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Tytuł:
NanoBERTa-ASP: predicting nanobody paratope based on a pretrained RoBERTa model.
Autorzy:
Li S; College of Big Data and Internet, Shenzhen Technology University, Shenzhen, China.
Meng X; College of Big Data and Internet, Shenzhen Technology University, Shenzhen, China.
Li R; College of Big Data and Internet, Shenzhen Technology University, Shenzhen, China.
Huang B; College of Big Data and Internet, Shenzhen Technology University, Shenzhen, China. .
Wang X; College of Big Data and Internet, Shenzhen Technology University, Shenzhen, China. .
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2024 Mar 21; Vol. 25 (1), pp. 122. Date of Electronic Publication: 2024 Mar 21.
Typ publikacji:
Journal Article
MeSH Terms:
Single-Domain Antibodies*/chemistry
Binding Sites, Antibody ; Antibodies ; Binding Sites ; Antibody Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The rise of big data: deep sequencing-driven computational methods are transforming the landscape of synthetic antibody design.
Autorzy:
Gallo E; Department of Medicinal Chemistry, Avance Biologicals, 950 Dupont Street, Toronto, ON, M6H 1Z2, Canada. .; Department of Protein Engineering, RevivAb, Av. Ipiranga, 6681, Partenon, Porto Alegre, RS, 90619-900, Brazil. .
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Źródło:
Journal of biomedical science [J Biomed Sci] 2024 Mar 16; Vol. 31 (1), pp. 29. Date of Electronic Publication: 2024 Mar 16.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Genomics*
High-Throughput Nucleotide Sequencing*
Binding Sites, Antibody
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
"Redirecting an anti-IL-1β antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A".
Autorzy:
Fischman S; Biolojic Design LTD, Rehovot, Israel.
Levin I; Biolojic Design LTD, Rehovot, Israel.; Enzymit LTD, Ness Ziona, Israel.
Rondeau JM; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Štrajbl M; Biolojic Design LTD, Rehovot, Israel.
Lehmann S; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Huber T; Novartis Institutes for Biomedical Research, Basel, Switzerland.; Ridgelinediscovery, Basel, Switzerland.
Nimrod G; Biolojic Design LTD, Rehovot, Israel. .
Cebe R; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Omer D; Biolojic Design LTD, Rehovot, Israel.; EmendoBio Inc., Rehovot, Israel.
Kovarik J; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Bernstein S; Biolojic Design LTD, Rehovot, Israel.
Sasson Y; Biolojic Design LTD, Rehovot, Israel.
Demishtein A; Biolojic Design LTD, Rehovot, Israel.; Anima Biotech, Ramat-Gan, Israel.
Shlamkovich T; Biolojic Design LTD, Rehovot, Israel.
Bluvshtein O; Biolojic Design LTD, Rehovot, Israel.; Enzymit LTD, Ness Ziona, Israel.
Grossman N; Biolojic Design LTD, Rehovot, Israel.
Barak-Fuchs R; Biolojic Design LTD, Rehovot, Israel.
Zhenin M; Biolojic Design LTD, Rehovot, Israel.
Fastman Y; Biolojic Design LTD, Rehovot, Israel.
Twito S; Biolojic Design LTD, Rehovot, Israel.; Enzymit LTD, Ness Ziona, Israel.
Vana T; Biolojic Design LTD, Rehovot, Israel.
Zur N; Biolojic Design LTD, Rehovot, Israel.
Ofran Y; Biolojic Design LTD, Rehovot, Israel.; The Goodman Faculty of Life Sciences, Nanotechnology Building, Bar Ilan University, Ramat Gan, Israel.
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Źródło:
Communications biology [Commun Biol] 2023 Sep 29; Vol. 6 (1), pp. 997. Date of Electronic Publication: 2023 Sep 29.
Typ publikacji:
Journal Article
MeSH Terms:
Interleukin-17*
Antibodies*
Epitopes/chemistry ; Antigens ; Binding Sites, Antibody
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Paratope-Enhanced Method to Determine Breadth and Depth TCR Clonal Metrics of the Private Human T-Cell Vaccine Response after SARS-CoV-2 Vaccination.
Autorzy:
Li D; Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Pavlovitch-Bedzyk AJ; Computational and Systems Immunology Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ebinger JE; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Khan A; Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Hamideh M; Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Merchant A; Cedars-Sinai Cancer and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Figueiredo JC; Cedars-Sinai Cancer and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Cheng S; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Davis MM; Computational and Systems Immunology Program, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Microbiology and Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
McGovern DPB; Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Melmed GY; Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Xu AM; Cedars-Sinai Cancer and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Braun J; Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 18; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 18.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19 Vaccines*
COVID-19*/prevention & control
Humans ; SARS-CoV-2 ; Binding Sites, Antibody ; Tumor Necrosis Factor Inhibitors ; CD8-Positive T-Lymphocytes ; Vaccination ; Receptors, Antigen, T-Cell/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unveiling CD59-Antibody Interactions to Design Paratope-Mimicking Peptides for Complement Modulation.
Autorzy:
Sandomenico A; Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), I-80131 Napoli, Italy.
Ruggiero A; Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), I-80131 Napoli, Italy.
Iaccarino E; Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), I-80131 Napoli, Italy.
Oliver A; Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), I-80131 Napoli, Italy.
Squeglia F; Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), I-80131 Napoli, Italy.
Moreira M; Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), I-80131 Napoli, Italy.
Esposito L; Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), I-80131 Napoli, Italy.
Ruvo M; Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), I-80131 Napoli, Italy.
Berisio R; Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), I-80131 Napoli, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 10; Vol. 24 (10). Date of Electronic Publication: 2023 May 10.
Typ publikacji:
Journal Article
MeSH Terms:
Complement System Proteins*/metabolism
HIV-1*/physiology
Humans ; Binding Sites, Antibody ; CD59 Antigens/metabolism ; Complement Membrane Attack Complex/metabolism ; Complement Inactivating Agents
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Using the antibody-antigen binding interface to train image-based deep neural networks for antibody-epitope classification.
Autorzy:
Ripoll DR; DoD Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), Bethesda, Maryland, United States of America.
Chaudhury S; DoD Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, Maryland, United States of America.; Center for Enabling Capabilities, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Wallqvist A; DoD Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, Maryland, United States of America.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2021 Mar 29; Vol. 17 (3), pp. e1008864. Date of Electronic Publication: 2021 Mar 29 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Antibodies*/chemistry
Antibodies*/classification
Antibodies*/metabolism
Binding Sites, Antibody*
Epitopes*/chemistry
Epitopes*/classification
Epitopes*/metabolism
Neural Networks, Computer*
Antibodies, Viral ; Computational Biology ; Deep Learning ; Humans ; Image Processing, Computer-Assisted ; Models, Molecular ; Virus Diseases/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Structural Characterization of Nanobodies during Germline Maturation.
Autorzy:
Seidler CA; Department of General, Inorganic and Theoretical Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria.
Kokot J; Department of General, Inorganic and Theoretical Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria.
Fernández-Quintero ML; Department of General, Inorganic and Theoretical Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria.
Liedl KR; Department of General, Inorganic and Theoretical Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria.
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Źródło:
Biomolecules [Biomolecules] 2023 Feb 17; Vol. 13 (2). Date of Electronic Publication: 2023 Feb 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Single-Domain Antibodies*/chemistry
Protein Conformation ; Antibodies/chemistry ; Binding Sites, Antibody ; Molecular Dynamics Simulation ; Antigens
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural Perspective of Gliadin Peptides Active in Celiac Disease.
Autorzy:
Falcigno L; Department of Pharmacy, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy.
Calvanese L; Department of Pharmacy, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy.
Conte M; Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, Italy.; European Laboratory for the Investigation of Food Induced Diseases (ELFID), University of Naples Federico II, 80131 Naples, Italy.
Nanayakkara M; Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, Italy.; European Laboratory for the Investigation of Food Induced Diseases (ELFID), University of Naples Federico II, 80131 Naples, Italy.
Barone MV; Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, Italy.; European Laboratory for the Investigation of Food Induced Diseases (ELFID), University of Naples Federico II, 80131 Naples, Italy.
D'Auria G; Department of Pharmacy, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 06; Vol. 21 (23). Date of Electronic Publication: 2020 Dec 06.
Typ publikacji:
Journal Article
MeSH Terms:
Binding Sites, Antibody*
Celiac Disease/*immunology
Gliadin/*chemistry
HLA-DQ Antigens/*immunology
Peptide Fragments/*chemistry
Adaptive Immunity ; Gliadin/immunology ; HLA-DQ Antigens/chemistry ; Humans ; Immunity, Innate ; Molecular Docking Simulation ; Peptide Fragments/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antibodies exhibit multiple paratope states influencing V H -V L domain orientations.
Autorzy:
Fernández-Quintero ML; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020, Innsbruck, Austria.
Pomarici ND; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020, Innsbruck, Austria.
Math BA; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020, Innsbruck, Austria.
Kroell KB; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020, Innsbruck, Austria.
Waibl F; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020, Innsbruck, Austria.
Bujotzek A; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany.
Georges G; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany.
Liedl KR; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020, Innsbruck, Austria. .
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Źródło:
Communications biology [Commun Biol] 2020 Oct 20; Vol. 3 (1), pp. 589. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Binding Sites, Antibody*
Protein Interaction Domains and Motifs*
Antibodies/*chemistry
Immunoglobulin Heavy Chains/*chemistry
Immunoglobulin Light Chains/*chemistry
Immunoglobulin Variable Region/*chemistry
Antibodies/immunology ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/immunology ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Light Chains/immunology ; Immunoglobulin Variable Region/immunology ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon.
Autorzy:
Soares IF; Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, (Fiocruz), Rio de Janeiro, RJ, Brazil.
López-Camacho C; Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, UK.
Rodrigues-da-Silva RN; Laboratório de Tecnologia em Anticorpos Monoclonais, Instituto de Tecnologia de Imunobiológicos, Fiocruz, Rio de Janeiro, Brazil.
da Silva Matos A; Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, (Fiocruz), Rio de Janeiro, RJ, Brazil.
de Oliveira Baptista B; Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Totino PRR; Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
de Souza RM; Centro de Pesquisa em Doenças Infecciosas, Centro Multidisciplinar, Campus Floresta, Universidade Federal do Acre, Rio Branco, Brazil.
Harrison K; Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, UK.
Gimenez AM; Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, UK.
de Freitas EO; Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, UK.
Kim YC; Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, UK.
Oliveira-Ferreira J; Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, (Fiocruz), Rio de Janeiro, RJ, Brazil.
Daniel-Ribeiro CT; Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.; Centro de Pesquisa, Diagnóstico e Treinamento em Malária, Fiocruz, Rio de Janeiro, RJ, Brazil.
Reyes-Sandoval A; Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, UK.
Pratt-Riccio LR; Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Lima-Junior JDC; Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, (Fiocruz), Rio de Janeiro, RJ, Brazil. .
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Źródło:
Scientific reports [Sci Rep] 2020 Aug 20; Vol. 10 (1), pp. 14020. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alleles*
Binding Sites, Antibody*
Antibodies, Protozoan/*immunology
Plasmodium vivax/*genetics
Protozoan Proteins/*genetics
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Brazil ; Case-Control Studies ; Child ; Child, Preschool ; Female ; HEK293 Cells ; Humans ; Immunoglobulin G/immunology ; Malaria Vaccines/immunology ; Malaria, Vivax/prevention & control ; Male ; Middle Aged ; Protozoan Proteins/immunology ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Significance of antibody numbering systems in the development of antibody engineering.
Autorzy:
Patel R; Innoplexus Consulting Services Pvt Ltd, Pune, Maharashtra, India.
Verma P; Innoplexus Consulting Services Pvt Ltd, Pune, Maharashtra, India.
Nagraj AK; Innoplexus Consulting Services Pvt Ltd, Pune, Maharashtra, India.
Gavade A; Innoplexus Consulting Services Pvt Ltd, Pune, Maharashtra, India.
Sharma OP; Innoplexus AG, Eschborn, Germany.
Patil J; Innoplexus Consulting Services Pvt Ltd, Pune, Maharashtra, India.
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Źródło:
Human antibodies [Hum Antibodies] 2023; Vol. 31 (4), pp. 71-80.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antibodies*/genetics
Antibodies*/chemistry
Complementarity Determining Regions*/chemistry
Humans ; Antibody Affinity ; Binding Sites, Antibody
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Turning antibodies off and on again using a covalently tethered blocking peptide.
Autorzy:
Brasino M; Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, 97201, USA. .
Wagnell E; Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, 97201, USA.
Hamilton S; Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, 97201, USA.; Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, OR, 97201, USA.
Ranganathan S; Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, 97201, USA.
Gomes MM; Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, 97201, USA.
Branchaud B; Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, 97201, USA.
Messmer B; Abreos Biosciences, San Diego, CA, 92122, USA.
Ibsen SD; Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, 97201, USA. .; Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, OR, 97201, USA. .
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Źródło:
Communications biology [Commun Biol] 2022 Dec 10; Vol. 5 (1), pp. 1357. Date of Electronic Publication: 2022 Dec 10.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies*
Peptides*
Binding Sites, Antibody ; Kinetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.
Autorzy:
Oyen D; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Aoto PC; Department of Pharmacology, University of California at San Diego, La Jolla, California, United States of America.
Flores-Garcia Y; Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Binter Š; Kymab Ltd., The Bennet Building (B930), Babraham Research Campus, Cambridge, United Kingdom.
Pholcharee T; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Carroll S; Atreca Inc., South San Francisco, California, United States of America.
Reponen S; Atreca Inc., South San Francisco, California, United States of America.
Wash R; Kymab Ltd., The Bennet Building (B930), Babraham Research Campus, Cambridge, United Kingdom.
Liang Q; Kymab Ltd., The Bennet Building (B930), Babraham Research Campus, Cambridge, United Kingdom.
Lemiale F; PATH's Malaria Vaccine Initiative, PATH Center for Vaccine Innovation and Access, Washington, United States of America.
Locke E; PATH's Malaria Vaccine Initiative, PATH Center for Vaccine Innovation and Access, Washington, United States of America.
Bradley A; Kymab Ltd., The Bennet Building (B930), Babraham Research Campus, Cambridge, United Kingdom.; Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
King CR; PATH's Malaria Vaccine Initiative, PATH Center for Vaccine Innovation and Access, Washington, United States of America.
Emerling D; Atreca Inc., South San Francisco, California, United States of America.
Kellam P; Kymab Ltd., The Bennet Building (B930), Babraham Research Campus, Cambridge, United Kingdom.; Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, United Kingdom.
Zavala F; Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2020 Mar 09; Vol. 16 (3), pp. e1008373. Date of Electronic Publication: 2020 Mar 09 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Binding Sites, Antibody*
Antibodies, Monoclonal, Murine-Derived/*chemistry
Antibodies, Protozoan/*chemistry
Epitopes/*chemistry
Plasmodium falciparum/*chemistry
Protozoan Proteins/*chemistry
Animals ; Antibodies, Monoclonal, Murine-Derived/immunology ; Antibodies, Protozoan/immunology ; Epitopes/immunology ; Female ; Male ; Mice ; Mice, Transgenic ; Plasmodium falciparum/immunology ; Protozoan Proteins/immunology ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural basis of polyethylene glycol recognition by antibody.
Autorzy:
Lee CC; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan. .
Su YC; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan.
Ko TP; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Lin LL; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Yang CY; Medigen Biotechnology Corporation, Taipei, Taiwan.
Chang SS; Medigen Biotechnology Corporation, Taipei, Taiwan.; Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Roffler SR; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. .
Wang AH; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan. .
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Źródło:
Journal of biomedical science [J Biomed Sci] 2020 Jan 07; Vol. 27 (1), pp. 12. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji:
Journal Article
MeSH Terms:
Antibody Specificity*
Binding Sites, Antibody*
Antibodies, Monoclonal, Murine-Derived/*chemistry
Immunoglobulin Fab Fragments/*chemistry
Polyethylene Glycols/*chemistry
Crystallography, X-Ray
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antigen-binding affinity and thermostability of chimeric mouse-chicken IgY and mouse-human IgG antibodies with identical variable domains.
Autorzy:
Choi J; Department of Biomedical Sciences, Graduate School, Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.; Department of Microbiology, Ajou University School of Medicine, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.
Kim M; Department of Biomedical Sciences, Graduate School, Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.; Department of Microbiology, Ajou University School of Medicine, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.
Lee J; Department of Biomedical Sciences, Graduate School, Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.; Department of Microbiology, Ajou University School of Medicine, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.
Seo Y; Department of Biomedical Sciences, Graduate School, Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.; Department of Microbiology, Ajou University School of Medicine, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.
Ham Y; Department of Biomedical Sciences, Graduate School, Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.; Department of Microbiology, Ajou University School of Medicine, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.
Lee J; Department of Biomedical Sciences, Graduate School, Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.; Department of Microbiology, Ajou University School of Medicine, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.
Lee J; Department of Biomedical Sciences, Graduate School, Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.; Department of Microbiology, Ajou University School of Medicine, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.
Kim JK; Department of Microbiology, Changwon National University, 20 Changwondaehak-ro, Uichang-gu, Changwon, 51140, South Korea.
Kwon MH; Department of Biomedical Sciences, Graduate School, Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea. .; Department of Microbiology, Ajou University School of Medicine, 206 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea. .
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Źródło:
Scientific reports [Sci Rep] 2019 Dec 17; Vol. 9 (1), pp. 19242. Date of Electronic Publication: 2019 Dec 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibody Affinity*
Binding Sites, Antibody*
Immunoglobulin G/*chemistry
Immunoglobulins/*chemistry
Recombinant Fusion Proteins/*chemistry
Animals ; Chickens ; Humans ; Immunoglobulin G/genetics ; Immunoglobulins/genetics ; Mice ; Protein Stability ; Recombinant Fusion Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Honing-in antigen-specific cells during antibody discovery: a user-friendly process to mine a deeper repertoire.
Autorzy:
Mahendra A; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA. .
Haque A; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA.
Prabakaran P; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA.
Mackness BC; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA.
Fuller TP; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA.
Liu X; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA.
Kathuria SV; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA.
Wang YH; Immunology & Inflammation Research, Genomics Center, Sanofi, 270 Albany Street, Cambridge, MA, USA.
Amatya N; Immunology & Inflammation Research, Genomics Center, Sanofi, 270 Albany Street, Cambridge, MA, USA.
Yu X; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA.
Hopke J; Molecular Expression and Screening Technologies, Sanofi, 270 Albany Street, Cambridge, MA, USA.
Hoffmann D; Molecular Expression and Screening Technologies, Sanofi, 270 Albany Street, Cambridge, MA, USA.
Bric-Furlong E; Molecular Expression and Screening Technologies, Sanofi, 270 Albany Street, Cambridge, MA, USA.
Zhang N; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA.
Cho HS; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA.
Zhang R; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA.
Sancho J; Neuroinflammation, Sanofi Genzyme, 49 New York Avenue, Framingham, MA, USA.
Saleh J; Neuroinflammation, Sanofi Genzyme, 49 New York Avenue, Framingham, MA, USA.
Rao SP; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA.
Wendt M; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA.
Chowdhury PS; Large Molecule Research, Sanofi, 49 New York Avenue, Framingham, MA, USA. .; Johnson & Johnson R&D Center, 1400 McKean Road, Spring House, PA, 19477, USA. .
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Źródło:
Communications biology [Commun Biol] 2022 Oct 30; Vol. 5 (1), pp. 1157. Date of Electronic Publication: 2022 Oct 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies*
Immunization*
Binding Sites, Antibody ; Gene Library ; Epitopes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Detailed Molecular Interactions between Respiratory Syncytial Virus Fusion Protein and the TLR4/MD-2 Complex In Silico.
Autorzy:
Akagawa M; Department of Health Science, Graduate School of Health Sciences, Gunma Paz University, Takasaki-shi 370-0006, Japan.
Shirai T; Advanced Medical Science Research Center, Gunma Paz University Research Institute, Shibukawa-shi 377-0008, Japan.
Sada M; Department of Health Science, Graduate School of Health Sciences, Gunma Paz University, Takasaki-shi 370-0006, Japan.
Nagasawa N; Department of Health Science, Graduate School of Health Sciences, Gunma Paz University, Takasaki-shi 370-0006, Japan.
Kondo M; Department of Clinical Engineering, Faculty of Medical Technology, Gunma Paz University, Takasaki-shi 370-0006, Japan.
Takeda M; Department of Virology III, National Institute of Infectious Diseases, Musashimurayama-shi, Tokyo 208-0011, Japan.
Nagasawa K; Department of Pediatrics, Graduate School of Medical Science, Chiba University, Chiba-shi 260-8670, Japan.
Kimura R; Advanced Medical Science Research Center, Gunma Paz University Research Institute, Shibukawa-shi 377-0008, Japan.; Department of Bacteriology, Graduate School of Medicine, Gunma University, Maebashi-shi 371-8514, Japan.
Okayama K; Department of Health Science, Graduate School of Health Sciences, Gunma Paz University, Takasaki-shi 370-0006, Japan.
Hayashi Y; Department of Health Science, Graduate School of Health Sciences, Gunma Paz University, Takasaki-shi 370-0006, Japan.
Sugai T; Department of Nursing Science, Graduate School of Health Science, Hiroshima University, Hiroshima-shi 734-8551, Japan.
Tsugawa T; Department of Pediatrics, School of Medicine, Sapporo Medical University, Sapporo-shi 060-8543, Japan.
Ishii H; Department of Respiratory Medicine, School of Medicine, Kyorin University, Mitaka-shi, Tokyo 181-8611, Japan.
Kawashima H; Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan.
Katayama K; Laboratory of Viral Infection Control, Graduate School of Infection Control Sciences, Ōmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.
Ryo A; Department of Microbiology, School of Medicine, Yokohama City University, Yokohama-shi 236-0004, Japan.
Kimura H; Department of Health Science, Graduate School of Health Sciences, Gunma Paz University, Takasaki-shi 370-0006, Japan.; Advanced Medical Science Research Center, Gunma Paz University Research Institute, Shibukawa-shi 377-0008, Japan.
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Źródło:
Viruses [Viruses] 2022 Oct 28; Vol. 14 (11). Date of Electronic Publication: 2022 Oct 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Respiratory Syncytial Virus Infections*
Respiratory Syncytial Virus, Human*
Humans ; Antibodies, Neutralizing ; Antibodies, Viral ; Binding Sites, Antibody ; Toll-Like Receptor 4/metabolism ; Viral Fusion Proteins ; ATP Binding Cassette Transporter, Subfamily B ; Protein Binding
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
G-Quadruplex Recognition by DARPIns through Epitope/Paratope Analogy.
Autorzy:
Miclot T; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, Università degli Studi di Palermo, Viale delle Scienze, 90128, Palermo, Italy.; Université de Lorraine and CNRS LPCT UMR 7019, 54000, Nancy, France.
Bignon E; Université de Lorraine and CNRS LPCT UMR 7019, 54000, Nancy, France.
Terenzi A; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, Università degli Studi di Palermo, Viale delle Scienze, 90128, Palermo, Italy.
Grandemange S; Université de Lorraine and CNRS CRAN UMR 7039, 54000, Nancy, France.
Barone G; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, Università degli Studi di Palermo, Viale delle Scienze, 90128, Palermo, Italy.
Monari A; Université de Lorraine and CNRS LPCT UMR 7019, 54000, Nancy, France.; Université Paris Cité and CNRS, ITODYS, 75006, Paris, France.
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Oct 12; Vol. 28 (57), pp. e202201824. Date of Electronic Publication: 2022 Aug 22.
Typ publikacji:
Journal Article
MeSH Terms:
G-Quadruplexes*
Nucleic Acids*
Binding Sites, Antibody ; Designed Ankyrin Repeat Proteins ; Epitopes ; Guanine/chemistry ; Humans ; Peptides/chemistry ; Proto-Oncogene Proteins c-bcl-2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Crystal structure of ultra-humanized anti-pTau Fab reveals how germline substitutions humanize CDRs without loss of binding'.
Autorzy:
Brinth AR; BioMedicine Design, Pfizer Worldwide R&D, Dublin, D22 V8F8, Ireland.
Svenson K; BioMedicine Design, Pfizer Worldwide R&D, Cambridge, MA, 02139, USA.
Mosyak L; BioMedicine Design, Pfizer Worldwide R&D, Cambridge, MA, 02139, USA.
Cunningham O; Ultrahuman Ltd. Kreston Reeves LLP Innovation Hs, Ramsgate Rd, Sandwich, CT13 9FF, UK.
Hickling T; BioMedicine Design, Pfizer Worldwide R&D, Andover, MA, 01810, USA.
Lambert M; BioMedicine Design, Pfizer Worldwide R&D, Dublin, D22 V8F8, Ireland. .
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Źródło:
Scientific reports [Sci Rep] 2022 May 24; Vol. 12 (1), pp. 8699. Date of Electronic Publication: 2022 May 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Antibodies*
Germ Cells*
Humans ; Amino Acid Sequence ; Amino Acids ; Binding Sites, Antibody
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Nanobody Paratope Ensembles in Solution Characterized by MD Simulations and NMR.
Autorzy:
Fernández-Quintero ML; Department of General, Inorganic and Theoretical Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
DeRose EF; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr. MD-MR-01, Research Triangle Park, NC 27709, USA.
Gabel SA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr. MD-MR-01, Research Triangle Park, NC 27709, USA.
Mueller GA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr. MD-MR-01, Research Triangle Park, NC 27709, USA.
Liedl KR; Department of General, Inorganic and Theoretical Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 May 12; Vol. 23 (10). Date of Electronic Publication: 2022 May 12.
Typ publikacji:
Journal Article
MeSH Terms:
Single-Domain Antibodies*
Binding Sites, Antibody ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy/methods ; Molecular Dynamics Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 786

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