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Wyświetlanie 1-9 z 9
Tytuł :
Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral Sclerosis.
Autorzy :
Dodge JC; Rare and Neurological Diseases Therapeutic Area .
Jensen EH; Rare and Neurological Diseases Therapeutic Area.
Yu J; Rare and Neurological Diseases Therapeutic Area.
Sardi SP; Rare and Neurological Diseases Therapeutic Area.
Bialas AR; Rare and Neurological Diseases Therapeutic Area.
Taksir TV; Global Discovery Pathology, Sanofi R+D, Framingham, Massachusetts 01701.
Bangari DS; Global Discovery Pathology, Sanofi R+D, Framingham, Massachusetts 01701.
Shihabuddin LS; Rare and Neurological Diseases Therapeutic Area.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Nov 18; Vol. 40 (47), pp. 9137-9147. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Retraction Note: Microglia-dependent synapse loss in type I interferon-mediated lupus.
Autorzy :
Bialas AR; Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, 02115, USA.
Presumey J; Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, 02115, USA.
Das A; Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, 02115, USA.
van der Poel CE; Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, 02115, USA.
Lapchak PH; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Mesin L; Laboratory for Lymphocyte Dynamics, The Rockefeller University, New York City, New York, USA.
Victora G; Laboratory for Lymphocyte Dynamics, The Rockefeller University, New York City, New York, USA.
Tsokos GC; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Mawrin C; Department of Neuropathology, University of Magdeburg, Magdeburg, Germany.; Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Herbst R; Department of Cancer Biology, MedImmune LLC, Gaithersburg, Maryland, 20878, USA.
Carroll MC; Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, 02115, USA. .
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Źródło :
Nature [Nature] 2020 Feb; Vol. 578 (7793), pp. 177.
Typ publikacji :
Journal Article; Retraction of Publication
Czasopismo naukowe
Tytuł :
Microglia-dependent synapse loss in type I interferon-mediated lupus.
Autorzy :
Bialas AR; Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Presumey J; Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Das A; Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.
van der Poel CE; Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Lapchak PH; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Mesin L; Laboratory for Lymphocyte Dynamics, The Rockefeller University, New York City, New York, USA.
Victora G; Laboratory for Lymphocyte Dynamics, The Rockefeller University, New York City, New York, USA.
Tsokos GC; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Mawrin C; Department of Neuropathology, University of Magdeburg, Magdeburg, Germany.; Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Herbst R; Department of Cancer Biology, MedImmune LLC, Gaithersburg, Maryland 20878, USA.
Carroll MC; Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.
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Źródło :
Nature [Nature] 2017 Jun 22; Vol. 546 (7659), pp. 539-543. Date of Electronic Publication: 2017 Jun 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Retracted Publication
MeSH Terms :
Interferon Type I/*immunology
Lupus Vasculitis, Central Nervous System/*immunology
Lupus Vasculitis, Central Nervous System/*pathology
Microglia/*immunology
Microglia/*pathology
Synapses/*pathology
Animals ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Behavior, Animal ; Disease Models, Animal ; Female ; Hippocampus/metabolism ; Hippocampus/pathology ; Humans ; Interferon Type I/antagonists & inhibitors ; Lupus Vasculitis, Central Nervous System/psychology ; Male ; Mice ; Microglia/metabolism ; Phenotype ; Signal Transduction ; Synapses/immunology ; Transcriptome
Czasopismo naukowe
Tytuł :
Complement System in Neural Synapse Elimination in Development and Disease.
Autorzy :
Presumey J; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, United States.
Bialas AR; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, United States.
Carroll MC; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, United States. Electronic address: .
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Źródło :
Advances in immunology [Adv Immunol] 2017; Vol. 135, pp. 53-79. Date of Electronic Publication: 2017 Jul 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Complement System Proteins/*immunology
Nerve Net/*immunology
Neurogenesis/*immunology
Neuronal Plasticity/*immunology
Synapses/*immunology
Animals ; Autistic Disorder/genetics ; Autistic Disorder/immunology ; Autistic Disorder/pathology ; Complement System Proteins/genetics ; Epilepsy/genetics ; Epilepsy/immunology ; Epilepsy/pathology ; Gene Expression Regulation, Developmental ; Humans ; Microglia/immunology ; Microglia/pathology ; Nerve Net/pathology ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/immunology ; Neurogenesis/genetics ; Neuronal Plasticity/genetics ; Neurons/immunology ; Neurons/pathology ; Schizophrenia/genetics ; Schizophrenia/immunology ; Schizophrenia/pathology ; Synapses/genetics ; Synapses/pathology ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Schizophrenia risk from complex variation of complement component 4.
Autorzy :
Sekar A; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; MD-PhD Program, Harvard Medical School, Boston, Massachusetts 02115, USA.
Bialas AR; Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
de Rivera H; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Davis A; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Hammond TR; Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Kamitaki N; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Tooley K; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Presumey J; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Baum M; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; MD-PhD Program, Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Van Doren V; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Genovese G; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Rose SA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Handsaker RE; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Daly MJ; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Carroll MC; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Stevens B; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
McCarroll SA; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
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Corporate Authors :
Schizophrenia Working Group of the Psychiatric Genomics Consortium
Źródło :
Nature [Nature] 2016 Feb 11; Vol. 530 (7589), pp. 177-83. Date of Electronic Publication: 2016 Jan 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Complement C4/*genetics
Genetic Predisposition to Disease/*genetics
Genetic Variation/*genetics
Schizophrenia/*genetics
Alleles ; Amino Acid Sequence ; Animals ; Axons/metabolism ; Base Sequence ; Brain/metabolism ; Brain/pathology ; Complement C4/chemistry ; Complement Pathway, Classical ; Dendrites/metabolism ; Gene Dosage/genetics ; Gene Expression Regulation/genetics ; Haplotypes/genetics ; Humans ; Major Histocompatibility Complex/genetics ; Mice ; Models, Animal ; Neuronal Plasticity/genetics ; Neuronal Plasticity/physiology ; Polymorphism, Single Nucleotide/genetics ; RNA, Messenger/analysis ; RNA, Messenger/genetics ; Risk Factors ; Schizophrenia/pathology ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets.
Autorzy :
Macosko EZ; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: .
Basu A; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
Satija R; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; New York Genome Center, New York, NY 10013, USA; Department of Biology, New York University, New York, NY 10003, USA.
Nemesh J; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Shekhar K; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Goldman M; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Tirosh I; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Bialas AR; The Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115, USA.
Kamitaki N; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Martersteck EM; Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Trombetta JJ; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Weitz DA; School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Department of Physics, Harvard University, Cambridge, MA 02138, USA.
Sanes JR; Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Shalek AK; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Institute for Medical Engineering and Science and Department of Chemistry, MIT, Cambridge, MA 02139, USA.
Regev A; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biology, MIT, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
McCarroll SA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: .
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Źródło :
Cell [Cell] 2015 May 21; Vol. 161 (5), pp. 1202-1214.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genome-Wide Association Study*
Microfluidic Analytical Techniques*
Single-Cell Analysis*
Gene Expression Profiling/*methods
Retina/*cytology
Animals ; High-Throughput Nucleotide Sequencing ; Mice ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development.
Autorzy :
Giera S; Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Deng Y; Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Luo R; Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Ackerman SD; Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Mogha A; Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Monk KR; 1] Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA [2] Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Ying Y; Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Jeong SJ; Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Makinodan M; 1] F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Bialas AR; 1] F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Chang BS; Comprehensive Epilepsy Center, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA.
Stevens B; 1] F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Corfas G; 1] F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Piao X; Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
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Źródło :
Nature communications [Nat Commun] 2015 Jan 21; Vol. 6, pp. 6121. Date of Electronic Publication: 2015 Jan 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Oligodendroglia/*cytology
Receptors, G-Protein-Coupled/*metabolism
Animals ; Axons/metabolism ; Brain/metabolism ; Cell Lineage ; Cell Proliferation ; Cell Survival ; Central Nervous System/embryology ; Central Nervous System/metabolism ; Corpus Callosum/metabolism ; Disease Models, Animal ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Malformations of Cortical Development/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Microscopy, Electron, Transmission ; Mutation ; Myelin Sheath/chemistry ; Myelin Sheath/metabolism ; Oligodendroglia/metabolism ; Optic Nerve/metabolism ; Signal Transduction ; Tamoxifen/chemistry ; rho GTP-Binding Proteins/metabolism ; rhoA GTP-Binding Protein
SCR Disease Name :
Polymicrogyria, Bilateral Frontoparietal
Czasopismo naukowe
Tytuł :
TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement.
Autorzy :
Bialas AR; 1] Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA.
Stevens B
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Źródło :
Nature neuroscience [Nat Neurosci] 2013 Dec; Vol. 16 (12), pp. 1773-82. Date of Electronic Publication: 2013 Oct 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Complement C1q/*metabolism
Gene Expression Regulation, Developmental/*physiology
Retinal Ganglion Cells/*metabolism
Signal Transduction/*physiology
Synapses/*physiology
Transforming Growth Factor beta/*metabolism
Age Factors ; Animals ; Animals, Newborn ; Cell Count ; Cells, Cultured ; Cerebral Cortex/cytology ; Complement C1q/genetics ; Gene Expression Regulation, Developmental/drug effects ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Homeodomain Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neuroglia/chemistry ; Neuroglia/physiology ; Protein-Serine-Threonine Kinases/deficiency ; Rats ; Rats, Sprague-Dawley ; Receptor, Transforming Growth Factor-beta Type II ; Receptors, Transforming Growth Factor beta/deficiency ; Retina/cytology ; Retina/drug effects ; Retina/growth & development ; Retina/metabolism ; Retinal Ganglion Cells/drug effects ; Signal Transduction/drug effects ; Synapses/drug effects ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Glia: regulating synaptogenesis from multiple directions.
Autorzy :
Bialas AR; Department of Neurobiology and Department of Neurology, F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Stevens B
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Źródło :
Current biology : CB [Curr Biol] 2012 Oct 09; Vol. 22 (19), pp. R833-5.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Drosophila/*metabolism
Drosophila Proteins/*metabolism
Neuroglia/*metabolism
Neuromuscular Junction/*growth & development
Synapses/*physiology
Transforming Growth Factor beta/*metabolism
Animals
Czasopismo naukowe
    Wyświetlanie 1-9 z 9

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