Autor: "Beurskens FJ" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: The novel tribody [(CD20)(2)xCD16] efficiently triggers effector cell-mediated lysis of malignant B cells.
Autorzy:: Glorius P
Baerenwaldt A
Kellner C
Staudinger M
Dechant M
Stauch M
Beurskens FJ
Parren PW
Winkel JG
Valerius T
Humpe A
Repp R
Gramatzki M
Nimmerjahn F
Peipp M; Pokaż więcej
Źródło:: Leukemia (08876924); Jan2013, Vol. 27 Issue 1, p190-201, 12p

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Skocz do pozycji: 2.

Tytuł:: Carbamylation reduces the capacity of IgG for hexamerization and complement activation.
Autorzy:: Lubbers R; Department Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.
Oostindie SC; Genmab, Utrecht, the Netherlands.; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
Dijkstra DJ; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
Parren PWHI; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.; Lava Therapeutics, Utrecht, the Netherlands.
Verheul MK; Department Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.
Abendstein L; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Sharp TH; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
de Ru A; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands.
Janssen GMC; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands.
van Veelen PA; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands.
van den Bremer ETJ; Genmab, Utrecht, the Netherlands.
Bleijlevens B; Genmab, Utrecht, the Netherlands.
de Kreuk BJ; Genmab, Utrecht, the Netherlands.
Beurskens FJ; Genmab, Utrecht, the Netherlands.
Trouw LA; Department Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.; Pokaż więcej
Źródło:: Clinical and experimental immunology [Clin Exp Immunol] 2020 Apr; Vol. 200 (1), pp. 1-11. Date of Electronic Publication: 2020 Jan 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Arthritis, Rheumatoid/*immunology
Complement Activation/*immunology
Complement C1q/*immunology
Immunoglobulin G/*immunology
Aged ; Amino Acid Sequence ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/metabolism ; Arthritis, Rheumatoid/metabolism ; Cell Line, Tumor ; Complement C1q/metabolism ; Cytotoxicity Tests, Immunologic ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoglobulin G/chemistry ; Immunoglobulin G/metabolism ; Male ; Mass Spectrometry ; Middle Aged ; Protein Carbamylation/immunology ; Protein Multimerization/immunology ; Synovial Fluid/immunology ; Synovial Fluid/metabolism ; Synovial Membrane/immunology ; Synovial Membrane/metabolism

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Skocz do pozycji: 3.

Tytuł:: Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody.
Autorzy:: Gulati S; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
Beurskens FJ; Genmab, Utrecht, the Netherlands.
de Kreuk BJ; Genmab, Utrecht, the Netherlands.
Roza M; Genmab, Utrecht, the Netherlands.
Zheng B; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
DeOliveira RB; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
Shaughnessy J; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
Nowak NA; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
Taylor RP; University of Virginia, Charlottesville, Virginia, United States of America.
Botto M; Center for Complement and Inflammation Research, Imperial College, London, United Kingdom.
He X; Boston University School of Medicine, Boston, Massachusetts, United States of America.
Ingalls RR; Boston University School of Medicine, Boston, Massachusetts, United States of America.
Woodruff TM; School of Biomedical Sciences, The University of Queensland, St. Lucia, Queensland, Brisbane, Australia.
Song WC; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.
Schuurman J; Genmab, Utrecht, the Netherlands.
Rice PA; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
Ram S; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.; Pokaż więcej
Źródło:: PLoS biology [PLoS Biol] 2019 Jun 19; Vol. 17 (6), pp. e3000323. Date of Electronic Publication: 2019 Jun 19 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Complement Activation/*immunology
Gonorrhea/*immunology
Neisseria gonorrhoeae/*immunology
Animals ; Antibodies, Bacterial/immunology ; Antibodies, Monoclonal/metabolism ; Antigens, Bacterial ; Complement C4b-Binding Protein/immunology ; Complement Factor H/immunology ; Complement System Proteins/immunology ; Complement System Proteins/metabolism ; Epitopes/immunology ; Female ; Healthy Volunteers ; Humans ; Immunoglobulin G/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Neisseria gonorrhoeae/pathogenicity

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Skocz do pozycji: 4.

Tytuł:: Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement.
Autorzy:: Ugurlar D; Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands.
Howes SC; Section of Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, Netherlands.
de Kreuk BJ; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands.
Koning RI; Section of Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, Netherlands.; NeCEN, Gorlaeus Laboratories, Leiden University, 2333 CC Leiden, Netherlands.
de Jong RN; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands.
Beurskens FJ; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands.
Schuurman J; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands.
Koster AJ; Section of Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, Netherlands.; NeCEN, Gorlaeus Laboratories, Leiden University, 2333 CC Leiden, Netherlands.
Sharp TH; Section of Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, Netherlands. .
Parren PWHI; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands. .; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
Gros P; Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands. .; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2018 Feb 16; Vol. 359 (6377), pp. 794-797.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Complement Activation*
Alarmins/*chemistry
Complement C1/*chemistry
Immunoglobulin G/*chemistry
Alarmins/ultrastructure ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/ultrastructure ; Binding Sites ; Complement C1/ultrastructure ; Cryoelectron Microscopy ; Humans ; Immunoglobulin G/genetics ; Immunoglobulin G/ultrastructure

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Skocz do pozycji: 5.

Tytuł:: A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface.
Autorzy:: de Jong RN; Genmab, Utrecht, The Netherlands.
Beurskens FJ; Genmab, Utrecht, The Netherlands.
Verploegen S; Genmab, Utrecht, The Netherlands.
Strumane K; Genmab, Utrecht, The Netherlands.
van Kampen MD; Genmab, Utrecht, The Netherlands.
Voorhorst M; Genmab, Utrecht, The Netherlands.
Horstman W; Genmab, Utrecht, The Netherlands.
Engelberts PJ; Genmab, Utrecht, The Netherlands.
Oostindie SC; Genmab, Utrecht, The Netherlands.
Wang G; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.; Netherlands Proteomics Centre, Utrecht, The Netherlands.
Heck AJ; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.; Netherlands Proteomics Centre, Utrecht, The Netherlands.
Schuurman J; Genmab, Utrecht, The Netherlands.
Parren PW; Genmab, Utrecht, The Netherlands.; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.; Pokaż więcej
Źródło:: PLoS biology [PLoS Biol] 2016 Jan 06; Vol. 14 (1), pp. e1002344. Date of Electronic Publication: 2016 Jan 06 (Print Publication: 2016).
Typ publikacji:: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antibody-Dependent Cell Cytotoxicity*
Immunoglobulin G/*metabolism
Immunotherapy/*methods
Animals ; Cell Line, Tumor ; Complement Activation ; Female ; Humans ; Immunoglobulin G/genetics ; Mice, SCID ; Mutation ; Neoplasm Transplantation ; Polymerization