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    Tytuł:
    Loss-of-function variants in K v 11.1 cardiac channels as a biomarker for SUDEP.
    Autorzy:
    Soh MS; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
    Bagnall RD; Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, The University of Sydney, Sydney, NSW, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
    Bennett MF; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.; Epilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC, Australia.
    Bleakley LE; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
    Mohamed Syazwan ES; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
    Phillips AM; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.; School of Biosciences, University of Melbourne, Melbourne, VIC, Australia.
    Chiam MDF; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
    McKenzie CE; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
    Hildebrand M; Epilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC, Australia.; Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia.
    Crompton D; Epilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC, Australia.; Neurology Department, Northern Health, Epping, VIC, Australia.
    Bahlo M; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.
    Semsarian C; Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, The University of Sydney, Sydney, NSW, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
    Scheffer IE; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.; Epilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC, Australia.; Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia.; Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, VIC, Australia.
    Berkovic SF; Epilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC, Australia.
    Reid CA; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.; Epilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC, Australia.
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    Źródło:
    Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2021 Jul; Vol. 8 (7), pp. 1422-1432. Date of Electronic Publication: 2021 May 18.
    Typ publikacji:
    Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
    MeSH Terms:
    ERG1 Potassium Channel/*genetics
    Epilepsy/*epidemiology
    Epilepsy/*genetics
    Genetic Variation/*physiology
    Sudden Unexpected Death in Epilepsy/*epidemiology
    Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Biomarkers/metabolism ; Child ; Cohort Studies ; ERG1 Potassium Channel/metabolism ; Epilepsy/metabolism ; Female ; Humans ; Infant ; Male ; Middle Aged ; Xenopus laevis ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    The hyperpolarization-activated cyclic nucleotide-gated 4 channel as a potential anti-seizure drug target.
    Autorzy:
    Kharouf Q; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
    Phillips AM; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.; School of Biosciences, University of Melbourne, Parkville, Victoria, Australia.
    Bleakley LE; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
    Morrisroe E; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
    Oyrer J; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
    Jia L; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
    Ludwig A; Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
    Jin L; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
    Nicolazzo JA; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
    Cerbai E; Department of Neurosciences, Psychology, Drug Research and Child Health, (NEUROFARBA), University of Florence, Florence, Italy.
    Romanelli MN; Department of Neurosciences, Psychology, Drug Research and Child Health, (NEUROFARBA), University of Florence, Florence, Italy.
    Petrou S; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
    Reid CA; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
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    Źródło:
    British journal of pharmacology [Br J Pharmacol] 2020 Aug; Vol. 177 (16), pp. 3712-3729. Date of Electronic Publication: 2020 Jun 17.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cyclic Nucleotide-Gated Cation Channels*/genetics
    Pharmaceutical Preparations*
    Animals ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Mice ; Nucleotides, Cyclic ; Seizures/drug therapy
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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