Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications.
Autorzy:
Swichkow CR; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America. BloomJS; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California, United States of America.; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California, United States of America. Kruglyak L; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California, United States of America.; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2022 Dec 16; Vol. 20 (12), pp. e3001911. Date of Electronic Publication: 2022 Dec 16 (Print Publication: 2022).
Genomic epidemiology of the Los Angeles COVID-19 outbreak and the early history of the B.1.43 strain in the USA.
Autorzy:
Guo L; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, USA.; Howard Hughes Medical Institute, HHMI, Chevy Chase, USA.; Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, USA. Boocock J; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, USA.; Howard Hughes Medical Institute, HHMI, Chevy Chase, USA.; Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, USA. Hilt EE; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, USA. Chandrasekaran S; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, USA. Zhang Y; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, USA. Munugala C; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, USA. Sathe L; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, USA. Alexander N; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, USA. Arboleda VA; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, USA.; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, USA. Flint J; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA. Eskin E; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, USA.; Department of Computer Science, Samueli School of Engineering, UCLA, Los Angeles, USA.; Department of Computational Medicine, David Geffen School of Medicine, UCLA, Los Angeles, USA. Luo C; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, USA. Yang S; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, USA. Garner OB; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, USA. Yin Y; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, USA. . BloomJS; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, USA. .; Howard Hughes Medical Institute, HHMI, Chevy Chase, USA. .; Octant, Inc, Los Angeles, USA. . Kruglyak L; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, USA. .; Howard Hughes Medical Institute, HHMI, Chevy Chase, USA. .; Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, USA. .
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BMC genomics [BMC Genomics] 2022 Apr 04; Vol. 23 (1), pp. 260. Date of Electronic Publication: 2022 Apr 04.
Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast.
Autorzy:
Boocock J; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biology, University of California, Los Angeles, Los Angeles, CA, USA. Sadhu MJ; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biology, University of California, Los Angeles, Los Angeles, CA, USA. Durvasula A; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA. BloomJS; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA. .; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biology, University of California, Los Angeles, Los Angeles, CA, USA. Kruglyak L; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA. .; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biology, University of California, Los Angeles, Los Angeles, CA, USA.
Reliable and accurate diagnostics from highly multiplexed sequencing assays.
Autorzy:
Booeshaghi AS; Department of Mechanical Engineering, California Institute of Technology, Pasadena, CA, USA. Lubock NB; Octant Inc., Emeryville, CA, USA. Cooper AR; Octant Inc., Emeryville, CA, USA. Simpkins SW; Octant Inc., Emeryville, CA, USA. BloomJS; Octant Inc., Emeryville, CA, USA.; Department of Human Genetics, University of California, Los Angeles, Los Angeles, USA. Gehring J; Department of Genome Sciences, University of Washington, Seattle, WA, USA. Luebbert L; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. Kosuri S; Octant Inc., Emeryville, CA, USA. Pachter L; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. .; Department of Computing and Mathematical Sciences, California Institute of Technology, Pasadena, CA, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Dec 10; Vol. 10 (1), pp. 21759. Date of Electronic Publication: 2020 Dec 10.
Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: Evidence for "polygenic epistasis".
Autorzy:
Rau CD; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America. Gonzales NM; Department of Human Genetics, University of Chicago, Chicago, IL, United States of America. BloomJS; Department of Human Genetics, UCLA, Los Angeles, CA, United States of America. Park D; Department of Medicine, UCSF, San Francisco, CA, United States of America. Ayroles J; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, United States of America. Palmer AA; Department of Psychiatry, and Institute for Genomic Medicine, UCSD, San Diego, CA, United States of America. Lusis AJ; Department of Human Genetics, UCLA, Los Angeles, CA, United States of America. Zaitlen N; Department of Neurology, UCLA, Los Angeles, CA, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2020 Oct 26; Vol. 16 (10), pp. e1009165. Date of Electronic Publication: 2020 Oct 26 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Analysis of the genetic basis of height in large Jewish nuclear families.
Autorzy:
Zeevi D; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California, United States of America.; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California, United States of America. BloomJS; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California, United States of America.; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California, United States of America. Sadhu MJ; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California, United States of America.; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California, United States of America. Ben Yehuda A; Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Israel. Zangen D; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Division of Pediatric Endocrinology, Hadassah Hebrew University Medical Center, Jerusalem, Israel. Levy-Lahad E; Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. Kruglyak L; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California, United States of America.; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2019 Jul 08; Vol. 15 (7), pp. e1008082. Date of Electronic Publication: 2019 Jul 08 (Print Publication: 2019).
Illuminating gravitational waves: A concordant picture of photons from a neutron star merger.
Autorzy:
Kasliwal MM; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. . Nakar E; The Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University, Tel Aviv 69978, Israel. Singer LP; Astroparticle Physics Laboratory, NASA Goddard Space Flight Center, Mail Code 661, Greenbelt, MD 20771, USA.; Joint Space-Science Institute, University of Maryland, College Park, MD 20742, USA. Kaplan DL; Department of Physics, University of Wisconsin, Milwaukee, WI 53201, USA. Cook DO; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Van Sistine A; Department of Physics, University of Wisconsin, Milwaukee, WI 53201, USA. Lau RM; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Fremling C; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Gottlieb O; The Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University, Tel Aviv 69978, Israel. Jencson JE; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Adams SM; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Feindt U; The Oskar Klein Centre, Department of Physics, Stockholm University, AlbaNova, SE-106 91 Stockholm, Sweden. Hotokezaka K; Center for Computational Astrophysics, Simons Foundation, Flatiron Institute, 162 5th Avenue, New York, NY 10010, USA.; Department of Astrophysical Sciences, Princeton University, Peyton Hall, Princeton, NJ 08544, USA. Ghosh S; Department of Physics, University of Wisconsin, Milwaukee, WI 53201, USA. Perley DA; Astrophysics Research Institute, Liverpool John Moores University, IC2, Liverpool Science Park, 146 Browlow Hill, Liverpool L3 5RF, UK. Yu PC; Graduate Institute of Astronomy, National Central University, No. 300, Zhongda Road, Zhongli District, Taoyuan City 32001, Taiwan. Piran T; Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. Allison JR; Sydney Institute for Astronomy, School of Physics A28, The University of Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for All-sky Astrophysics in 3 Dimensions, Australia. Anupama GC; Indian Institute of Astrophysics, II Block Koramangala, Bangalore 560034, India. Balasubramanian A; Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pashan, Pune 411008, India. Bannister KW; Australia Telescope National Facility, Astronomy and Space Science, Commonwealth Scientific and Industrial Research Organisation, Post Office Box 76, Epping, New South Wales 1710, Australia. Bally J; Department of Astrophysical and Planetary Sciences, University of Colorado, Boulder, CO 80305, USA. Barnes J; Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027, USA. Barway S; South African Astronomical Observatory, Post Office Box 9, Observatory, Cape Town 7935, South Africa. Bellm E; Department of Astronomy, University of Washington, Seattle, WA 98195, USA. Bhalerao V; Department of Physics, Indian Institute of Technology Bombay, Mumbai 400076, India. Bhattacharya D; Inter-University Centre for Astronomy and Astrophysics, Post Office Bag 4, Ganeshkhind, Pune 411007, India. Blagorodnova N; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. BloomJS; Department of Astronomy, University of California, Berkeley, CA 94720-3411, USA.; Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 50B-4206, Berkeley, CA 94720, USA. Brady PR; Department of Physics, University of Wisconsin, Milwaukee, WI 53201, USA. Cannella C; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Chatterjee D; Department of Physics, University of Wisconsin, Milwaukee, WI 53201, USA. Cenko SB; Astroparticle Physics Laboratory, NASA Goddard Space Flight Center, Mail Code 661, Greenbelt, MD 20771, USA.; Joint Space-Science Institute, University of Maryland, College Park, MD 20742, USA. Cobb BE; Department of Physics, George Washington University, Washington, DC 20052, USA. Copperwheat C; Astrophysics Research Institute, Liverpool John Moores University, IC2, Liverpool Science Park, 146 Browlow Hill, Liverpool L3 5RF, UK. Corsi A; Department of Physics and Astronomy, Texas Tech University, Box 41051, Lubbock, TX 79409-1051, USA. De K; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Dobie D; Sydney Institute for Astronomy, School of Physics A28, The University of Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for All-sky Astrophysics, Australia.; Australia Telescope National Facility, Astronomy and Space Science, Commonwealth Scientific and Industrial Research Organisation, Post Office Box 76, Epping, New South Wales 1710, Australia. Emery SWK; University College London, Mullard Space Science Laboratory, Holmbury St. Mary, Dorking RH5 6NT, UK. Evans PA; X-ray and Observational Astronomy Research Group, Leicester Institute for Space and Earth Observation, Department of Physics and Astronomy, University of Leicester, University Road, Leicester, LE1 7RH, UK. Fox OD; Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218, USA. Frail DA; National Radio Astronomy Observatory, Socorro, NM 87825, USA. Frohmaier C; Department of Physics and Astronomy, University of Southampton, Southampton, Hampshire SO17 1BJ, UK.; Institute of Cosmology and Gravitation, Dennis Sciama Building, University of Portsmouth, Burnaby Road, Portsmouth PO1 3FX, UK. Goobar A; The Oskar Klein Centre, Department of Physics, Stockholm University, AlbaNova, SE-106 91 Stockholm, Sweden. Hallinan G; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Harrison F; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Helou G; Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125, USA. Hinderer T; Institute of Mathematics, Astrophysics and Particle Physics, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, Netherlands. Ho AYQ; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Horesh A; Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. Ip WH; Department of Astrophysical Sciences, Princeton University, Peyton Hall, Princeton, NJ 08544, USA. Itoh R; Department of Physics, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551, Japan. Kasen D; Department of Astronomy, University of California, Berkeley, CA 94720-3411, USA.; Department of Physics, University of California, Berkeley, CA 94720, USA. Kim H; Gemini Observatory, Casilla 603, La Serena, Chile. Kuin NPM; University College London, Mullard Space Science Laboratory, Holmbury St. Mary, Dorking RH5 6NT, UK. Kupfer T; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Lynch C; Sydney Institute for Astronomy, School of Physics A28, The University of Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for All-sky Astrophysics, Australia. Madsen K; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Mazzali PA; Astrophysics Research Institute, Liverpool John Moores University, IC2, Liverpool Science Park, 146 Browlow Hill, Liverpool L3 5RF, UK.; Max-Planck Institute for Astrophysics, Garching, Germany. Miller AA; Center for Interdisciplinary Exploration and Research in Astrophysics and Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208, USA.; The Adler Planetarium, Chicago, IL 60605, USA. Mooley K; Astrophysics, Department of Physics, University of Oxford, Keble Road, Oxford OX1 3RH, UK. Murphy T; Sydney Institute for Astronomy, School of Physics A28, The University of Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for All-sky Astrophysics, Australia. Ngeow CC; Graduate Institute of Astronomy, National Central University, No. 300, Zhongda Road, Zhongli District, Taoyuan City 32001, Taiwan. Nichols D; Institute of Mathematics, Astrophysics and Particle Physics, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, Netherlands. Nissanke S; Institute of Mathematics, Astrophysics and Particle Physics, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, Netherlands. Nugent P; Department of Astronomy, University of California, Berkeley, CA 94720-3411, USA.; Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 50B-4206, Berkeley, CA 94720, USA. Ofek EO; Department of Particle Physics and Astrophysics, Weizmann Institute of Science, Rehovot 7610001, Israel. Qi H; Department of Physics, University of Wisconsin, Milwaukee, WI 53201, USA. Quimby RM; Department of Astronomy, San Diego State University, San Diego, CA 92182, USA.; Kavli Institute for the Physics and Mathematics of the Universe (WPI), The University of Tokyo Institutes for Advanced Study, The University of Tokyo, Kashiwa, Chiba 277-8583, Japan. Rosswog S; The Oskar Klein Centre, Department of Astronomy, Stockholm University, AlbaNova, SE-106 91 Stockholm, Sweden. Rusu F; School of Engineering (EECS), University of California, Merced, CA 95343, USA. Sadler EM; Sydney Institute for Astronomy, School of Physics A28, The University of Sydney, New South Wales 2006, Australia.; Australian Research Council Centre of Excellence for All-sky Astrophysics, Australia. Schmidt P; Institute of Mathematics, Astrophysics and Particle Physics, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, Netherlands. Sollerman J; The Oskar Klein Centre, Department of Astronomy, Stockholm University, AlbaNova, SE-106 91 Stockholm, Sweden. Steele I; Astrophysics Research Institute, Liverpool John Moores University, IC2, Liverpool Science Park, 146 Browlow Hill, Liverpool L3 5RF, UK. Williamson AR; Institute of Mathematics, Astrophysics and Particle Physics, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, Netherlands. Xu Y; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Yan L; Division of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.; Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125, USA. Yatsu Y; Department of Physics, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551, Japan. Zhang C; Department of Physics, University of Wisconsin, Milwaukee, WI 53201, USA. Zhao W; School of Engineering (EECS), University of California, Merced, CA 95343, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2017 Dec 22; Vol. 358 (6370), pp. 1559-1565. Date of Electronic Publication: 2017 Oct 16.
BloomJS; Department of Astronomy, University of California, Berkeley, CA 94720, USA. .; Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Sigurdsson S; Department of Astronomy and Astrophysics, Penn State University, University Park, PA 16802, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2017 Oct 20; Vol. 358 (6361), pp. 301-302. Date of Electronic Publication: 2017 Oct 16.
CRISPR-directed mitotic recombination enables genetic mapping without crosses.
Autorzy:
Sadhu MJ; Department of Human Genetics, Department of Biological Chemistry, and Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. . BloomJS; Department of Human Genetics, Department of Biological Chemistry, and Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. . Day L; Department of Human Genetics, Department of Biological Chemistry, and Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Kruglyak L; Department of Human Genetics, Department of Biological Chemistry, and Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2016 May 27; Vol. 352 (6289), pp. 1113-6. Date of Electronic Publication: 2016 May 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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