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Wyświetlanie 21-40 z 116
Tytuł:
The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor.
Autorzy:
Lacombe ML; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Lamarche F; Université Grenoble Alpes, INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics (LBFA), and SFR Environmental and Systems Biology (BEeSy), Grenoble, France.
De Wever O; Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
Padilla-Benavides T; Molecular Biology and Biochemistry Department, Wesleyan University, Middletown, USA.
Carlson A; Molecular Biology and Biochemistry Department, Wesleyan University, Middletown, USA.
Khan I; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, USA.
Huna A; Cancer Research Center of Lyon, INSERM U1052, CNRS UMR 5286, Léon Bérard Center, Lyon University, Lyon, France.
Vacher S; Unit of Pharmacogenetics, Department of Genetics, Curie Institute, Paris, France.
Calmel C; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Desbourdes C; Université Grenoble Alpes, INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics (LBFA), and SFR Environmental and Systems Biology (BEeSy), Grenoble, France.
Cottet-Rousselle C; Université Grenoble Alpes, INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics (LBFA), and SFR Environmental and Systems Biology (BEeSy), Grenoble, France.
Hininger-Favier I; Université Grenoble Alpes, INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics (LBFA), and SFR Environmental and Systems Biology (BEeSy), Grenoble, France.
Attia S; Université Grenoble Alpes, INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics (LBFA), and SFR Environmental and Systems Biology (BEeSy), Grenoble, France.
Nawrocki-Raby B; Reims Champagne Ardenne University, INSERM, P3Cell UMR-S 1250, SFR CAP-SANTE, Reims, France.
Raingeaud J; INSERM U1279, Gustave Roussy Institute, Villejuif, France.
Machon C; Cancer Research Center of Lyon, INSERM U1052, CNRS UMR 5286, Léon Bérard Center, Lyon University, Lyon, France.
Guitton J; Cancer Research Center of Lyon, INSERM U1052, CNRS UMR 5286, Léon Bérard Center, Lyon University, Lyon, France.
Le Gall M; Proteomics Platform 3P5, Paris University, Cochin Institute, INSERM, U1016, CNRS, UMR8104, Paris, France.
Clary G; Proteomics Platform 3P5, Paris University, Cochin Institute, INSERM, U1016, CNRS, UMR8104, Paris, France.
Broussard C; Proteomics Platform 3P5, Paris University, Cochin Institute, INSERM, U1016, CNRS, UMR8104, Paris, France.
Chafey P; Proteomics Platform 3P5, Paris University, Cochin Institute, INSERM, U1016, CNRS, UMR8104, Paris, France.
Thérond P; AP-HP, CHU Bicêtre, Laboratory of Biochemistry, Le Kremlin-Bicêtre Hospital, Le Kremlin-Bicêtre, France.; EA7537, Paris Saclay University, Châtenay-Malabry, France.
Bernard D; Cancer Research Center of Lyon, INSERM U1052, CNRS UMR 5286, Léon Bérard Center, Lyon University, Lyon, France.
Fontaine E; Université Grenoble Alpes, INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics (LBFA), and SFR Environmental and Systems Biology (BEeSy), Grenoble, France.
Tokarska-Schlattner M; Université Grenoble Alpes, INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics (LBFA), and SFR Environmental and Systems Biology (BEeSy), Grenoble, France.
Steeg P; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, USA.
Bièche I; Unit of Pharmacogenetics, Department of Genetics, Curie Institute, Paris, France.
Schlattner U; Université Grenoble Alpes, INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics (LBFA), Institut Universitaire de France (IUF), Grenoble, France. .
Boissan M; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France. .; AP-HP, Laboratory of Biochemistry and Hormonology, Tenon Hospital, Paris, France. .
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Źródło:
BMC biology [BMC Biol] 2021 Oct 21; Vol. 19 (1), pp. 228. Date of Electronic Publication: 2021 Oct 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neoplasms*/genetics
Neoplasms*/metabolism
Nucleoside-Diphosphate Kinase*/genetics
Nucleoside-Diphosphate Kinase*/metabolism
Animals ; Intracellular Membranes ; Mice ; Mitochondria ; NM23 Nucleoside Diphosphate Kinases/genetics ; NM23 Nucleoside Diphosphate Kinases/metabolism ; Nucleoside Diphosphate Kinase D/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease.
Autorzy:
Audain E; Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Kiel, Germany.; German Center for Cardiovascular Research (DZHK), Kiel, Germany.
Wilsdon A; School of Life Sciences, University of Nottingham, University Park, Nottingham, United Kingdom.
Breckpot J; Centre for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium.
Izarzugaza JMG; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.
Fitzgerald TW; European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, United Kingdom.
Kahlert AK; Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Kiel, Germany.; German Center for Cardiovascular Research (DZHK), Kiel, Germany.; Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Sifrim A; Department of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium.; Sanger Institute-EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
Wünnemann F; Montreal Heart Institute, Université de Montréal, Québec, Canada.
Perez-Riverol Y; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.
Abdul-Khaliq H; Clinic for Pediatric Cardiology-University Hospital of Saarland, Homburg (Saar), Germany.
Bak M; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Bassett AS; Toronto Congenital Cardiac Centre for Adults, and Division of Cardiology, Department of Medicine, University Health Network, Toronto, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada.
Benson DW; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Berger F; Department of Congenital Heart Disease-Pediatric Cardiology, German Heart Center Berlin, Berlin, Germany.
Daehnert I; Department of Pediatric Cardiology and Congenital Heart Disease, Heart Center, University of Leipzig, Leipzig, Germany.
Devriendt K; Centre for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium.
Dittrich S; Department of Pediatric Cardiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Daubeney PE; Division of Paediatric Cardiology, Royal Brompton Hospital, London, United Kingdom.
Garg V; The Heart Center, Nationwide Children's Hospital, Columbus, Ohio, United States of America.; Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, United States of America.; Center for Cardiovascular Research, Nationwide Children's Hospital, Columbus, Ohio, United States of America.; Department of Pediatrics, The Ohio State University, Columbus, Ohio, United States of America.
Hackmann K; Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Hoff K; Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Kiel, Germany.; German Center for Cardiovascular Research (DZHK), Kiel, Germany.
Hofmann P; Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Kiel, Germany.; German Center for Cardiovascular Research (DZHK), Kiel, Germany.
Dombrowsky G; Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Kiel, Germany.; German Center for Cardiovascular Research (DZHK), Kiel, Germany.
Pickardt T; Competence Network for Congenital Heart Defects, Berlin, Germany.
Bauer U; Competence Network for Congenital Heart Defects, Berlin, Germany.
Keavney BD; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.; Division of Evolution & Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
Klaassen S; Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Cardiology, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Kramer HH; Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Kiel, Germany.; German Center for Cardiovascular Research (DZHK), Kiel, Germany.
Marshall CR; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Canada.; Genome Diagnostics, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada.
Milewicz DM; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Lemaire S; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America.
Coselli JS; Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Mitchell ME; Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Tomita-Mitchell A; Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Prakash SK; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Stamm K; Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Stewart AFR; Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada.
Silversides CK; Toronto Congenital Cardiac Centre for Adults, and Division of Cardiology, Department of Medicine, University Health Network, Toronto, Canada.
Siebert R; Institute of Human Genetics, University Hospital Ulm, Ulm, Germany.; Department of Human Genetics, University Medical Center Schleswig-Holstein (UKSH), Kiel, Germany.
Stiller B; Department of Congenital Heart Disease and Pediatric Cardiology, University Heart Center Freiburg-Bad Krozingen, Freiburg, Germany.
Rosenfeld JA; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Vater I; Department of Human Genetics, University Medical Center Schleswig-Holstein (UKSH), Kiel, Germany.
Postma AV; Department of Medical Biology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Caliebe A; Department of Human Genetics, University Medical Center Schleswig-Holstein (UKSH), Kiel, Germany.
Brook JD; School of Life Sciences, University of Nottingham, University Park, Nottingham, United Kingdom.
Andelfinger G; Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Saint-Justine Research Centre, Université de Montréal, Montreal, Canada.
Hurles ME; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
Thienpont B; Centre for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium.; Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.
Larsen LA; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Hitz MP; Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Kiel, Germany.; German Center for Cardiovascular Research (DZHK), Kiel, Germany.; Department of Human Genetics, University Medical Center Schleswig-Holstein (UKSH), Kiel, Germany.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
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Źródło:
PLoS genetics [PLoS Genet] 2021 Jul 29; Vol. 17 (7), pp. e1009679. Date of Electronic Publication: 2021 Jul 29 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Copy Number Variations/*genetics
Haploinsufficiency/*genetics
Heart Defects, Congenital/*genetics
Databases, Genetic ; Gene Expression/genetics ; Gene Expression Profiling/methods ; Genetic Predisposition to Disease/genetics ; Genomics/methods ; Humans ; Ion Channels/genetics ; Membrane Proteins/genetics ; Polymorphism, Single Nucleotide/genetics ; Transcriptome/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Author Correction: Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.
Autorzy:
Trevino CE; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Holleman AM; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Corbitt H; Division of Cardiovascular Medicine and the Heart Research Center, Oregon Health and Science University, Portland, OR, USA.
Maslen CL; Division of Cardiovascular Medicine and the Heart Research Center, Oregon Health and Science University, Portland, OR, USA.
Rosser TC; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Cutler DJ; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Johnston HR; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Rambo-Martin BL; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Oberoi J; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Dooley KJ; Sibley Heart Center Cardiology, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA.
Capone GT; Kennedy Krieger Institute, Baltimore, MD, USA.
Reeves RH; Department of Physiology and the Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cordell HJ; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Keavney BD; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Agopian AJ; Human Genetics Center; Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, TX, USA.
Goldmuntz E; Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Gruber PJ; Department of Surgery, Yale School of Medicine, New Haven, CT, USA.
O'Brien JE Jr; The Ward Family Heart Center, Section of Cardiac Surgery, Children's Mercy Hospital, Kansas City, MO, USA.
Bittel DC; College of Biosciences, Kansas City University of Medicine and Biosciences, Kansas City, MO, USA.
Wadhwa L; Texas Children's Hospital, Houston, TX, USA.
Cua CL; Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
Moskowitz IP; Departments of Pediatrics, Pathology, and Human Genetics, The University of Chicago, Chicago, IL, USA.
Mulle JG; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Epstein MP; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Sherman SL; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Zwick ME; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA. .; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jul 20; Vol. 11 (1), pp. 15164. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji:
Published Erratum
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Loss of the Metastasis Suppressor NME1, But Not of Its Highly Related Isoform NME2, Induces a Hybrid Epithelial-Mesenchymal State in Cancer Cells.
Autorzy:
Huna A; Cancer Research Center of Lyon, INSERM U1052, CNRS UMR 5286, Léon Bérard Center, Lyon University, 69008 Lyon, France.
Nawrocki-Raby B; Université de Reims Champagne Ardenne, INSERM, P3Cell UMR-S 1250, SFR CAP-SANTE, 51097 Reims, France.
Padilla-Benavides T; Molecular Biology and Biochemistry Department, Wesleyan University, Middletown, CT 06459, USA.
Gavard J; Team SOAP, CRCINA, Inserm, CNRS, Université de Nantes, Université d'Angers, 44000 Nantes, France.; Integrated Center for Oncology, ICO, 44800 St. Herblain, France.
Coscoy S; Institut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie, 75005 Paris, France.; Equipe Labellisée «Ligue Contre le Cancer», 75006 Paris, France.
Bernard D; Cancer Research Center of Lyon, INSERM U1052, CNRS UMR 5286, Léon Bérard Center, Lyon University, 69008 Lyon, France.
Boissan M; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, 75012 Paris, France.; Laboratory of Biochemistry and Hormonology, Tenon Hospital, AP-HP, 75020 Paris, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 02; Vol. 22 (7). Date of Electronic Publication: 2021 Apr 02.
Typ publikacji:
Journal Article
MeSH Terms:
Epithelial-Mesenchymal Transition*
NM23 Nucleoside Diphosphate Kinases/*metabolism
Animals ; Cadherins/metabolism ; Cell Adhesion ; Cell Line, Tumor ; Female ; Gene Editing ; Humans ; MAP Kinase Signaling System ; Mice, Nude ; Triple Negative Breast Neoplasms/metabolism ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.
Autorzy:
Trevino CE; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Holleman AM; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Corbitt H; Division of Cardiovascular Medicine and the Heart Research Center, Oregon Health and Science University, Portland, OR, USA.
Maslen CL; Division of Cardiovascular Medicine and the Heart Research Center, Oregon Health and Science University, Portland, OR, USA.
Rosser TC; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Cutler DJ; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Johnston HR; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Rambo-Martin BL; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Oberoi J; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Dooley KJ; Sibley Heart Center Cardiology, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA.
Capone GT; Kennedy Krieger Institute, Baltimore, MD, USA.
Reeves RH; Department of Physiology and the Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cordell HJ; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Keavney BD; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Agopian AJ; Human Genetics Center; Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, TX, USA.
Goldmuntz E; Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Gruber PJ; Department of Surgery, Yale School of Medicine, New Haven, CT, USA.
O'Brien JE Jr; The Ward Family Heart Center, Section of Cardiac Surgery, Children's Mercy Hospital, Kansas City, MO, USA.
Bittel DC; College of Biosciences, Kansas City University of Medicine and Biosciences, Kansas City, MO, USA.
Wadhwa L; Texas Children's Hospital, Houston, TX, USA.
Cua CL; Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
Moskowitz IP; Departments of Pediatrics, Pathology, and Human Genetics, The University of Chicago, Chicago, IL, USA.
Mulle JG; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Epstein MP; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.
Sherman SL; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Zwick ME; Department of Human Genetics, Emory University School of Medicine, 300 Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA, 30322, USA. .; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Oct 22; Vol. 10 (1), pp. 18051. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, Neoplasm*
Cell Cycle Proteins*
Cytoskeletal Proteins*
Genome-Wide Association Study*
Receptor, Notch4*
Down Syndrome/*genetics
Heart Septal Defects/*genetics
Cohort Studies ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Risk ; Whole Genome Sequencing
SCR Disease Name:
Atrioventricular Septal Defect
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Heritability of haemodynamics in the ascending aorta.
Autorzy:
McGurk KA; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. .; National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK. .
Owen B; Department of Mechanical, Aerospace and Civil Engineering, Faculty of Science and Engineering, University of Manchester, Manchester, UK.; School of Engineering, Multiscale Thermofluids Institute, University of Edinburgh, Edinburgh, UK.
Watson WD; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Nethononda RM; Division of Cardiology, Chris Hani Baragwanath Hospital, Soweto and the University of Witwatersrand, Johannesburg, South Africa.
Cordell HJ; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Newcastle upon Tyne, UK.
Farrall M; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Rider OJ; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Watkins H; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Revell A; Department of Mechanical, Aerospace and Civil Engineering, Faculty of Science and Engineering, University of Manchester, Manchester, UK.
Keavney BD; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Bernard..; Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Bernard..
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Źródło:
Scientific reports [Sci Rep] 2020 Sep 01; Vol. 10 (1), pp. 14356. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pedigree*
Polymorphism, Single Nucleotide*
Aorta/*diagnostic imaging
Aorta/*physiopathology
Cardiovascular Abnormalities/*genetics
Genetic Predisposition to Disease/*genetics
Hemodynamics/*genetics
Adult ; Aged ; Blood Flow Velocity ; Cohort Studies ; Female ; Genotyping Techniques ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Phenotype ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides.
Autorzy:
Greco I; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958, Frederiksberg, Denmark.
Molchanova N; Department of Science and Environment, Roskilde University, 4000, Roskilde, Denmark.; The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Holmedal E; Department of Chemistry, Biomaterial & Textile, RISE Research Institutes of Sweden, Box 857, 501 15, Borås, Sweden.
Jenssen H; Department of Science and Environment, Roskilde University, 4000, Roskilde, Denmark.
Hummel BD; Zoetis Inc., 333 Portage St, Kalamazoo, MI, 49007, USA.
Watts JL; Zoetis Inc., 333 Portage St, Kalamazoo, MI, 49007, USA.
Håkansson J; Department of Chemistry, Biomaterial & Textile, RISE Research Institutes of Sweden, Box 857, 501 15, Borås, Sweden.
Hansen PR; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.
Svenson J; Department of Chemistry, Biomaterial & Textile, RISE Research Institutes of Sweden, Box 857, 501 15, Borås, Sweden. .; Cawthron Institute, 98 Halifax Street East, Nelson, 7010, New Zealand. .; Department of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Box 440, 405 30, Gothenburg, Sweden. .
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Źródło:
Scientific reports [Sci Rep] 2020 Aug 06; Vol. 10 (1), pp. 13206. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hemolysis/*drug effects
Pore Forming Cytotoxic Proteins/*toxicity
Amino Acid Sequence ; Animals ; Dose-Response Relationship, Drug ; Erythrocytes/cytology ; Erythrocytes/drug effects ; Humans ; Pore Forming Cytotoxic Proteins/chemistry ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells.
Autorzy:
Huang C; Department of Animal Science, Institute for Systems Genomics, University of Connecticut, 1390 Storrs Rd, Storrs, CT, 06269, USA.
Bernard D; Atomwise Inc, 717 Market Street, Suite 800, San Francisco, CA, 94103, USA.
Zhu J; Department of Animal Science, Institute for Systems Genomics, University of Connecticut, 1390 Storrs Rd, Storrs, CT, 06269, USA.
Dash RC; Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Rd, Storrs, CT, 06029, USA.
Chu A; Department of Animal Science, Institute for Systems Genomics, University of Connecticut, 1390 Storrs Rd, Storrs, CT, 06269, USA.
Knupp A; Department of Animal Science, Institute for Systems Genomics, University of Connecticut, 1390 Storrs Rd, Storrs, CT, 06269, USA.
Hakey A; Department of Animal Science, Institute for Systems Genomics, University of Connecticut, 1390 Storrs Rd, Storrs, CT, 06269, USA.
Hadden MK; Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Rd, Storrs, CT, 06029, USA.
Garmendia A; Department of Pathobiology and Veterinary Sciences, University of Connecticut, 61 North Eagleville Road, Storrs, CT, 06269, USA. .
Tang Y; Department of Animal Science, Institute for Systems Genomics, University of Connecticut, 1390 Storrs Rd, Storrs, CT, 06269, USA. .
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Źródło:
Virology journal [Virol J] 2020 Jul 30; Vol. 17 (1), pp. 116. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Macrophages, Alveolar/*drug effects
Macrophages, Alveolar/*virology
Porcine respiratory and reproductive syndrome virus/*drug effects
Receptors, Cell Surface/*antagonists & inhibitors
Small Molecule Libraries/*pharmacology
Animals ; Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; Artificial Intelligence ; Cell Line ; HEK293 Cells ; Humans ; Porcine respiratory and reproductive syndrome virus/metabolism ; Protein Domains ; Swine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.
Autorzy:
Donovan M; L'Oréal Research & Innovation, Aulnay-sous-Bois, France.
Salamito M; L'Oréal Research & Innovation, Aulnay-sous-Bois, France.
Thomas-Collignon A; CNRS, Gif-sur-Yvette, France.
Simonetti L; L'Oréal Research & Innovation, Aulnay-sous-Bois, France.
Desbouis S; L'Oréal Research & Innovation, Aulnay-sous-Bois, France.
Rain JC; Hybrigenics Services, Evry, France.
Formstecher E; Hybrigenics Services, Evry, France.
Bernard D; L'Oréal Research & Innovation, Aulnay-sous-Bois, France.
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Źródło:
PloS one [PLoS One] 2020 May 21; Vol. 15 (5), pp. e0232679. Date of Electronic Publication: 2020 May 21 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aspartic Acid Endopeptidases/*metabolism
S100 Proteins/*metabolism
Skin/*metabolism
Aspartic Acid Endopeptidases/analysis ; Enzyme Activation ; Filaggrin Proteins ; Humans ; Protein Interaction Domains and Motifs ; Protein Interaction Maps ; S100 Proteins/analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1.
Autorzy:
Jaber S; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Goehrig D; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Bertolino P; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Massemin A; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Bihl F; Université Côte d'Azur (UCA), Centre National de la Recherche Scientifique (CNRS), Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), UMR7275, Valbonne, Sophia Antipolis, France.
Chabry J; Université Côte d'Azur (UCA), Centre National de la Recherche Scientifique (CNRS), Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), UMR7275, Valbonne, Sophia Antipolis, France.
Lambeau G; Université Côte d'Azur (UCA), Centre National de la Recherche Scientifique (CNRS), Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), UMR7275, Valbonne, Sophia Antipolis, France.
Vindrieux D; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Bernard D; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France. david.bernard@lyon.unicancer.fr.
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Źródło:
Scientific reports [Sci Rep] 2020 May 18; Vol. 10 (1), pp. 8190. Date of Electronic Publication: 2020 May 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Disease Models, Animal*
Receptors, Phospholipase A2/*genetics
Animals ; Gene Expression ; Genotyping Techniques ; Humans ; Mice ; Mice, Transgenic ; Organ Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Severe Dengue Epidemic, Sri Lanka, 2017.
Autorzy:
Tissera HA
Jayamanne BDW
Raut R
Janaki SMD
Tozan Y
Samaraweera PC
Liyanage P
Ghouse A
Rodrigo C
de Silva AM
Fernando SD
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Źródło:
Emerging infectious diseases [Emerg Infect Dis] 2020 Apr; Vol. 26 (4), pp. 682-691.
Typ publikacji:
Journal Article
MeSH Terms:
Dengue*/epidemiology
Dengue Virus*/genetics
Epidemics*
Severe Dengue*/diagnosis
Severe Dengue*/epidemiology
Child ; Humans ; Sri Lanka/epidemiology ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes.
Autorzy:
Griveau A; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Wiel C; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Ziegler DV; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Bergo MO; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Bernard D; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
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Źródło:
Aging cell [Aging Cell] 2020 Apr; Vol. 19 (4), pp. e13122. Date of Electronic Publication: 2020 Mar 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aging, Premature/*genetics
Janus Kinase Inhibitors/*pharmacology
Pyrazoles/*pharmacology
Aging, Premature/metabolism ; Animals ; Cell Cycle Checkpoints/drug effects ; Cell Line ; Cell Nucleus/drug effects ; Cellular Senescence/drug effects ; Fibroblasts/drug effects ; Humans ; Janus Kinase 1/antagonists & inhibitors ; Janus Kinase 1/metabolism ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 2/metabolism ; Mice ; Nitriles ; Phenotype ; Pyrimidines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Marked variation in heritability estimates of left ventricular mass depending on modality of measurement.
Autorzy:
Nethononda RM; Division of Cardiology, Chris Hani Baragwanath Hospital, Soweto and the University of Witwatersrand, Johannesburg, South Africa.
McGurk KA; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Whitworth P; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford Cardiovascular Clinical Research Facility (CCRF), John Radcliffe Hospital, Oxford, UK.
Francis J; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Clinical Magnetic Resonance Research (OCMR), John Radcliffe Hospital, Oxford, UK.
Mamasoula C; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Cordell HJ; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Neubauer S; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Clinical Magnetic Resonance Research (OCMR), John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Keavney BD; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Mayosi BM; Department of Medicine, University of Cape Town, Cape Town, South Africa.
Farrall M; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Watkins H; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. .; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. .
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Źródło:
Scientific reports [Sci Rep] 2019 Sep 19; Vol. 9 (1), pp. 13556. Date of Electronic Publication: 2019 Sep 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Electrocardiography/*methods
Hypertrophy, Left Ventricular/*diagnostic imaging
Magnetic Resonance Imaging, Cine/*methods
Aged ; Family ; Female ; Humans ; Male ; Middle Aged ; Phenotype ; United Kingdom
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Same Test, Better Scores: Boosting the Reliability of Short Online Intelligence Recruitment Tests with Nested Logit Item Response Theory Models.
Autorzy:
Storme M; IESEG School of Management, 59800 Lille, France. .; LEM-CNRS 9221, 59800 Lille, France. .
Myszkowski N; Department of Psychology, Pace University, New York, NY 10038, USA.
Baron S; Assess First, 75000 Paris, France.
Bernard D; Assess First, 75000 Paris, France.
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Źródło:
Journal of Intelligence [J Intell] 2019 Jul 10; Vol. 7 (3). Date of Electronic Publication: 2019 Jul 10.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Reconstructed Skin Models Revealed Unexpected Differences in Epidermal African and Caucasian Skin.
Autorzy:
Girardeau-Hubert S; L'Oréal Research and Innovation, 1 avenue E. Schueller, 93600, Aulnay-sous-Bois, France. .
Deneuville C; L'Oréal Research and Innovation, 1 avenue E. Schueller, 93600, Aulnay-sous-Bois, France.
Pageon H; L'Oréal Research and Innovation, 1 avenue E. Schueller, 93600, Aulnay-sous-Bois, France.
Abed K; L'Oréal Research and Innovation, 1 avenue E. Schueller, 93600, Aulnay-sous-Bois, France.
Tacheau C; L'Oréal Research and Innovation, 1 avenue E. Schueller, 93600, Aulnay-sous-Bois, France.
Cavusoglu N; L'Oréal Research and Innovation, 1 avenue E. Schueller, 93600, Aulnay-sous-Bois, France.
Donovan M; L'Oréal Research and Innovation, 1 avenue E. Schueller, 93600, Aulnay-sous-Bois, France.
Bernard D; L'Oréal Research and Innovation, 1 avenue E. Schueller, 93600, Aulnay-sous-Bois, France.
Asselineau D; L'Oréal Research and Innovation, 1 avenue E. Schueller, 93600, Aulnay-sous-Bois, France.
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Źródło:
Scientific reports [Sci Rep] 2019 May 15; Vol. 9 (1), pp. 7456. Date of Electronic Publication: 2019 May 15.
Typ publikacji:
Journal Article
MeSH Terms:
Epidermis/*pathology
Skin/*metabolism
Skin/*pathology
Black People/genetics ; Cell Differentiation ; Dermis/cytology ; Epidermal Cells/metabolism ; Epidermal Cells/pathology ; Fibroblasts/metabolism ; Humans ; Keratinocytes/cytology ; Models, Biological ; Morphogenesis ; Proteomics/methods ; White People/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Advancing Risk-Informed Decision Making in Managing Defense Nuclear Waste in the United States: Opportunities and Challenges for Risk Analysis.
Autorzy:
Greenberg MR; Bloustein School of Planning and Public Policy, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Apostolakis G; Massachusetts Institute of Technology, Cambridge, MA, USA.
Fields T; MDB, Inc., Washington, DC, USA.
Goldstein BD; Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Kosson D; Department of Civil, Environmental and Chemical Engineering, Vanderbilt University, Nashville, TN, USA.
Krahn S; Department of Civil, Environmental and Chemical Engineering, Vanderbilt University, Nashville, TN, USA.
Matthews RB; Independent Consultant, Goleta, CA, USA.
Rispoli J; Center for Nuclear Energy Facilities and Structures, North Carolina State University, Raleigh, NC, USA.
Stewart J; International Environmental Legal Assistance Program, New York University School of Law, New York, NY, USA.
Stewart R; NYU Law School, New York, NY, USA.
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Źródło:
Risk analysis : an official publication of the Society for Risk Analysis [Risk Anal] 2019 Feb; Vol. 39 (2), pp. 375-388. Date of Electronic Publication: 2018 Jun 29.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling.
Autorzy:
Ma X; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Warnier M; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Raynard C; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Ferrand M; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Kirsh O; Epigenetics and Cell Fate, Sorbonne Paris Cité, CNRS UMR 7216, Université Paris Diderot, Paris, France.
Defossez PA; Epigenetics and Cell Fate, Sorbonne Paris Cité, CNRS UMR 7216, Université Paris Diderot, Paris, France.
Martin N; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Bernard D; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
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Źródło:
Aging cell [Aging Cell] 2018 Dec; Vol. 17 (6), pp. e12831. Date of Electronic Publication: 2018 Sep 14.
Typ publikacji:
Journal Article
MeSH Terms:
Calcium Signaling*/drug effects
Cellular Senescence*/drug effects
Retinoid X Receptor alpha/*metabolism
Calcium/metabolism ; Calcium Channels/metabolism ; Cell Line ; Chelating Agents/pharmacology ; DNA Damage ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Mitochondria/drug effects ; Mitochondria/metabolism ; RNA, Small Interfering/metabolism ; Reactive Oxygen Species/metabolism ; Repressor Proteins/metabolism ; Transcription, Genetic/drug effects ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes.
Autorzy:
Griveau A; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Wiel C; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Le Calvé B; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Ziegler DV; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Djebali S; Centre International de Recherche en Infectiologie, Inserm U1111, CNRS, UMR5308, École Normale Supérieure de Lyon, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Warnier M; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Martin N; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Marvel J; Centre International de Recherche en Infectiologie, Inserm U1111, CNRS, UMR5308, École Normale Supérieure de Lyon, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Vindrieux D; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
Bergo MO; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Bernard D; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
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Źródło:
Aging cell [Aging Cell] 2018 Dec; Vol. 17 (6), pp. e12835. Date of Electronic Publication: 2018 Sep 14.
Typ publikacji:
Journal Article
MeSH Terms:
Aging, Premature/*metabolism
Aging, Premature/*pathology
Receptors, Phospholipase A2/*metabolism
Animals ; Cell Line ; Cell Nucleus/metabolism ; Cell Nucleus/pathology ; Cell Nucleus Shape ; Cellular Senescence ; Disease Models, Animal ; Geranyltranstransferase/metabolism ; Humans ; Lamin Type A/metabolism ; Mice, Inbred C57BL ; Phenotype ; Progeria/metabolism ; Progeria/pathology ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway.
Autorzy:
Warnier M; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Flaman JM; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Chouabe C; Inserm UMR-U1060 CarMeN Laboratory, INRA U1235, INSA-Lyon, Facultés de médecine Rockefeller, University Lyon 1, Lyon, France.
Wiel C; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Gras B; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Griveau A; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Blanc E; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Foy JP; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Mathot P; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Saintigny P; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Van Coppenolle F; Inserm UMR-U1060 CarMeN Laboratory, INRA U1235, INSA-Lyon, Facultés de médecine Rockefeller, University Lyon 1, Lyon, France.
Vindrieux D; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Martin N; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Bernard D; Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Pokaż więcej
Źródło:
Aging cell [Aging Cell] 2018 Jun; Vol. 17 (3), pp. e12736. Date of Electronic Publication: 2018 Feb 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence/*genetics
NAV1.7 Voltage-Gated Sodium Channel/*genetics
Retinoblastoma Protein/*genetics
Humans ; Oncogenes ; Signal Transduction ; Transfection
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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