- Tytuł :
-
P7C3-A20 treatment one year after TBI in mice repairs the
blood -brain barrier , arrests chronic neurodegeneration, and restores cognition. - Autorzy :
- Źródło :
- Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 03; Vol. 117 (44), pp. 27667-27675. Date of Electronic Publication: 2020 Oct 21.
- Typ publikacji :
- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
- MeSH Terms :
-
Blood -Brain Barrier /*drug effectsBrain Injuries, Traumatic/*drug therapy
Carbazoles/*pharmacology
Cognition/*drug effects
Neurodegenerative Diseases/*drug therapy
Neuroprotective Agents/*pharmacology
Animals ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ;Blood -Brain Barrier /cytology ;Blood -Brain Barrier /pathology ;Blood -Brain Barrier /ultrastructure ;Brain Injuries, Traumatic/complications ;Brain Injuries, Traumatic/pathology ; Carbazoles/therapeutic use ; Cells, Cultured ; Chronic Disease/drug therapy ; Cognition/physiology ; Disease Models, Animal ; Endothelial Cells ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/pathology ; Humans ; Male ; Mice ; Microscopy, Electron ; Microvessels/cytology ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/physiopathology ; Neuroprotective Agents/therapeutic use ; Primary Cell Culture ; Survivors -
Czasopismo naukowe