Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution.
Autorzy:
Jonsson VD; Department of Computing and Mathematical Sciences, California Institute of Technology, Pasadena, CA, USA. BlakelyCM; Department of Medicine, University of California, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. Lin L; Department of Medicine, University of California, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. Asthana S; Department of Medicine, University of California, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. Matni N; Department of Computing and Mathematical Sciences, California Institute of Technology, Pasadena, CA, USA. Olivas V; Department of Medicine, University of California, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. Pazarentzos E; Department of Medicine, University of California, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. Gubens MA; Department of Medicine, University of California, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. Bastian BC; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, CA, USA. Taylor BS; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, USA.; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, USA.; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan, Kettering Cancer Center, New York, NY, USA. Doyle JC; Department of Control and Dynamical Systems, California Institute of Technology, Pasadena, CA, USA.; Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.; Department of Biological Engineering, California Institute of Technology, Pasadena, CA, USA. Bivona TG; Department of Medicine, University of California, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.
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Źródło:
Scientific reports [Sci Rep] 2017 Mar 13; Vol. 7, pp. 44206. Date of Electronic Publication: 2017 Mar 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.
Autorzy:
Hrustanovic G; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA. Olivas V; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA. Pazarentzos E; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA. Tulpule A; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA. Asthana S; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA. BlakelyCM; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA. Okimoto RA; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA. Lin L; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA. Neel DS; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA. Sabnis A; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA. Flanagan J; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA. Chan E; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA. Varella-Garcia M; Department of Medicine, University of Colorado Anschutz Medical Campus, Denver, Colorado, USA.; Department of Pathology, University of Colorado Anschutz Medical Campus, Denver, Colorado, USA. Aisner DL; Department of Pathology, University of Colorado Anschutz Medical Campus, Denver, Colorado, USA. Vaishnavi A; Department of Medicine, University of Colorado Anschutz Medical Campus, Denver, Colorado, USA. Ou SH; Division of Hematology-Oncology, University of California Irvine School of Medicine, Orange, California, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Orange, California, USA. Collisson EA; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA. Ichihara E; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. Mack PC; University of California Davis School of Medicine.; Comprehensive Cancer Center, Sacramento, California, USA. Lovly CM; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. Karachaliou N; Cancer Biology and Precision Medicine Program Catalan Institute of Oncology Hospital Germans Trias i Pujol Badalona, Barcelona, Spain. Rosell R; Cancer Biology and Precision Medicine Program Catalan Institute of Oncology Hospital Germans Trias i Pujol Badalona, Barcelona, Spain. Riess JW; University of California Davis School of Medicine.; Comprehensive Cancer Center, Sacramento, California, USA. Doebele RC; Department of Medicine, University of Colorado Anschutz Medical Campus, Denver, Colorado, USA. Bivona TG; Department of Medicine, University of California at San Francisco, San Francisco, California, USA.; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Sep; Vol. 21 (9), pp. 1038-47. Date of Electronic Publication: 2015 Aug 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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