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Tytuł :
Two Novel Precursors of the HIV-1 Protease Inhibitor Darunavir Target the UPR/Proteasome System in Human Hepatocellular Carcinoma Cell Line HepG2.
Autorzy :
Rinaldi R; Department of Sciences, Università degli Studi della Basilicata, 85100 Potenza, Italy.
Miglionico R; Department of Sciences, Università degli Studi della Basilicata, 85100 Potenza, Italy.
Nigro I; Department of Sciences, Università degli Studi della Basilicata, 85100 Potenza, Italy.
D'Orsi R; Department of Sciences, Università degli Studi della Basilicata, 85100 Potenza, Italy.
Chiummiento L; Department of Sciences, Università degli Studi della Basilicata, 85100 Potenza, Italy.
Funicello M; Department of Sciences, Università degli Studi della Basilicata, 85100 Potenza, Italy.
Lupattelli P; Department of Sciences, Università degli Studi della Basilicata, 85100 Potenza, Italy.
Laurenzana I; Laboratory of Preclinical and Translational Research, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), 85028 Rionero in Vulture, Italy.
Sgambato A; Scientific Direction, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), 85028 Rionero in Vulture, Italy.
Monné M; Department of Sciences, Università degli Studi della Basilicata, 85100 Potenza, Italy.
Bisaccia F; Department of Sciences, Università degli Studi della Basilicata, 85100 Potenza, Italy.
Armentano MF; Department of Sciences, Università degli Studi della Basilicata, 85100 Potenza, Italy.
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Źródło :
Cells [Cells] 2021 Nov 06; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 06.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Effect of Quercetin on ABCC6 Transporter: Implication in HepG2 Migration.
Autorzy :
Abruzzese V; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Matera I; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Martinelli F; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Carmosino M; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Koshal P; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Milella L; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Bisaccia F; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Ostuni A; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 08; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article
MeSH Terms :
Ion Channel Gating/*drug effects
Multidrug Resistance-Associated Proteins/*metabolism
Quercetin/*pharmacology
Actins/metabolism ; Cell Movement/drug effects ; Cell Survival/drug effects ; Drug Resistance, Multiple/drug effects ; Drug Resistance, Neoplasm/drug effects ; Gene Expression Regulation/drug effects ; Hep G2 Cells ; Humans ; Multidrug Resistance-Associated Proteins/genetics ; Protein Multimerization/drug effects ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Structural and Functional Characterization of the ABCC6 Transporter in Hepatic Cells: Role on PXE, Cancer Therapy and Drug Resistance.
Autorzy :
Bisaccia F; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Koshal P; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Abruzzese V; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Castiglione Morelli MA; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Ostuni A; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 11; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Mutation*
Hepatocytes/*metabolism
Multidrug Resistance-Associated Proteins/*genetics
Neoplasms/*genetics
Pseudoxanthoma Elasticum/*genetics
Animals ; Antineoplastic Agents/therapeutic use ; Drug Resistance/genetics ; Hep G2 Cells ; Humans ; Multidrug Resistance-Associated Proteins/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Pseudoxanthoma Elasticum/metabolism
Czasopismo naukowe
Tytuł :
Extracellular Citrate Is a Trojan Horse for Cancer Cells.
Autorzy :
Petillo A; Laboratory of Cell Biochemistry, Department of Sciences, University of Basilicata, Potenza, Italy.
Abruzzese V; Laboratory of Cell Biochemistry, Department of Sciences, University of Basilicata, Potenza, Italy.
Koshal P; Laboratory of Cell Biochemistry, Department of Sciences, University of Basilicata, Potenza, Italy.
Ostuni A; Laboratory of Cell Biochemistry, Department of Sciences, University of Basilicata, Potenza, Italy.
Bisaccia F; Laboratory of Cell Biochemistry, Department of Sciences, University of Basilicata, Potenza, Italy.
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Źródło :
Frontiers in molecular biosciences [Front Mol Biosci] 2020 Nov 12; Vol. 7, pp. 593866. Date of Electronic Publication: 2020 Nov 12 (Print Publication: 2020).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Hura crepitans L. Extract: Phytochemical Characterization, Antioxidant Activity, and Nanoformulation.
Autorzy :
Vassallo A; Department of Scienze, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Armentano MF; Department of Scienze, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.; Spinoff BioActiPlant s.r.l., Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Miglionico R; Department of Scienze, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Caddeo C; Department of Scienze della Vita e dell'Ambiente, Sezione di Scienze del Farmaco, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
Chirollo C; Department of Veterinary Medicine and Animal Production, University of Napoli Federico II, Via Delpino 1, 80137 Napoli, Italy.
Gualtieri MJ; Department of Pharmacognosy and Organic Medicaments, University of Los Andes, 5101 Mérida, Venezuela.
Ostuni A; Department of Scienze, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.; Spinoff BioActiPlant s.r.l., Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Bisaccia F; Department of Scienze, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.; Spinoff BioActiPlant s.r.l., Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Faraone I; Department of Scienze, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.; Spinoff BioActiPlant s.r.l., Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Milella L; Department of Scienze, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.; Spinoff BioActiPlant s.r.l., Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
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Źródło :
Pharmaceutics [Pharmaceutics] 2020 Jun 15; Vol. 12 (6). Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Inhibition of ABCC6 Transporter Modifies Cytoskeleton and Reduces Motility of HepG2 Cells via Purinergic Pathway.
Autorzy :
Ostuni A; Department of Sciences, University of Basilicata, viale Ateneo Lucano 10, 85100 Potenza, Italy.
Carmosino M; Department of Sciences, University of Basilicata, viale Ateneo Lucano 10, 85100 Potenza, Italy.
Miglionico R; Department of Sciences, University of Basilicata, viale Ateneo Lucano 10, 85100 Potenza, Italy.
Abruzzese V; Department of Sciences, University of Basilicata, viale Ateneo Lucano 10, 85100 Potenza, Italy.
Martinelli F; Department of Sciences, University of Basilicata, viale Ateneo Lucano 10, 85100 Potenza, Italy.
Russo D; Department of Sciences, University of Basilicata, viale Ateneo Lucano 10, 85100 Potenza, Italy.
Laurenzana I; Laboratory of Preclinical and Translational Research, IRCCS-Referral Cancer Center of Basilicata (CROB), 85028 Rionero in Vulture, Italy.
Petillo A; Department of Sciences, University of Basilicata, viale Ateneo Lucano 10, 85100 Potenza, Italy.
Bisaccia F; Department of Sciences, University of Basilicata, viale Ateneo Lucano 10, 85100 Potenza, Italy.
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Źródło :
Cells [Cells] 2020 Jun 05; Vol. 9 (6). Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Movement*
Cytoskeleton/*metabolism
Multidrug Resistance-Associated Proteins/*antagonists & inhibitors
Purines/*metabolism
Adenosine Triphosphate/metabolism ; Cell Cycle/drug effects ; Cytoskeleton/drug effects ; Extracellular Space/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Silencing/drug effects ; Hep G2 Cells ; Humans ; Multidrug Resistance-Associated Proteins/metabolism ; Probenecid/pharmacology
Czasopismo naukowe
Tytuł :
Phytochemical Profile of Capsicum annuum L. cv Senise, Incorporation into Liposomes, and Evaluation of Cellular Antioxidant Activity.
Autorzy :
Sinisgalli C; Department of Science, University of Basilicata, via dell'Ateneo Lucano 10, 85100 Potenza, Italy.; Spinoff Bioactiplant, via dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Faraone I; Department of Science, University of Basilicata, via dell'Ateneo Lucano 10, 85100 Potenza, Italy.; Spinoff Bioactiplant, via dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Vassallo A; Department of Science, University of Basilicata, via dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Caddeo C; Department of Science della Vita e dell'Ambiente, Sezione di Scienze del Farmaco, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
Bisaccia F; Department of Science, University of Basilicata, via dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Armentano MF; Department of Science, University of Basilicata, via dell'Ateneo Lucano 10, 85100 Potenza, Italy.; Spinoff Bioactiplant, via dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Milella L; Department of Science, University of Basilicata, via dell'Ateneo Lucano 10, 85100 Potenza, Italy.; Spinoff Bioactiplant, via dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Ostuni A; Department of Science, University of Basilicata, via dell'Ateneo Lucano 10, 85100 Potenza, Italy.; Spinoff Bioactiplant, via dell'Ateneo Lucano 10, 85100 Potenza, Italy.
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Źródło :
Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2020 May 15; Vol. 9 (5). Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
New heteroaryl carbamates: Synthesis and biological screening in vitro and in mammalian cells of wild-type and mutant HIV-protease inhibitors.
Autorzy :
Tramutola F; Dipartimento di Scienze, Università della Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.
Armentano MF; Dipartimento di Scienze, Università della Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.
Berti F; Dipartimento di Scienze Chimiche e Farmaceutiche, Università di Trieste, via Giorgieri, 1, 34127 Trieste, Italy.
Chiummiento L; Dipartimento di Scienze, Università della Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.
Lupattelli P; Dipartimento di Scienze, Università della Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.
D'Orsi R; Dipartimento di Scienze, Università della Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.
Miglionico R; Dipartimento di Scienze, Università della Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.
Milella L; Dipartimento di Scienze, Università della Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.
Bisaccia F; Dipartimento di Scienze, Università della Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.
Funicello M; Dipartimento di Scienze, Università della Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2019 May 01; Vol. 27 (9), pp. 1863-1870. Date of Electronic Publication: 2019 Mar 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carbamates/*chemistry
HIV Protease/*genetics
HIV Protease Inhibitors/*chemical synthesis
Binding Sites ; Carbamates/pharmacology ; Catalytic Domain ; Drug Resistance, Neoplasm/drug effects ; HEK293 Cells ; HIV Protease/metabolism ; HIV Protease Inhibitors/pharmacology ; HIV-1/drug effects ; Humans ; Molecular Docking Simulation ; Mutation
Czasopismo naukowe
Tytuł :
The P-glycoprotein inhibitor diltiazem-like 8-(4-chlorophenyl)-5-methyl-8-[(2Z)-pent-2-en-1-yloxy]-8H-[1,2,4]oxadiazolo[3,4-c][1,4]thiazin-3-one inhibits esterase activity and H3 histone acetylation.
Autorzy :
Cuviello F; Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, Potenza, 85100, Italy.
Bisaccia F; Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, Potenza, 85100, Italy.
Spinelli D; Department of Chemistry 'G. Ciamician', Alma Mater Studiorum-University of Bologna, Via F. Selmi 2, Bologna, 40126, Italy.
Armentano MF; Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, Potenza, 85100, Italy.
Bufo SA; Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, Potenza, 85100, Italy.
Cosimelli B; Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131, Napoli, 80131, Italy. Electronic address: .
Ostuni A; Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, Potenza, 85100, Italy. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 Feb 15; Vol. 164, pp. 1-7. Date of Electronic Publication: 2018 Dec 17.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily B, Member 1/*antagonists & inhibitors
Diltiazem/*analogs & derivatives
Diltiazem/*chemistry
Esterases/*antagonists & inhibitors
Histones/*metabolism
Thiadiazines/*pharmacology
ATP-Binding Cassette Transporters/antagonists & inhibitors ; Acetylation ; Carboxylesterase/antagonists & inhibitors ; Diltiazem/pharmacology ; Drug Resistance, Multiple/drug effects ; Enzyme Inhibitors ; Humans ; Multidrug Resistance-Associated Proteins/antagonists & inhibitors ; Thiadiazines/chemistry
Czasopismo naukowe
Tytuł :
Structural characterization of the L0 cytoplasmic loop of human multidrug resistance protein 6 (MRP6).
Autorzy :
Ostuni A; Department of Sciences, University of Basilicata, viale Ateneo Lucano 10, Potenza 85100, Italy. Electronic address: .
Castiglione Morelli MA; Department of Sciences, University of Basilicata, viale Ateneo Lucano 10, Potenza 85100, Italy.
Cuviello F; Department of Sciences, University of Basilicata, viale Ateneo Lucano 10, Potenza 85100, Italy.
Bavoso A; Department of Sciences, University of Basilicata, viale Ateneo Lucano 10, Potenza 85100, Italy.
Bisaccia F; Department of Sciences, University of Basilicata, viale Ateneo Lucano 10, Potenza 85100, Italy.
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Źródło :
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2019 Feb 01; Vol. 1861 (2), pp. 380-386. Date of Electronic Publication: 2018 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
Cytoplasm/*metabolism
Multidrug Resistance-Associated Proteins/*chemistry
Multidrug Resistance-Associated Proteins/*metabolism
Amino Acid Sequence ; Circular Dichroism ; Humans ; Magnetic Resonance Spectroscopy ; Multidrug Resistance-Associated Proteins/isolation & purification ; Protein Structure, Secondary ; Spectrometry, Fluorescence ; Structural Homology, Protein ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Future in the Past: Azorella glabra Wedd. as a Source of New Natural Compounds with Antiproliferative and Cytotoxic Activity on Multiple Myeloma Cells.
Autorzy :
Lamorte D; Laboratory of Preclinical and Translational Research, IRCCS 'Referral Cancer Center of Basilicata' (CROB), 85028 Rionero in Vulture, PZ, Italy. .
Faraone I; Department of Science, University of Basilicata, 85100 Potenza, Italy. .
Laurenzana I; Laboratory of Preclinical and Translational Research, IRCCS 'Referral Cancer Center of Basilicata' (CROB), 85028 Rionero in Vulture, PZ, Italy. .
Milella L; Department of Science, University of Basilicata, 85100 Potenza, Italy. .
Trino S; Laboratory of Preclinical and Translational Research, IRCCS 'Referral Cancer Center of Basilicata' (CROB), 85028 Rionero in Vulture, PZ, Italy. .
De Luca L; Laboratory of Preclinical and Translational Research, IRCCS 'Referral Cancer Center of Basilicata' (CROB), 85028 Rionero in Vulture, PZ, Italy. .
Del Vecchio L; Department of Molecular Medicine and Medical Biotechnology, Federico II University, 80131 Naples, Italy. .
Armentano MF; Department of Science, University of Basilicata, 85100 Potenza, Italy. .
Sinisgalli C; Department of Science, University of Basilicata, 85100 Potenza, Italy. .
Chiummiento L; Department of Science, University of Basilicata, 85100 Potenza, Italy. .
Russo D; Department of Science, University of Basilicata, 85100 Potenza, Italy. .
Bisaccia F; Department of Science, University of Basilicata, 85100 Potenza, Italy. faustino.bisaccia@unibas.it.
Musto P; Hematology and Stem Cell Transplantation Unit, IRCCS 'Referral Cancer Center of Basilicata' (CROB), 85028 Rionero in Vulture, PZ, Italy. .
Caivano A; Laboratory of Preclinical and Translational Research, IRCCS 'Referral Cancer Center of Basilicata' (CROB), 85028 Rionero in Vulture, PZ, Italy. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2018 Oct 26; Vol. 19 (11). Date of Electronic Publication: 2018 Oct 26.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*chemistry
Antineoplastic Agents, Phytogenic/*pharmacology
Apiaceae/*chemistry
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Multiple Myeloma/*drug therapy
Antioxidants/chemistry ; Antioxidants/pharmacology ; Cell Cycle Checkpoints/drug effects ; Cell Survival/drug effects ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Humans ; Polyphenols/chemistry ; Polyphenols/pharmacology ; Terpenes/chemistry ; Terpenes/pharmacology
Czasopismo naukowe

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