Autor: "Borghans LGJM" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: First-in-human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS-penetrant soluble guanylyl cyclase stimulator.
Autorzy:: van Kraaij SJW; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.
Gal P; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.
Borghans LGJM; Centre for Human Drug Research, Leiden, The Netherlands.
Klaassen ES; Centre for Human Drug Research, Leiden, The Netherlands.
Dijkstra F; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.
Winrow C; Cyclerion Therapeutics, Cambridge, Massachusetts, USA.
Glasser C; Cyclerion Therapeutics, Cambridge, Massachusetts, USA.
Groeneveld GJ; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.; Pokaż więcej
Źródło:: Clinical and translational science [Clin Transl Sci] 2023 Aug; Vol. 16 (8), pp. 1381-1395. Date of Electronic Publication: 2023 May 03.
Typ publikacji:: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Neurodegenerative Diseases*
Humans ; Area Under Curve ; Central Nervous System ; Dose-Response Relationship, Drug ; Double-Blind Method ; Soluble Guanylyl Cyclase ; Vasodilator Agents

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Skocz do pozycji: 2.

Tytuł:: The effects of the soluble guanylate cyclase stimulator riociguat on memory performance in healthy volunteers with a biperiden-induced memory impairment.
Autorzy:: Borghans LGJM; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands. lgjm.borghans@maastrichtuniversity.nl.
Sambeth A; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands.
Prickaerts J; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Faculty of Medicine, Health & Life Science, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
Ramaekers JG; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands.
Blokland A; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands.; Pokaż więcej
Źródło:: Psychopharmacology [Psychopharmacology (Berl)] 2018 Aug; Vol. 235 (8), pp. 2407-2416. Date of Electronic Publication: 2018 Jun 07.
Typ publikacji:: Journal Article; Randomized Controlled Trial
MeSH Terms:: Cognition/*drug effects
Enzyme Activators/*pharmacology
Memory/*drug effects
Memory Disorders/*drug therapy
Pyrazoles/*pharmacology
Pyrimidines/*pharmacology
Soluble Guanylyl Cyclase/*pharmacology
Adult ; Attention/drug effects ; Biperiden/pharmacology ; Blood Pressure/drug effects ; Cross-Over Studies ; Double-Blind Method ; Female ; Guanylate Cyclase ; Heart Rate/drug effects ; Humans ; Male ; Reaction Time/drug effects ; Signal Transduction ; Verbal Learning/drug effects ; Young Adult

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