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Tytuł:
Distinguishing activated T regulatory cell and T conventional cells by single-cell technologies.
Autorzy:
Reinhardt J; Center for Regenerative Therapies Dresden, Faculty of Medicine, TU Dresden, Dresden, Germany.
Sharma V; Center for Regenerative Therapies Dresden, Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD), Faculty of Medicine, Paul Langerhans Institute Dresden of Helmholtz Centre Munich at University Clinic Carl Gustav Carus of TU Dresden, Dresden, Germany.
Stavridou A; Center for Regenerative Therapies Dresden, Faculty of Medicine, TU Dresden, Dresden, Germany.
Lindner A; Center for Regenerative Therapies Dresden, Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD), Faculty of Medicine, Paul Langerhans Institute Dresden of Helmholtz Centre Munich at University Clinic Carl Gustav Carus of TU Dresden, Dresden, Germany.
Reinhardt S; Center for Molecular and Cellular Bioengineering (CMCB), DRESDEN-concept Genome Center, Technische Universität Dresden, Dresden, Germany.
Petzold A; Center for Molecular and Cellular Bioengineering (CMCB), DRESDEN-concept Genome Center, Technische Universität Dresden, Dresden, Germany.
Lesche M; Center for Molecular and Cellular Bioengineering (CMCB), DRESDEN-concept Genome Center, Technische Universität Dresden, Dresden, Germany.
Rost F; Center for Regenerative Therapies Dresden, Faculty of Medicine, TU Dresden, Dresden, Germany.; Center for Information Services and High-Performance Computing (ZIH), TU Dresden, Dresden, Germany.
Bonifacio E; Center for Regenerative Therapies Dresden, Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD), Faculty of Medicine, Paul Langerhans Institute Dresden of Helmholtz Centre Munich at University Clinic Carl Gustav Carus of TU Dresden, Dresden, Germany.
Eugster A; Center for Regenerative Therapies Dresden, Faculty of Medicine, TU Dresden, Dresden, Germany.
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Źródło:
Immunology [Immunology] 2022 May; Vol. 166 (1), pp. 121-137. Date of Electronic Publication: 2022 Mar 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lymphocyte Activation*
T-Lymphocytes, Regulatory*
Biomarkers/metabolism ; Flow Cytometry ; Forkhead Transcription Factors/metabolism ; Lymphocyte Count
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes.
Autorzy:
Syed F; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Tersey SA; Kovler Diabetes Center and Department of Medicine, The University of Chicago, 900 E. 57th Street, KCBD-8130, Chicago, IL, 60637, USA.
Turatsinze JV; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Felton JL; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Kang NJ; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Nelson JB; Kovler Diabetes Center and Department of Medicine, The University of Chicago, 900 E. 57th Street, KCBD-8130, Chicago, IL, 60637, USA.
Sims EK; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Defrance M; Laboratory for Cancer Epigenetics, Faculty of Medicine, and ULB Cancer Research Center, Université Libre de Bruxelles, Brussels, Belgium.
Bizet M; Laboratory for Cancer Epigenetics, Faculty of Medicine, and ULB Cancer Research Center, Université Libre de Bruxelles, Brussels, Belgium.
Fuks F; Laboratory for Cancer Epigenetics, Faculty of Medicine, and ULB Cancer Research Center, Université Libre de Bruxelles, Brussels, Belgium.
Cnop M; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.; Division of Endocrinology (ULB Erasmus Hospital), Université Libre de Bruxelles, Brussels, Belgium.
Bugliani M; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Marchetti P; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Ziegler AG; Technische Universität München, Munich, Germany.
Bonifacio E; Technische Universität Dresden, Dresden, Germany.
Webb-Robertson BJ; Pacific Northwest National Laboratory, Richland, WA, USA.
Balamurugan AN; Department of Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Department of Surgery, University of Cincinnati, Cincinnati, OH, 45229, USA.
Evans-Molina C; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.; Roudebush VA Medical Center, Indianapolis, IN, USA.
Eizirik DL; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.; Indiana Biosciences Research Institute, Indianapolis, IN, USA.
Mather KJ; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Arslanian S; Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Mirmira RG; Kovler Diabetes Center and Department of Medicine, The University of Chicago, 900 E. 57th Street, KCBD-8130, Chicago, IL, 60637, USA. .
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Źródło:
Clinical epigenetics [Clin Epigenetics] 2020 Jul 31; Vol. 12 (1), pp. 116. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Islets of Langerhans*
Cell Death/*genetics
Cell-Free Nucleic Acids/*blood
Diabetes Mellitus/*blood
Insulin/*blood
Nuclear Proteins/*blood
Pediatric Obesity/*blood
Transcription Factors/*blood
Cell-Free Nucleic Acids/genetics ; Child ; Diabetes Mellitus/genetics ; Female ; Humans ; Insulin/genetics ; Male ; Nuclear Proteins/genetics ; Pediatric Obesity/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Birth and coming of age of islet autoantibodies.
Autorzy:
Bonifacio E; Technische Universität Dresden, DFG Center for Regenerative Therapies Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital Carl Gustav Carus and Faculty of Medicine, TU Dresden, Dresden, Germany.
Achenbach P; Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.; Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Forschergruppe Diabetes, Munich, Germany.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2019 Dec; Vol. 198 (3), pp. 294-305. Date of Electronic Publication: 2019 Sep 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Autoantibodies/*immunology
Diabetes Mellitus, Type 1/*immunology
Islets of Langerhans/*immunology
Antibody Specificity/immunology ; Autoimmunity/immunology ; Diabetes Mellitus, Type 1/diagnosis ; Glutamate Decarboxylase/immunology ; Humans ; Mass Screening/methods ; Population Surveillance/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Landmark models to define the age-adjusted risk of developing stage 1 type 1 diabetes across childhood and adolescence.
Autorzy:
Hoffmann VS; Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstr. 1, 85764, Munich-Neuherberg, Germany.
Weiß A; Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstr. 1, 85764, Munich-Neuherberg, Germany.
Winkler C; Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstr. 1, 85764, Munich-Neuherberg, Germany.; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.
Knopff A; Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstr. 1, 85764, Munich-Neuherberg, Germany.
Jolink M; Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstr. 1, 85764, Munich-Neuherberg, Germany.; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.
Bonifacio E; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany. ezio.bonifacio@tu-dresden.de.; Technische Universität Dresden, DFG Center for Regenerative Therapies Dresden, Fetscherstrasse 105, 01307, Dresden, Germany. ezio.bonifacio@tu-dresden.de.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital Carl Gustav Carus and Faculty of Medicine, Dresden, TU, Germany. ezio.bonifacio@tu-dresden.de.
Ziegler AG; Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstr. 1, 85764, Munich-Neuherberg, Germany. .; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany. .; Forschergruppe Diabetes, Technical University Munich at Klinikum rechts der Isar, Munich, Germany. .
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Źródło:
BMC medicine [BMC Med] 2019 Jul 09; Vol. 17 (1), pp. 125. Date of Electronic Publication: 2019 Jul 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 1/*genetics
Age Factors ; Child ; Child, Preschool ; Cohort Studies ; Diabetes Mellitus, Type 1/pathology ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Neoplasm Staging ; Prospective Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Common patterns of gene regulation associated with Cesarean section and the development of islet autoimmunity - indications of immune cell activation.
Autorzy:
Laimighofer M; Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.; Department of Mathematics, Technische Universität München, Garching, Germany.
Lickert R; Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Fuerst R; Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Theis FJ; Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.; Department of Mathematics, Technische Universität München, Garching, Germany.
Winkler C; Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Bonifacio E; DFG Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Technische Universität Dresden, Dresden, Germany.
Ziegler AG; Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Krumsiek J; Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany. .; German Center for Diabetes Research (DZD), Neuherberg, Germany. .; Institute for Computational Biomedicine, Englander Institute for Precision Medicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Apr 18; Vol. 9 (1), pp. 6250. Date of Electronic Publication: 2019 Apr 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation*
Autoimmunity/*genetics
Cesarean Section/*adverse effects
Islets of Langerhans/*immunology
Autoantibodies/blood ; CD4-Positive T-Lymphocytes ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/immunology ; Female ; Humans ; Infant ; Leukocytes, Mononuclear/physiology ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.
Autorzy:
Bonifacio E; DFG-Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Beyerlein A; Institute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany.; Forschergruppe Diabetes, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany.; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, Munich, Germany.
Hippich M; Institute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany.; Forschergruppe Diabetes, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany.; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, Munich, Germany.
Winkler C; Institute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany.; Forschergruppe Diabetes, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany.; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, Munich, Germany.
Vehik K; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America.
Weedon MN; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, United Kingdom.
Laimighofer M; Institute of Computational Biology, Helmholtz Zentrum München, Munich, Germany.
Hattersley AT; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, United Kingdom.
Krumsiek J; Institute of Computational Biology, Helmholtz Zentrum München, Munich, Germany.
Frohnert BI; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, United States of America.
Steck AK; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, United States of America.
Hagopian WA; Pacific Northwest Diabetes Research Institute, Seattle, Washington, United States of America.
Krischer JP; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America.
Lernmark Å; Department of Clinical Sciences, Clinical Research Centre, Skåne University Hospital, Lund University, Malmo, Sweden.
Rewers MJ; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, United States of America.
She JX; Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, United States of America.
Toppari J; Department of Pediatrics, Turku University Hospital, Turku, Finland.; Department of Physiology, University of Turku, Turku, Finland.
Akolkar B; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Oram RA; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, United Kingdom.; Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada.; National Institute for Health Research, Exeter Clinical Research Facility, Exeter, United Kingdom.
Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America.
Ziegler AG; Institute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany.; Forschergruppe Diabetes, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany.; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, Munich, Germany.
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Corporate Authors:
TEDDY Study Group
Źródło:
PLoS medicine [PLoS Med] 2018 Apr 03; Vol. 15 (4), pp. e1002548. Date of Electronic Publication: 2018 Apr 03 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Genetic Testing*
Autoantibodies/*metabolism
Diabetes Mellitus, Type 1/*genetics
Diabetes Mellitus, Type 1/*immunology
Islets of Langerhans/*immunology
Case-Control Studies ; Child ; Child, Preschool ; Family ; Female ; Genetic Predisposition to Disease ; Humans ; Infant ; Infant, Newborn ; Male ; Risk Assessment ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Generation of high-avidity, WT1-reactive CD8+ cytotoxic T cell clones with anti-leukemic activity by streptamer technology.
Autorzy:
Tunger A; a Institute of Immunology, Medical Faculty , TU Dresden , Dresden , Germany.
Wehner R; a Institute of Immunology, Medical Faculty , TU Dresden , Dresden , Germany.; b National Center for Tumor Diseases , University Hospital Carl Gustav Carus, TU Dresden , Germany.
von Bonin M; b National Center for Tumor Diseases , University Hospital Carl Gustav Carus, TU Dresden , Germany.; c Department of Medicine I , University Hospital of Dresden , Dresden , Germany.; d German Cancer Consortium (DKTK) , Dresden , Germany.; e German Cancer Research Center (DKFZ) , Heidelberg , Germany.
Kühn D; f Center for Regenerative Therapies Dresden (CRTD), Medical Faculty, TU Dresden , Dresden , Germany.
Heidenreich F; c Department of Medicine I , University Hospital of Dresden , Dresden , Germany.
Matko S; g Institute of Transfusion Medicine, German Red Cross Blood Donation Service North-East , Dresden , Germany.
Nauerth M; h Institute for Medical Microbiology, Immunology and Hygiene, TU Munich , Munich , Germany.
Rücker-Braun E; c Department of Medicine I , University Hospital of Dresden , Dresden , Germany.
Dietz S; f Center for Regenerative Therapies Dresden (CRTD), Medical Faculty, TU Dresden , Dresden , Germany.
Link CS; c Department of Medicine I , University Hospital of Dresden , Dresden , Germany.; f Center for Regenerative Therapies Dresden (CRTD), Medical Faculty, TU Dresden , Dresden , Germany.
Eugster A; f Center for Regenerative Therapies Dresden (CRTD), Medical Faculty, TU Dresden , Dresden , Germany.
Odendahl M; g Institute of Transfusion Medicine, German Red Cross Blood Donation Service North-East , Dresden , Germany.
Busch DH; h Institute for Medical Microbiology, Immunology and Hygiene, TU Munich , Munich , Germany.
Tonn T; d German Cancer Consortium (DKTK) , Dresden , Germany.; e German Cancer Research Center (DKFZ) , Heidelberg , Germany.; f Center for Regenerative Therapies Dresden (CRTD), Medical Faculty, TU Dresden , Dresden , Germany.; g Institute of Transfusion Medicine, German Red Cross Blood Donation Service North-East , Dresden , Germany.
Bonifacio E; f Center for Regenerative Therapies Dresden (CRTD), Medical Faculty, TU Dresden , Dresden , Germany.
Germeroth L; i Juno Therapeutics GmbH , Göttingen , Germany.
Schetelig J; c Department of Medicine I , University Hospital of Dresden , Dresden , Germany.
Bachmann MP; b National Center for Tumor Diseases , University Hospital Carl Gustav Carus, TU Dresden , Germany.; d German Cancer Consortium (DKTK) , Dresden , Germany.; e German Cancer Research Center (DKFZ) , Heidelberg , Germany.; f Center for Regenerative Therapies Dresden (CRTD), Medical Faculty, TU Dresden , Dresden , Germany.; j Department of Radioimmunology , Institute of Radiopharmaceutical Cancer Research, Helmholtz Center Dresden-Rossendorf , Dresden , Germany.
Bornhäuser M; b National Center for Tumor Diseases , University Hospital Carl Gustav Carus, TU Dresden , Germany.; c Department of Medicine I , University Hospital of Dresden , Dresden , Germany.; d German Cancer Consortium (DKTK) , Dresden , Germany.; e German Cancer Research Center (DKFZ) , Heidelberg , Germany.; f Center for Regenerative Therapies Dresden (CRTD), Medical Faculty, TU Dresden , Dresden , Germany.
Schmitz M; a Institute of Immunology, Medical Faculty , TU Dresden , Dresden , Germany.; b National Center for Tumor Diseases , University Hospital Carl Gustav Carus, TU Dresden , Germany.; d German Cancer Consortium (DKTK) , Dresden , Germany.; e German Cancer Research Center (DKFZ) , Heidelberg , Germany.; f Center for Regenerative Therapies Dresden (CRTD), Medical Faculty, TU Dresden , Dresden , Germany.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2017 May; Vol. 58 (5), pp. 1246-1249. Date of Electronic Publication: 2016 Nov 16.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Cytotoxicity, Immunologic*
Clonal Evolution/*immunology
Leukemia/*immunology
T-Lymphocytes, Cytotoxic/*immunology
WT1 Proteins/*immunology
Amino Acid Sequence ; Biomarkers ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Coculture Techniques ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Epitopes, T-Lymphocyte/immunology ; Humans ; Immunophenotyping ; Leukemia/metabolism ; Peptides/immunology ; T-Cell Antigen Receptor Specificity ; WT1 Proteins/chemistry
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CD8 T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage.
Autorzy:
Fuchs YF; DFG Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Eugster A; DFG Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Dietz S; DFG Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Sebelefsky C; Institute of Diabetes Research, Helmholtz Zentrum München, Neuherberg, Germany.
Kühn D; DFG Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Wilhelm C; DFG Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Lindner A; DFG Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Gavrisan A; Forschergruppe Diabetes e.V., Neuherberg, Germany.
Knoop J; Institute of Diabetes Research, Helmholtz Zentrum München, Neuherberg, Germany.; Forschergruppe Diabetes e.V., Neuherberg, Germany.
Dahl A; Deep-Sequencing Facility SFB655, Biotechnology Center, Technische Universität Dresden, Dresden, Germany.
Ziegler AG; Institute of Diabetes Research, Helmholtz Zentrum München, Neuherberg, Germany.; Forschergruppe Diabetes e.V., Neuherberg, Germany.; Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Bonifacio E; DFG Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.; Forschergruppe Diabetes e.V., Neuherberg, Germany.
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Źródło:
Scientific reports [Sci Rep] 2017 Mar 16; Vol. 7, pp. 44661. Date of Electronic Publication: 2017 Mar 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autoantigens/*metabolism
CD8-Positive T-Lymphocytes/*immunology
Glucose-6-Phosphatase/*metabolism
Islets of Langerhans/*metabolism
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
Amino Acid Motifs ; Amino Acid Sequence ; Clone Cells ; Female ; Glucose-6-Phosphatase/chemistry ; Humans ; Male ; Sequence Analysis, Protein ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
T cell receptor repertoires after adoptive transfer of expanded allogeneic regulatory T cells.
Autorzy:
Theil A; DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.; Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Wilhelm C; DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.
Kuhn M; Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, Dresden, Germany.
Petzold A; Deep Sequencing Group, Biotechnology Center, Technische Universität Dresden, Dresden, Germany.
Tuve S; Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Oelschlägel U; Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Dahl A; Deep Sequencing Group, Biotechnology Center, Technische Universität Dresden, Dresden, Germany.
Bornhäuser M; Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Bonifacio E; DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.
Eugster A; DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2017 Feb; Vol. 187 (2), pp. 316-324. Date of Electronic Publication: 2016 Nov 27.
Typ publikacji:
Journal Article
MeSH Terms:
Hematopoietic Stem Cell Transplantation*
Graft vs Host Disease/*diagnosis
Immunotherapy, Adoptive/*methods
Receptors, Antigen, T-Cell, alpha-beta/*genetics
T-Lymphocytes, Regulatory/*physiology
Cell Proliferation ; Cells, Cultured ; Female ; Graft vs Host Disease/prevention & control ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Middle Aged ; Prognosis ; T-Lymphocytes, Regulatory/transplantation ; Transplantation, Homologous ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Incomplete immune response to coxsackie B viruses associates with early autoimmunity against insulin.
Autorzy:
Ashton MP; DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.
Eugster A; DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.
Walther D; DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.
Daehling N; DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.
Riethausen S; Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Neuherberg, Germany.
Kuehn D; DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.
Klingel K; Department of Molecular Pathology, University Hospital Tübingen, Tübingen, Germany.
Beyerlein A; Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Neuherberg, Germany.
Zillmer S; Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Neuherberg, Germany.
Ziegler AG; Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Neuherberg, Germany.; Forschergruppe Diabetes e.V., Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Bonifacio E; DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.; Forschergruppe Diabetes e.V., Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
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Źródło:
Scientific reports [Sci Rep] 2016 Sep 08; Vol. 6, pp. 32899. Date of Electronic Publication: 2016 Sep 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autoimmunity*
Coxsackievirus Infections/*immunology
Diabetes Mellitus, Type 1/*virology
Enterovirus B, Human/*immunology
Insulin/*immunology
Adolescent ; Antibodies/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Capsid Proteins/immunology ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/immunology ; Female ; Glutamate Decarboxylase/immunology ; Glutamate Decarboxylase/metabolism ; Humans ; Male
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Validation of a rapid type 1 diabetes autoantibody screening assay for community-based screening of organ donors to identify subjects at increased risk for the disease.
Autorzy:
Wasserfall C; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL.
Montgomery E; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL.
Yu L; Univeristy of Colorado, Aurora.
Michels A; Univeristy of Colorado, Aurora.
Gianani R; Rocky Vista University, Parker, CO.
Pugliese A; University of Miami, Miami, FL.
Nierras C; JDRF, New York, NY.
Kaddis JS; City of Hope, Duarte, CA.
Schatz DA; Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA.
Bonifacio E; Technical University of Dresden, Dresden, Germany.
Atkinson MA; Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2016 Jul; Vol. 185 (1), pp. 33-41. Date of Electronic Publication: 2016 May 04.
Typ publikacji:
Journal Article; Validation Study
MeSH Terms:
Autoantibodies/*blood
Donor Selection/*standards
Enzyme-Linked Immunosorbent Assay/*standards
Tissue Donors/*supply & distribution
Adolescent ; Adult ; Area Under Curve ; Cation Transport Proteins/antagonists & inhibitors ; Cation Transport Proteins/genetics ; Cation Transport Proteins/immunology ; Child ; Diabetes Mellitus, Type 1/pathology ; Diabetes Mellitus, Type 1/surgery ; Female ; Glutamate Decarboxylase/antagonists & inhibitors ; Glutamate Decarboxylase/genetics ; Glutamate Decarboxylase/immunology ; Humans ; Male ; Middle Aged ; Receptor-Like Protein Tyrosine Phosphatases, Class 8/antagonists & inhibitors ; Receptor-Like Protein Tyrosine Phosphatases, Class 8/genetics ; Receptor-Like Protein Tyrosine Phosphatases, Class 8/immunology ; Risk ; Sensitivity and Specificity ; Zinc Transporter 8
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Abundant cytomegalovirus (CMV) reactive clonotypes in the CD8(+) T cell receptor alpha repertoire following allogeneic transplantation.
Autorzy:
Link CS; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus.; DFG Research Center for Regenerative Therapies Dresden, Dresden, Germany.
Eugster A; DFG Research Center for Regenerative Therapies Dresden, Dresden, Germany.
Heidenreich F; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus.
Rücker-Braun E; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus.
Schmiedgen M; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus.
Oelschlägel U; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus.
Kühn D; DFG Research Center for Regenerative Therapies Dresden, Dresden, Germany.
Dietz S; DFG Research Center for Regenerative Therapies Dresden, Dresden, Germany.
Fuchs Y; DFG Research Center for Regenerative Therapies Dresden, Dresden, Germany.
Dahl A; DFG Research Center for Regenerative Therapies Dresden, Dresden, Germany.; BIOTEChnology Center, TU Dresden, Dresden, Germany.
Domingues AM; DFG Research Center for Regenerative Therapies Dresden, Dresden, Germany.
Klesse C; DKMS Clinical Trials Unit, Dresden, Germany.
Schmitz M; DFG Research Center for Regenerative Therapies Dresden, Dresden, Germany.; Institut Für Immunologie, Medizinische Fakultät, TU Dresden, Dresden, Germany.
Ehninger G; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus.; DFG Research Center for Regenerative Therapies Dresden, Dresden, Germany.
Bornhäuser M; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus.; DFG Research Center for Regenerative Therapies Dresden, Dresden, Germany.
Schetelig J; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus.; DKMS Clinical Trials Unit, Dresden, Germany.
Bonifacio E; DFG Research Center for Regenerative Therapies Dresden, Dresden, Germany.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2016 Jun; Vol. 184 (3), pp. 389-402. Date of Electronic Publication: 2016 Mar 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, Viral/*immunology
CD8-Positive T-Lymphocytes/*immunology
Cytomegalovirus/*immunology
Cytomegalovirus Infections/*immunology
Epitopes/*immunology
Hematopoietic Stem Cell Transplantation/*adverse effects
Receptors, Antigen, T-Cell, alpha-beta/*immunology
Aged ; Amino Acid Sequence ; Antigens, Viral/genetics ; CD8-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/virology ; Clone Cells ; Cytomegalovirus/growth & development ; Cytomegalovirus Infections/etiology ; Cytomegalovirus Infections/genetics ; Cytomegalovirus Infections/virology ; Epitopes/genetics ; Female ; Gene Expression Regulation ; HLA-A2 Antigen/genetics ; HLA-A2 Antigen/immunology ; Humans ; Immunologic Memory ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy ; Leukemia, Myeloid, Acute/immunology ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/therapy ; Male ; Middle Aged ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Sequence Analysis, DNA ; Signal Transduction ; Single-Cell Analysis ; Transplantation, Homologous
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Longitudinal Frequencies of Blood Leukocyte Subpopulations Differ between NOD and NOR Mice but Do Not Predict Diabetes in NOD Mice.
Autorzy:
Telieps T; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
Köhler M; Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
Treise I; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Trogerstraße 30, 81675 Munich, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
Foertsch K; Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; Forschergruppe Diabetes e.V., Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
Adler T; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Trogerstraße 30, 81675 Munich, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
Busch DH; Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Trogerstraße 30, 81675 Munich, Germany.
Hrabě de Angelis M; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; School of Life Science Weihenstephan, Technical University of Munich, Alte Akademie 8, 85354 Freising, Germany.
Verschoor A; Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Trogerstraße 30, 81675 Munich, Germany; Institute for Systemic Inflammation Research, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Adler K; Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; Forschergruppe Diabetes e.V., Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
Bonifacio E; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; Forschergruppe Diabetes e.V., Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; DFG Research Center for Regenerative Therapies Dresden, Medical Faculty, Technische Universität Dresden, Fetscherstrasse 105, 01307 Dresden, Germany.
Ziegler AG; Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; Forschergruppe Diabetes e.V., Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
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Źródło:
Journal of diabetes research [J Diabetes Res] 2016; Vol. 2016, pp. 4208156. Date of Electronic Publication: 2016 Feb 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 1/*immunology
Leukocytes/*immunology
Age Factors ; Animals ; Autoantibodies/blood ; Biomarkers/blood ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/genetics ; Female ; Genetic Predisposition to Disease ; Immunophenotyping ; Insulin/immunology ; Leukocyte Count ; Mice, Inbred NOD ; Phenotype ; Species Specificity ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
IGRP and insulin vaccination induce CD8+ T cell-mediated autoimmune diabetes in the RIP-CD80GP mouse.
Autorzy:
Fuchs YF; DFG - Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany; Paul Langerhans Institute Dresden-German Center for Diabetes Research (DZD), Dresden, Germany.
Adler K
Lindner A
Karasinsky A
Wilhelm C
Weigelt M
Balke H
Förtsch K
Mortler-Hildebrandt LF
Harlan DM
Pechhold K
Ziegler AG
Bonifacio E
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2014 May; Vol. 176 (2), pp. 199-206.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CD8-Positive T-Lymphocytes/*immunology
Diabetes Mellitus, Type 1/*immunology
Glucose-6-Phosphatase/*immunology
Insulin/*immunology
Protein Precursors/*immunology
Vaccination/*methods
Animals ; B7-1 Antigen/genetics ; B7-1 Antigen/immunology ; CD8-Positive T-Lymphocytes/metabolism ; DNA/genetics ; DNA/immunology ; Diabetes Mellitus, Type 1/etiology ; Diabetes Mellitus, Type 1/genetics ; Freund's Adjuvant/immunology ; Glucose-6-Phosphatase/genetics ; Glycoproteins/genetics ; Glycoproteins/immunology ; Insulin/genetics ; Islets of Langerhans/immunology ; Kaplan-Meier Estimate ; Lipids/immunology ; Lymphocytic choriomeningitis virus/genetics ; Lymphocytic choriomeningitis virus/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Promoter Regions, Genetic/genetics ; Promoter Regions, Genetic/immunology ; Protein Precursors/genetics ; Rats ; Time Factors ; Vaccination/adverse effects ; Vaccines, DNA/immunology ; Viral Proteins/genetics ; Viral Proteins/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A genomic toolkit to investigate kinesin and myosin motor function in cells.
Autorzy:
Maliga Z; Max-Planck Institute for Cell Biology and Genetics (CBG), Dresden 01307, Germany. />Junqueira M
Toyoda Y
Ettinger A
Mora-Bermúdez F
Klemm RW
Vasilj A
Guhr E
Ibarlucea-Benitez I
Poser I
Bonifacio E
Huttner WB
Shevchenko A
Hyman AA
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Źródło:
Nature cell biology [Nat Cell Biol] 2013 Mar; Vol. 15 (3), pp. 325-34. Date of Electronic Publication: 2013 Feb 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genomics*
Cell Movement/*physiology
Embryonic Stem Cells/*metabolism
Kinesins/*metabolism
Microtubule-Associated Proteins/*metabolism
Myosins/*metabolism
Animals ; Biological Transport ; Biomarkers/metabolism ; Blotting, Western ; Centrosome/metabolism ; Chromatography, Affinity ; Chromosomes, Artificial, Bacterial ; Embryonic Stem Cells/cytology ; Fluorescent Antibody Technique ; Gene Expression Profiling ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HeLa Cells ; Humans ; Immunoprecipitation ; Kinesins/genetics ; Mice ; Mice, Transgenic ; Microtubule-Associated Proteins/genetics ; Microtubules ; Mitosis/physiology ; Myosins/genetics ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Neurons/cytology ; Neurons/metabolism ; Oligonucleotide Array Sequence Analysis ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Phylogeny ; Protein Multimerization ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Stem Cells/cytology ; Stem Cells/metabolism ; Transgenes/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes.
Autorzy:
Winkler C; Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität, München, Germany.
Krumsiek J
Lempainen J
Achenbach P
Grallert H
Giannopoulou E
Bunk M
Theis FJ
Bonifacio E
Ziegler AG
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Źródło:
Genes and immunity [Genes Immun] 2012 Oct; Vol. 13 (7), pp. 549-55. Date of Electronic Publication: 2012 Aug 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease*
Diabetes Mellitus, Type 1/*genetics
Adolescent ; Child ; Child, Preschool ; Gene Frequency ; Genetic Loci ; HLA Antigens/genetics ; Humans ; Infant ; Polymorphism, Single Nucleotide ; Prospective Studies ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The effect of gestation and fetal mismatching on the development of autoimmune diabetes in non-obese diabetic mice.
Autorzy:
Adler K; Diabetes Research Institute, Forschergruppe Diabetes e.V, Munich, Germany.
Krause S
Fuchs YF
Foertsch K
Ziegler AG
Bonifacio E
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2012 Jun; Vol. 168 (3), pp. 274-8.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Histocompatibility*/immunology
Diabetes Mellitus, Type 1/*immunology
Insulin-Secreting Cells/*pathology
Animals ; Diabetes Mellitus, Type 1/pathology ; Disease Models, Animal ; Female ; Humans ; Immunity, Maternally-Acquired ; Isoantigens/immunology ; Male ; Maternal-Fetal Exchange ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Pregnancy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Insulin autoantibodies with high affinity to the bovine milk protein alpha casein.
Autorzy:
Adler K; Diabetes Research Institute, Forschergruppe Diabetes e.V., Munich Center for Regenerative Therapies - Dresden, Dresden University of Technology, Dresden, Germany.
Mueller DB
Achenbach P
Krause S
Heninger AK
Ziegler AG
Bonifacio E
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2011 Apr; Vol. 164 (1), pp. 42-9. Date of Electronic Publication: 2011 Mar 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Autoantibodies/*immunology
Caseins/*immunology
Insulin/*immunology
Insulin Antibodies/*immunology
Adolescent ; Animals ; Autoantibodies/metabolism ; Binding, Competitive ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Caseins/metabolism ; Caseins/pharmacology ; Cattle ; Cell Proliferation/drug effects ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/metabolism ; Flow Cytometry ; Humans ; Infant ; Infant Food ; Insulin/metabolism ; Insulin/pharmacology ; Insulin Antibodies/metabolism ; Iodine Radioisotopes ; Milk Proteins/immunology ; Milk Proteins/metabolism ; Milk Proteins/pharmacology ; Protein Binding ; Serum Albumin, Bovine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice.
Autorzy:
Melzi R; San Raffaele Diabetes Research Institute (HSR-DRI), Division of Immunology, Transplantation and Infectious Disease, San Raffaele Scientific Institute, Milan, Italy.
Antonioli B
Mercalli A
Battaglia M
Valle A
Pluchino S
Galli R
Sordi V
Bosi E
Martino G
Bonifacio E
Doglioni C
Piemonti L
Pokaż więcej
Źródło:
PloS one [PLoS One] 2010 Apr 27; Vol. 5 (4), pp. e10357. Date of Electronic Publication: 2010 Apr 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transplantation Tolerance*
Diabetes Mellitus, Experimental/*therapy
Graft Rejection/*prevention & control
Islets of Langerhans Transplantation/*methods
Stem Cell Transplantation/*methods
Adult Stem Cells ; Animals ; Islets of Langerhans ; Islets of Langerhans Transplantation/adverse effects ; Mice ; Mice, Inbred BALB C ; Neoplasms/etiology ; Neoplasms/pathology ; Neoplastic Stem Cells/pathology ; Neurons ; Stem Cell Transplantation/adverse effects ; Transplantation, Homologous
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Immunomagnetic isolation of CD4+CD25+FoxP3+ natural T regulatory lymphocytes for clinical applications.
Autorzy:
Di Ianni M; Department of Internal Medicine and Public Health, Chair of Hematology, University of L'Aquila, Italy. />Del Papa B
Cecchini D
Bonifacio E
Moretti L
Zei T
Ostini RI
Falzetti F
Fontana L
Tagliapietra G
Maldini C
Martelli MF
Tabilio A
Pokaż więcej
Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2009 May; Vol. 156 (2), pp. 246-53. Date of Electronic Publication: 2009 Mar 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CD4-Positive T-Lymphocytes/*cytology
Forkhead Transcription Factors/*immunology
Interleukin-2 Receptor alpha Subunit/*immunology
Adult ; CD4-Positive T-Lymphocytes/immunology ; Forkhead Transcription Factors/genetics ; Humans ; Immunomagnetic Separation ; Immunophenotyping/methods ; Interleukin-2 Receptor alpha Subunit/analysis ; Interleukin-5 Receptor alpha Subunit/analysis ; Interleukin-7 Receptor alpha Subunit/genetics ; Leukapheresis/methods ; Middle Aged ; Phenotype ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Spectral Karyotyping/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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