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Tytuł :
Eg5 targeting agents: From new anti-mitotic based inhibitor discovery to cancer therapy and resistance.
Autorzy :
Garcia-Saez I; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), 38000 Grenoble, France.
Skoufias DA; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), 38000 Grenoble, France. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Feb; Vol. 184, pp. 114364. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antimitotic Agents/*pharmacology
Antineoplastic Agents/*pharmacology
Kinesin/*antagonists & inhibitors
Kinesin/*metabolism
Adenosine Triphosphate/metabolism ; Animals ; Antimitotic Agents/chemistry ; Antimitotic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacokinetics ; Binding Sites ; Biological Products/chemistry ; Biological Products/pharmacology ; Clinical Trials as Topic ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/physiology ; Humans ; Kinesin/chemistry ; Molecular Targeted Therapy/methods
Czasopismo naukowe
Tytuł :
Phosphatase magnesium-dependent 1 δ (PPM1D), serine/threonine protein phosphatase and novel pharmacological target in cancer.
Autorzy :
Nahta R; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA.
Castellino RC; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Feb; Vol. 184, pp. 114362. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Molecular Targeted Therapy/*methods
Protein Phosphatase 2C/*antagonists & inhibitors
Protein Phosphatase 2C/*physiology
Animals ; Cell Cycle ; DNA Damage ; Female ; Fertility/physiology ; Gene Expression Regulation, Developmental ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/physiology ; Humans ; Male ; Mice
Czasopismo naukowe
Tytuł :
The effect of metformin in EML 4 -ALK+ lung cancer alone and in combination with crizotinib in cell and rodent models.
Autorzy :
Bland AR; Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Shrestha N; Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Bower RL; Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Rosengren RJ; Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Ashton JC; Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jan; Vol. 183, pp. 114345. Date of Electronic Publication: 2020 Nov 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Oncogene Proteins, Fusion*/genetics
Antineoplastic Agents/*administration & dosage
Crizotinib/*administration & dosage
Lung Neoplasms/*drug therapy
Metformin/*administration & dosage
A549 Cells ; Animals ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Humans ; Lung Neoplasms/genetics ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Rodentia
Czasopismo naukowe
Tytuł :
Targeting tumor-associated macrophages as an antitumor strategy.
Autorzy :
Cheng N; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210046, PR China.
Bai X; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210046, PR China.
Shu Y; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210046, PR China.
Ahmad O; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210046, PR China.
Shen P; Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University Carson Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen 518060, China; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210046, PR China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jan; Vol. 183, pp. 114354. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents/*administration & dosage
Drug Delivery Systems/*methods
Immunotherapy/*methods
Neoplasms/*immunology
Tumor Microenvironment/*immunology
Tumor-Associated Macrophages/*immunology
Animals ; Drug Delivery Systems/trends ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunotherapy/trends ; Neoplasms/drug therapy ; Receptors, Chimeric Antigen/antagonists & inhibitors ; Receptors, Chimeric Antigen/immunology ; Tumor Microenvironment/drug effects ; Tumor-Associated Macrophages/drug effects
Czasopismo naukowe
Tytuł :
A multi-kinase inhibitor APG-2449 enhances the antitumor effect of ibrutinib in esophageal squamous cell carcinoma via EGFR/FAK pathway inhibition.
Autorzy :
Luo QY; Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China.
Zhou SN; Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China.
Pan WT; Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China.
Sun J; Department of Clinical Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, PR China.
Yang LQ; Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China.
Zhang L; Department of Clinical Laboratory, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, PR China.
Qiu MZ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou 510060, PR China. Electronic address: .
Yang DJ; Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jan; Vol. 183, pp. 114318. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenine/*analogs & derivatives
Antineoplastic Agents/*administration & dosage
Esophageal Neoplasms/*metabolism
Esophageal Squamous Cell Carcinoma/*metabolism
Focal Adhesion Kinase 1/*metabolism
Piperidines/*administration & dosage
Protein Kinase Inhibitors/*administration & dosage
Adenine/administration & dosage ; Adenine/chemistry ; Animals ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Synergism ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Esophageal Neoplasms/drug therapy ; Esophageal Squamous Cell Carcinoma/drug therapy ; Female ; Focal Adhesion Kinase 1/antagonists & inhibitors ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Piperidines/chemistry ; Protein Kinase Inhibitors/chemistry ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Influence of lysosomal protease sensitivity in the immunogenicity of the antitumor biopharmaceutical asparaginase.
Autorzy :
Rodrigues MAD; Departamento de Tecnologia Bioquímico-Farmacêutica, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Pimenta MV; Departamento de Tecnologia Bioquímico-Farmacêutica, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Costa IM; Departamento de Tecnologia Bioquímico-Farmacêutica, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Zenatti PP; Centro Infantil Boldrini, Campinas, São Paulo, Brazil.
Migita NA; Centro Infantil Boldrini, Campinas, São Paulo, Brazil; Department of Medical Genetics, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo, Brazil.
Yunes JA; Centro Infantil Boldrini, Campinas, São Paulo, Brazil; Department of Medical Genetics, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo, Brazil.
Rangel-Yagui CO; Departamento de Tecnologia Bioquímico-Farmacêutica, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
de Sá MM; Heart Institute (InCor), Medical School, University of São Paulo, São Paulo, São Paulo, Brazil.
Pessoa A; Departamento de Tecnologia Bioquímico-Farmacêutica, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Costa-Silva TA; Departamento de Tecnologia Bioquímico-Farmacêutica, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Toyama MH; Biosciences Institute, UNESP - São Paulo State University, Coastal Campus, São Vicente, São Paulo, Brazil.
Breyer CA; Biosciences Institute, UNESP - São Paulo State University, Coastal Campus, São Vicente, São Paulo, Brazil.
de Oliveira MA; Biosciences Institute, UNESP - São Paulo State University, Coastal Campus, São Vicente, São Paulo, Brazil.
Santiago VF; Department of Parasitology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
Palmisano G; Department of Parasitology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
Barbosa CMV; Department of Clinical and Toxicological Analysis, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Hebeda CB; Department of Clinical and Toxicological Analysis, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Farsky SHP; Department of Clinical and Toxicological Analysis, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Monteiro G; Departamento de Tecnologia Bioquímico-Farmacêutica, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, Brazil. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114230. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Asparaginase/*pharmacology
Biological Products/*pharmacology
Immunogenetic Phenomena/*drug effects
Lysosomes/*immunology
Peptide Hydrolases/*pharmacology
Amino Acid Sequence ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Asparaginase/chemistry ; Asparaginase/therapeutic use ; Biological Products/chemistry ; Biological Products/therapeutic use ; Cattle ; Cell Survival/drug effects ; Cell Survival/physiology ; Chickens ; Dose-Response Relationship, Drug ; Escherichia coli ; Female ; Horses ; Humans ; Immunogenetic Phenomena/physiology ; Jurkat Cells ; Lysosomes/chemistry ; Mice ; Mice, Inbred BALB C ; Peptide Hydrolases/chemistry ; Peptide Hydrolases/therapeutic use ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Protein Structure, Secondary
Czasopismo naukowe
Tytuł :
Cardiac glycosides inhibit cancer through Na/K-ATPase-dependent cell death induction.
Autorzy :
Geng X; Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
Wang F; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, People's Republic of China.
Tian D; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, People's Republic of China.
Huang L; International Academic Support & Delivery Unit, BGI Genomics, Co., Ltd., Shenzhen 518083, People's Republic of China.
Streator E; Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Zhu J; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, People's Republic of China.
Kurihara H; Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, People's Republic of China.
He R; Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, People's Republic of China.
Yao X; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, People's Republic of China.
Zhang Y; Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: .
Tang J; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114226. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Cardiac Glycosides/*therapeutic use
Neoplasms/*enzymology
Sodium-Potassium-Exchanging ATPase/*biosynthesis
A549 Cells ; Animals ; Antineoplastic Agents/pharmacology ; Cardiac Glycosides/pharmacology ; Cell Death/drug effects ; Cell Death/physiology ; Enzyme Induction/drug effects ; Enzyme Induction/physiology ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasms/drug therapy ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Inhibitors of DNA double-strand break repair at the crossroads of cancer therapy and genome editing.
Autorzy :
Ray U; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.
Raghavan SC; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114195. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Breaks, Double-Stranded*/drug effects
Antineoplastic Agents/*pharmacology
DNA Repair/*genetics
Gene Editing/*methods
Neoplasms/*genetics
Animals ; Antineoplastic Agents/therapeutic use ; DNA End-Joining Repair/drug effects ; DNA Repair/drug effects ; Gene Editing/trends ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Targeting mitochondrial respiration for the treatment of acute myeloid leukemia.
Autorzy :
Carter JL; Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI, USA; MD/PhD Program, Wayne State University School of Medicine, Detroit, MI, USA.
Hege K; Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI, USA.
Kalpage HA; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA.
Edwards H; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.
Hüttemann M; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA.
Taub JW; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA; Division of Pediatric Hematology and Oncology, Children's Hospital of Michigan, Detroit, MI, USA. Electronic address: .
Ge Y; Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI, USA; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114253. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*administration & dosage
Antineoplastic Agents/*metabolism
Drug Delivery Systems/*methods
Leukemia, Myeloid, Acute/*drug therapy
Leukemia, Myeloid, Acute/*metabolism
Mitochondria/*metabolism
Animals ; Cell Respiration/drug effects ; Cell Respiration/physiology ; Drug Delivery Systems/trends ; Humans ; Mitochondria/drug effects ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism
Czasopismo naukowe
Tytuł :
N6-methyladenosine RNA modification in cancer therapeutic resistance: Current status and perspectives.
Autorzy :
Xu Z; Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Peng B; Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Cai Y; Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Wu G; Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Huang J; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Gao M; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Guo G; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Zeng S; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Gong Z; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Yan Y; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114258. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Adenosine/*analogs & derivatives
Antineoplastic Agents/*pharmacology
Drug Resistance, Neoplasm/*drug effects
Neoplasms/*metabolism
RNA/*metabolism
Adenosine/pharmacology ; Adenosine/therapeutic use ; Animals ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Drug Resistance, Neoplasm/physiology ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; RNA/genetics
Czasopismo naukowe
Tytuł :
Dual inhibitors of histone deacetylases and other cancer-related targets: A pharmacological perspective.
Autorzy :
Gao Y; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, PR China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, PR China; Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, PR China; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China; School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510000, PR China.
Zhang H; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, PR China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, PR China; Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, PR China; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China; School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510000, PR China; Department of Basic Medicine, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China.
Lirussi F; INSERM, U1231, Label LipSTIC, and Ligue Nationale contre le Cancer, Dijon, France; Université de Bourgogne-Franche Comté, I-SITE, France; University Hospital of Dijon (CHU), France.
Garrido C; INSERM, U1231, Label LipSTIC, and Ligue Nationale contre le Cancer, Dijon, France; Université de Bourgogne-Franche Comté, I-SITE, France; Anti-cancer Center George-François Leclerc, CGFL, Dijon, France. Electronic address: .
Ye XY; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, PR China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, PR China; Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, PR China; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China. Electronic address: .
Xie T; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, PR China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, PR China; Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, PR China; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114224. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents/*metabolism
Drug Delivery Systems/*methods
Histone Deacetylase Inhibitors/*metabolism
Histone Deacetylases/*metabolism
Neoplasms/*drug therapy
Neoplasms/*metabolism
Animals ; Antineoplastic Agents/administration & dosage ; Histone Deacetylase Inhibitors/administration & dosage ; Humans
Czasopismo naukowe
Tytuł :
Therapeutic potential of targeting mitochondrial dynamics in cancer.
Autorzy :
Rodrigues T; Centro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC (UFABC), Santo André, SP, Brazil. Electronic address: .
Ferraz LS; Centro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC (UFABC), Santo André, SP, Brazil.
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114282. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents/*administration & dosage
Drug Delivery Systems/*methods
Mitochondria/*drug effects
Mitochondrial Dynamics/*drug effects
Neoplasms/*drug therapy
Animals ; Antineoplastic Agents/metabolism ; Drug Delivery Systems/trends ; Humans ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; Mitochondrial Dynamics/physiology ; Neoplasms/metabolism ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms.
Autorzy :
Laussel C; Université de Paris, CNRS, Institut Jacques Monod, F-75006 Paris, France.
Léon S; Université de Paris, CNRS, Institut Jacques Monod, F-75006 Paris, France. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114213. Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents/*toxicity
Apoptosis/*drug effects
Deoxyglucose/*toxicity
Drug Resistance, Neoplasm/*drug effects
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Apoptosis/physiology ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Clinical Trials as Topic/methods ; Deoxyglucose/chemistry ; Deoxyglucose/therapeutic use ; Drug Resistance, Neoplasm/physiology ; Glucose/antagonists & inhibitors ; Glucose/metabolism ; Glycolysis/drug effects ; Glycolysis/physiology ; Humans
Czasopismo naukowe
Tytuł :
The active second-generation proteasome inhibitor oprozomib reverts the oxaliplatin-induced neuropathy symptoms.
Autorzy :
Caputi FF; Dept. of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.
Di Cesare Mannelli L; Dept. of Neuroscience, Psychology Drug Research and Child Health Neurofarba, Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
Rullo L; Dept. of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.
Micheli L; Dept. of Neuroscience, Psychology Drug Research and Child Health Neurofarba, Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
Stamatakos S; Dept. of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.
Posa L; Neurobiological Psychiatry Unit and Alan Edwards Centre for Research on Pain, Dept. of Psychiatry, McGill University, Montreal, QC, Canada.
Ghelardini C; Dept. of Neuroscience, Psychology Drug Research and Child Health Neurofarba, Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
Romualdi P; Dept. of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Irnerio 48, 40126 Bologna, Italy. Electronic address: .
Candeletti S; Dept. of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114255. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*toxicity
Neuralgia/*chemically induced
Neuralgia/*drug therapy
Oligopeptides/*therapeutic use
Oxaliplatin/*toxicity
Proteasome Inhibitors/*therapeutic use
Animals ; Neuralgia/pathology ; Oligopeptides/pharmacology ; Proteasome Inhibitors/pharmacology ; Rats ; Rats, Sprague-Dawley ; Spinal Cord/drug effects ; Spinal Cord/pathology
Czasopismo naukowe
Tytuł :
Preclinical studies of a novel snake venom-derived recombinant disintegrin with antitumor activity: A review.
Autorzy :
Schönthal AH; Department of Molecular Microbiology and Immunology, Keck School of Medicine (KSOM), University of Southern California (USC), Los Angeles, CA 90089, USA.
Swenson SD; Department of Neurological Surgery, KSOM, USC, Los Angeles, CA 90089, USA; Department of Biochemistry and Molecular Medicine, KSOM, USC, Los Angeles, CA 90089, USA.
Chen TC; Department of Neurological Surgery, KSOM, USC, Los Angeles, CA 90089, USA.
Markland FS; Department of Biochemistry and Molecular Medicine, KSOM, USC, Los Angeles, CA 90089, USA. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Nov; Vol. 181, pp. 114149. Date of Electronic Publication: 2020 Jul 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Disintegrins/*pharmacology
Neoplasms/*drug therapy
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Disintegrins/chemistry ; Disintegrins/therapeutic use ; Drug Evaluation, Preclinical/methods ; Humans ; Platelet Aggregation Inhibitors/chemistry ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Aggregation Inhibitors/therapeutic use ; Snake Venoms/chemistry ; Snake Venoms/metabolism
Czasopismo naukowe
Tytuł :
Inhibition of RUNX1 promotes cisplatin-induced apoptosis in ovarian cancer cells.
Autorzy :
Xiao L; Department of Biological Sciences & Technology, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Peng Z; Department of Biological Sciences & Technology, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Zhu A; Department of Biological Sciences & Technology, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Xue R; Department of Biological Sciences & Technology, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Lu R; Department of Biological Sciences & Technology, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Mi J; Department of Biological Sciences & Technology, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Xi S; Department of Biological Sciences & Technology, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Chen W; Department of Gynecology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jiang S; Department of Biological Sciences & Technology, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114116. Date of Electronic Publication: 2020 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Cisplatin/*pharmacology
Core Binding Factor Alpha 2 Subunit/*antagonists & inhibitors
Ovarian Neoplasms/*metabolism
Apoptosis/genetics ; Cell Culture Techniques ; Cell Line, Tumor ; Core Binding Factor Alpha 2 Subunit/genetics ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Knockdown Techniques ; Humans ; Kaplan-Meier Estimate ; MicroRNAs/genetics ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Proto-Oncogene Proteins c-bcl-2/genetics
Czasopismo naukowe
Tytuł :
Macrophages confer resistance to BET inhibition in triple-negative breast cancer by upregulating IKBKE.
Autorzy :
Qiao J; Department of Breast Disease, Henan Breast Cancer Center, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital. Zhengzhou 450008 China.
Chen Y; Genetic and Prenatal Diagnosis Center, Department of Gynecology and Obstetrics, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Mi Y; Department of Medical Oncology, Xiamen Key Laboratory of Antitumor Drug Transformation Research and Thoracic Tumor Diagnosis & Treatment, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen 361003, China.
Jin H; MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China; Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Wang L; Department of Breast Disease, Henan Breast Cancer Center, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital. Zhengzhou 450008 China.
Huang T; MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China; Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Li H; MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China; Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Song Y; Genetic and Prenatal Diagnosis Center, Department of Gynecology and Obstetrics, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Cao J; Genetic and Prenatal Diagnosis Center, Department of Gynecology and Obstetrics, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Wu B; MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China; Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Wang Q; Department of Clinical Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital. Zhengzhou 450008, China. Electronic address: .
Zou Z; MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China; Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114126. Date of Electronic Publication: 2020 Jun 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Drug Resistance, Neoplasm/*drug effects
I-kappa B Kinase/*genetics
Proteins/*antagonists & inhibitors
Triple Negative Breast Neoplasms/*metabolism
Tumor-Associated Macrophages/*metabolism
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; Coculture Techniques ; Drug Resistance, Neoplasm/genetics ; Female ; Humans ; MCF-7 Cells ; Mice, Nude ; THP-1 Cells ; Triple Negative Breast Neoplasms/pathology ; Tumor-Associated Macrophages/pathology ; Up-Regulation ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Aconitase 2 sensitizes MCF-7 cells to cisplatin eliciting p53-mediated apoptosis in a ROS-dependent manner.
Autorzy :
Ciccarone F; Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.
De Falco P; Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.
Ciriolo MR; Department of Biology, University of Rome 'Tor Vergata', Rome, Italy; IRCCS San Raffaele Pisana, Rome, Italy. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114202. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aconitate Hydratase/*metabolism
Antineoplastic Agents/*pharmacology
Apoptosis/*physiology
Cisplatin/*pharmacology
Reactive Oxygen Species/*metabolism
Tumor Suppressor Protein p53/*metabolism
Apoptosis/drug effects ; DNA Damage/drug effects ; DNA Damage/physiology ; DNA, Mitochondrial/metabolism ; Humans ; MCF-7 Cells
Czasopismo naukowe
Tytuł :
The BCL-2 family members NOXA and BIM mediate fluorizoline-induced apoptosis in multiple myeloma cells.
Autorzy :
Cosialls AM; Departament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Oncobell-IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), L'Hospitalet de Llobregat, Barcelona, Spain.
Sánchez-Vera I; Departament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Oncobell-IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), L'Hospitalet de Llobregat, Barcelona, Spain.
Pomares H; Departament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Oncobell-IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), L'Hospitalet de Llobregat, Barcelona, Spain; Servei d'Hematologia Clínica, Institut Català d'Oncologia, Oncobell-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Perramon-Andújar J; Departament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Oncobell-IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), L'Hospitalet de Llobregat, Barcelona, Spain.
Sanchez-Esteban S; Departament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Oncobell-IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), L'Hospitalet de Llobregat, Barcelona, Spain.
Palmeri CM; Departament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Oncobell-IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), L'Hospitalet de Llobregat, Barcelona, Spain.
Iglesias-Serret D; Departament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Oncobell-IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), L'Hospitalet de Llobregat, Barcelona, Spain; Facultat de Medicina, Universitat de Vic - Universitat Central de Catalunya (UVic- UCC), Vic, Barcelona, Spain.
Saura-Esteller J; Departament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Oncobell-IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), L'Hospitalet de Llobregat, Barcelona, Spain.
Núñez-Vázquez S; Departament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Oncobell-IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), L'Hospitalet de Llobregat, Barcelona, Spain.
Lavilla R; Laboratory of Medical Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Medicine (IBUB), University of Barcelona, Barcelona, Spain.
González-Barca EM; Servei d'Hematologia Clínica, Institut Català d'Oncologia, Oncobell-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Pons G; Departament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Oncobell-IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), L'Hospitalet de Llobregat, Barcelona, Spain.
Gil J; Departament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Oncobell-IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114198. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*metabolism
Apoptosis/*physiology
Bcl-2-Like Protein 11/*metabolism
Multiple Myeloma/*metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Line, Tumor ; Cells, Cultured ; Dose-Response Relationship, Drug ; Female ; HEK293 Cells ; Humans ; Male ; Middle Aged ; Multiple Myeloma/drug therapy ; Multiple Myeloma/pathology ; Protein Binding/physiology ; Repressor Proteins/antagonists & inhibitors ; Repressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
A novel small molecule STAT3 inhibitor SLSI-1216 suppresses proliferation and tumor growth of triple-negative breast cancer cells through apoptotic induction.
Autorzy :
Park SK; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
Byun WS; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
Lee S; College of Pharmacy, CHA University, Gyeonggi-do 11160, Republic of Korea.
Han YT; College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea.
Jeong YS; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Jang K; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Chung SJ; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Lee J; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Suh YG; College of Pharmacy, CHA University, Gyeonggi-do 11160, Republic of Korea. Electronic address: .
Lee SK; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Aug; Vol. 178, pp. 114053. Date of Electronic Publication: 2020 May 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Growth Inhibitors/*pharmacology
STAT3 Transcription Factor/*antagonists & inhibitors
Triple Negative Breast Neoplasms/*metabolism
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Apoptosis/physiology ; Cell Line, Tumor ; Cell Proliferation/physiology ; Female ; Growth Inhibitors/chemistry ; Growth Inhibitors/therapeutic use ; HEK293 Cells ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; STAT3 Transcription Factor/metabolism ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/pathology ; Tumor Burden/drug effects ; Tumor Burden/physiology ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe

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