- Tytuł:
- Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
- Autorzy:
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Kato N; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Loh M; Institute of Health Sciences, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (ASTAR), Singapore.
Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Wang X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.
Kelly TN; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Saleheen D; Center for Non-Communicable Diseases, Karachi, Pakistan.; Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.; Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Leach IM; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Drong AW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Abbott J; Bioinformatics Support Service, Imperial College London, London, UK.
Wahl S; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Tan ST; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.; National Heart and Lung Institute, Imperial College London, London, UK.
Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK.
Campanella G; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Chadeau-Hyam M; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Afzal U; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.
Ahluwalia TS; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Copenhagen Prospective Studies on Asthma in Childhood (COSPAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center, Gentofte, Denmark.Bonder MJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Chen P; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Dehghan A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Edwards TL; Vanderbilt Epidemiology Center, Center for Human Genetics Research, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Esko T; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Go MJ; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Harris SE; Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and Medical Research Council (MRC) Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Hartiala J; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.; Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Kasela S; Estonian Genome Center, University of Tartu, Tartu, Estonia.
Kasturiratne A; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Khor CC; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.; Genome Institute of Singapore, ASTAR, Singapore.; Department of Ophthalmology, National University of Singapore, Singapore.; Department of Paediatrics, National University of Singapore, Singapore.
Kleber ME; Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Li H; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Yu Mok Z; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Nakatochi M; Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.
Sapari NS; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Saxena R; Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Stewart AFR; University of Ottawa Heart Institute, Cardiovascular Research Methods Centre, Ottawa, Ontario, Canada.; Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, Ontario, Canada.
Stolk L; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Teh AL; Singapore Institute for Clinical Sciences (SICS), ASTAR, Singapore.
Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; School of Chinese Medicine, China Medical University, Taichung, Taiwan.
Zhang Y; State Key Laboratory of Medical Genetics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Hypertension, Shanghai, China.
Aits I; Institute of Epidemiology and Biobank popgen, Christian Albrechts University of Kiel, Kiel, Germany.
Da Silva Couto Alves A; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (PHE) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Das S; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (PHE) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Dorajoo R; Genome Institute of Singapore, ASTAR, Singapore.
Hopewell JC; Clinical Trials Support Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Kim YK; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Koivula RW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.
Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland.
Nguyen QN; Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam.
Pereira MA; School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Postmus I; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands.
Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Scannell Bryan M; Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Sorice R; Institute of Genetics and Biophysics A Buzzati-Traverso, CNR, Naples, Italy.
Tragante V; Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Traglia M; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.; Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) 'Burlo Garofolo', Trieste, Italy.
White J; University College London Genetics Institute, Department of Genetics, Environment and Evolution, University College London, London, UK.
Yamamoto K; Division of Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Zhang Y; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina, USA.
Ahmed A; UChicago Research Bangladesh, Uttara, Dhaka, Bangladesh.
Akiyama K; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Asif R; Center for Non-Communicable Diseases, Karachi, Pakistan.
Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Barroso I; Metabolic Disease Group, Wellcome Trust Sanger Institute, Cambridge, UK.; National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.; University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Bjonnes A; Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Braun TR; Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Cai H; Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.; Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Chang LC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; School of Chinese Medicine, China Medical University, Taichung, Taiwan.
Cheng CY; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.; Department of Ophthalmology, National University of Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of Singapore Graduate Medical School, Singapore.
Chong YS; Singapore Institute for Clinical Sciences (SICS), ASTAR, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Collins R; Clinical Trials Support Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Courtney R; Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.; Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Davies G; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK.
Delgado G; Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Do LD; Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam.
Doevendans PA; Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Gansevoort RT; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Gao YT; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Grammer TB; Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Grarup N; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Grewal J; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.
Gu D; Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wander GS; Dayanand Medical College and Hospital Unit, Hero DMC Heart Institute, Ludhiana, India.
Hartikainen AL; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.; Medical Research Center, University of Oulu, Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland.
Hazen SL; Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
He J; Department of Biostatistics, Vanderbilt University, Nashville, Tennessee, USA.
Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, Singapore.
Hixson JE; Human Genetics Center, University of Texas School of Public Health at Houston, Houston, Texas, USA.
Hofman A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Hsu C; University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Huang W; Department of Genetics, Chinese National Human Genomic Center, Shanghai, China.
Husemoen LLN; Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
Hwang JY; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Ichihara S; Graduate School of Regional Innovation Studies, Mie University, Tsu, Japan.
Igase M; Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Isono M; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Justesen JM; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan.
Kibriya MG; Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
Kim YJ; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Kishimoto M; National Center for Global Health and Medicine, Toyama, Japan.
Koh WP; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.; Duke-National University of Singapore Graduate Medical School, Singapore.
Kohara K; Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Kumari M; Department of Epidemiology and Public Health, University College London, London, UK.
Kwek K; K.K. Women's and Children's Hospital, Singapore.
Lee NR; University of San Carlos Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.; Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, Philippines.
Lee J; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Liao J; Department of Ophthalmology, National University of Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Lieb W; Institute of Epidemiology and Biobank popgen, Christian Albrechts University of Kiel, Kiel, Germany.
Liewald DCM; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK.
Matsubara T; Department of Internal Medicine, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
Matsushita Y; National Center for Global Health and Medicine, Toyama, Japan.
Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany.
Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia.
Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia.
Mills R; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.
Mononen N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland.
Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, Ludwig Maximilians University Munich, Munich, Germany.; German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.
Nabika T; Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan.
Nakashima E; Division of Endocrinology and Diabetes, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Diabetes and Endocrinology, Chubu Rosai Hospital, Nagoya, Japan.
Ng HK; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Nikus K; Heart Centre, Department of Cardiology, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland.
Nutile T; Institute of Genetics and Biophysics A Buzzati-Traverso, CNR, Naples, Italy.
Ohkubo T; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
Ohnaka K; Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Parish S; Clinical Trials Support Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Paternoster L; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Peng H; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Peters A; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.
Pham ST; Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam.
Pinidiyapathirage MJ; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Rahman M; UChicago Research Bangladesh, Uttara, Dhaka, Bangladesh.; Research and Evaluation Division, Bangladesh Rehabilitation Assistance Committee (BRAC), Dhaka, Bangladesh.
Rakugi H; Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan.
Rolandsson O; Department of Public Health and Clinical Medicine, Section for Family Medicine, Umeå Universitet, Umeå, Sweden.
Ann Rozario M; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Ruggiero D; Institute of Genetics and Biophysics A Buzzati-Traverso, CNR, Naples, Italy.
Sala CF; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Sarju R; Dayanand Medical College and Hospital Unit, Hero DMC Heart Institute, Ludhiana, India.
Shimokawa K; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Sparsø T; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Spiering W; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Starr JM; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
Stott DJ; Academic Section of Geriatric Medicine, Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK.
Stram DO; University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Sugiyama T; Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan.
Szymczak S; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Tang WHW; Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Tong L; Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Turjanmaa V; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland.
Ueshima H; Department of Health Science, Shiga University of Medical Science, Otsu, Japan.; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan.
Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Umemura S; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Vaarasmaki M; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.; Medical Research Center, University of Oulu, Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland.
van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
van Gilst WH; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
van Veldhuisen DJ; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Viikari JS; Division of Medicine, Turku University Hospital, Turku, Finland.; Department of Medicine, University of Turku, Turku, Finland.
Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Wang Y; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Wang A; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Wilson R; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Wong TY; Department of Ophthalmology, National University of Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Xiang YB; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Yamaguchi S; Third Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan.
Ye X; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Young RD; Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Young TL; Neuroscience and Behavioural Disorders (NBD) Program, Duke-National University of Singapore Graduate Medical School, Singapore.; Duke Eye Center, Duke University Medical Center, Durham, North Carolina, USA.
Yuan JM; Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
Zhou X; Bioinformatics Division, Tsinghua National Laboratory for Informatics Science and Technology (TNLIST), Ministry of Education Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Beijing, China.; Center for Synthetic and Systems Biology, TNLIST, Ministry of Education Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Beijing, China.; Department of Psychiatry, University of Hong Kong, Hong Kong.
Asselbergs FW; Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of the Netherlands (ICIN)-Netherlands Heart Institute, Utrecht, the Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.
Ciullo M; Institute of Genetics and Biophysics A Buzzati-Traverso, CNR, Naples, Italy.
Clarke R; Clinical Trials Support Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Deloukas P; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; King Abdulaziz University, Jeddah, Saudi Arabia.
Franke A; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Public Health and Clinical Medicine, Section for Family Medicine, Umeå Universitet, Umeå, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Franks S; Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, UK.
Friedlander Y; Hebrew University, School of Public Health, Jerusalem, Israel.
Gross MD; School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Guo Z; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Hansen T; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jarvelin MR; Institute of Health Sciences, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (PHE) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Center for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Jørgensen T; Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of the Netherlands (ICIN)-Netherlands Heart Institute, Utrecht, the Netherlands.; ICIN, Utrecht, the Netherlands.
Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland.
Kajio H; National Center for Global Health and Medicine, Toyama, Japan.
Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK.
Lee JY; Ministry of Health and Welfare, Seoul, Republic of Korea.; THERAGEN ETEX Bio Institute, Suwon, Republic of Korea.
Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland.
Linneberg A; Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Miki T; Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Pedersen O; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
Sørensen TIA; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Takayanagi R; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
Toniolo D; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy.
Ahsan H; Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
Allayee H; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.; Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Chen YT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Danesh J; Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.
Deary IJ; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK.
Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Franke L; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Heijman BT; Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Holbrook JD; Singapore Institute for Clinical Sciences (SICS), ASTAR, Singapore.
Isaacs A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Kim BJ; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Lin X; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Liu J; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.; Genome Institute of Singapore, ASTAR, Singapore.
März W; Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.; Synlab Academy, Synlab Services, Mannheim, Germany.
Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia.
Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Sanghera DK; Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Shu XO; Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.; Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
van Meurs JBJ; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Vithana E; Department of Ophthalmology, National University of Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Neuroscience and Behavioural Disorders (NBD) Program, Duke-National University of Singapore Graduate Medical School, Singapore.
Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Wijmenga C; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Wolffenbuttel BHW; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Yokota M; Department of Genome Science, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
Zheng W; Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.; Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Zhu D; State Key Laboratory of Medical Genetics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Hypertension, Shanghai, China.
Vineis P; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Kyrtopoulos SA; National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
Kleinjans JCS; Department of Toxicogenomics, Maastricht University, Maastricht, the Netherlands.
McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Soong R; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Department of Pathology, National University of Singapore, Singapore.
Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Scott J; National Heart and Lung Institute, Imperial College London, London, UK.
Teo YY; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.; Genome Institute of Singapore, ASTAR, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; National University of Singapore Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore.
He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Elliott P; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of the Netherlands (ICIN)-Netherlands Heart Institute, Utrecht, the Netherlands.
Kooner JS; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.; National Heart and Lung Institute, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, UK.
Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.; Imperial College Healthcare NHS Trust, London, UK. - Pokaż więcej
- Corporate Authors:
-
BIOS-consortium
CARDIo GRAMplusCD
LifeLines Cohort Study
InterAct Consortium - Źródło:
- Nature genetics [Nat Genet] 2015 Nov; Vol. 47 (11), pp. 1282-1293. Date of Electronic Publication: 2015 Sep 21.
- Typ publikacji:
- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
- MeSH Terms:
-
DNA Methylation*
Blood Pressure/*genetics
Genetic Loci/*genetics
Genome-Wide Association Study/*methods
Adult ; Aged ; Aged, 80 and over ; Asian People/genetics ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/ethnology ; Cardiovascular Diseases/genetics ; Female ; Genetic Predisposition to Disease/ethnology ; Genetic Predisposition to Disease/genetics ; Genetic Variation ; Genotype ; Humans ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Polymorphism, Single Nucleotide ; Regression Analysis ; Risk Factors ; White People/genetics
Czasopismo naukowe