Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Binding, Competitive"" wg kryterium: Temat


Tytuł :
Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level.
Autorzy :
Moss RB; Adamis Pharmaceuticals Corp, San Diego, CA, United States of America.
Pryor MM; Rosa & Co. LLC, San Carlos, CA, United States of America.
Baillie R; Rosa & Co. LLC, San Carlos, CA, United States of America.
Kudrycki K; Rosa & Co. LLC, San Carlos, CA, United States of America.
Friedrich C; Rosa & Co. LLC, San Carlos, CA, United States of America.
Reed M; Rosa & Co. LLC, San Carlos, CA, United States of America.
Carlo DJ; Adamis Pharmaceuticals Corp, San Diego, CA, United States of America.
Pokaż więcej
Źródło :
PloS one [PLoS One] 2020 Jun 16; Vol. 15 (6), pp. e0234683. Date of Electronic Publication: 2020 Jun 16 (Print Publication: 2020).
Typ publikacji :
Journal Article
Journal Info :
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS ONE Subsets: MEDLINE
MeSH Terms :
Binding, Competitive*
Models, Theoretical*
Fentanyl/*metabolism
Naloxone/*administration & dosage
Receptors, Opioid, mu/*metabolism
Analgesics, Opioid/metabolism ; Computer Simulation ; Dose-Response Relationship, Drug ; Drug Overdose/drug therapy ; Fentanyl/toxicity ; Humans ; Naloxone/therapeutic use ; Narcotic Antagonists/administration & dosage ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Evaluation of competitive binding interaction of neratinib and tamoxifen to serum albumin in multidrug therapy.
Autorzy :
Wani TA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia. Electronic address: .
Bakheit AH; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia; Department of Chemistry, Faculty of Science and Technology, Al-Neelain University, Khartoum, Sudan.
Zargar S; Department of Biochemistry, College of Science, King Saud University, PO Box 22452, Riyadh, 11451, Saudi Arabia.
Rizwana H; Department of Microbiology and Botany, College of Science, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Al-Majed AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Pokaż więcej
Źródło :
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2020 Feb 15; Vol. 227, pp. 117691. Date of Electronic Publication: 2019 Oct 30.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE
MeSH Terms :
Binding, Competitive*
Quinolines/*metabolism
Serum Albumin/*metabolism
Tamoxifen/*metabolism
Drug Therapy, Combination ; Humans ; Kinetics ; Protein Binding ; Serum Albumin, Bovine/metabolism ; Serum Albumin, Human/metabolism ; Spectrometry, Fluorescence
Czasopismo naukowe
Tytuł :
Identifying neural substrates of competitive interactions and sequence transitions during mechanosensory responses in Drosophila.
Autorzy :
Masson JB; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, United States of America.; Decision and Bayesian Computation, USR 3756 (C3BI/DBC) & Neuroscience Department, Institut Pasteur & CNRS, Paris, France.
Laurent F; Decision and Bayesian Computation, USR 3756 (C3BI/DBC) & Neuroscience Department, Institut Pasteur & CNRS, Paris, France.
Cardona A; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, United States of America.; Department of Physiology, Development, and Neuroscience, Cambridge University, Cambridge, United Kingdom.; MRC Laboratory of Molecular Biology, Trumpington, Cambridge, United Kingdom.
Barré C; Decision and Bayesian Computation, USR 3756 (C3BI/DBC) & Neuroscience Department, Institut Pasteur & CNRS, Paris, France.
Skatchkovsky N; Decision and Bayesian Computation, USR 3756 (C3BI/DBC) & Neuroscience Department, Institut Pasteur & CNRS, Paris, France.
Zlatic M; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, United States of America.; MRC Laboratory of Molecular Biology, Trumpington, Cambridge, United Kingdom.; Department of Zoology, Cambridge University, Cambridge, United Kingdom.
Jovanic T; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, United States of America.; Decision and Bayesian Computation, USR 3756 (C3BI/DBC) & Neuroscience Department, Institut Pasteur & CNRS, Paris, France.; Université Paris-Saclay, CNRS, Institut des Neurosciences Paris Saclay, Gif-sur-Yvette, France.
Pokaż więcej
Źródło :
PLoS genetics [PLoS Genet] 2020 Feb 14; Vol. 16 (2), pp. e1008589. Date of Electronic Publication: 2020 Feb 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet. Subsets: MEDLINE
MeSH Terms :
Binding, Competitive*/physiology
Action Potentials/*physiology
Mechanotransduction, Cellular/*physiology
Neural Pathways/*physiology
Neurons/*physiology
Sensory Receptor Cells/*physiology
Synaptic Transmission/*physiology
Animals ; Animals, Genetically Modified ; Brain/anatomy & histology ; Brain/metabolism ; Brain Mapping ; Cues ; Drosophila melanogaster/genetics ; Neural Pathways/metabolism ; Neurons/metabolism ; Phenotype
Czasopismo naukowe
Tytuł :
Dynamics of competitive binding and separation of monoclonal antibody monomer-dimer mixtures in ceramic hydroxyapatite columns.
Autorzy :
Wang Y; Department of Chemical Engineering, University of Virginia, Charlottesville, VA, USA.
Carta G; Department of Chemical Engineering, University of Virginia, Charlottesville, VA, USA. Electronic address: .
Pokaż więcej
Źródło :
Journal of chromatography. A [J Chromatogr A] 2020 Jan 04; Vol. 1609, pp. 460504. Date of Electronic Publication: 2019 Aug 30.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE
MeSH Terms :
Binding, Competitive*
Dimerization*
Antibodies, Monoclonal/*isolation & purification
Ceramics/*chemistry
Durapatite/*chemistry
Adsorption ; Diffusion ; Kinetics ; Models, Theoretical
Czasopismo naukowe
Tytuł :
Biotin analytical interference on Siemens immunoanalysis on Dimension EXL®: impact on cardiac troponin I and total vitamin D (D 2 +D 3 ) assays.
Transliterated Title :
Étude de l’interférence analytique de la biotine avec les immunoanalyses Siemens sur l’automate Dimension EXL® : impact sur les dosages de troponine I cardiaque et de vitamine D totale (D 2 +D 3 ).
Autorzy :
Djebrani M; Laboratoire de biochimie médicale, Hôpital Raymond Poincaré, Garches, France.
Jabbour F; Laboratoire de biochimie médicale, Hôpital Raymond Poincaré, Garches, France.
Hulot FD; Écologie systématique évolution, UMR 8079, Université Paris-Sud, Agro Paris Tech, CNRS, Université Paris-Saclay, Orsay, France.
De Mazancourt P; Laboratoire de biochimie hormonologie et génétique moléculaire, UMR 1179, Hôpital Ambroise Paré, Boulogne-Billancourt, France.
Pokaż więcej
Źródło :
Annales de biologie clinique [Ann Biol Clin (Paris)] 2019 Dec 01; Vol. 77 (6), pp. 693-696.
Typ publikacji :
Journal Article
Journal Info :
Publisher: John Libbey Eurotext Country of Publication: France NLM ID: 2984690R Publication Model: Print Cited Medium: Internet ISSN: 1950-6112 (Electronic) Linking ISSN: 00033898 NLM ISO Abbreviation: Ann. Biol. Clin. (Paris) Subsets: MEDLINE
MeSH Terms :
Binding, Competitive*
Diagnostic Tests, Routine*/instrumentation
Diagnostic Tests, Routine*/methods
Diagnostic Tests, Routine*/standards
Biotin/*metabolism
Hyperthyroidism/*diagnosis
Streptavidin/*metabolism
Troponin I/*analysis
Vitamin D/*analysis
Adult ; Artifacts ; Biotin/administration & dosage ; Biotin/adverse effects ; Cholecalciferol/analysis ; Cholecalciferol/blood ; Coronary Disease/blood ; Coronary Disease/diagnosis ; Diagnostic Errors ; Ergocalciferols/analysis ; Ergocalciferols/blood ; Humans ; Hyperthyroidism/blood ; Immunoassay/instrumentation ; Immunoassay/methods ; Myocardium/chemistry ; Myocardium/metabolism ; Troponin I/blood ; Troponin I/metabolism ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/diagnosis
Czasopismo naukowe
Tytuł :
Structural Analysis, Molecular Modelling and Preliminary Competition Binding Studies of AM-DAN as a NMDA Receptor PCP-Site Fluorescent Ligand.
Autorzy :
Ndzibongwana S; Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.
Ngobese S; Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.
Sayed A; Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.
Shongwe C; Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.
White-Phillips S; Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.
Joubert J; Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2019 Nov 13; Vol. 24 (22). Date of Electronic Publication: 2019 Nov 13.
Typ publikacji :
Journal Article
Journal Info :
Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
MeSH Terms :
Binding Sites*
Binding, Competitive*
Drug Discovery*
Ligands*
Models, Molecular*
Receptors, N-Methyl-D-Aspartate/*chemistry
Fluorescent Dyes ; Molecular Conformation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2.
Autorzy :
Chan KK; Orthogonal Biologics, Champaign, IL 61821, USA.
Dorosky D; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Sharma P; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA.
Abbasi SA; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Kranz DM; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA.
Procko E; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA. .
Pokaż więcej
Źródło :
Science (New York, N.Y.) [Science] 2020 Sep 04; Vol. 369 (6508), pp. 1261-1265. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
MeSH Terms :
Protein Engineering*
Betacoronavirus/*metabolism
Peptidyl-Dipeptidase A/*genetics
Peptidyl-Dipeptidase A/*metabolism
Receptors, Virus/*genetics
Receptors, Virus/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Amino Acid Substitution ; Binding Sites ; Binding, Competitive ; Cell Line ; Humans ; Models, Molecular ; Mutagenesis ; Mutation ; Peptidyl-Dipeptidase A/chemistry ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Receptors, Virus/chemistry ; Spike Glycoprotein, Coronavirus/chemistry
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Autorzy :
Kim JJ; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Gharpure A; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Teng J; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zhuang Y; Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden.
Howard RJ; Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden.
Zhu S; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Noviello CM; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Walsh RM Jr; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Lindahl E; Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden.; Department of Applied Physics, Swedish e-Science Research Center, KTH Royal Institute of Technology, Solna, Sweden.
Hibbs RE; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA. .
Pokaż więcej
Źródło :
Nature [Nature] 2020 Sep; Vol. 585 (7824), pp. 303-308. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
MeSH Terms :
Cryoelectron Microscopy*
Anesthetics, General/*chemistry
Anesthetics, General/*pharmacology
Barbiturates/*chemistry
Barbiturates/*pharmacology
Benzodiazepines/*chemistry
Benzodiazepines/*pharmacology
Receptors, GABA-A/*chemistry
Allosteric Regulation/drug effects ; Anesthetics, General/metabolism ; Barbiturates/metabolism ; Benzodiazepines/metabolism ; Bicuculline/chemistry ; Bicuculline/metabolism ; Bicuculline/pharmacology ; Binding Sites ; Binding, Competitive/drug effects ; Diazepam/chemistry ; Diazepam/metabolism ; Diazepam/pharmacology ; Electrophysiology ; Etomidate/chemistry ; Etomidate/metabolism ; Etomidate/pharmacology ; Flumazenil/pharmacology ; GABA-A Receptor Antagonists/chemistry ; GABA-A Receptor Antagonists/metabolism ; GABA-A Receptor Antagonists/pharmacology ; Humans ; Ligands ; Models, Molecular ; Molecular Conformation ; Molecular Dynamics Simulation ; Phenobarbital/chemistry ; Phenobarbital/metabolism ; Phenobarbital/pharmacology ; Picrotoxin/chemistry ; Picrotoxin/metabolism ; Picrotoxin/pharmacology ; Propofol/chemistry ; Propofol/metabolism ; Propofol/pharmacology ; Receptors, GABA-A/metabolism ; Receptors, GABA-A/ultrastructure ; gamma-Aminobutyric Acid/chemistry ; gamma-Aminobutyric Acid/metabolism ; gamma-Aminobutyric Acid/pharmacology
Czasopismo naukowe
Tytuł :
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.
Autorzy :
Huo J; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot, UK.; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK.
Le Bas A; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK.
Ruza RR; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Duyvesteyn HME; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Mikolajek H; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Malinauskas T; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Tan TK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Rijal P; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.; Centre for Translational Immunology, Chinse Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.
Dumoux M; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot, UK.
Ward PN; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK.
Ren J; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Zhou D; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Harrison PJ; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK.
Weckener M; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot, UK.
Clare DK; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Vogirala VK; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Radecke J; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Moynié L; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot, UK.
Zhao Y; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Gilbert-Jaramillo J; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Knight ML; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Tree JA; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Buttigieg KR; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Coombes N; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Elmore MJ; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Carroll MW; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Carrique L; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Shah PNM; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
James W; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Townsend AR; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.; Centre for Translational Immunology, Chinse Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.
Stuart DI; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Owens RJ; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot, UK. .; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK. .; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK. .
Naismith JH; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot, UK. .; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK. .; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK. .
Pokaż więcej
Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Sep; Vol. 27 (9), pp. 846-854. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
MeSH Terms :
Coronavirus Infections*
Pandemics*
Pneumonia, Viral*
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Betacoronavirus/*immunology
Peptidyl-Dipeptidase A/*metabolism
Receptors, Virus/*metabolism
Single-Domain Antibodies/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Amino Acid Sequence ; Antibodies, Neutralizing/metabolism ; Antibodies, Neutralizing/ultrastructure ; Antibodies, Viral/metabolism ; Antibodies, Viral/ultrastructure ; Antibody Affinity ; Antigen-Antibody Reactions/immunology ; Betacoronavirus/metabolism ; Binding, Competitive ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Epitopes/immunology ; Humans ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin Fc Fragments/immunology ; Models, Molecular ; Peptide Library ; Peptidyl-Dipeptidase A/ultrastructure ; Protein Binding ; Protein Conformation ; Receptors, Virus/ultrastructure ; Recombinant Fusion Proteins/immunology ; Recombinant Fusion Proteins/metabolism ; Sequence Homology, Amino Acid ; Single-Domain Antibodies/metabolism ; Single-Domain Antibodies/ultrastructure ; Spike Glycoprotein, Coronavirus/metabolism ; Spike Glycoprotein, Coronavirus/ultrastructure
SCR Disease Name :
COVID-19
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
Discovery of strong inhibitory properties of a monoclonal antibody of PKA and use of the antibody and a competitive photoluminescent orthosteric probe for analysis of the protein kinase.
Autorzy :
Nonga OE; Institute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.
Lavogina D; Institute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.
Ivan T; Institute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.
Viht K; Institute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.
Enkvist E; Institute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.
Uri A; Institute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia. Electronic address: .
Pokaż więcej
Źródło :
Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2020 Aug; Vol. 1868 (8), pp. 140427. Date of Electronic Publication: 2020 Apr 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1454 (Electronic) Linking ISSN: 15709639 NLM ISO Abbreviation: Biochim Biophys Acta Proteins Proteom Subsets: MEDLINE
MeSH Terms :
Immunoassay*
Antibodies, Monoclonal/*chemistry
Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/*analysis
Molecular Probes/*chemistry
Peptides/*chemistry
Adenosine Triphosphate/chemistry ; Adenosine Triphosphate/metabolism ; Antibody Specificity ; Binding Sites ; Binding, Competitive ; Cell Line, Tumor ; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/chemistry ; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/metabolism ; HeLa Cells ; Humans ; Kinetics ; Luminescent Measurements ; Models, Molecular ; Peptides/metabolism ; Phosphorylation ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Structure, Tertiary
Czasopismo naukowe
Tytuł :
A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2.
Autorzy :
Shi R; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Shan C; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Duan X; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Chen Z; Center of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Liu P; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Song J; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.
Song T; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Shanxi Academy of Advanced Research and Innovation, Taiyuan, China.; College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, China.
Bi X; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Institute of Physical Science and Information, Anhui University, Hefei, China.
Han C; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Wu L; Institute of Physical Science and Information, Anhui University, Hefei, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Gao G; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Hu X; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Zhang Y; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Tong Z; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Huang W; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, Beijing, China.
Liu WJ; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Wu G; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Zhang B; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Wang L; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, Beijing, China.
Qi J; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Feng H; Shanghai Junshi Biosciences Co. Ltd, Shanghai, China.
Wang FS; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China. .
Wang Q; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. .; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. .; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China. .
Gao GF; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. .
Yuan Z; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. .
Yan J; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. .; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. .; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China. .
Pokaż więcej
Źródło :
Nature [Nature] 2020 Aug; Vol. 584 (7819), pp. 120-124. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Betacoronavirus/*immunology
Coronavirus Infections/*immunology
Coronavirus Infections/*virology
Pneumonia, Viral/*immunology
Pneumonia, Viral/*virology
Spike Glycoprotein, Coronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*immunology
Animals ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/pharmacology ; Antibodies, Viral/chemistry ; Antibodies, Viral/pharmacology ; Betacoronavirus/chemistry ; Binding, Competitive ; Cell Line ; Chlorocebus aethiops ; Crystallization ; Crystallography, X-Ray ; Female ; Humans ; In Vitro Techniques ; Macaca mulatta/immunology ; Macaca mulatta/virology ; Male ; Models, Molecular ; Neutralization Tests ; Pandemics ; Peptidyl-Dipeptidase A/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Protein Binding/drug effects ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Spike Glycoprotein, Coronavirus/metabolism ; Vero Cells ; Viral Load/immunology
SCR Disease Name :
COVID-19
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
Potently neutralizing and protective human antibodies against SARS-CoV-2.
Autorzy :
Zost SJ; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Gilchuk P; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Case JB; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Binshtein E; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Chen RE; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Nkolola JP; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Reidy JX; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Trivette A; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Nargi RS; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Sutton RE; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Suryadevara N; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Martinez DR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Williamson LE; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Chen EC; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Jones T; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Day S; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Myers L; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Hassan AO; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Kafai NM; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Winkler ES; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Fox JM; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Shrihari S; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Mueller BK; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.
Meiler J; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.; Leipzig University Medical School, Institute for Drug Discovery, Leipzig, Germany.
Chandrashekar A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Mercado NB; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Steinhardt JJ; Antibody Discovery and Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
Ren K; Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
Loo YM; Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
Kallewaard NL; Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
McCune BT; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Keeler SP; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO, USA.
Holtzman MJ; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO, USA.
Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Gralinski LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Thackray LB; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Diamond MS; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA.
Carnahan RH; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA. .; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. .
Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA. .; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. .; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. .
Pokaż więcej
Źródło :
Nature [Nature] 2020 Aug; Vol. 584 (7821), pp. 443-449. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info :
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Betacoronavirus/*immunology
Coronavirus Infections/*immunology
Coronavirus Infections/*prevention & control
Pandemics/*prevention & control
Pneumonia, Viral/*immunology
Pneumonia, Viral/*prevention & control
Animals ; Antibodies, Monoclonal/immunology ; Betacoronavirus/chemistry ; Binding, Competitive ; Cell Line ; Cross Reactions ; Disease Models, Animal ; Epitopes, B-Lymphocyte/chemistry ; Epitopes, B-Lymphocyte/immunology ; Female ; Humans ; Macaca mulatta ; Male ; Mice ; Middle Aged ; Neutralization Tests ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pre-Exposure Prophylaxis ; SARS Virus/chemistry ; SARS Virus/immunology ; Severe Acute Respiratory Syndrome/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism
SCR Disease Name :
COVID-19
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
A HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-Terminal domain of capsid.
Autorzy :
Zhang DW; Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, 213001, China; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.
Luo RH; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, The National Kunming High Level Biosafety Research Center for Nonhuman Primate, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China.
Xu L; Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, 213001, China.
Yang LM; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, The National Kunming High Level Biosafety Research Center for Nonhuman Primate, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China.
Xu XS; Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, 213001, China.
Bedwell GJ; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.
Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.
Zheng YT; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, The National Kunming High Level Biosafety Research Center for Nonhuman Primate, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China. Electronic address: .
Chang S; Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, 213001, China. Electronic address: .
Pokaż więcej
Źródło :
Antiviral research [Antiviral Res] 2019 Sep; Vol. 169, pp. 104544. Date of Electronic Publication: 2019 Jun 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res. Subsets: MEDLINE
MeSH Terms :
Binding, Competitive*
Fluorescence*
Capsid Proteins/*drug effects
Drug Evaluation, Preclinical/*methods
HIV-1/*drug effects
High-Throughput Screening Assays/*methods
Virus Assembly/*drug effects
Capsid/drug effects ; Capsid Proteins/genetics ; Capsid Proteins/metabolism ; Cell Line ; Drug Liberation ; Recombinant Proteins ; T-Lymphocytes ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor.
Autorzy :
Bosma R; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.
Stoddart LA; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, Midlands, UK.
Georgi V; Drug Discovery, Bayer AG, Berlin, Germany.
Bouzo-Lorenzo M; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, Midlands, UK.
Bushby N; IMED Operations, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom.
Inkoom L; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.
Waring MJ; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom.; Northern Institute for Cancer Research, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom.
Briddon SJ; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, Midlands, UK.
Vischer HF; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.
Sheppard RJ; Medicinal Chemistry, Cardiovascular, Renal, and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Fernández-Montalván A; Drug Discovery, Bayer AG, Berlin, Germany.; Servier Research Institute 125, Chemin de Ronde, 78290, Croissy-sur-Seine, France.
Hill SJ; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, Midlands, UK.
Leurs R; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2019 May 27; Vol. 9 (1), pp. 7906. Date of Electronic Publication: 2019 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
MeSH Terms :
Binding, Competitive*
Histamine H1 Antagonists/*pharmacokinetics
Molecular Probes/*chemistry
Radioligand Assay/*methods
Receptors, Histamine H1/*metabolism
Cetirizine/chemistry ; Cetirizine/pharmacokinetics ; Datasets as Topic ; Fluorescence Resonance Energy Transfer/methods ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/pharmacokinetics ; HEK293 Cells ; Histamine H1 Antagonists/chemistry ; Humans ; Ligands ; Molecular Probes/pharmacokinetics ; Olopatadine Hydrochloride/chemistry ; Olopatadine Hydrochloride/pharmacokinetics ; Protein Binding ; Pyrilamine/chemistry ; Pyrilamine/pharmacokinetics ; Tritium
Czasopismo naukowe
Tytuł :
Kinetics of competitive Cd binding pathways: the realistic structure of intrinsically disordered, partially metallated metallothioneins.
Autorzy :
Wong DL; Department of Chemistry, the University of Western Ontario, 1151 Richmond St. London, Ontario, CanadaN6A5B7. .
Korkola NC
Stillman MJ
Pokaż więcej
Źródło :
Metallomics : integrated biometal science [Metallomics] 2019 May 22; Vol. 11 (5), pp. 894-905.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: RSC Publishing Country of Publication: England NLM ID: 101478346 Publication Model: Print Cited Medium: Internet ISSN: 1756-591X (Electronic) Linking ISSN: 17565901 NLM ISO Abbreviation: Metallomics Subsets: MEDLINE
MeSH Terms :
Binding, Competitive*
Cadmium/*metabolism
Intrinsically Disordered Proteins/*chemistry
Intrinsically Disordered Proteins/*metabolism
Metallothionein/*chemistry
Metallothionein/*metabolism
Guanidine/pharmacology ; Humans ; Hydrogen-Ion Concentration ; Kinetics ; Protein Denaturation/drug effects ; Spectrometry, Mass, Electrospray Ionization ; Temperature
Czasopismo naukowe
Tytuł :
Development of a Competition-Binding Assay to Determine Binding Affinity of Molecules to Neuromelanin via Fluorescence Spectroscopy.
Autorzy :
Fink J; School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA. .
Pathak H; School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA. .
Smith J; School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA. .
Achat-Mendes C; School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA. .
Haining RL; School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA. .
Pokaż więcej
Źródło :
Biomolecules [Biomolecules] 2019 May 08; Vol. 9 (5). Date of Electronic Publication: 2019 May 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE
MeSH Terms :
Binding, Competitive*
Biological Assay*
Melanins/*metabolism
Animals ; Catecholamines/metabolism ; Cells, Cultured ; Humans ; Nicotine/metabolism ; Nicotine/pharmacology ; Oxidation-Reduction ; Oxidopamine/metabolism ; Polymerization ; Rats ; Signal Transduction ; Spectrometry, Fluorescence
Czasopismo naukowe
Tytuł :
Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins.
Autorzy :
Fujita K; Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodaicho, Nada-ku, Kobe, Hyogo, 657-8501, Japan.
Kondoh Y; RIKEN Center for Sustainable Resource Science, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Honda K; RIKEN Center for Sustainable Resource Science, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Haga Y; Hyogo Prefectural Institute of Environmental Sciences, 3-1-18 Yukihiracho, Suma-ku, Kobe, Hyogo, 654-0037, Japan.
Osada H; RIKEN Center for Sustainable Resource Science, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Matsumura C; Hyogo Prefectural Institute of Environmental Sciences, 3-1-18 Yukihiracho, Suma-ku, Kobe, Hyogo, 654-0037, Japan.
Inui H; Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodaicho, Nada-ku, Kobe, Hyogo, 657-8501, Japan; Biosignal Research Center, Kobe University, 1-1 Rokkodaicho, Nada-ku, Kobe, Hyogo, 657-8501, Japan. Electronic address: .
Pokaż więcej
Źródło :
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2020 Nov; Vol. 266 (Pt 2), pp. 115179. Date of Electronic Publication: 2020 Jul 18.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6424 (Electronic) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ. Pollut. Subsets: MEDLINE
MeSH Terms :
Cucurbita*
Environmental Pollutants*
Pesticides/*analysis
Soil Pollutants/*analysis
Binding, Competitive ; Latex ; Plant Roots/chemistry
Czasopismo naukowe
Tytuł :
Taste compound - Nanocellulose interaction assessment by fluorescence indicator displacement assay.
Autorzy :
Manninen H; Tampere University, Faculty of Engineering and Natural Sciences, FI-33014 Tampere University, Finland. Electronic address: .
Durandin N; Tampere University, Faculty of Engineering and Natural Sciences, FI-33014 Tampere University, Finland.
Hopia A; University of Turku, Functional Foods Forum, FI-20014 Turku, Finland.
Vuorimaa-Laukkanen E; Tampere University, Faculty of Engineering and Natural Sciences, FI-33014 Tampere University, Finland.
Laaksonen T; Tampere University, Faculty of Engineering and Natural Sciences, FI-33014 Tampere University, Finland; Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, FI-00014 University of Helsinki, Finland.
Pokaż więcej
Źródło :
Food chemistry [Food Chem] 2020 Jul 15; Vol. 318, pp. 126511. Date of Electronic Publication: 2020 Feb 27.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE
MeSH Terms :
Cellulose/*metabolism
Fluorescent Dyes/*chemistry
Nanostructures/*chemistry
Aspartame/chemistry ; Aspartame/metabolism ; Benzenesulfonates/chemistry ; Binding, Competitive ; Caffeine/metabolism ; Cellulose/chemistry ; Congo Red/chemistry ; Diterpenes, Kaurane/metabolism ; Flavanones/metabolism ; Glucosides/metabolism ; Spectrophotometry, Ultraviolet ; Taste
Czasopismo naukowe
Tytuł :
Structure and activity of human surfactant protein D from different natural sources.
Autorzy :
Arroyo R; Department of Biochemistry, Faculty of Biology, Complutense University, Madrid, Spain.; Research Institut 'Hospital 12 de Octubre (imas12)', Madrid, Spain.
Echaide M; Department of Biochemistry, Faculty of Biology, Complutense University, Madrid, Spain.; Research Institut 'Hospital 12 de Octubre (imas12)', Madrid, Spain.
Wilmanowski R; Glycotope GmbH, Berlin, Germany.
Martín-González A; Department of Macromolecular Structures, National Center of Biotechnology, CSIC, Madrid, Spain.
Batllori E; Research Institut 'Hospital 12 de Octubre (imas12)', Madrid, Spain.; Department of Obstetrics and Gyneacology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Galindo A; Research Institut 'Hospital 12 de Octubre (imas12)', Madrid, Spain.; Department of Obstetrics and Gyneacology, Hospital Universitario 12 de Octubre, Madrid, Spain.; Fetal Medicine Unit-SAMID, Hospital Universitario 12 de Octubre, Madrid, Spain.
Rosenbaum JS; Research and Development Department, Airway Therapeutics LLC, Cincinnati, Ohio.
Moreno-Herrero F; Department of Macromolecular Structures, National Center of Biotechnology, CSIC, Madrid, Spain.
Kingma PS; Division of Neonatology and Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Pérez-Gil J; Department of Biochemistry, Faculty of Biology, Complutense University, Madrid, Spain.; Research Institut 'Hospital 12 de Octubre (imas12)', Madrid, Spain.
Pokaż więcej
Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2020 Jul 01; Vol. 319 (1), pp. L148-L158. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901229 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1504 (Electronic) Linking ISSN: 10400605 NLM ISO Abbreviation: Am J Physiol Lung Cell Mol Physiol Subsets: MEDLINE
MeSH Terms :
Pulmonary Surfactant-Associated Protein D/*chemistry
Pulmonary Surfactant-Associated Protein D/*metabolism
Amniotic Fluid/metabolism ; Asparagine/metabolism ; Binding, Competitive ; Chromatography, Affinity ; Female ; Glycosylation ; Humans ; Polysaccharides/metabolism ; Pregnancy ; Protein Binding ; Protein Multimerization ; Pulmonary Alveolar Proteinosis/metabolism ; Pulmonary Surfactant-Associated Protein D/isolation & purification ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Competitive binding assays for measuring the binding affinity of thyroid-disrupting chemicals for integrin α v β 3 .
Autorzy :
Li J; Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing, 100875, China.
Liu H; Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing, 100875, China.
Zuo R; Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing, 100875, China.
Yang J; Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing, 100875, China.
Li N; Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China. Electronic address: .
Pokaż więcej
Źródło :
Chemosphere [Chemosphere] 2020 Jun; Vol. 249, pp. 126034. Date of Electronic Publication: 2020 Feb 01.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 0320657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1298 (Electronic) Linking ISSN: 00456535 NLM ISO Abbreviation: Chemosphere Subsets: MEDLINE
MeSH Terms :
Biological Assay*
Integrin alphaVbeta3/*metabolism
Receptors, Thyroid Hormone/*metabolism
Thyroid Gland/*drug effects
Binding, Competitive ; Dibutyl Phthalate ; Esters ; Phthalic Acids/toxicity ; Thyroid Gland/metabolism ; Thyroxine/analogs & derivatives
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies