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    Wyświetlanie 1-9 z 9
    Tytuł:
    Potential Binding Sites of Pharmacological Chaperone NCGC00241607 on Mutant β-Glucocerebrosidase and Its Efficacy on Patient-Derived Cell Cultures in Gaucher and Parkinson's Disease.
    Autorzy:
    Kopytova AE; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.; Department of Molecular Genetic and Nanobiological Technologies, Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg 197022, Russia.
    Rychkov GN; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.; Institute of Biomedical Systems and Biotechnology, Peter the Great St.Petersburg Polytechnic University, Saint-Petersburg 195251, Russia.
    Cheblokov AA; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.
    Grigor'eva EV; Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.; Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk 630055, Russia.
    Nikolaev MA; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.; Department of Molecular Genetic and Nanobiological Technologies, Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg 197022, Russia.
    Yarkova ES; Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.
    Sorogina DA; Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.
    Ibatullin FM; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.
    Baydakova GV; Research Centre for Medical Genetics, Moscow 115522, Russia.
    Izyumchenko AD; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.; Department of Molecular Genetic and Nanobiological Technologies, Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg 197022, Russia.
    Bogdanova DA; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.
    Boitsov VM; Laboratory of Nanobiotechnology, Saint-Petersburg National Research Academic University of the Russian Academy of Sciences, Saint-Petersburg 194021, Russia.
    Rybakov AV; N.P. Bechtereva Institute of the Human Brain RAS, Saint-Petersburg 197376, Russia.
    Miliukhina IV; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.; N.P. Bechtereva Institute of the Human Brain RAS, Saint-Petersburg 197376, Russia.
    Bezrukikh VA; Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia.
    Salogub GN; Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia.
    Zakharova EY; Research Centre for Medical Genetics, Moscow 115522, Russia.
    Pchelina SN; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.; Department of Molecular Genetic and Nanobiological Technologies, Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg 197022, Russia.
    Emelyanov AK; Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.; Department of Molecular Genetic and Nanobiological Technologies, Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg 197022, Russia.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2023 May 22; Vol. 24 (10). Date of Electronic Publication: 2023 May 22.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Parkinson Disease*/drug therapy
    Parkinson Disease*/genetics
    Gaucher Disease*/drug therapy
    Gaucher Disease*/genetics
    Humans ; Glucosylceramidase/genetics ; Glucosylceramidase/metabolism ; Molecular Docking Simulation ; Cell Culture Techniques ; Binding Sites ; Glycolipids ; Mutation
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    11 H -Benzo[4,5]imidazo[1,2- a ]indol-11-one as a New Precursor of Azomethine Ylides: 1,3-Dipolar Cycloaddition Reactions with Cyclopropenes and Maleimides.
    Autorzy:
    Filatov AS; Department of Chemistry, Saint-Petersburg State University, Saint Petersburg 199034, Russia.
    Pronina YA; Department of Organic Chemistry, Saint-Petersburg State Institute of Technology, Saint Petersburg 190013, Russia.
    Selivanov SI; Department of Organic Chemistry, Saint-Petersburg State Institute of Technology, Saint Petersburg 190013, Russia.; Laboratory of Biomolecular NMR, Saint-Petersburg State University, Saint Petersburg 199034, Russia.
    Shmakov SV; Laboratory of Nanobiotechnologies, Saint-Petersburg National Research Academic University of the Russian Academy of Sciences, Saint Petersburg 194021, Russia.
    Uspenski AA; Department of Monitoring and Research of the Chemical Composition of the Atmosphere, Voeikov Main Geophysical Observatory, Saint Petersburg 194021, Russia.
    Boitsov VM; Laboratory of Nanobiotechnologies, Saint-Petersburg National Research Academic University of the Russian Academy of Sciences, Saint Petersburg 194021, Russia.
    Stepakov AV; Department of Chemistry, Saint-Petersburg State University, Saint Petersburg 199034, Russia.; Department of Organic Chemistry, Saint-Petersburg State Institute of Technology, Saint Petersburg 190013, Russia.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2022 Oct 30; Vol. 23 (21). Date of Electronic Publication: 2022 Oct 30.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Cycloaddition Reaction*
    Humans ; Maleimides/chemistry ; Stereoisomerism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Biological Evaluation of 3-Azaspiro[Bicyclo[3.1.0]Hexane-2,5'-Pyrimidines] as Potential Antitumor Agents.
    Autorzy:
    Shmakov SV; Laboratory of Nanobiotechnologies, Saint-Petersburg National Research Academic University of the Russian Academy of Sciences, 194021 Saint-Petersburg, Russia.
    Latypova DK; Laboratory of Nanobiotechnologies, Saint-Petersburg National Research Academic University of the Russian Academy of Sciences, 194021 Saint-Petersburg, Russia.
    Shmakova TV; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, 194156 Saint-Petersburg, Russia.
    Rubinshtein AA; Scientific Research Center, Pavlov First Saint Petersburg State Medical University, 197022 Saint-Petersburg, Russia.
    Chukin MV; Scientific Research Center, Pavlov First Saint Petersburg State Medical University, 197022 Saint-Petersburg, Russia.
    Zhuravskii SG; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, 194156 Saint-Petersburg, Russia.; Scientific Research Center, Pavlov First Saint Petersburg State Medical University, 197022 Saint-Petersburg, Russia.
    Knyazev NA; Institute of Cytology, Russian Academy of Sciences, 194064 Saint-Petersburg, Russia.; Saint-Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological), 197758 Saint-Petersburg, Russia.
    Stepakov AV; Department of Chemistry, Saint-Petersburg State University, 199034 Saint-Petersburg, Russia.; Department of Organic Chemistry, Saint Petersburg State Institute of Technology, 190013 Saint-Petersburg, Russia.
    Galagudza MM; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, 194156 Saint-Petersburg, Russia.
    Boitsov VM; Laboratory of Nanobiotechnologies, Saint-Petersburg National Research Academic University of the Russian Academy of Sciences, 194021 Saint-Petersburg, Russia.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2022 Sep 15; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 15.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antineoplastic Agents*/pharmacology
    Carcinoma*
    Actins ; Animals ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Chlorocebus aethiops ; Drug Screening Assays, Antitumor ; HeLa Cells ; Hexanes/pharmacology ; Humans ; Mice ; Pyrimidines/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Identification of Spiro-Fused Pyrrolo[3,4- a ]pyrrolizines and Tryptanthrines as Potential Antitumor Agents: Synthesis and In Vitro Evaluation.
    Autorzy:
    Latypova DK; Saint-Petersburg National Research Academic University of the Russian Academy of Sciences, 194021 Saint-Petersburg, Russia.
    Shmakov SV; Saint-Petersburg National Research Academic University of the Russian Academy of Sciences, 194021 Saint-Petersburg, Russia.
    Pechkovskaya SA; Institute of Cytology, Russian Academy of Sciences, 194064 Saint-Petersburg, Russia.
    Filatov AS; Department of Chemistry, Saint-Petersburg State University, 199034 Saint Petersburg, Russia.
    Stepakov AV; Department of Chemistry, Saint-Petersburg State University, 199034 Saint Petersburg, Russia.; Department of Organic Chemistry, Saint Petersburg State Institute of Technology, 190013 Saint-Petersburg, Russia.
    Knyazev NA; Institute of Cytology, Russian Academy of Sciences, 194064 Saint-Petersburg, Russia.; Saint-Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological), 197758 Saint-Petersburg, Russia.
    Boitsov VM; Saint-Petersburg National Research Academic University of the Russian Academy of Sciences, 194021 Saint-Petersburg, Russia.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2021 Nov 05; Vol. 22 (21). Date of Electronic Publication: 2021 Nov 05.
    Typ publikacji:
    Evaluation Study; Journal Article
    MeSH Terms:
    Antineoplastic Agents/*pharmacology
    Leukemia, Erythroblastic, Acute/*drug therapy
    Pyrrolidines/*chemical synthesis
    Pyrrolidines/*pharmacology
    Quinazolines/*pharmacology
    Spiro Compounds/*pharmacology
    Uterine Cervical Neoplasms/*drug therapy
    Antineoplastic Agents/chemical synthesis ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Female ; Humans ; Leukemia, Erythroblastic, Acute/metabolism ; Leukemia, Erythroblastic, Acute/pathology ; Quinazolines/chemical synthesis ; Spiro Compounds/chemical synthesis ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Identification of Spiro-Fused [3-azabicyclo[3.1.0]hexane]oxindoles as Potential Antitumor Agents: Initial In Vitro Evaluation of Anti-Proliferative Effect and Actin Cytoskeleton Transformation in 3T3 and 3T3-SV40 Fibroblast.
    Autorzy:
    Knyazev NA; Saint-Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological), 197758 Saint Petersburg, Russia.; Institute of Cytology, Russian Academy of Sciences, 194064 Saint Petersburg, Russia.
    Shmakov SV; Saint Petersburg National Research Academic University of the Russian Academy of Sciences, 194021 Saint Petersburg, Russia.
    Pechkovskaya SA; Institute of Cytology, Russian Academy of Sciences, 194064 Saint Petersburg, Russia.
    Filatov AS; Department of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.
    Stepakov AV; Department of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.
    Boitsov VM; Saint Petersburg National Research Academic University of the Russian Academy of Sciences, 194021 Saint Petersburg, Russia.; Scientific and Research Centre, Pavlov First Saint Petersburg State Medical University, 197022 Saint Petersburg, Russia.
    Filatova NA; Institute of Cytology, Russian Academy of Sciences, 194064 Saint Petersburg, Russia.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2021 Jul 31; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 31.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Actin Cytoskeleton/*drug effects
    Antineoplastic Agents/*pharmacology
    Cell Proliferation/*drug effects
    Oxindoles/*pharmacology
    3T3 Cells ; Animals ; Humans ; K562 Cells ; Mice ; Oxindoles/chemistry ; Pyrrolidines/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-9 z 9

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