Triangle Park, NC, USA.
Kilbride S; GlaxoSmithKline, Stockley Park, UK.
Lange P; Medical Dept, Herlev and Gentofte Hospital, Herlev, Denmark.; University of Copenhagen, Copenhagen, Denmark.
Lipson DA; GlaxoSmithKline, Collegeville, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lomas DA; UCL Respiratory, University College London, London, UK.
Martinez FJ; New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA.
Pascoe S; GlaxoSmithKline, Collegeville, PA, USA.; Sanofi, Philadelphia, PA, USA.
Singh D; University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Hospitals Trust, Manchester, UK.
Wise R; Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medicine, Baltimore, MD, USA.
Criner GJ; Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
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Źródło :
The European respiratory journal [Eur Respir J] 2020 May 21; Vol. 55 (5). Date of Electronic Publication: 2020 May 21 (Print Publication: 2020).
Typ publikacji :
Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Androstadienes/*administration & dosage
Benzyl Alcohols/*administration & dosage
Chlorobenzenes/*administration & dosage
Lung/*drug effects
Pulmonary Disease, Chronic Obstructive/*drug therapy
Quinuclidines/*administration & dosage
Administration, Inhalation ; Adrenergic beta-2 Receptor Agonists/administration & dosage ; Adrenergic beta-2 Receptor Agonists/adverse effects ; Aged ; Androstadienes/adverse effects ; Benzyl Alcohols/adverse effects ; Bronchodilator Agents/administration & dosage ; Bronchodilator Agents/adverse effects ; Chlorobenzenes/adverse effects ; Disease Progression ; Double-Blind Method ; Drug Combinations ; Female ; Health Status ; Humans ; Lung/physiopathology ; Male ; Middle Aged ; Muscarinic Antagonists/administration & dosage ; Muscarinic Antagonists/adverse effects ; Nebulizers and Vaporizers ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Quinuclidines/adverse effects ; Recovery of Function ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Effects of gastrodin against carbon tetrachloride induced kidney inflammation and fibrosis in mice associated with the AMPK/Nrf2/HMGB1 pathway.
Autorzy :
Ma JQ; School of Chemistry Engineering, Sichuan University of Science and Engineering, No. 180, Huixing Road, 643000, Zigong City, Sichuan Province, PR China. .
Sun YZ
Ming QL
Tian ZK
Zhang YJ
Liu CM
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Źródło :
Food & function [Food Funct] 2020 May 01; Vol. 11 (5), pp. 4615-4624. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article
MeSH Terms :
Benzyl Alcohols/*therapeutic use
Fibrosis/*prevention & control
Glucosides/*therapeutic use
Inflammation/*prevention & control
Kidney Diseases/*prevention & control
Animals ; Benzyl Alcohols/administration & dosage ; Carbon Tetrachloride ; Disease Models, Animal ; Glucosides/administration & dosage ; HMGB1 Protein/metabolism ; Male ; Mice ; Mice, Inbred ICR ; NF-E2-Related Factor 2/metabolism ; Phytotherapy ; Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Pharmacological Effects of 1'-Acetoxychavicol Acetate, a Major Constituent in the Rhizomes of Alpinia galanga and Alpinia conchigera .
Autorzy :
Kojima-Yuasa A; Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Osaka, Japan.
Matsui-Yuasa I; Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Osaka, Japan.
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Źródło :
Journal of medicinal food [J Med Food] 2020 May; Vol. 23 (5), pp. 465-475. Date of Electronic Publication: 2020 Feb 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alpinia/*chemistry
Benzyl Alcohols/*pharmacology
Plant Extracts/*pharmacology
Anti-Infective Agents ; Benzyl Alcohols/chemistry ; Dementia/drug therapy ; Humans ; Neoplasms/drug therapy ; Obesity/drug therapy ; Rhizome/chemistry
Czasopismo naukowe
Tytuł :
Cost-consequence analysis of fluticasone furoate/vilanterol for asthma management in Spain: an analysis based on the Salford Lung Study in asthma.
Autorzy :
Vallejo-Aparicio LA; Market Access, GSK (GlaxoSmithKline), Madrid, Spain. .
Molina J; Centro de Salud Francia, Fuenlabrada, Madrid, Spain.
Ojanguren I; Servicio de Neumología, Hospital Universitario Vall d'Hebron, Barcelona, Spain.; Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Barcelona, Spain.
Viejo Casas A; Centro de Salud Pisueña Cayon, Cantabria, Spain.
Huerta A; Market Access, GSK (GlaxoSmithKline), Madrid, Spain.
Svedsater H; Value Evidence and Outcomes, GSK, Brentford, UK.
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Źródło :
The European journal of health economics : HEPAC : health economics in prevention and care [Eur J Health Econ] 2020 Feb; Vol. 21 (1), pp. 7-17. Date of Electronic Publication: 2019 Sep 23.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Androstadienes/*therapeutic use
Asthma/*drug therapy
Benzyl Alcohols/*therapeutic use
Bronchodilator Agents/*therapeutic use
Chlorobenzenes/*therapeutic use
Administration, Inhalation ; Androstadienes/administration & dosage ; Androstadienes/economics ; Benzyl Alcohols/administration & dosage ; Benzyl Alcohols/economics ; Bronchodilator Agents/administration & dosage ; Bronchodilator Agents/economics ; Chlorobenzenes/administration & dosage ; Chlorobenzenes/economics ; Costs and Cost Analysis ; Dose-Response Relationship, Drug ; Drug Combinations ; Forced Expiratory Volume ; Humans ; Models, Economic ; Severity of Illness Index ; Spain
Czasopismo naukowe
Tytuł :
Population Pharmacokinetic Analysis of Fluticasone Furoate/Umeclidinium Bromide/Vilanterol in Patients with Chronic Obstructive Pulmonary Disease.
Autorzy :
Mehta R; GSK, Research Triangle Park, NC, USA. .
Farrell C; ICON Development Solutions, Marlow, UK.
Hayes S; ICON Development Solutions, Marlow, UK.
Birk R; GSK, Uxbridge, UK.
Okour M; GSK, Collegeville, PA, USA.
Lipson DA; GSK, Collegeville, PA, USA.
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Źródło :
Clinical pharmacokinetics [Clin Pharmacokinet] 2020 Jan; Vol. 59 (1), pp. 67-79.
Typ publikacji :
Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Androstadienes/*pharmacokinetics
Benzyl Alcohols/*pharmacokinetics
Bromides/*pharmacokinetics
Chlorobenzenes/*pharmacokinetics
Pulmonary Disease, Chronic Obstructive/*drug therapy
Quinuclidines/*pharmacokinetics
Administration, Inhalation ; Aged ; Androstadienes/administration & dosage ; Androstadienes/blood ; Androstadienes/therapeutic use ; Anticonvulsants/administration & dosage ; Anticonvulsants/blood ; Anticonvulsants/pharmacokinetics ; Anticonvulsants/therapeutic use ; Benzyl Alcohols/administration & dosage ; Benzyl Alcohols/blood ; Benzyl Alcohols/therapeutic use ; Bromides/administration & dosage ; Bromides/blood ; Bromides/therapeutic use ; Chlorobenzenes/administration & dosage ; Chlorobenzenes/blood ; Chlorobenzenes/therapeutic use ; Drug Combinations ; Female ; Humans ; Male ; Middle Aged ; Muscarinic Antagonists/administration & dosage ; Muscarinic Antagonists/blood ; Muscarinic Antagonists/pharmacokinetics ; Muscarinic Antagonists/therapeutic use ; Predictive Value of Tests ; Pulmonary Disease, Chronic Obstructive/ethnology ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Quinuclidines/administration & dosage ; Quinuclidines/blood ; Quinuclidines/therapeutic use
Czasopismo naukowe
Tytuł :
The IMPACT Study - Single Inhaler Triple Therapy (FF/UMEC/VI) Versus FF/VI And UMEC/VI In Patients With COPD: Efficacy And Safety In A Japanese Population.
Autorzy :
Kato M; Chest Disease Clinical and Research Institute, Kishiwada City Hospital, Kishiwada, Japan.
Tomii K; Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
Hashimoto K; Evidence Generation Department, GlaxoSmithKline K.K., Tokyo, Japan.
Nezu Y; Evidence Generation Department, GlaxoSmithKline K.K., Tokyo, Japan.
Ishii T; MA Respiratory Department, GlaxoSmithKline K.K., Tokyo, Japan.
Jones CE; Development, R&D, GlaxoSmithKline, Research Triangle Park, NC, USA.
Kilbride S; Biostatistics, GlaxoSmithKline, Uxbridge, Middlesex, UK.
Gross AS; Clinical Pharmacology Modelling & Simulation, GlaxoSmithKline R&D, Sydney, Australia.
Clifton CS; Clinical Pharmacology Modelling & Simulation, GlaxoSmithKline R&D, Sydney, Australia.
Lipson DA; Clinical Sciences, GlaxoSmithKline, Collegeville, PA, USA.; Pulmonary, Allergy and Critical Care Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
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Źródło :
International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2019 Dec 06; Vol. 14, pp. 2849-2861. Date of Electronic Publication: 2019 Dec 06 (Print Publication: 2019).
Typ publikacji :
Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Adrenergic beta-2 Receptor Agonists/*administration & dosage
Androstadienes/*administration & dosage
Benzyl Alcohols/*administration & dosage
Bronchodilator Agents/*administration & dosage
Chlorobenzenes/*administration & dosage
Lung/*drug effects
Muscarinic Antagonists/*administration & dosage
Pulmonary Disease, Chronic Obstructive/*drug therapy
Quinuclidines/*administration & dosage
Administration, Inhalation ; Adrenergic beta-2 Receptor Agonists/adverse effects ; Aged ; Androstadienes/adverse effects ; Benzyl Alcohols/adverse effects ; Bronchodilator Agents/adverse effects ; Chlorobenzenes/adverse effects ; Disease Progression ; Double-Blind Method ; Drug Combinations ; Female ; Forced Expiratory Volume ; Health Status ; Humans ; Japan ; Lung/physiopathology ; Male ; Middle Aged ; Muscarinic Antagonists/adverse effects ; Nebulizers and Vaporizers ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Quinuclidines/adverse effects ; Recovery of Function ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Salicin inhibits AGE-induced degradation of type II collagen and aggrecan in human SW1353 chondrocytes: therapeutic potential in osteoarthritis.
Autorzy :
Gao F; a Department of Orthopedics , The Second Hospital of Jilin University , Changchun , Jilin , China.
Zhang S; b Department of Spine Surgery , The Second Hospital of Jilin University , Changchun , Jilin , China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2019 Dec; Vol. 47 (1), pp. 1043-1049.
Typ publikacji :
Journal Article
MeSH Terms :
Aggrecans/*metabolism
Benzyl Alcohols/*pharmacology
Chondrocytes/*drug effects
Collagen Type II/*metabolism
Glucosides/*pharmacology
Glycation End Products, Advanced/*pharmacology
Osteoarthritis/*drug therapy
Proteolysis/*drug effects
Benzyl Alcohols/therapeutic use ; Chemokines/metabolism ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Glucosides/therapeutic use ; Humans ; NF-kappa B/metabolism ; Osteoarthritis/metabolism ; Osteoarthritis/pathology ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Cost-Effectiveness Of Once-Daily Single-Inhaler Triple Therapy In COPD: The IMPACT Trial.
Autorzy :
Ismaila AS; Value Evidence and Outcomes, GlaxoSmithKline plc, Collegeville, PA, USA.; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Risebrough N; ICON Health Economics, ICON plc, Toronto, ON, Canada.
Schroeder M; Value Evidence and Outcomes, GlaxoSmithKline plc, Brentford, UK.
Shah D; ICON Health Economics, ICON plc, New York, NY, USA.
Martin A; Value Evidence and Outcomes, GlaxoSmithKline plc, Uxbridge, UK.
Goodall EC; Health Economics and Outcomes Research, GlaxoSmithKline plc, Mississauga, ON, Canada.
Ndirangu K; ICON Health Economics, ICON plc, New York, NY, USA.
Criner G; Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Dransfield M; Division of Pulmonary, Allergy, and Critical Care Medicine, Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Halpin DM; Department of Respiratory Medicine, Royal Devon and Exeter Hospital, Exeter, UK.
Han MK; University of Michigan, Pulmonary and Critical Care, Ann Arbor, MI, USA.
Lomas DA; UCL Respiratory, University College London, London, UK.
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Źródło :
International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2019 Nov 29; Vol. 14, pp. 2681-2695. Date of Electronic Publication: 2019 Nov 29 (Print Publication: 2019).
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Drug Costs*
Androstadienes/*administration & dosage
Androstadienes/*economics
Benzyl Alcohols/*administration & dosage
Benzyl Alcohols/*economics
Bronchodilator Agents/*administration & dosage
Bronchodilator Agents/*economics
Chlorobenzenes/*administration & dosage
Chlorobenzenes/*economics
Lung/*drug effects
Pulmonary Disease, Chronic Obstructive/*drug therapy
Pulmonary Disease, Chronic Obstructive/*economics
Quinuclidines/*administration & dosage
Quinuclidines/*economics
Administration, Inhalation ; Aged ; Androstadienes/adverse effects ; Benzyl Alcohols/adverse effects ; Bronchodilator Agents/adverse effects ; Canada ; Chlorobenzenes/adverse effects ; Clinical Trials, Phase III as Topic ; Cost-Benefit Analysis ; Disease Progression ; Drug Combinations ; Female ; Humans ; Lung/physiopathology ; Male ; Models, Economic ; Nebulizers and Vaporizers ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Quality of Life ; Quality-Adjusted Life Years ; Quinuclidines/adverse effects ; Recovery of Function ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
HPLC-UV and spectrofluorimetric methods for simultaneous estimation of fluticasone furoate and vilanterol in rabbit plasma: A pharmacokinetic study.
Autorzy :
Patel D; Department of Chemistry, Banasthali Vidyapith, Banasthali, Rajasthan 304022, India.
Namdev KK; Department of Chemistry, Banasthali Vidyapith, Banasthali, Rajasthan 304022, India.
Verma K; Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan 304022, India.
Gururani R; Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan 304022, India.
Tiwari A; Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan 304022, India.
Kumar P; KIET School of Pharmacy, KIET Group of Institutions, Ghaziabad, Uttar Pradesh 201206, India.
Dewangan RP; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Wabaidur SM; Department of Chemistry, Banasthali Vidyapith, Banasthali, Rajasthan 304022, India; Advanced Materials Research Chair, Department of Chemistry, King Saud University, Riyadh, Saudi Arabia.
Sharma S; Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan 304022, India. Electronic address: .
Dwivedi J; Department of Chemistry, Banasthali Vidyapith, Banasthali, Rajasthan 304022, India. Electronic address: .
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Źródło :
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2019 Nov 15; Vol. 1132, pp. 121842. Date of Electronic Publication: 2019 Oct 21.
Typ publikacji :
Journal Article
MeSH Terms :
Androstadienes/*blood
Benzyl Alcohols/*blood
Benzyl Alcohols/*pharmacokinetics
Chlorobenzenes/*blood
Chlorobenzenes/*pharmacokinetics
Chromatography, High Pressure Liquid/*methods
Androstadienes/chemistry ; Androstadienes/pharmacokinetics ; Animals ; Benzyl Alcohols/chemistry ; Chlorobenzenes/chemistry ; Linear Models ; Male ; Rabbits ; Reproducibility of Results ; Sensitivity and Specificity ; Spectrometry, Fluorescence
Czasopismo naukowe

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