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Tytuł :
Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever.
Autorzy :
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Maurer DP; Adimab, LLC, Lebanon, NH 03766, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA; The Geneva Foundation, Tacoma, WA 98402, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Vergnolle O; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Cross RW; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77550, USA.
Abelson DM; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Moyer CL; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Mishra AK; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Aguilan JT; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Pauli NT; Adimab, LLC, Lebanon, NH 03766, USA.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Nyakatura EK; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Hellert J; Structural Virology Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, Paris 75724, France.
Quevedo G; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Lobel L; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Balinandi S; Uganda Virus Research Institute, Entebbe, Uganda.
Lutwama JJ; Uganda Virus Research Institute, Entebbe, Uganda.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Geisbert TW; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77550, USA.
Rey FA; Structural Virology Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, Paris 75724, France.
Sidoli S; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
McLellan JS; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Lai JR; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA. Electronic address: zachary.bornholdt@mappbio.com.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Electronic address: .
Walker LM; Adimab, LLC, Lebanon, NH 03766, USA; Adagio Therapeutics, Inc., Waltham, MA 02451, USA. Electronic address: .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 May 26. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins.
Autorzy :
Dang HV; Department of Biochemistry, University of Washington, Seattle, WA, USA.
Cross RW; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Borisevich V; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
West BR; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Chan YP; Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Mire CE; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Da Silva SC; Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Dimitrov AS; Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Yan L; Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Amaya M; Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Navaratnarajah CK; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Geisbert TW; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Broder CC; Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Veesler D; Department of Biochemistry, University of Washington, Seattle, WA, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 May; Vol. 28 (5), pp. 426-434. Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Combination therapy protects macaques against advanced Marburg virus disease.
Autorzy :
Cross RW; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.
Bornholdt ZA; Mapp Biopharmaceutical, Inc., 6160 Lusk Blvd Ste C200, San Diego, CA, USA.
Prasad AN; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.
Borisevich V; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.
Agans KN; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.
Deer DJ; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.
Abelson DM; Mapp Biopharmaceutical, Inc., 6160 Lusk Blvd Ste C200, San Diego, CA, USA.
Kim DH; Mapp Biopharmaceutical, Inc., 6160 Lusk Blvd Ste C200, San Diego, CA, USA.
Shestowsky WS; Mapp Biopharmaceutical, Inc., 6160 Lusk Blvd Ste C200, San Diego, CA, USA.
Campbell LA; Mapp Biopharmaceutical, Inc., 6160 Lusk Blvd Ste C200, San Diego, CA, USA.
Bunyan E; Gilead Sciences, Inc., 333 Lakeside Dr, Foster City, CA, USA.
Geisbert JB; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.
Fenton KA; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA.
Zeitlin L; Mapp Biopharmaceutical, Inc., 6160 Lusk Blvd Ste C200, San Diego, CA, USA. .
Porter DP; Gilead Sciences, Inc., 333 Lakeside Dr, Foster City, CA, USA. .
Geisbert TW; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA. .; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 25; Vol. 12 (1), pp. 1891. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Adenosine Monophosphate/*analogs & derivatives
Alanine/*analogs & derivatives
Antibodies, Monoclonal/*therapeutic use
Antibodies, Viral/*therapeutic use
Marburg Virus Disease/*drug therapy
Marburgvirus/*drug effects
Adenosine Monophosphate/therapeutic use ; Alanine/therapeutic use ; Animals ; Disease Models, Animal ; Drug Therapy, Combination ; Macaca mulatta ; Marburg Virus Disease/prevention & control ; Viral Load/drug effects
Czasopismo naukowe
Tytuł :
Therapy for Argentine hemorrhagic fever in nonhuman primates with a humanized monoclonal antibody.
Autorzy :
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121; .
Cross RW; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Geisbert JB; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Borisevich V; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Agans KN; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Prasad AN; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Enterlein S; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878.
Aman MJ; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878.
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Brennan MB; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Campbell L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Kim D; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Mlakar N; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Moyer CL; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Pauly MH; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Shestowsky W; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Whaley KJ; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Fenton KA; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Geisbert TW; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Mar 16; Vol. 118 (11).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antibodies, Monoclonal, Humanized/*pharmacology
Antibodies, Viral/*pharmacology
Hemorrhagic Fever, American/*prevention & control
Junin virus/*metabolism
Animals ; Disease Models, Animal ; Female ; Guinea Pigs ; Hemorrhagic Fever, American/blood ; Humans ; Macaca fascicularis
Czasopismo naukowe
Tytuł :
Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers.
Autorzy :
Wan W; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany.
Clarke M; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Norris MJ; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, United States.
Kolesnikova L; Institut für Virologie, Philipps-Universität Marburg, Hans-Meerwein-Straße, Marburg, Germany.
Koehler A; Institut für Virologie, Philipps-Universität Marburg, Hans-Meerwein-Straße, Marburg, Germany.
Bornholdt ZA; The Scripps Research Institute, La Jolla, United States.
Becker S; Institut für Virologie, Philipps-Universität Marburg, Hans-Meerwein-Straße, Marburg, Germany.
Saphire EO; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, United States.
Briggs JA; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
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Źródło :
ELife [Elife] 2020 Oct 05; Vol. 9. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Multimerization*
Ebolavirus/*physiology
Marburgvirus/*physiology
Viral Matrix Proteins/*chemistry
Cell Membrane/physiology ; Ebolavirus/chemistry ; Marburgvirus/chemistry
Czasopismo naukowe
Tytuł :
Prior vaccination with rVSV-ZEBOV does not interfere with but improves efficacy of postexposure antibody treatment.
Autorzy :
Cross RW; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.
Bornholdt ZA; Mapp Biopharmaceutical Inc., 6160 Lusk Blvd Ste C200, San Diego, CA, 92121, USA.
Prasad AN; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.
Geisbert JB; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.
Borisevich V; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.
Agans KN; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.
Deer DJ; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.
Melody K; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.
Fenton KA; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA.
Feldmann H; Laboratory of Virology, Division of Intramural Research, NIAID/NIH, Hamilton, MT, 59840, USA.
Sprecher A; Médecins Sans Frontières, Rue Arbre Benit 46, 1050, Brussels, Belgium.
Zeitlin L; Mapp Biopharmaceutical Inc., 6160 Lusk Blvd Ste C200, San Diego, CA, 92121, USA.
Geisbert TW; Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA. .; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0610, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 27; Vol. 11 (1), pp. 3736. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
Post-Exposure Prophylaxis*
Vaccination*
Antibodies, Monoclonal/*therapeutic use
Antibodies, Viral/*therapeutic use
Ebola Vaccines/*immunology
Hemorrhagic Fever, Ebola/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Vesicular stomatitis Indiana virus/*immunology
Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/immunology ; Antibodies, Viral/administration & dosage ; Antibodies, Viral/immunology ; Hemorrhagic Fever, Ebola/pathology ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Kaplan-Meier Estimate ; Macaca mulatta ; Treatment Outcome ; Viral Load/immunology
Czasopismo naukowe
Tytuł :
Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38.
Autorzy :
Mishra AK; Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA.
Moyer CL; Mapp Biopharmaceutical, San Diego, California, USA.
Abelson DM; Mapp Biopharmaceutical, San Diego, California, USA.
Deer DJ; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
El Omari K; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom.
Duman R; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom.
Lobel L; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Lutwama JJ; Department of Arbovirology, Emerging and Re-emerging Infection, Uganda Virus Research Institute, Entebbe, Uganda.
Dye JM; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Wagner A; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Cross RW; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Geisbert TW; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Zeitlin L; Mapp Biopharmaceutical, San Diego, California, USA.
Bornholdt ZA; Mapp Biopharmaceutical, San Diego, California, USA.
McLellan JS; Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA .
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Źródło :
Journal of virology [J Virol] 2020 Mar 31; Vol. 94 (8). Date of Electronic Publication: 2020 Mar 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Glycoproteins/*chemistry
Glycoproteins/*genetics
Hemorrhagic Fever Virus, Crimean-Congo/*genetics
Hemorrhagic Fever Virus, Crimean-Congo/*metabolism
Animals ; Antibodies, Viral/immunology ; Cloning, Molecular ; Crystallography, X-Ray ; Disease Models, Animal ; Female ; Glycoproteins/metabolism ; Hemorrhagic Fever, Crimean/immunology ; Hemorrhagic Fever, Crimean/mortality ; Hemorrhagic Fever, Crimean/prevention & control ; Hemorrhagic Fever, Crimean/virology ; Humans ; Intercellular Signaling Peptides and Proteins ; Mice ; Mice, Knockout ; Models, Molecular ; Protein Conformation ; STAT1 Transcription Factor/genetics ; Sequence Analysis, Protein
Czasopismo naukowe
Tytuł :
Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine.
Autorzy :
Wec AZ; Adimab, LLC, Lebanon, NH 03766.
Haslwanter D; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Abdiche YN; Carterra Inc., Salt Lake City, UT 84103.
Shehata L; Adimab, LLC, Lebanon, NH 03766.
Pedreño-Lopez N; Department of Pathology, University of Miami, Miami, FL 33146.
Moyer CL; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Lilov A; Adimab, LLC, Lebanon, NH 03766.
Nett JH; Adimab, LLC, Lebanon, NH 03766.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Brown M; Adimab, LLC, Lebanon, NH 03766.
Watkins DI; Department of Pathology, University of Miami, Miami, FL 33146.
Ahlm C; Division of Infection & Immunology, Department of Clinical Microbiology, Umeå University, 90187 Umeå, Sweden.
Forsell MN; Division of Infection & Immunology, Department of Clinical Microbiology, Umeå University, 90187 Umeå, Sweden.
Rey FA; Structural Virology Unit, CNRS UMR 3569, Virology Department, Institut Pasteur, 75015 Paris, France.
Barba-Spaeth G; Structural Virology Unit, CNRS UMR 3569, Virology Department, Institut Pasteur, 75015 Paris, France.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Walker LM; Adimab, LLC, Lebanon, NH 03766; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 24; Vol. 117 (12), pp. 6675-6685. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Viral/*immunology
Antigens, Viral/*immunology
B-Lymphocytes/*immunology
Immunologic Memory/*immunology
Yellow Fever/*prevention & control
Yellow Fever Vaccine/*immunology
Yellow fever virus/*immunology
Adult ; Humans ; Vaccination ; Vaccines, Attenuated/immunology ; Viral Envelope Proteins/immunology ; Virus Replication ; Yellow Fever/immunology ; Yellow Fever/virology ; Yellow Fever Vaccine/administration & dosage
Czasopismo naukowe
Tytuł :
Development of an antibody cocktail for treatment of Sudan virus infection.
Autorzy :
Herbert AS; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Froude JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Ortiz RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Kuehne AI; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Dorosky DE; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Bakken RR; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Zak SE; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Josleyn NM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Musiychuk K; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Jones RM; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Green B; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Streatfield SJ; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Bohorova N; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Bohorov O; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Kim DH; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Pauly MH; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Velasco J; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Whaley KJ; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Stonier SW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Sampey D; BioFactura, Inc., Frederick, MD 21701.
Yusibov V; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Dye JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 18; Vol. 117 (7), pp. 3768-3778. Date of Electronic Publication: 2020 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Viral/*administration & dosage
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*drug therapy
Animals ; Antibodies, Monoclonal/administration & dosage ; Disease Models, Animal ; Ebolavirus/genetics ; Female ; Glycoproteins/immunology ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunotherapy ; Macaca mulatta ; Male ; Mice ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Passive immunization with an extended half-life monoclonal antibody protects Rhesus macaques against aerosolized ricin toxin.
Autorzy :
Roy CJ; Tulane National Primate Research Center, Covington, LA, 70433, USA. .
Van Slyke G; Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY, 12208, USA.
Ehrbar D; Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY, 12208, USA.
Bornholdt ZA; Mapp Biopharmaceutical, Inc, San Diego, CA, 92121, USA.
Brennan MB; Mapp Biopharmaceutical, Inc, San Diego, CA, 92121, USA.
Campbell L; Mapp Biopharmaceutical, Inc, San Diego, CA, 92121, USA.
Chen M; Mapp Biopharmaceutical, Inc, San Diego, CA, 92121, USA.
Kim D; Mapp Biopharmaceutical, Inc, San Diego, CA, 92121, USA.
Mlakar N; Mapp Biopharmaceutical, Inc, San Diego, CA, 92121, USA.
Whaley KJ; Mapp Biopharmaceutical, Inc, San Diego, CA, 92121, USA.
Froude JW; Clinical Pharmacology Branch, Walter Reed Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910, USA.; Vaccines and Therapeutics Division, Defense Threat Reduction Agency, 8725 John J. Kingman Rd., Fort Belvoir, VA, 22060, USA.
Torres-Velez FJ; Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY, 12208, USA.
Vitetta E; Departments of Immunology and Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Didier PJ; Tulane National Primate Research Center, Covington, LA, 70433, USA.
Doyle-Meyers L; Tulane National Primate Research Center, Covington, LA, 70433, USA.
Zeitlin L; Mapp Biopharmaceutical, Inc, San Diego, CA, 92121, USA. .
Mantis NJ; Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY, 12208, USA. .
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Źródło :
NPJ vaccines [NPJ Vaccines] 2020 Feb 13; Vol. 5 (1), pp. 13. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry.
Autorzy :
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Spence JS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Bortz RH 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Bornholdt ZA; Mapp Biopharmaceutical Inc., San Diego, California, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA .
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Źródło :
MBio [mBio] 2019 Jul 09; Vol. 10 (4). Date of Electronic Publication: 2019 Jul 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Virus Internalization*
Ebolavirus/*physiology
Viral Envelope Proteins/*genetics
Animals ; Chlorocebus aethiops ; Ebolavirus/genetics ; Mutation ; Niemann-Pick C1 Protein/genetics ; Vero Cells
Czasopismo naukowe
Tytuł :
A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates.
Autorzy :
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Mire CE; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Cross RW; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Abelson DM; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Geisbert JB; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
James RM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Rahim MN; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.
Zhu W; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Borisevich V; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Banadyga L; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Gunn BM; The Ragon Institute, Cambridge, MA, USA.
Agans KN; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Goodwin E; Adimab LLC, Lebanon, NH, USA.
Tierney K; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Shestowsky WS; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Bohorov O; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Bohorova N; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Velasco J; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Ailor E; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Kim D; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Pauly MH; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Whaley KJ; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Alter G; The Ragon Institute, Cambridge, MA, USA.
Walker LM; Adimab LLC, Lebanon, NH, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA, USA. Electronic address: .
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada. Electronic address: .
Geisbert TW; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA. Electronic address: .
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2019 Jan 09; Vol. 25 (1), pp. 49-58.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Monoclonal/*therapeutic use
Antibodies, Viral/*immunology
Antibodies, Viral/*therapeutic use
Ebolavirus/*pathogenicity
Ferrets/*virology
Hemorrhagic Fever, Ebola/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Animal Welfare ; Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/administration & dosage ; Cell Line ; Chlorocebus aethiops ; Disease Models, Animal ; Female ; Filoviridae/immunology ; Filoviridae Infections/immunology ; Filoviridae Infections/prevention & control ; Filoviridae Infections/virology ; Glycoproteins/immunology ; Guinea Pigs ; HEK293 Cells ; Hemorrhagic Fever, Ebola/virology ; Humans ; Killer Cells, Natural ; Macaca ; Macaca fascicularis ; Male ; Primates ; Survival Analysis ; Treatment Outcome ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection.
Autorzy :
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bornholdt ZA; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Goodwin E; Adimab, LLC, Lebanon, NH 03766, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Gunn BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Zhang Z; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Zhu W; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Liu G; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Abelson DM; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Moyer CL; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
James RM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Bohorova N; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Bohorov O; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Kim DH; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Pauly MH; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Velasco J; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Bortz RH 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Whaley KJ; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Goldstein T; One Health Institute and Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Anthony SJ; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Walker LM; Adimab, LLC, Lebanon, NH 03766, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Zeitlin L; Mapp Biopharmaceutical, San Diego, CA 92121, USA. Electronic address: .
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. Electronic address: .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2019 Jan 09; Vol. 25 (1), pp. 39-48.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Viral/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Animal Welfare ; Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/administration & dosage ; Antibodies, Viral/therapeutic use ; Antiviral Agents ; Disease Models, Animal ; Ebolavirus/pathogenicity ; Epitopes/immunology ; Female ; Filoviridae/immunology ; Guinea Pigs ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunotherapy ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Recombinant Proteins/immunology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop.
Autorzy :
Murin CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Bruhn JF; Laboratory of Genetics and Helmsley Center for Genomic Medicine, The Salk Institute for Biological Sciences, La Jolla, CA 92037, USA.
Bornholdt ZA; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Copps J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Stanfield R; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2018 Sep 04; Vol. 24 (10), pp. 2723-2732.e4.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antibodies, Neutralizing/*metabolism
Ebolavirus/*metabolism
Filoviridae/*metabolism
Glycoproteins/*immunology
Glycoproteins/*metabolism
Antibodies, Neutralizing/genetics ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Antibodies, Viral/metabolism ; Cryoelectron Microscopy ; Crystallography ; Ebolavirus/genetics ; Filoviridae/genetics ; Glycoproteins/genetics ; Promoter Regions, Genetic/genetics ; Protein Structure, Secondary
Czasopismo naukowe
Tytuł :
Ebola virus vaccination and the longevity of total versus neutralising antibody response-is it enough?
Autorzy :
Bornholdt ZA; Antibody Discovery, Mapp Biopharmaceutical, San Diego, CA, USA.
Bradfute SB; Internal Medicine, Center for Global Health, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: .
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Źródło :
The Lancet. Infectious diseases [Lancet Infect Dis] 2018 Jul; Vol. 18 (7), pp. 699-700. Date of Electronic Publication: 2018 Apr 05.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Ebola Vaccines*
Hemorrhagic Fever, Ebola*
Ebolavirus/*immunology
Antibodies, Neutralizing ; Antibodies, Viral ; Cohort Studies ; Humans ; Vaccination
Czasopismo naukowe
Tytuł :
Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses.
Autorzy :
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Murin CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Abelson DM; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
James RM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
de La Vega MA; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Zhu W; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Goodwin E; Adimab, LLC, Lebanon, NH 03766, USA.
Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Zeitlin L; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Walker LM; Adimab, LLC, Lebanon, NH 03766, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Electronic address: .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
Bornholdt ZA; Mapp Biopharmaceutical, San Diego, CA 92121, USA. Electronic address: zachary.bornholdt@mappbio.com.
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Źródło :
Cell [Cell] 2017 May 18; Vol. 169 (5), pp. 878-890.e15.
Typ publikacji :
Journal Article
MeSH Terms :
Survivors*
Antibodies, Neutralizing/*isolation & purification
Antibodies, Viral/*isolation & purification
Ebola Vaccines/*immunology
Hemorrhagic Fever, Ebola/*immunology
Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/chemistry ; Antibodies, Viral/immunology ; Chlorocebus aethiops ; Cross Reactions ; Ebolavirus/classification ; Ebolavirus/immunology ; Female ; Ferrets ; Hemorrhagic Fever, Ebola/virology ; Humans ; Kinetics ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Sequence Alignment ; Vero Cells
Czasopismo naukowe
Tytuł :
A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
Autorzy :
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Howell KA; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Holtsberg FW; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Mittler E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Christin JR; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Shulenin S; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bharrhan S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Bornholdt ZA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.
Flyak AI; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 10550, USA.
Crowe JE Jr; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA. .; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
Aman MJ; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA. .
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. .
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2016 Oct 21; Vol. 354 (6310), pp. 350-354. Date of Electronic Publication: 2016 Sep 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Carrier Proteins/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Membrane Glycoproteins/*immunology
Receptors, Virus/*immunology
Viral Envelope Proteins/*immunology
Animals ; Antibodies, Monoclonal/immunology ; Binding Sites/immunology ; Cell Line, Tumor ; Endosomes/virology ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immunotherapy/methods ; Intracellular Signaling Peptides and Proteins ; Mice ; Mice, Inbred BALB C ; Virus Internalization
Czasopismo naukowe
Tytuł :
Analytical Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection.
Autorzy :
Cross RW; Galveston National Laboratory, University of Texas Medical Branch.
Boisen ML; Corgenix, Broomfield, Colorado Department of Microbiology and Immunology Zalgen Labs, Germantown, Maryland.
Millett MM; Corgenix, Broomfield, Colorado.
Nelson DS; Corgenix, Broomfield, Colorado Zalgen Labs, Germantown, Maryland.
Oottamasathien D; Corgenix, Broomfield, Colorado.
Hartnett JN; Department of Microbiology and Immunology.
Jones AB; Corgenix, Broomfield, Colorado.
Goba A; Lassa Fever Program, Kenema Government Hospital Ministry of Health and Sanitation.
Momoh M; Lassa Fever Program, Kenema Government Hospital Ministry of Health and Sanitation Eastern Polytechnic Institute, Kenema, Sierra Leone.
Fullah M; Lassa Fever Program, Kenema Government Hospital Ministry of Health and Sanitation Eastern Polytechnic Institute, Kenema, Sierra Leone.
Bornholdt ZA; The Scripps Research Institute, La Jolla, California.
Fusco ML; The Scripps Research Institute, La Jolla, California.
Abelson DM; The Scripps Research Institute, La Jolla, California.
Oda S; The Scripps Research Institute, La Jolla, California.
Brown BL; Corgenix, Broomfield, Colorado.
Pham H; Corgenix, Broomfield, Colorado.
Rowland MM; Zalgen Labs, Germantown, Maryland.
Agans KN; Galveston National Laboratory, University of Texas Medical Branch.
Geisbert JB; Galveston National Laboratory, University of Texas Medical Branch.
Heinrich ML; Zalgen Labs, Germantown, Maryland.
Kulakosky PC; Autoimmune Technologies, New Orleans, Louisiana.
Shaffer JG; School of Public Health and Tropical Medicine, Tulane University.
Schieffelin JS; Section of Infectious Diseases, Department of Pediatrics, School of Medicine.
Kargbo B; Ministry of Health and Sanitation.
Gbetuwa M; Lassa Fever Program, Kenema Government Hospital Ministry of Health and Sanitation.
Gevao SM; Lassa Fever Program, Kenema Government Hospital University of Sierra Leone, Freetown.
Wilson RB; Autoimmune Technologies, New Orleans, Louisiana.
Saphire EO; The Scripps Research Institute, La Jolla, California.
Pitts KR; Corgenix, Broomfield, Colorado.
Khan SH; Lassa Fever Program, Kenema Government Hospital Ministry of Health and Sanitation.
Grant DS; Lassa Fever Program, Kenema Government Hospital Ministry of Health and Sanitation.
Geisbert TW; Galveston National Laboratory, University of Texas Medical Branch.
Branco LM; Zalgen Labs, Germantown, Maryland.
Garry RF; Department of Microbiology and Immunology Zalgen Labs, Germantown, Maryland.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2016 Oct 15; Vol. 214 (suppl 3), pp. S210-S217. Date of Electronic Publication: 2016 Aug 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Disease Outbreaks*
Point-of-Care Systems*
Antigens, Viral/*blood
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*diagnosis
Viral Matrix Proteins/*blood
Africa, Western/epidemiology ; Animals ; Ebolavirus/isolation & purification ; Enzyme-Linked Immunosorbent Assay ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunoassay ; Limit of Detection ; Reagent Kits, Diagnostic ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.
Autorzy :
Bornholdt ZA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Murin CD; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Li W; Adimab, Lebanon, NH 03766, USA.
Sok D; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Souders CA; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
Piper AE; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Goff A; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Shamblin JD; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Wollen SE; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Sprague TR; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Fusco ML; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Pommert KB; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Cavacini LA; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
Smith HL; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
Klempner M; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
Reimann KA; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
Krauland E; Adimab, Lebanon, NH 03766, USA.
Gerngross TU; Adimab, Lebanon, NH 03766, USA.
Wittrup KD; Adimab, Lebanon, NH 03766, USA.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Burton DR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02142, USA.
Glass PJ; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Walker LM; Adimab, Lebanon, NH 03766, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2016 Mar 04; Vol. 351 (6277), pp. 1078-83. Date of Electronic Publication: 2016 Feb 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Monoclonal/*isolation & purification
Antibodies, Neutralizing/*isolation & purification
Antibodies, Viral/*isolation & purification
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*immunology
Viral Envelope Proteins/*immunology
Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/chemistry ; Antibodies, Viral/therapeutic use ; Antibody Formation ; Antigen-Antibody Complex/chemistry ; Democratic Republic of the Congo/epidemiology ; Disease Outbreaks ; Ebola Vaccines/immunology ; Ebola Vaccines/therapeutic use ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immunization, Passive ; Mice ; Survivors ; Tissue Donors ; Viral Envelope Proteins/chemistry ; Virion/immunology
Czasopismo naukowe

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