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Tytuł:
Boolean logic in synthetic biology and biomaterials: Towards living materials in mammalian cell therapeutics.
Autorzy:
Bressler EM; Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, Massachusetts, USA.
Adams S; Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, Massachusetts, USA.
Liu R; Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Colson YL; Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Wong WW; Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, Massachusetts, USA.
Grinstaff MW; Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, Massachusetts, USA.; Department of Chemistry and Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2023 Jul; Vol. 13 (7), pp. e1244.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms:
Synthetic Biology*
Biocompatible Materials*/therapeutic use
Animals ; Cell- and Tissue-Based Therapy ; Drug Delivery Systems ; Immunotherapy, Adoptive ; Mammals
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species.
Autorzy:
Cordes H; Drug Metabolism & Pharmacokinetics, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, Frankfurt am Main, Germany.
Rapp H; Research Drug Metabolism & Pharmacokinetics, Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 Mar; Vol. 12 (3), pp. 311-319. Date of Electronic Publication: 2023 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Computational Biology*
Drug Development*
Animals ; Humans ; Reproducibility of Results ; Drug Evaluation, Preclinical ; Models, Biological ; Gene Expression ; Pharmacokinetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis).
Autorzy:
Li X; Drug Safety Research & Development and Comparative Medicine, Pfizer, Inc, Groton, Connecticut, USA.
Santos R; Drug Safety Research & Development and Comparative Medicine, Pfizer, Inc, Groton, Connecticut, USA.
Bernal JE; Drug Safety Research & Development and Comparative Medicine, Pfizer, Inc, Groton, Connecticut, USA.
Li DD; Early Clinical Development, Pfizer, Inc, Groton, Connecticut, USA.
Hargaden M; Drug Safety Research & Development and Comparative Medicine, Pfizer, Inc, Groton, Connecticut, USA.
Khan NK; Drug Safety Research & Development and Comparative Medicine, Pfizer, Inc, Groton, Connecticut, USA.
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Źródło:
Journal of medical primatology [J Med Primatol] 2023 Feb; Vol. 52 (1), pp. 64-78. Date of Electronic Publication: 2022 Oct 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Biology*
Male ; Female ; Animals ; Macaca fascicularis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway.
Autorzy:
Benson HE; Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.
Watterson S; Northern Ireland Centre for Stratified Medicine, University of Ulster, C-Tric, Derry, UK.
Sharman JL; Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.
Mpamhanga CP; Centre for Cardiovascular Science, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK.
Parton A; Northern Ireland Centre for Stratified Medicine, University of Ulster, C-Tric, Derry, UK.
Southan C; Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.
Harmar AJ; Centre for Cardiovascular Science, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK.
Ghazal P; Division of Infection and Pathway Medicine, University of Edinburgh Medical School, Edinburgh, UK.; Centre for Synthetic and Systems Biology, CH Waddington Building, King's Buildings, Edinburgh, UK.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2017 Dec; Vol. 174 (23), pp. 4362-4382. Date of Electronic Publication: 2017 Nov 26.
Typ publikacji:
Journal Article
MeSH Terms:
Models, Biological*
Systems Biology*
Anticholesteremic Agents/*pharmacology
Cholesterol/*biosynthesis
Animals ; Anticholesteremic Agents/administration & dosage ; Anticholesteremic Agents/adverse effects ; Computational Biology ; Drug Design ; Drug Therapy, Combination ; Humans ; Mevalonic Acid/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Editorial overview: Celebrating the advances in cell biology from China.
Autorzy:
Tooze SA; The Francis Crick Institute, London, UK.
Chen Q; Institute for Zoology, Chinese Academy of Sciences, Beijing, China.
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Źródło:
Traffic (Copenhagen, Denmark) [Traffic] 2017 Jun; Vol. 18 (6), pp. 335.
Typ publikacji:
Editorial; Introductory Journal Article
MeSH Terms:
Cell Biology*
Research*
Animals ; Biology ; China ; Editorial Policies ; Humans ; Publications
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A decision support system based on artificial intelligence and systems biology for the simulation of pancreatic cancer patient status.
Autorzy:
Junet V; Anaxomics Biotech SL, Barcelona, Spain.; Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Matos-Filipe P; Anaxomics Biotech SL, Barcelona, Spain.; Structural Bioinformatics (GRIB-IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
García-Illarramendi JM; Anaxomics Biotech SL, Barcelona, Spain.; Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Ramírez E; Iteraset Solutions SL, Barcelona, Spain.
Oliva B; Structural Bioinformatics (GRIB-IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
Farrés J; Anaxomics Biotech SL, Barcelona, Spain.
Daura X; Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, Cerdanyola del Vallès, Spain.
Mas JM; Anaxomics Biotech SL, Barcelona, Spain.
Morales R; Hospital La Mancha Centro, Alcázar de San Juan, Spain.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 Jul; Vol. 12 (7), pp. 916-928. Date of Electronic Publication: 2023 Mar 31.
Typ publikacji:
Journal Article
MeSH Terms:
Artificial Intelligence*
Pancreatic Neoplasms*/genetics
Humans ; Systems Biology ; Computer Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cell-level systems biology model to study inflammatory bowel diseases and their treatment options.
Autorzy:
Stübler S; Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany.; Graduate Research Training Program PharMetrX: Pharmacometrics & Computational Disease Modelling, Freie Universität Berlin & University of Potsdam, Berlin, Germany.
Kloft C; Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany.
Huisinga W; Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany.; Institute of Mathematics, University of Potsdam, Potsdam/Golm, Germany.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 May; Vol. 12 (5), pp. 690-705. Date of Electronic Publication: 2023 Feb 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tumor Necrosis Factor Inhibitors*/therapeutic use
Inflammatory Bowel Diseases*/drug therapy
Humans ; Systems Biology ; Intestines ; Inflammation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Beating the bushes for biomarkers.
Autorzy:
Richards AM; Cardiovascular Research Institute, National University of Singapore, Singapore.; Christchurch Heart Institute, University of Otago, Dunedin, New Zealand.
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Źródło:
European journal of heart failure [Eur J Heart Fail] 2020 Nov; Vol. 22 (11), pp. 2075-2077. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji:
Editorial; Comment
MeSH Terms:
Computational Biology*
Heart Failure*
Adaptor Proteins, Signal Transducing ; Biomarkers ; Humans
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Quantitative Systems Pharmacology Model of Gaucher Disease Type 1 Provides Mechanistic Insight Into the Response to Substrate Reduction Therapy With Eliglustat.
Autorzy:
Abrams R; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
Kaddi CD; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
Tao M; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
Leiser RJ; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
Simoni G; Fondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
Reali F; Fondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
Tolsma J; RES Group Inc, Needham, Massachusetts, USA.
Jasper P; RES Group Inc, Needham, Massachusetts, USA.
van Rijn Z; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
Li J; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
Niesner B; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
Barrett JS; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
Marchetti L; Fondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
Peterschmitt MJ; Sanofi Genzyme, Cambridge, Massachusetts, USA.
Azer K; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
Neves-Zaph S; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2020 Jul; Vol. 9 (7), pp. 374-383. Date of Electronic Publication: 2020 Jun 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Biological*
Systems Biology*
Gaucher Disease/*drug therapy
Pyrrolidines/*pharmacology
Adult ; Enzyme Inhibitors/pharmacology ; Gaucher Disease/physiopathology ; Humans ; Severity of Illness Index ; Splenomegaly/drug therapy ; Splenomegaly/etiology ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identification of functional long non-coding RNAs in gastric cancer by bioinformatics analysis.
Autorzy:
Li Y; General Surgery Department, Chengdu Shang Jin Nan Fu Hospital West China Hospital, Sichuan, China.
Ma D; General Surgery Department, Chengdu Shang Jin Nan Fu Hospital West China Hospital, Sichuan, China.
Li T; General Surgery Department, Chengdu Shang Jin Nan Fu Hospital West China Hospital, Sichuan, China.
Yin Y; Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Sichuan, China.
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Źródło:
International journal of experimental pathology [Int J Exp Pathol] 2020 Jun; Vol. 101 (3-4), pp. 96-105. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Computational Biology*
Gene Regulatory Networks*
RNA, Long Noncoding/*genetics
Stomach Neoplasms/*genetics
Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Databases, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; Neoplasm Invasiveness ; RNA, Long Noncoding/metabolism ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Leveraging Quantitative Systems Pharmacology Approach into Development of Human Recombinant Follistatin Fusion Protein for Duchenne Muscular Dystrophy.
Autorzy:
Nguyen HQ; Shire HGT, Inc. (a Takeda company), Lexington, Massachusetts, USA.
Iskenderian A; Shire HGT, Inc. (a Takeda company), Lexington, Massachusetts, USA.
Ehmann D; Shire HGT, Inc. (a Takeda company), Lexington, Massachusetts, USA.
Jasper P; RES Group, Inc., Needham, Massachusetts, USA.
Zhang Z; RES Group, Inc., Needham, Massachusetts, USA.
Rong H; Kymera Therapeutics, Cambridge, Massachusetts, USA.
Welty D; Nuventra Pharma Sciences, Research Triangle Park, North Carolina, USA.
Narayanan R; Shire HGT, Inc. (a Takeda company), Lexington, Massachusetts, USA.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2020 Jun; Vol. 9 (6), pp. 342-352. Date of Electronic Publication: 2020 Jun 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Biological*
Systems Biology*
Follistatin/*pharmacokinetics
Muscle, Skeletal/*drug effects
Muscular Dystrophy, Duchenne/*drug therapy
Neuromuscular Agents/*pharmacokinetics
Activin Receptors, Type II/antagonists & inhibitors ; Activin Receptors, Type II/metabolism ; Animals ; Drug Dosage Calculations ; Follistatin/administration & dosage ; Humans ; Ligands ; Muscle, Skeletal/growth & development ; Muscle, Skeletal/metabolism ; Muscular Dystrophy, Duchenne/metabolism ; Muscular Dystrophy, Duchenne/physiopathology ; Myostatin/antagonists & inhibitors ; Myostatin/metabolism ; Neuromuscular Agents/administration & dosage ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/pharmacokinetics ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically-Based Pharmacokinetic Modeling.
Autorzy:
Wojtyniak JG; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
Britz H; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.
Selzer D; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.
Schwab M; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; Department of Clinical Pharmacology, Pharmacy and Biochemistry, University Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.
Lehr T; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2020 Jun; Vol. 9 (6), pp. 322-331. Date of Electronic Publication: 2020 Jun 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Models, Biological*
Pharmacokinetics*
Systems Biology*
Pharmaceutical Preparations/*metabolism
Computer Simulation ; Humans ; Numerical Analysis, Computer-Assisted ; Reproducibility of Results ; Software Design
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cocaine perturbs mitovesicle biology in the brain.
Autorzy:
D'Acunzo P; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York, USA.
Ungania JM; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
Kim Y; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York, USA.
Barreto BR; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
DeRosa S; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
Pawlik M; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
Canals-Baker S; Division of Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
Erdjument-Bromage H; Department of Cell Biology, New York University Grossman School of Medicine, New York, New York, USA.; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, New York, USA.
Hashim A; Division of Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
Goulbourne CN; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
Neubert TA; Department of Cell Biology, New York University Grossman School of Medicine, New York, New York, USA.; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, New York, USA.
Saito M; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York, USA.; Division of Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
Sershen H; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York, USA.; Division of Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
Levy E; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York, USA.; Department of Biochemistry & Molecular Pharmacology, New York University Grossman School of Medicine, New York, New York, USA.; NYU Neuroscience Institute, New York University Grossman School of Medicine, New York, New York, USA.
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Źródło:
Journal of extracellular vesicles [J Extracell Vesicles] 2023 Jan; Vol. 12 (1), pp. e12301.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cocaine*/metabolism
Cocaine*/pharmacology
Extracellular Vesicles*/metabolism
Mice ; Animals ; Brain/metabolism ; Mitochondria/metabolism ; Biology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Conceptual and organizational barriers to quantitative systems pharmacology modeling of pathophysiological systemic drug hypotheses.
Autorzy:
Gieschke R; Schopfheim, Germany.
Carr R; In Silico Biosciences, Lexington, Massachusetts, USA.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2022 Dec; Vol. 11 (12), pp. 1556-1559. Date of Electronic Publication: 2022 Nov 07.
Typ publikacji:
Journal Article
MeSH Terms:
Network Pharmacology*
Pharmacology*
Humans ; Systems Biology ; Drug Discovery ; Models, Biological
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Gene-dosage effect of Pfkfb3 on monocyte/macrophage biology in atherosclerosis.
Autorzy:
Guo S; School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University, Guangzhou, China.
Li A; School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University, Guangzhou, China.; Department of Radiology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Fu X; School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University, Guangzhou, China.
Li Z; School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University, Guangzhou, China.
Cao K; School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University, Guangzhou, China.
Song M; School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University, Guangzhou, China.
Huang S; School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University, Guangzhou, China.
Li Z; School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University, Guangzhou, China.
Yan J; School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University, Guangzhou, China.
Wang L; School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University, Guangzhou, China.; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Dai X; Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Feng D; School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University, Guangzhou, China.
Wang Y; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
He J; Department of Rehabilitation Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Huo Y; Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Xu Y; School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University, Guangzhou, China.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2022 Nov; Vol. 179 (21), pp. 4974-4991. Date of Electronic Publication: 2022 Aug 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Atherosclerosis*/drug therapy
Atherosclerosis*/genetics
Atherosclerosis*/metabolism
Monocytes*/metabolism
Actins/metabolism ; Animals ; Apolipoproteins E/genetics ; Apolipoproteins E/metabolism ; Biology ; Macrophages ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphofructokinase-2 ; Pyridines ; Quinolines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Thyroid carcinoma-featured telomerase activation and telomere maintenance: Biology and translational/clinical significance.
Autorzy:
Yuan X; Laboratory Animal Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Yuan H; Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Zhang N; Department of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, China.
Liu T; Department of Pathology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xu D; Department of Medicine, Division of Hematology, Bioclinicum and Center for Molecular Medicine (CMM), Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2022 Nov; Vol. 12 (11), pp. e1111.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Telomerase*/genetics
Telomerase*/metabolism
Thyroid Neoplasms*/diagnosis
Thyroid Neoplasms*/genetics
Humans ; Telomere/genetics ; Telomere/metabolism ; Telomere Homeostasis/genetics ; Biology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges.
Autorzy:
Musuamba FT; EMA Modelling and Simulation Working Party, Amsterdam, The Netherlands.; Federal Agency for Medicines and Health Products, Brussels, Belgium.; Faculté des Sciences Pharmaceutiques, Université de Lubumbashi, Lubumbashi, DR Congo.
Bursi R; InSilicoTrials Technologies, Milano, Italy.
Manolis E; EMA Modelling and Simulation Working Party, Amsterdam, The Netherlands.; European Medicines Agency, Amsterdam, The Netherlands.
Karlsson K; EMA Modelling and Simulation Working Party, Amsterdam, The Netherlands.; Medical Products Agency, Uppsala, Sweden.
Kulesza A; Novadiscovery, Lyon, France.
Courcelles E; Novadiscovery, Lyon, France.
Boissel JP; Novadiscovery, Lyon, France.
Lesage R; KU Leuven, Leuven, Belgium.
Crozatier C; Voisin Consulting Life Sciences, Boulogne (Paris), France.
Voisin EM; Voisin Consulting Life Sciences, Boulogne (Paris), France.
Rousseau CF; Voisin Consulting Life Sciences, Boulogne (Paris), France.
Marchal T; Ansys, Wavre, Belgium.
Alessandrello R; AQuAS - Agency for Health Quality and Assessment of Catalonia, Catalonia, Spain.
Geris L; KU Leuven, Leuven, Belgium.; Université de Liège, Liège, Belgium.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2020 Apr; Vol. 9 (4), pp. 195-197. Date of Electronic Publication: 2020 Apr 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Systems Biology*
Computer Simulation/*standards
Drug Development/*methods
Humans ; Models, Biological ; Pharmacology ; Validation Studies as Topic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Quantitative Systems Pharmacology: A Regulatory Perspective on Translation.
Autorzy:
Zineh I; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2019 Jun; Vol. 8 (6), pp. 336-339. Date of Electronic Publication: 2019 Apr 11.
Typ publikacji:
Journal Article
MeSH Terms:
Legislation, Drug/*organization & administration
Pharmacology, Clinical/*legislation & jurisprudence
Systems Biology/*methods
Humans ; Models, Theoretical ; Systems Biology/legislation & jurisprudence ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 127035

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