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Tytuł:
Phosphorylation status of BolA affects its role in transcription and biofilm development.
Autorzy:
Galego L; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Barahona S; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Romão CV; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Arraiano CM; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
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Źródło:
The FEBS journal [FEBS J] 2021 Feb; Vol. 288 (3), pp. 961-979. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Bacterial*
Biofilms/*growth & development
Escherichia coli/*genetics
Escherichia coli Proteins/*genetics
Transcription Factors/*genetics
Amino Acid Sequence ; Binding Sites/genetics ; Blotting, Western ; Escherichia coli/metabolism ; Escherichia coli/physiology ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/metabolism ; Mass Spectrometry/methods ; Mutation ; Phosphorylation ; Protein Domains ; Reverse Transcriptase Polymerase Chain Reaction ; Sequence Homology, Amino Acid ; Serine/chemistry ; Serine/genetics ; Serine/metabolism ; Threonine/chemistry ; Threonine/genetics ; Threonine/metabolism ; Transcription Factors/chemistry ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Four and a Half LIM Domains 2 (FHL2) Contribute to the Epithelial Ovarian Cancer Carcinogenesis.
Autorzy:
Wang C; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Lv X; Olson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198-3255, USA.; Vincent Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
He C; Olson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198-3255, USA.; Vincent Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Davis JS; Olson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198-3255, USA.; Omaha Veterans Affairs Medical Center, Omaha, NE 68105, USA.
Wang C; Olson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198-3255, USA.; Vincent Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Hua G; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 20; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 20.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Ovarian Epithelial/*metabolism
LIM-Homeodomain Proteins/*metabolism
Muscle Proteins/*metabolism
Ovarian Neoplasms/*metabolism
Transcription Factors/*metabolism
Animals ; Blotting, Western ; Carcinogenesis/genetics ; Carcinoma, Ovarian Epithelial/genetics ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; LIM-Homeodomain Proteins/genetics ; Mice, Nude ; Muscle Proteins/genetics ; Ovarian Neoplasms/genetics ; RNA Interference ; RNAi Therapeutics/methods ; Transcription Factors/genetics ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Insights into irr and rirA gene regulation on the virulence of Brucella melitensis M5-90.
Autorzy:
Zhang H; School of Animal Science and Technology, Shihezi University, Shihezi City, Xinjiang 832000, P.R. China.
Wang B; School of Life Science, Shihezi University, Shihezi City, Xinjiang 832000, P.R. China.
Wu W; School of Animal Science and Technology, Shihezi University, Shihezi City, Xinjiang 832000, P.R. China.
Deng X; School of Animal Science and Technology, Shihezi University, Shihezi City, Xinjiang 832000, P.R. China.
Shao Z; School of Animal Science and Technology, Shihezi University, Shihezi City, Xinjiang 832000, P.R. China.
Yi J; School of Animal Science and Technology, Shihezi University, Shihezi City, Xinjiang 832000, P.R. China.
Wang Z; School of Animal Science and Technology, Shihezi University, Shihezi City, Xinjiang 832000, P.R. China.
Yang N; School of Animal Science and Technology, Shihezi University, Shihezi City, Xinjiang 832000, P.R. China.
Wang Y; School of Animal Science and Technology, Shihezi University, Shihezi City, Xinjiang 832000, P.R. China.
Wang Y; School of Medicine, Shihezi University, Shihezi City, Xinjiang 832000, P.R. China.
Chen C; School of Animal Science and Technology, Shihezi University, Shihezi City, Xinjiang 832000, P.R. China.
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Źródło:
Canadian journal of microbiology [Can J Microbiol] 2020 May; Vol. 66 (5), pp. 351-358. Date of Electronic Publication: 2020 Feb 10.
Typ publikacji:
Journal Article
MeSH Terms:
Bacterial Proteins/*genetics
Brucella melitensis/*genetics
Brucella melitensis/*pathogenicity
Gene Expression Regulation, Bacterial/*physiology
Iron/*metabolism
Transcription Factors/*genetics
Animals ; Anti-Infective Agents, Local/toxicity ; Blotting, Western ; Brucella Vaccine/immunology ; Brucellosis/prevention & control ; Colony Count, Microbial ; Female ; Hydrogen Peroxide/toxicity ; Macrophages/microbiology ; Mice ; Mice, Inbred BALB C ; Spleen/microbiology ; Virulence/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Islet-1 synergizes with Gcn5 to promote MSC differentiation into cardiomyocytes.
Autorzy:
Xu H; Department of Clinical Laboratory; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child development and Critical Disorders; Children's Hospital of Chongqing Medical University, Chongqing, P.R. China.
Zhou Q; Department of Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child development and Critical Disorders; Children's Hospital of Chongqing Medical University, Chongqing, P.R. China.; Chongqing Key Laboratory of Pediatrics, Chongqing, P.R. China.
Yi Q; Department of Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child development and Critical Disorders; Children's Hospital of Chongqing Medical University, Chongqing, P.R. China.; Chongqing Key Laboratory of Pediatrics, Chongqing, P.R. China.
Tan B; Department of Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child development and Critical Disorders; Children's Hospital of Chongqing Medical University, Chongqing, P.R. China.; Chongqing Key Laboratory of Pediatrics, Chongqing, P.R. China.
Tian J; Department of Cardiovascular (Internal Medicine), Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child development and Critical Disorders; Children's Hospital of Chongqing Medical University, Chongqing, P.R. China.
Chen X; Department of Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child development and Critical Disorders; Children's Hospital of Chongqing Medical University, Chongqing, P.R. China.; Chongqing Key Laboratory of Pediatrics, Chongqing, P.R. China.
Wang Y; Department of Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child development and Critical Disorders; Children's Hospital of Chongqing Medical University, Chongqing, P.R. China.; Chongqing Key Laboratory of Pediatrics, Chongqing, P.R. China.
Yu X; Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, P.R. China.
Zhu J; Department of Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child development and Critical Disorders; Children's Hospital of Chongqing Medical University, Chongqing, P.R. China. .; Chongqing Key Laboratory of Pediatrics, Chongqing, P.R. China. .
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Źródło:
Scientific reports [Sci Rep] 2020 Feb 04; Vol. 10 (1), pp. 1817. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Differentiation*/physiology
LIM-Homeodomain Proteins/*physiology
Mesenchymal Stem Cells/*physiology
Myocytes, Cardiac/*physiology
Transcription Factors/*physiology
p300-CBP Transcription Factors/*physiology
Acetylation ; Animals ; Blotting, Western ; Chromatin Immunoprecipitation ; DNA Methylation ; GATA4 Transcription Factor/metabolism ; Histone Deacetylase 1/metabolism ; Histones/metabolism ; Immunoprecipitation ; LIM-Homeodomain Proteins/metabolism ; Mesenchymal Stem Cells/metabolism ; Mice ; Myocytes, Cardiac/metabolism ; Promoter Regions, Genetic ; Transcription Factors/metabolism ; p300-CBP Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum.
Autorzy:
Kajiho H; Division of Membrane Dynamics, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan.
Yamamoto Y; Division of Membrane Dynamics, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan.
Sakisaka T; Division of Membrane Dynamics, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2019 Sep 11; Vol. 9 (1), pp. 13152. Date of Electronic Publication: 2019 Sep 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Interaction Maps*
Endoplasmic Reticulum/*metabolism
Membrane Proteins/*metabolism
Transcription Factors/*metabolism
Animals ; Binding Sites/genetics ; Blotting, Western ; COS Cells ; Chlorocebus aethiops ; Humans ; Membrane Proteins/genetics ; Mutation ; Protein Binding ; RNA Interference ; Transcription Factors/genetics ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesized glucocorticoid-induced leucine zipper peptide inhibits photoreceptor apoptosis and protects retinal function in light-induced retinal degeneration model.
Autorzy:
Gu R; Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
Tang W; Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
Lei B; Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
Jiang C; Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
Song F; Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
Xu G; Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China.; NHC Key Laboratory of Myopia, Fudan University, Shanghai, China.; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.
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Źródło:
Clinical & experimental ophthalmology [Clin Exp Ophthalmol] 2019 Jul; Vol. 47 (5), pp. 646-657. Date of Electronic Publication: 2019 Jan 02.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Light/*adverse effects
Photoreceptor Cells, Vertebrate/*physiology
Photoreceptor Cells, Vertebrate/*radiation effects
Radiation Injuries, Experimental/*prevention & control
Retinal Degeneration/*prevention & control
Transcription Factors/*pharmacology
Animals ; Blotting, Western ; Electroretinography ; Ependymoglial Cells/drug effects ; In Situ Nick-End Labeling ; Intravitreal Injections ; Leucine Zippers ; Male ; Peptide Fragments/chemical synthesis ; Radiation Injuries, Experimental/etiology ; Radiation Injuries, Experimental/physiopathology ; Rats ; Rats, Sprague-Dawley ; Retinal Degeneration/etiology ; Retinal Degeneration/physiopathology ; Transcription Factors/chemical synthesis ; Transcription Factors/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Efp promotes in vitro and in vivo growth of endometrial cancer cells along with the activation of nuclear factor-κB signaling.
Autorzy:
Sato W; Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama, Japan.
Ikeda K; Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama, Japan.
Urano T; Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.
Abe Y; Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama, Japan.; Department of Obstetrics and Gynecology, School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.
Nakasato N; Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama, Japan.; Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, Kawagoe-shi, Saitama, Japan.
Horie-Inoue K; Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama, Japan.
Takeda S; Department of Obstetrics and Gynecology, School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.; Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, Kawagoe-shi, Saitama, Japan.
Inoue S; Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama, Japan.; Functional Biogerontology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.
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Źródło:
PloS one [PLoS One] 2018 Dec 26; Vol. 13 (12), pp. e0208351. Date of Electronic Publication: 2018 Dec 26 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA-Binding Proteins/*metabolism
Endometrial Neoplasms/*metabolism
Transcription Factors/*metabolism
Tripartite Motif Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
14-3-3 Proteins/genetics ; 14-3-3 Proteins/metabolism ; Animals ; Blotting, Western ; Cell Cycle/genetics ; Cell Cycle/physiology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Movement/physiology ; Cell Proliferation/genetics ; Cell Proliferation/physiology ; Cell Survival/genetics ; Cell Survival/physiology ; DNA-Binding Proteins/genetics ; Endometrial Neoplasms/genetics ; Female ; Humans ; Mice ; Mice, Nude ; Polymerase Chain Reaction ; RNA, Small Interfering/genetics ; Signal Transduction/genetics ; Signal Transduction/physiology ; Transcription Factors/genetics ; Tripartite Motif Proteins/genetics ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of DACH1 on proliferation and invasion of laryngeal squamous cell carcinoma.
Autorzy:
Zhang J; Department of Otorhinolaryngology, Head and Neck Surgery, Second Affiliated Hospital, Harbin Medical University, Harbin, 150081, China.
Ren X; Department of Otorhinolaryngology, Head and Neck Surgery, Second Affiliated Hospital, Harbin Medical University, Harbin, 150081, China.
Wang B; Department of Otorhinolaryngology, Head and Neck Surgery, Second Affiliated Hospital, Harbin Medical University, Harbin, 150081, China.
Cao J; Department of Otorhinolaryngology, Head and Neck Surgery, Second Affiliated Hospital, Harbin Medical University, Harbin, 150081, China.
Tian L; Department of Otorhinolaryngology, Head and Neck Surgery, Second Affiliated Hospital, Harbin Medical University, Harbin, 150081, China. .
Liu M; Department of Otorhinolaryngology, Head and Neck Surgery, Second Affiliated Hospital, Harbin Medical University, Harbin, 150081, China. .
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Źródło:
Head & face medicine [Head Face Med] 2018 Sep 27; Vol. 14 (1), pp. 20. Date of Electronic Publication: 2018 Sep 27.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Carcinoma, Squamous Cell/*genetics
Cell Proliferation/*genetics
Eye Proteins/*genetics
Laryngeal Neoplasms/*genetics
Transcription Factors/*genetics
Aged ; Biopsy, Needle ; Blotting, Western ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Case-Control Studies ; Female ; Humans ; Immunohistochemistry ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/surgery ; Male ; Middle Aged ; Neoplasm Invasiveness/pathology ; Neoplasm Staging ; Prognosis ; Real-Time Polymerase Chain Reaction ; Retrospective Studies ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MCPIP1-induced autophagy mediates ischemia/reperfusion injury in endothelial cells via HMGB1 and CaSR.
Autorzy:
Xie X; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Zhu T; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China. .; Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu, 210009, China. .
Chen L; Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu, 210009, China.
Ding S; Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu, 210009, China.
Chu H; Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu, 210009, China.
Wang J; Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu, 210009, China.
Yao H; Department of Pharmacology, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.; Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, 210096, China.
Chao J; Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu, 210009, China. .; Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, 210096, China. .; Department of Respiration, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China. .
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Źródło:
Scientific reports [Sci Rep] 2018 Jan 29; Vol. 8 (1), pp. 1735. Date of Electronic Publication: 2018 Jan 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*
Endothelial Cells/*pathology
HMGB1 Protein/*metabolism
Receptors, Calcium-Sensing/*metabolism
Reperfusion Injury/*pathology
Ribonucleases/*metabolism
Transcription Factors/*metabolism
Blotting, Western ; Cell Movement ; Cells, Cultured ; Gene Expression Regulation ; Gene Knockdown Techniques ; HMGB1 Protein/genetics ; Humans ; Immunohistochemistry ; Ribonucleases/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Expression of MYSM1 is associated with tumor progression in colorectal cancer.
Autorzy:
Li Y; Department of Colorectal Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
Li J; Department of Colorectal Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
Liu H; Department of Colorectal Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
Liu Y; Department of Colorectal Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
Cui B; Department of Colorectal Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
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Źródło:
PloS one [PLoS One] 2017 May 12; Vol. 12 (5), pp. e0177235. Date of Electronic Publication: 2017 May 12 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*genetics
Colorectal Neoplasms/*genetics
DNA-Binding Proteins/*genetics
Transcription Factors/*genetics
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism ; Blotting, Western ; Cell Line, Tumor ; Colorectal Neoplasms/physiopathology ; DNA-Binding Proteins/metabolism ; Disease Progression ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplastic Processes ; Prognosis ; RNA Interference ; RNA, Small Interfering ; Trans-Activators ; Transcription Factors/metabolism ; Ubiquitin-Specific Proteases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
SnoN upregulation ameliorates renal fibrosis in diabetic nephropathy.
Autorzy:
Liu L; Department of Clinical Hematology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Shi M; Department of Pathophysiology, Guizhou Medical University, Guiyang, Guizhou, China.
Wang Y; Department of Pathophysiology, Guizhou Medical University, Guiyang, Guizhou, China.
Zhang C; Department of Respiratory Medicine, People's Hospital of Guizhou Province, Guiyang, Guizhou, China.
Su B; Department of Pathology, Nanyang Central Hospital, Nanyang, Henan, China.
Xiao Y; Department of Pathophysiology, Guizhou Medical University, Guiyang, Guizhou, China.
Guo B; Department of Pathophysiology, Guizhou Medical University, Guiyang, Guizhou, China.
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Źródło:
PloS one [PLoS One] 2017 Mar 28; Vol. 12 (3), pp. e0174471. Date of Electronic Publication: 2017 Mar 28 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Up-Regulation*
Diabetic Nephropathies/*metabolism
Kidney/*metabolism
Nerve Tissue Proteins/*metabolism
Transcription Factors/*metabolism
Animals ; Blotting, Western ; Cadherins/genetics ; Cadherins/metabolism ; Cell Line ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Nephropathies/genetics ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial-Mesenchymal Transition/drug effects ; Epithelial-Mesenchymal Transition/genetics ; Fibrosis/genetics ; Fibrosis/metabolism ; Glucose/metabolism ; Glucose/pharmacology ; Humans ; Kidney/drug effects ; Kidney/pathology ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/metabolism ; Male ; Nerve Tissue Proteins/genetics ; RNA Interference ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; Transcription Factors/genetics ; Transcriptional Activation/drug effects ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
SET protein overexpression contributes to paclitaxel resistance in MCF-7/S cells through PI3K/Akt pathway.
Autorzy:
Zhang W; a Department of Pharmacy , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , PR China.; b Department of Pharmacy , The Eighth Hospital of Xi'an , Xi'an , PR China.
Zheng X; a Department of Pharmacy , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , PR China.
Meng T; a Department of Pharmacy , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , PR China.
You H; a Department of Pharmacy , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , PR China.
Dong Y; a Department of Pharmacy , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , PR China.
Xing J; c School of Pharmacy, Xi'an Jiaotong University , Xi'an , PR China.
Chen S; a Department of Pharmacy , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , PR China.
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Źródło:
Journal of drug targeting [J Drug Target] 2017 Mar; Vol. 25 (3), pp. 255-263. Date of Electronic Publication: 2016 Oct 20.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Phytogenic/*pharmacology
Histone Chaperones/*metabolism
Paclitaxel/*pharmacology
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Transcription Factors/*metabolism
Blotting, Western ; DNA-Binding Proteins ; Down-Regulation ; Drug Resistance, Neoplasm ; Enzyme Activation ; Female ; Flow Cytometry ; Humans ; MCF-7 Cells ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Precise Temperature-Responsive Bistable Switch Controlling Yersinia Virulence.
Autorzy:
Nuss AM; Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Schuster F; Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Roselius L; Institute of Microbiology, Technical University Braunschweig, Braunschweig, Germany.
Klein J; Institute of Microbiology, Technical University Braunschweig, Braunschweig, Germany.
Bücker R; Institute of Systems Biotechnology, Saarland University, Saarbrücken, Germany.
Herbst K; Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Heroven AK; Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Pisano F; Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Wittmann C; Institute of Systems Biotechnology, Saarland University, Saarbrücken, Germany.
Münch R; Institute of Microbiology, Technical University Braunschweig, Braunschweig, Germany.
Müller J; Institute of Mathematics, Technical University Munich, Munich, Germany.; Institute of Computational Biology, Helmholtz Centre Munich, Neuherberg, Germany.
Jahn D; Institute of Microbiology, Technical University Braunschweig, Braunschweig, Germany.
Dersch P; Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
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Źródło:
PLoS pathogens [PLoS Pathog] 2016 Dec 22; Vol. 12 (12), pp. e1006091. Date of Electronic Publication: 2016 Dec 22 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Bacterial Proteins/*metabolism
Transcription Factors/*metabolism
Virulence Factors/*metabolism
Yersinia pseudotuberculosis/*pathogenicity
Yersinia pseudotuberculosis Infections/*parasitology
Animals ; Blotting, Western ; Disease Models, Animal ; Electrophoretic Mobility Shift Assay ; Female ; Flow Cytometry ; Mice ; Mice, Inbred BALB C ; Temperature ; Time-Lapse Imaging ; Virulence
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi's Sarcoma-Associated Herpesvirus.
Autorzy:
Kumar B; H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States Of America.
Dutta D; H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States Of America.
Iqbal J; H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States Of America.
Ansari MA; H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States Of America.
Roy A; H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States Of America.
Chikoti L; H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States Of America.
Pisano G; H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States Of America.
Veettil MV; H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States Of America.
Chandran B; H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States Of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2016 Oct 20; Vol. 12 (10), pp. e1005960. Date of Electronic Publication: 2016 Oct 20 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Herpesviridae Infections*
Virus Internalization*
DNA-Binding Proteins/*metabolism
Endosomal Sorting Complexes Required for Transport/*metabolism
Endothelial Cells/*virology
Host-Parasite Interactions/*physiology
Transcription Factors/*metabolism
Blotting, Western ; Fluorescent Antibody Technique ; Herpesvirus 8, Human ; Humans ; Immunoprecipitation ; Microscopy, Fluorescence ; Pinocytosis ; Real-Time Polymerase Chain Reaction ; Transfection
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4.
Autorzy:
Ren K; Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.; Jiangsu Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.
Zhang W; Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.; Jiangsu Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.
Chen X; The Hoffmann Institute of Immunology, Guangzhou Medical University, Guangzhou, China.
Ma Y; Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.; Jiangsu Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.
Dai Y; Jiangsu Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.
Fan Y; Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
Hou Y; Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
Tan RX; Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.; Jiangsu Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.; Nanjing University of Chinese Medicine, Nanjing, China.
Li E; Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.; Jiangsu Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.
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Źródło:
PLoS pathogens [PLoS Pathog] 2016 Oct 20; Vol. 12 (10), pp. e1005950. Date of Electronic Publication: 2016 Oct 20 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Epigenesis, Genetic*
Herpes Simplex*
Herpesvirus 1, Human*/drug effects
Herpesvirus 2, Human*/drug effects
Host-Parasite Interactions/*physiology
Nuclear Proteins/*metabolism
Transcription Factors/*metabolism
Virus Replication/*physiology
Azepines/pharmacology ; Blotting, Western ; Cell Cycle Proteins ; Chromatin Immunoprecipitation ; Gene Knockdown Techniques ; Humans ; Microscopy, Confocal ; Polymerase Chain Reaction ; Positive Transcriptional Elongation Factor B/metabolism ; RNA, Small Interfering ; Transfection ; Triazoles/pharmacology ; Virus Replication/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis.
Autorzy:
Kirchdoerfer RN; Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California, United States of America.
Moyer CL; Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California, United States of America.
Abelson DM; Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California, United States of America.
Saphire EO; Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California, United States of America.; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2016 Oct 18; Vol. 12 (10), pp. e1005937. Date of Electronic Publication: 2016 Oct 18 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Ebolavirus/*genetics
Nucleoproteins/*chemistry
Nucleoproteins/*genetics
RNA, Viral/*biosynthesis
Transcription Factors/*chemistry
Transcription Factors/*genetics
Viral Proteins/*chemistry
Viral Proteins/*genetics
Blotting, Western ; Ebolavirus/chemistry ; Fluorescent Antibody Technique ; Immunoprecipitation ; Real-Time Polymerase Chain Reaction ; Transcription, Genetic/physiology ; Virus Replication/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
HIV-1 Vpr Abrogates the Effect of TSG101 Overexpression to Support Virus Release.
Autorzy:
Chutiwitoonchai N; Viral Infectious Diseases Unit, RIKEN, Wako, Saitama, Japan.; Japan Foundation for AIDS Prevention, Chiyoda-ku, Tokyo, Japan.
Siarot L; Viral Infectious Diseases Unit, RIKEN, Wako, Saitama, Japan.; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, Japan.
Takeda E; Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Shioda T; Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Ueda M; Nano Medical Engineering Laboratory, RIKEN, Wako, Saitama, Japan.
Aida Y; Viral Infectious Diseases Unit, RIKEN, Wako, Saitama, Japan.
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Źródło:
PloS one [PLoS One] 2016 Sep 20; Vol. 11 (9), pp. e0163100. Date of Electronic Publication: 2016 Sep 20 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
DNA-Binding Proteins/*metabolism
Endosomal Sorting Complexes Required for Transport/*metabolism
Gene Products, gag/*metabolism
HIV-1/*physiology
Transcription Factors/*metabolism
Virus Release/*physiology
vpr Gene Products, Human Immunodeficiency Virus/*metabolism
Blotting, Western ; DNA-Binding Proteins/genetics ; Endosomal Sorting Complexes Required for Transport/genetics ; Endosomes/metabolism ; Fluorescence Resonance Energy Transfer ; Gene Products, gag/genetics ; HEK293 Cells ; HIV-1/genetics ; HIV-1/metabolism ; HeLa Cells ; Humans ; Lysosomes/metabolism ; Microscopy, Fluorescence/methods ; Mutation ; Protein Binding ; Transcription Factors/genetics ; Virion/genetics ; Virion/metabolism ; Virion/physiology ; Virus Assembly/genetics ; Virus Release/genetics ; vpr Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Silence of MACC1 decreases cell migration and invasion in human malignant melanoma through inhibiting the EMT.
Autorzy:
Ding Y; Department of Dermatology, The First Affiliated Hospital of Zhejiang University.
Li X
Hong D
Jiang L
He Y
Fang H
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Źródło:
Bioscience trends [Biosci Trends] 2016 Sep 05; Vol. 10 (4), pp. 258-64. Date of Electronic Publication: 2016 Aug 03.
Typ publikacji:
Journal Article; Retracted Publication
MeSH Terms:
Cell Movement/*genetics
Epithelial-Mesenchymal Transition/*genetics
Melanoma/*genetics
Neoplasm Invasiveness/*genetics
Transcription Factors/*physiology
Blotting, Western ; Cadherins/genetics ; Cadherins/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Microscopy, Fluorescence ; Neoplasm Metastasis/genetics ; RNA Interference ; Real-Time Polymerase Chain Reaction ; Trans-Activators ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Vimentin/genetics ; Vimentin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Possible Contribution of Zerumbone-Induced Proteo-Stress to Its Anti-Inflammatory Functions via the Activation of Heat Shock Factor 1.
Autorzy:
Igarashi Y; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Ohnishi K; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Irie K; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Murakami A; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
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Źródło:
PloS one [PLoS One] 2016 Aug 18; Vol. 11 (8), pp. e0161282. Date of Electronic Publication: 2016 Aug 18 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Inflammatory Agents/*pharmacology
DNA-Binding Proteins/*physiology
Protein Aggregation, Pathological/*chemically induced
Sesquiterpenes/*pharmacology
Transcription Factors/*physiology
Animals ; Blotting, Western ; Enzyme-Linked Immunosorbent Assay ; HSP72 Heat-Shock Proteins/metabolism ; Heat Shock Transcription Factors ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Mice ; Nitric Oxide Synthase Type II/metabolism ; Protein Aggregation, Pathological/physiopathology ; RAW 264.7 Cells/drug effects ; RAW 264.7 Cells/physiology ; RNA Interference/physiology ; Real-Time Polymerase Chain Reaction ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Overexpression of Pleomorphic Adenoma Gene-Like 2 Is a Novel Poor Prognostic Marker of Prostate Cancer.
Autorzy:
Guo J; Department of Urology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, PR China.
Wang M; Department of Urology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, PR China.
Wang Z; Department of Urology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, PR China.
Liu X; Department of Urology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, PR China.
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Źródło:
PloS one [PLoS One] 2016 Aug 18; Vol. 11 (8), pp. e0158667. Date of Electronic Publication: 2016 Aug 18 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
DNA-Binding Proteins/*analysis
Prostatic Neoplasms/*diagnosis
RNA-Binding Proteins/*analysis
Transcription Factors/*analysis
Biomarkers, Tumor/analysis ; Blotting, Western ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; Prognosis ; Prostate/chemistry ; Prostate-Specific Antigen/blood ; Prostatic Hyperplasia/diagnosis ; Prostatic Neoplasms/chemistry ; Prostatic Neoplasms/mortality ; Real-Time Polymerase Chain Reaction ; Survival Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 535

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