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Tytuł :
Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor.
Autorzy :
Li J; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Zou W; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Yu K; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Liu B; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Liang W; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Wang L; Department of Medicinal Chemistry, PharmaBlock Sciences (Nanjing), Inc., Nanjing, China.
Lu Y; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Jiang Z; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Wang A; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Zhu J; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 903-913.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antineoplastic Agents/*pharmacology
Biological Products/*pharmacology
Cell Cycle Proteins/*antagonists & inhibitors
Transcription Factors/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Biological Products/chemical synthesis ; Biological Products/chemistry ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Structure-Activity Relationship ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Anti-inflammatory natural products as potential therapeutic agents of rheumatoid arthritis: A systematic review.
Autorzy :
Gandhi GR; Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences (CAAS), Chengdu National Agricultural Science and Technology Center, Chengdu 600103, China; Postgraduate Program of Health Sciences (PPGCS), Federal University of Sergipe (UFS), Prof. João Cardoso Nascimento Campus, Aracaju, Sergipe 49060-108, Brazil.
Jothi G; Department of Biochemistry, Srimad Andavan Arts and Science College (Autonomous) (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu 620005, India.
Mohana T; Department of Biochemistry, Madha Dental College and Hospital, Kundrathur, Chennai 600069, India.
Vasconcelos ABS; Postgraduate Program of Physiological Sciences (PROCFIS), Federal University of Sergipe (UFS), Campus São Cristóvão, São Cristóvão, Sergipe 49100-000, Brazil.
Montalvão MM; Postgraduate Program of Physiological Sciences (PROCFIS), Federal University of Sergipe (UFS), Campus São Cristóvão, São Cristóvão, Sergipe 49100-000, Brazil.
Hariharan G; Department of Biochemistry, Srimad Andavan Arts and Science College (Autonomous) (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu 620005, India.
Sridharan G; Department of Biochemistry, Srimad Andavan Arts and Science College (Autonomous) (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu 620005, India.
Kumar PM; Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, Karnataka 570020, India.
Gurgel RQ; Postgraduate Program of Health Sciences (PPGCS), Federal University of Sergipe (UFS), Prof. João Cardoso Nascimento Campus, Aracaju, Sergipe 49060-108, Brazil.
Li HB; Department of Nutrition, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
Zhang J; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Gan RY; Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences (CAAS), Chengdu National Agricultural Science and Technology Center, Chengdu 600103, China; School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Dec; Vol. 93, pp. 153766. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Arthritis, Rheumatoid*/drug therapy
Biological Products*/pharmacology
Biological Products*/therapeutic use
Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Cytokines ; Humans ; Quality of Life
Czasopismo naukowe
Tytuł :
Inhibition of catechol- O -methyltransferase by natural pentacyclic triterpenes: structure-activity relationships and kinetic mechanism.
Autorzy :
Wang FY; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wei GL; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Fan YF; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhao DF; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wang P; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zou LW; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yang L; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1079-1087.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Products/*pharmacology
Catechol O-Methyltransferase/*metabolism
Enzyme Inhibitors/*pharmacology
Pentacyclic Triterpenes/*pharmacology
Biological Products/chemical synthesis ; Biological Products/chemistry ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Kinetics ; Membrane Potential, Mitochondrial/drug effects ; Molecular Conformation ; Molecular Docking Simulation ; Pentacyclic Triterpenes/chemical synthesis ; Pentacyclic Triterpenes/chemistry ; Recombinant Proteins/metabolism ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Spike protein recognizer receptor ACE2 targeted identification of potential natural antiviral drug candidates against SARS-CoV-2.
Autorzy :
Pokhrel S; Department of Biomedical Engineering, State University of New York (SUNY), Binghamton, NY 13902, USA.
Bouback TA; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Samad A; Department of Genetic Engineering and Biotechnology, Faculty of Biological Science, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore 7408, Bangladesh.
Nur SM; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Alam R; Department of Genetic Engineering and Biotechnology, Faculty of Biological Science, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore 7408, Bangladesh.
Abdullah-Al-Mamun M; Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh.
Nain Z; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore 7408, Bangladesh; School of Medicine, University of Utah, Salt Lake City, UT 84112, USA.
Imon RR; Department of Genetic Engineering and Biotechnology, Faculty of Biological Science, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore 7408, Bangladesh.
Talukder MEK; Department of Genetic Engineering and Biotechnology, Faculty of Biological Science, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore 7408, Bangladesh.
Tareq MMI; Department of Genetic Engineering and Biotechnology, Faculty of Biological Science, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore 7408, Bangladesh.
Hossen MS; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore 7408, Bangladesh; Department of Biology, School of Life Science, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Karpiński TM; Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, 61-712 Poznań, Poland.
Ahammad F; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore 7408, Bangladesh. Electronic address: .
Qadri I; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: .
Rahman MS; Department of Genetic Engineering and Biotechnology, Faculty of Biological Science, Jashore University of Science and Technology, Jashore 7408, Bangladesh. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Nov 30; Vol. 191, pp. 1114-1125. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2/*chemistry
Antiviral Agents/*chemistry
Biological Products/*chemistry
SARS-CoV-2/*drug effects
Spike Glycoprotein, Coronavirus/*chemistry
Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/toxicity ; Binding Sites ; Biological Products/pharmacokinetics ; Biological Products/toxicity ; Computer Simulation ; Drug Evaluation, Preclinical/methods ; Humans ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Spike Glycoprotein, Coronavirus/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
New keys to unlock the treasure trove of microbial natural products.
Autorzy :
Udwary DW; DOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Otani H; DOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Mouncey NJ; DOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. .
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Źródło :
Nature reviews. Microbiology [Nat Rev Microbiol] 2021 Nov; Vol. 19 (11), pp. 683.
Typ publikacji :
Journal Article
MeSH Terms :
Bacteria/*metabolism
Biological Products/*metabolism
Biological Products/*pharmacology
Biological Products/chemistry ; Cloning, Molecular ; DNA, Bacterial/genetics ; Genome, Bacterial ; Multigene Family
Czasopismo naukowe
Tytuł :
Natural Products Targeting Cancer Stem Cells: A Revisit.
Autorzy :
Cui J; School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Qian J; School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Chow LM; Department of Applied Biology and Chemical Technology and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Jia J; School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
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Źródło :
Current medicinal chemistry [Curr Med Chem] 2021 Oct 25; Vol. 28 (33), pp. 6773-6804.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Biological Products*/pharmacology
Biological Products*/therapeutic use
Neoplasms*/drug therapy
Drug Resistance, Multiple ; Humans ; Neoplastic Stem Cells
Czasopismo naukowe
Tytuł :
Plant-Based Natural Products and Extracts: Potential Source to Develop New Antiviral Drug Candidates.
Autorzy :
Thomas E; Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA.
Stewart LE; Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA.
Darley BA; Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA.
Pham AM; Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA.
Esteban I; Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA.
Panda SS; Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Oct 14; Vol. 26 (20). Date of Electronic Publication: 2021 Oct 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Development*
Antiviral Agents/*isolation & purification
Antiviral Agents/*pharmacology
Biological Products/*pharmacology
Plant Extracts/*pharmacology
Animals ; Anti-HIV Agents/chemistry ; Anti-HIV Agents/isolation & purification ; Anti-HIV Agents/pharmacology ; Antiviral Agents/chemistry ; Biological Products/chemistry ; Biological Products/isolation & purification ; Drug Discovery ; Flavivirus/drug effects ; Hepatitis Viruses/drug effects ; Humans ; Molecular Structure ; Orthomyxoviridae/drug effects ; Plant Extracts/chemistry ; Simplexvirus/drug effects
Czasopismo naukowe
Tytuł :
In Silico Exploration of Potential Natural Inhibitors against SARS-Cov-2 nsp10.
Autorzy :
Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
Khalifa MM; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, Almaarefa University, Riyadh 13713, Saudi Arabia.
Hafez EE; Department of Plant Protection and Biomolecular Diagnosis, ALCRI, City of Scientific Research and Technological Applications, New Borg El-Arab City 21934, Egypt.
Alsfouk AA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh 11564, Saudi Arabia.
Metwaly AM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Oct 12; Vol. 26 (20). Date of Electronic Publication: 2021 Oct 12.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*chemistry
Biological Products/*chemistry
SARS-CoV-2/*metabolism
Viral Regulatory and Accessory Proteins/*antagonists & inhibitors
Antiviral Agents/metabolism ; Antiviral Agents/therapeutic use ; Binding Sites ; Biological Products/metabolism ; Biological Products/therapeutic use ; COVID-19/drug therapy ; COVID-19/pathology ; Density Functional Theory ; Humans ; Ligands ; Molecular Docking Simulation ; S-Adenosylmethionine/chemistry ; S-Adenosylmethionine/metabolism ; SARS-CoV-2/isolation & purification ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/metabolism ; Small Molecule Libraries/therapeutic use ; Vidarabine/chemistry ; Vidarabine/metabolism ; Vidarabine/therapeutic use ; Viral Regulatory and Accessory Proteins/metabolism
Czasopismo naukowe
Tytuł :
Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR).
Autorzy :
Ferreira JPS; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
Albuquerque HMT; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
Cardoso SM; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
Silva AMS; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address: .
Silva VLM; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 05; Vol. 221, pp. 113492. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Acetylcholinesterase/*metabolism
Alzheimer Disease/*drug therapy
Amyloid Precursor Protein Secretases/*antagonists & inhibitors
Aspartic Acid Endopeptidases/*antagonists & inhibitors
Biological Products/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Neuroprotective Agents/*pharmacology
Alzheimer Disease/metabolism ; Amyloid Precursor Protein Secretases/metabolism ; Aspartic Acid Endopeptidases/metabolism ; Biological Products/chemical synthesis ; Biological Products/chemistry ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Humans ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry
Czasopismo naukowe
Tytuł :
Pharmacokinetics and tissue distribution of cantharidin after oral administration of aqueous extracts from Mylabris in rats.
Autorzy :
Duan C; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China.; School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.
Cheng W; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China.; School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.
Chen Q; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China.; School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.
Li X; School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.
Zhang J; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China.; School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2021 Oct; Vol. 35 (10), pp. e5172. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Products*/administration & dosage
Biological Products*/pharmacokinetics
Cantharidin*/analysis
Cantharidin*/chemistry
Cantharidin*/pharmacokinetics
Coleoptera*
Administration, Oral ; Animals ; Female ; Gas Chromatography-Mass Spectrometry/methods ; Male ; Medicine, Chinese Traditional ; Rats ; Rats, Sprague-Dawley ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Targeting interleukin-β by plant-derived natural products: Implications for the treatment of atherosclerotic cardiovascular disease.
Autorzy :
Vahdat-Lasemi F; Department of Medical Biotechnology and Nanotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Aghaee-Bakhtiari SH; Bioinformatics Research Group, Mashhad University of Medical Sciences, Mashhad, Iran.
Tasbandi A; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Jaafari MR; Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Sahebkar A; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.; School of Medicine, The University of Western Australia, Perth, Australia.
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Źródło :
Phytotherapy research : PTR [Phytother Res] 2021 Oct; Vol. 35 (10), pp. 5596-5622. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Atherosclerosis*/drug therapy
Biological Products*/pharmacology
Biological Products*/therapeutic use
Cardiovascular Diseases*
Antibodies, Monoclonal ; Endothelial Cells ; Humans ; Interleukin-1beta
Czasopismo naukowe
Tytuł :
Treatment Adherence and Clinical Outcomes of Patients with Inflammatory Bowel Disease on Biological Agents During the SARS-CoV-2 Pandemic.
Autorzy :
Iborra I; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.
Puig M; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.
Marín L; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.
Calafat M; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.; Centro de Investigación Biomédica en red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Catalonia, Spain.
Cañete F; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.; Centro de Investigación Biomédica en red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Catalonia, Spain.
Quiñones C; Pharmacy Department, Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain.
González-González L; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.
Cardona G; Pharmacy Department, Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain.
Mañosa M; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.; Centro de Investigación Biomédica en red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Catalonia, Spain.
Domènech E; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain. .; Centro de Investigación Biomédica en red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Catalonia, Spain. .; Departament de Medicina, Universitat Autònoma de Barcelona, Catalonia, Spain. .
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Źródło :
Digestive diseases and sciences [Dig Dis Sci] 2021 Dec; Vol. 66 (12), pp. 4191-4196. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Medication Adherence*
Biological Products/*administration & dosage
COVID-19/*prevention & control
Colitis, Ulcerative/*drug therapy
Crohn Disease/*drug therapy
Delivery of Health Care, Integrated/*organization & administration
Biological Products/adverse effects ; COVID-19/transmission ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/immunology ; Crohn Disease/diagnosis ; Crohn Disease/immunology ; Cross-Sectional Studies ; Drug Administration Schedule ; Drug Therapy, Combination ; Fear ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Immunosuppressive Agents/administration & dosage ; Infusions, Intravenous ; Injections, Subcutaneous ; Male ; Patient Satisfaction ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Beneficial effects of natural products on female sexual dysfunction: A systematic review and meta-analysis.
Autorzy :
Sha'ari N; Department of Psychiatry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur, Malaysia; Department of Psychiatry, Hospital Tengku Ampuan Rahimah, Jalan Langat, Klang, Selangor, Malaysia.
Woon LS; Department of Psychiatry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur, Malaysia.
Sidi H; Department of Psychiatry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur, Malaysia.
Das S; Department of Human & Clinical Anatomy, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman.
Bousman CA; Department of Medical Genetics, Psychiatry, and Physiology and Pharmacology, The University of Calgary, Canada.
Mohamed Saini S; Department of Psychiatry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur, Malaysia. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Dec; Vol. 93, pp. 153760. Date of Electronic Publication: 2021 Sep 26.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Biological Products*/pharmacology
Sexual Dysfunction, Physiological*/therapy
Female ; Humans
Czasopismo naukowe
Tytuł :
Natural products: Potential targets of TME related long non-coding RNAs in lung cancer.
Autorzy :
Malla RR; Cancer Biology Lab, Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh 530045, India; Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be) University, Visakhapatnam, Andhra Pradesh 530045, India. Electronic address: .
Padmaraju V; Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be) University, Visakhapatnam, Andhra Pradesh 530045, India.
Marni R; Cancer Biology Lab, Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh 530045, India; Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be) University, Visakhapatnam, Andhra Pradesh 530045, India.
Kamal MA; West China School of Nursing / Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia; Enzymoics, Novel Global Community Educational Foundation, Australia.
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Dec; Vol. 93, pp. 153782. Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biological Products*/pharmacology
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
RNA, Long Noncoding*/genetics
Humans ; Neoplastic Stem Cells ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Natural products are an important source for proteasome regulating agents.
Autorzy :
An P; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Pudong New Area, Shanghai 201203, China.
Zhang LJ; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Pudong New Area, Shanghai 201203, China.
Peng W; School of pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Chen YY; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Pudong New Area, Shanghai 201203, China.
Liu QP; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Pudong New Area, Shanghai 201203, China.
Luan X; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Pudong New Area, Shanghai 201203, China. Electronic address: .
Zhang H; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Pudong New Area, Shanghai 201203, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Dec; Vol. 93, pp. 153799. Date of Electronic Publication: 2021 Oct 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biological Products*/pharmacology
Proteasome Endopeptidase Complex*
China ; Cytoplasm ; Ubiquitin
Czasopismo naukowe
Tytuł :
Biologic and pathologic aspects of osteocytes in the setting of medication-related osteonecrosis of the jaw (MRONJ).
Autorzy :
Aguirre JI; Department of Physiological Sciences, University of Florida (UF), Gainesville, FL, United States of America. Electronic address: .
Castillo EJ; Department of Physiological Sciences, University of Florida (UF), Gainesville, FL, United States of America. Electronic address: .
Kimmel DB; Department of Physiological Sciences, University of Florida (UF), Gainesville, FL, United States of America.
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Źródło :
Bone [Bone] 2021 Dec; Vol. 153, pp. 116168. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Biological Products*
Bisphosphonate-Associated Osteonecrosis of the Jaw*
Bone Density Conservation Agents*
Osteonecrosis*/chemically induced
Diphosphonates ; Humans ; Osteoclasts ; Osteocytes
Czasopismo naukowe
Tytuł :
Progress in structure, synthesis and biological activity of natural cephalotane diterpenoids.
Autorzy :
Jiang C; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Xue J; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Yuan Y; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Li Y; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Zhao C; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Jing Q; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Zhang X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Yang M; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Han T; Department of Pharmaceutical Engineering, College of Life Science & Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng Road, Daqing, 163319, PR China.
Bai J; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Li Z; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Li D; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China. Electronic address: .
Hua H; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China. Electronic address: .
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Źródło :
Phytochemistry [Phytochemistry] 2021 Dec; Vol. 192, pp. 112939. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents, Phytogenic*/pharmacology
Biological Products*/pharmacology
Cephalotaxus*
Diterpenes*/pharmacology
Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Incidence of COVID-19 in a cohort of dermatology patients receiving immunomodulating biologic medications.
Autorzy :
Alamgir M; Department of Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, NJ, USA.
Jamgochian M; Department of Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, NJ, USA.
Cucalon J; St George's University School of Medicine, Grenada, Dominica.
Razi S; Rao Dermatology, New York, NY, USA.
Farabi B; Department of Internal Medicine, St Peter's University Hospital, New Brunswick, NJ, USA.
Rao B; Department of Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, NJ, USA.; Rao Dermatology, New York, NY, USA.
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Źródło :
International journal of dermatology [Int J Dermatol] 2021 Dec; Vol. 60 (12), pp. e500-e501. Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Letter
MeSH Terms :
Biological Products*/adverse effects
COVID-19*
Dermatology*
Humans ; Incidence ; SARS-CoV-2
Opinia redakcyjna
Tytuł :
Anti-SARS-CoV-2 Antibody Responses in Patients With IBD Treated With Biologics: Are We Finding CLARITY?
Autorzy :
Chapman TP; Department of Gastroenterology, St Richard's and Worthing Hospitals, University Hospitals Sussex, National Health Service Foundation Trust, West Sussex, United Kingdom; Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom.
Revés J; Surgical Department, Gastroenterology Division, Hospital Beatriz Ângelo, Loures, Portugal.
Torres J; Surgical Department, Gastroenterology Division, Hospital Beatriz Ângelo, Loures, Portugal; Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Satsangi J; Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom.
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Źródło :
Gastroenterology [Gastroenterology] 2021 Dec; Vol. 161 (6), pp. 2057-2059. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Biological Products*/adverse effects
COVID-19*
Inflammatory Bowel Diseases*/drug therapy
Antibody Formation ; Humans ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Fast isolation of the environmentally relevant halogenated natural product MHC-1 by means of countercurrent chromatography.
Autorzy :
Wu Q; University of Hohenheim, Institute of Food Chemistry (170b), Garbenstraße 28, D-70599, Stuttgart, Germany.
Müller M; University of Hohenheim, Institute of Food Chemistry (170b), Garbenstraße 28, D-70599, Stuttgart, Germany.
Hammerschick T; University of Hohenheim, Institute of Food Chemistry (170b), Garbenstraße 28, D-70599, Stuttgart, Germany.
Mitschang W; University of Hohenheim, Institute of Food Chemistry (170b), Garbenstraße 28, D-70599, Stuttgart, Germany.
Kuhlenkamp R; Phycomarin, Bredenbergsweg 5, D-21149, Hamburg, Germany.
Vetter W; University of Hohenheim, Institute of Food Chemistry (170b), Garbenstraße 28, D-70599, Stuttgart, Germany. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2021 Dec; Vol. 284, pp. 131310. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Products*
Seaweed*
Countercurrent Distribution ; Gas Chromatography-Mass Spectrometry ; Reproducibility of Results
Czasopismo naukowe

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