Distinct microglial transcriptomic signatures within the hippocampus.
Autorzy:
Chintamen S; Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, United States of America. Gaur P; Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America. Vo N; Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America. BradshawEM; Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America. Menon V; Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America. Kernie SG; Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, United States of America.; Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America.
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Źródło:
PloS one [PLoS One] 2024 Jan 05; Vol. 19 (1), pp. e0296280. Date of Electronic Publication: 2024 Jan 05 (Print Publication: 2024).
The aging immune system in Alzheimer's and Parkinson's diseases.
Autorzy:
Heavener KS; Department of Neurology, Columbia University Irving Medical Center, New York, NY, 10032, USA. BradshawEM; Department of Neurology, Columbia University Irving Medical Center, New York, NY, 10032, USA. .
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Źródło:
Seminars in immunopathology [Semin Immunopathol] 2022 Sep; Vol. 44 (5), pp. 649-657. Date of Electronic Publication: 2022 May 03.
Deconvolving the contributions of cell-type heterogeneity on cortical gene expression.
Autorzy:
Patrick E; School of Mathematics and Statistics, The University of Sydney, Sydney, New South Wales, Australia.; The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia. Taga M; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York City, New York, United States of America. Ergun A; Research and Development, Biogen, Cambridge, Massachusetts, United States of America. Ng B; Departments of Statistics and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia, Canada. Casazza W; Departments of Statistics and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia, Canada.; The Bioinformatics Training Program, University of British Columbia, Vancouver, Canada. Cimpean M; Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, St. Louis, Missouri, United States of America. Yung C; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York City, New York, United States of America. Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America. Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America. Gaiteri C; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America. De Jager PL; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York City, New York, United States of America. BradshawEM; Department of Neurology, Columbia University Medical Center, New York City, New York, United States of America. Mostafavi S; Departments of Statistics and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia, Canada.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2020 Aug 17; Vol. 16 (8), pp. e1008120. Date of Electronic Publication: 2020 Aug 17 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology.
Autorzy:
Taga M; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA. Petyuk VA; Pacific Northwest National Laboratory, Richland, WA, USA. White C; Cell Circuits Program, Broad Institute, Cambridge, MA, USA. Marsh G; Biogen, 225 Binney St, Cambridge, MA, 02142, USA. Ma Y; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA. Klein HU; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA. Connor SM; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA. Kroshilina A; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA. Yung CJ; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA. Khairallah A; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA. Olah M; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA. Schneider J; Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. Karhohs K; Imaging Platform, Broad Institute, Cambridge, MA, USA. Carpenter AE; Imaging Platform, Broad Institute, Cambridge, MA, USA. Ransohoff R; Third Rock Ventures, 29 Newbury Street, Suite 301, Boston, MA, 02116, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Bennett DA; Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. Crotti A; Biogen, 225 Binney St, Cambridge, MA, 02142, USA. BradshawEM; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA. De Jager PL; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA. .; Cell Circuits Program, Broad Institute, Cambridge, MA, USA. .
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Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2020 Jul 29; Vol. 15 (1), pp. 44. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
CD33 modulates TREM2: convergence of Alzheimer loci.
Autorzy:
Chan G; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA. White CC; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. Winn PA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. Cimpean M; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. Replogle JM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA. Glick LR; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. Cuerdon NE; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. Ryan KJ; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA. Johnson KA; Harvard Medical School, Boston, Massachusetts, USA.; Center for Alzheimer's Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA. Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA. Chibnik LB; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA. Sperling RA; Harvard Medical School, Boston, Massachusetts, USA.; Center for Alzheimer's Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. BradshawEM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA. De Jager PL; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.
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Źródło:
Nature neuroscience [Nat Neurosci] 2015 Nov; Vol. 18 (11), pp. 1556-8. Date of Electronic Publication: 2015 Sep 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
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