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Tytuł:
Subtyping and grading of lower-grade gliomas using integrated feature selection and support vector machine.
Autorzy:
Munquad S; Department of Biotechnology, National Institute of Technology Warangal, Warangal 506004, Telangana, India.
Si T; Department of Computer Science and Engineering, Bankura Unnayani Institute of Engineering, Bankura 722146, West Bengal, India.
Mallik S; Department of Environmental Epigenetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Li A; Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Das AB; Department of Biotechnology, National Institute of Technology Warangal, Warangal 506004, Telangana, India.
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Źródło:
Briefings in functional genomics [Brief Funct Genomics] 2022 Sep 16; Vol. 21 (5), pp. 408-421.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Neoplasms*/genetics
Glioma*/genetics
Humans ; Magnetic Resonance Imaging/methods ; Neoplasm Grading ; Support Vector Machine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neuroinflammation and immunoregulation in glioblastoma and brain metastases: Recent developments in imaging approaches.
Autorzy:
Roesler R; Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Dini SA; The Center for Advanced Neurology and Neurosurgery (CEANNE)-Brazil, Porto Alegre, RS, Brazil.
Isolan GR; The Center for Advanced Neurology and Neurosurgery (CEANNE)-Brazil, Porto Alegre, RS, Brazil.; Mackenzie Evangelical University of Paraná (FEMPAR), Curitiba, PR, Brazil.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2021 Dec; Vol. 206 (3), pp. 314-324. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Brain Neoplasms/*diagnostic imaging
Brain Neoplasms/*secondary
Glioblastoma/*diagnostic imaging
Magnetic Resonance Imaging/*methods
Neuroinflammatory Diseases/*pathology
Positron-Emission Tomography/*methods
Brain/pathology ; Brain Neoplasms/pathology ; Glioblastoma/diagnosis ; Glioblastoma/pathology ; Humans ; Neuroimaging/methods ; Radiopharmaceuticals/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
An artificial neural network model based on DNA damage response genes to predict outcomes of lower-grade glioma patients.
Autorzy:
Chen J; Division of Life Sciences and Medicine, Department of Oncology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, China.
Qian X; Division of Life Sciences and Medicine, Department of Oncology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, China.
He Y; Division of Life Sciences and Medicine, Department of Oncology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, China.
Han X; Division of Life Sciences and Medicine, Department of Oncology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, China.
Pan Y; Division of Life Sciences and Medicine, Department of Oncology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, China.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2021 Nov 05; Vol. 22 (6).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biomarkers, Tumor*
DNA Damage*
Neural Networks, Computer*
Brain Neoplasms/*genetics
Brain Neoplasms/*mortality
Glioma/*genetics
Glioma/*mortality
Brain Neoplasms/diagnosis ; Computational Biology/methods ; Databases, Genetic ; Gene Expression Regulation, Neoplastic ; Glioma/diagnosis ; Humans ; Neoplasm Grading ; Prognosis ; Proportional Hazards Models ; Web Browser
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Machine learning revealed stemness features and a novel stemness-based classification with appealing implications in discriminating the prognosis, immunotherapy and temozolomide responses of 906 glioblastoma patients.
Autorzy:
Wang Z; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Wang Y; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Yang T; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Xing H; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Wang Y; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Gao L; Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Guo X; Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Xing B; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Wang Y; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Ma W; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2021 Sep 02; Vol. 22 (5).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Machine Learning*
Transcriptome*
Antineoplastic Agents, Alkylating/*therapeutic use
Brain Neoplasms/*drug therapy
Glioblastoma/*drug therapy
Neoplastic Stem Cells/*drug effects
Temozolomide/*therapeutic use
Adult ; Aged ; Atlases as Topic ; Brain Neoplasms/genetics ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Glioblastoma/genetics ; Glioblastoma/mortality ; Glioblastoma/pathology ; Humans ; Immunotherapy/methods ; Male ; Middle Aged ; Neoplastic Stem Cells/immunology ; Neoplastic Stem Cells/pathology ; Patient Selection ; Prognosis ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/immunology ; Survival Analysis ; Treatment Outcome ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
m6A regulator-mediated methylation modification patterns and characteristics of immunity and stemness in low-grade glioma.
Autorzy:
Du J; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin 150081, China.
Ji H; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin 150081, China.
Ma S; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Jin J; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin 150081, China.
Mi S; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin 150081, China.
Hou K; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin 150081, China.
Dong J; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Wang F; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin 150081, China.
Zhang C; Department of Neurosurgery, First Hospital of Jilin University, Changchun 130000, China.
Li Y; Department of Pharmacology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Hu S; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2021 Sep 02; Vol. 22 (5).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunity, Innate*
Adenosine/*analogs & derivatives
Alpha-Ketoglutarate-Dependent Dioxygenase FTO/*genetics
Brain Neoplasms/*genetics
Brain Neoplasms/*immunology
DNA Methylation/*genetics
Gene Expression Regulation, Neoplastic/*immunology
Glioma/*genetics
Glioma/*immunology
Methyltransferases/*genetics
RNA-Binding Proteins/*genetics
Adenosine/genetics ; Biomarkers, Tumor/genetics ; Brain Neoplasms/pathology ; DNA Copy Number Variations ; Epigenesis, Genetic ; Glioma/pathology ; Humans ; Lymphocytes, Tumor-Infiltrating/immunology ; Machine Learning ; Mutation Rate ; Phenotype ; Prognosis ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bioinformatics and machine learning methodologies to identify the effects of central nervous system disorders on glioblastoma progression.
Autorzy:
Rahman MH; Institute of Automation Chinese Academy of Sciences, Beijing 100190, China.; University of Chinese Academy of Sciences, Beijing 100190, China.; Department of Computer Science and Engineering, Islamic University, Kushtia 7003, Bangladesh.
Rana HK; Department of Computer Science and Engineering, Green University of Bangladesh, Bangladesh.
Peng S; Institute of Automation Chinese Academy of Sciences, Beijing 100190, China.; University of Chinese Academy of Sciences, Beijing 100190, China.
Hu X; Institute of Automation Chinese Academy of Sciences, Beijing 100190, China.; University of Chinese Academy of Sciences, Beijing 100190, China.
Chen C; Institute of Automation Chinese Academy of Sciences, Beijing 100190, China.; University of Chinese Academy of Sciences, Beijing 100190, China.
Quinn JMW; Bone Biology Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; The Surgical Education and Research Training Institute, Royal North Shore Hospital, Sydney, Australia.
Moni MA; Bone Biology Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; WHO Collaborating Centre on eHealth, School of Public Health and Community Medicine, Faculty of Medicine, The University of New South Wales, Sydney, Australia.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2021 Sep 02; Vol. 22 (5).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Regulatory Networks*
Machine Learning*
Brain Neoplasms/*genetics
Central Nervous System/*metabolism
Glioblastoma/*genetics
Neoplasm Proteins/*genetics
Atlases as Topic ; Brain Neoplasms/metabolism ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Central Nervous System/pathology ; Computational Biology/methods ; Datasets as Topic ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Ontology ; Glioblastoma/metabolism ; Glioblastoma/mortality ; Glioblastoma/pathology ; Glutamic Acid/metabolism ; Humans ; Kaplan-Meier Estimate ; Molecular Sequence Annotation ; Neoplasm Proteins/classification ; Neoplasm Proteins/metabolism ; Proportional Hazards Models ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
XGSEA: CROSS-species gene set enrichment analysis via domain adaptation.
Autorzy:
Cai M; School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an, 710049, China.
Hao Nguyen C; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, 6110011, Japan.
Mamitsuka H; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, 6110011, Japan.; Department of Computer Science, Aalto Unviersity, Espoo, Finland.
Li L; School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an, 710049, China.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2021 Sep 02; Vol. 22 (5).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Machine Learning*
Brain Neoplasms/*genetics
Melanoma/*genetics
Ovarian Neoplasms/*genetics
Skin Neoplasms/*genetics
Animals ; Brain Neoplasms/immunology ; Brain Neoplasms/pathology ; Computational Biology/methods ; Datasets as Topic ; Embryo, Mammalian ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Melanoma/immunology ; Melanoma/pathology ; Mice ; Ovarian Neoplasms/immunology ; Ovarian Neoplasms/pathology ; Skin Neoplasms/immunology ; Skin Neoplasms/pathology ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; Zebrafish
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Normal tissue content impact on the GBM molecular classification.
Autorzy:
Madurga R; Biostatistics and Bioinformatics at Fundación de Investigación HM Hospitales and Professor at the Faculty of Experimental Sciences of the Universidad Francisco de Vitoria.
García-Romero N; Molecular Biology at Fundación Vithas and professor at Francisco de Vitoria University.
Jiménez B; HM Hospitales.
Collazo A; HM Hospitales.
Pérez-Rodríguez F; HM Hospitales.
Hernández-Laín A; Hospital Universitario 12 de octubre.
Fernández-Carballal C; Hospital Universitario Gregorio Marañón.
Prat-Acín R; Hospital Universitario la Fe.
Zanin M; Institute for Cross-Disciplinary Physics and Complex Systems, Spain.
Menasalvas E; Department of Computer Systems Languages and Software Engineering at the Faculty of Computer Science of Universidad Politecnica de Madrid.
Ayuso-Sacido Á; Brain Tumour Laboratory, Scientific Director at Vithas Hospitals, Managing Director at Fundación Vithas and Professor at the Medial School of Francisco de Vitoria University.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2021 May 20; Vol. 22 (3).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms:
Biomarkers, Tumor*/biosynthesis
Biomarkers, Tumor*/genetics
Brain*/metabolism
Brain*/pathology
Brain Neoplasms*/classification
Brain Neoplasms*/genetics
Brain Neoplasms*/metabolism
Brain Neoplasms*/pathology
Gene Expression Profiling*
Gene Expression Regulation, Neoplastic*
Glioblastoma*/classification
Glioblastoma*/genetics
Glioblastoma*/metabolism
Glioblastoma*/pathology
Female ; Humans ; Male ; Microdissection
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Accumulation of amyloid beta in human glioblastomas.
Autorzy:
Zayas-Santiago A; Physiology Department, Medical School, Universidad Central del Caribe, Bayamon, Puerto Rico.
Díaz-García A; Physiology Department, Medical School, Universidad Central del Caribe, Bayamon, Puerto Rico.
Nuñez-Rodríguez R; Biochemistry Department, Medical School, Universidad Central del Caribe, Bayamon, Puerto Rico.
Inyushin M; Physiology Department, Medical School, Universidad Central del Caribe, Bayamon, Puerto Rico.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2020 Dec; Vol. 202 (3), pp. 325-334. Date of Electronic Publication: 2020 Aug 11.
Typ publikacji:
Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Amyloid beta-Peptides/*immunology
Brain Neoplasms/*immunology
Glioblastoma/*immunology
Neoplasm Proteins/*immunology
Peptide Fragments/*immunology
Tumor Microenvironment/*immunology
Adult ; Aged ; Brain Neoplasms/pathology ; Female ; Glioblastoma/pathology ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Single-cell transcriptome-based multilayer network biomarker for predicting prognosis and therapeutic response of gliomas.
Autorzy:
Zhang J; Department of Neurosurgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Guan M; School of Mathematics, Sun Yat-Sen University, Guangzhou, China.
Wang Q; School of Life Science, Sun Yat-Sen University, Guangzhou, China.
Zhang J; School of Mathematics, Sun Yat-Sen University, Guangzhou, China.
Zhou T; School of Mathematics, Sun Yat-Sen University, Guangzhou, China.
Sun X; School of Mathematics, Sun Yat-Sen University, Guangzhou, China.; Department of Medical Informatics, Zhong-shan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China; Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Chinese Ministry of Education, Guangzhou, Guangdong, China.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2020 May 21; Vol. 21 (3), pp. 1080-1097.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transcriptome*
Brain Neoplasms/*genetics
Glioma/*genetics
Single-Cell Analysis/*methods
Biomarkers/analysis ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Glioma/pathology ; Glioma/therapy ; Humans ; Prognosis ; Sequence Analysis, RNA/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered NK cell phenotype in glioblastoma.
Autorzy:
Close HJ; Leeds Institute of Medical Research at St James's, University of Leeds School of Medicine, St James's University Hospital, Leeds, UK.
Stead LF; Leeds Institute of Medical Research at St James's, University of Leeds School of Medicine, St James's University Hospital, Leeds, UK.
Nsengimana J; Leeds Institute of Medical Research at St James's, University of Leeds School of Medicine, St James's University Hospital, Leeds, UK.
Reilly KA; Leeds Institute of Medical Research at St James's, University of Leeds School of Medicine, St James's University Hospital, Leeds, UK.
Droop A; MRC Medical Bioinformatics Centre, University of Leeds, Leeds, UK.
Wurdak H; Leeds Institute of Medical Research at St James's, University of Leeds School of Medicine, St James's University Hospital, Leeds, UK.
Mathew RK; Leeds Institute of Medical Research at St James's, University of Leeds School of Medicine, St James's University Hospital, Leeds, UK.; Department of Neurosurgery, Leeds General Infirmary, Leeds, UK.
Corns R; Department of Neurosurgery, Leeds General Infirmary, Leeds, UK.
Newton-Bishop J; Leeds Institute of Medical Research at St James's, University of Leeds School of Medicine, St James's University Hospital, Leeds, UK.
Melcher AA; Institute of Cancer Research, London, UK.
Short SC; Leeds Institute of Medical Research at St James's, University of Leeds School of Medicine, St James's University Hospital, Leeds, UK.
Cook GP; Leeds Institute of Medical Research at St James's, University of Leeds School of Medicine, St James's University Hospital, Leeds, UK.
Wilson EB; Leeds Institute of Medical Research at St James's, University of Leeds School of Medicine, St James's University Hospital, Leeds, UK.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2020 Apr; Vol. 200 (1), pp. 33-44. Date of Electronic Publication: 2019 Dec 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Neoplasms/*immunology
Gene Expression Profiling/*methods
Glioblastoma/*immunology
Immune Tolerance/*immunology
Killer Cells, Natural/*immunology
Neoplastic Stem Cells/*immunology
Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cells, Cultured ; Cohort Studies ; Cytotoxicity, Immunologic/genetics ; Cytotoxicity, Immunologic/immunology ; Gene Expression Regulation, Neoplastic/immunology ; Gene Regulatory Networks/immunology ; Glioblastoma/genetics ; Glioblastoma/pathology ; Humans ; Immune Tolerance/genetics ; Killer Cells, Natural/metabolism ; Neoplastic Stem Cells/metabolism ; Phenotype ; Prognosis ; Signal Transduction/genetics ; Signal Transduction/immunology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
LncRNA DLGAP1-AS2 modulates glioma development by up-regulating YAP1 expression.
Autorzy:
Miao W; Department of Neurosurgery, Zhongda Hospital, Southeast University, 87 DingJiaQiao Road, Gulou District, Nanjing, Jiangsu 210009, China.
Li N; Department of Neurosurgery, Zhongda Hospital, Southeast University, 87 DingJiaQiao Road, Gulou District, Nanjing, Jiangsu 210009, China.
Gu B; Department of Neurosurgery, Zhongda Hospital, Southeast University, 87 DingJiaQiao Road, Gulou District, Nanjing, Jiangsu 210009, China.
Yi G; Department of Neurosurgery, Zhongda Hospital, Southeast University, 87 DingJiaQiao Road, Gulou District, Nanjing, Jiangsu 210009, China.
Su Z; Department of Neurosurgery, Zhongda Hospital, Southeast University, 87 DingJiaQiao Road, Gulou District, Nanjing, Jiangsu 210009, China.
Cheng H; Department of Neurosurgery, Zhongda Hospital, Southeast University, 87 DingJiaQiao Road, Gulou District, Nanjing, Jiangsu 210009, China.
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Źródło:
Journal of biochemistry [J Biochem] 2020 Apr 01; Vol. 167 (4), pp. 411-418.
Typ publikacji:
Journal Article
MeSH Terms:
Up-Regulation*
Adaptor Proteins, Signal Transducing/*metabolism
Brain Neoplasms/*metabolism
Glioma/*metabolism
RNA, Long Noncoding/*metabolism
SAP90-PSD95 Associated Proteins/*metabolism
Transcription Factors/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Apoptosis ; Brain Neoplasms/diagnosis ; Cell Movement ; Cell Proliferation ; Glioma/diagnosis ; Humans ; RNA, Long Noncoding/genetics ; SAP90-PSD95 Associated Proteins/genetics ; Transcription Factors/genetics ; YAP-Signaling Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SMAD3 silencing enhances DNA damage in radiation therapy by interacting with MRE11-RAD50-NBS1 complex in glioma.
Autorzy:
Jiang Z; Department of Neurosurgery, Qilu Hospital of Shandong University, No. 107 Wenhua West Road, Lixia District, Jinan, Shandong Province, P. R. China.
Guo Y; Department of Internal Medicine, People's Hospital of Qingzhou, No. 1726 Linglongshan Road, Qingzhou, Shandong Province, P. R. China.
Miao L; Department of Neurosurgery, Dezhou People Hospital, No. 1751 Xinhu Street, Dezhou, Shandong Province, P. R. China.
Han L; Department of Neurosurgery, Qilu Hospital of Shandong University, No. 107 Wenhua West Road, Lixia District, Jinan, Shandong Province, P. R. China.
Zhang W; Department of Neurosurgery, Weifang Yidu Central Hospital, No. 4138 Linglongshan Road, Qingzhou, Shandong Province, P. R. China.
Jiang Y; Department of Neurosurgery, Qilu Hospital of Shandong University, No. 107 Wenhua West Road, Lixia District, Jinan, Shandong Province, P. R. China.
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Źródło:
Journal of biochemistry [J Biochem] 2019 Apr 01; Vol. 165 (4), pp. 317-322.
Typ publikacji:
Journal Article
MeSH Terms:
Brain Neoplasms*/genetics
Brain Neoplasms*/metabolism
Brain Neoplasms*/pathology
Brain Neoplasms*/radiotherapy
Cell Cycle Proteins*/genetics
Cell Cycle Proteins*/metabolism
DNA Repair Enzymes*/genetics
DNA Repair Enzymes*/metabolism
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Gene Silencing*
Glioblastoma*/genetics
Glioblastoma*/metabolism
Glioblastoma*/pathology
Glioblastoma*/radiotherapy
MRE11 Homologue Protein*/genetics
MRE11 Homologue Protein*/metabolism
Multiprotein Complexes*/genetics
Multiprotein Complexes*/metabolism
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Nuclear Proteins*/genetics
Nuclear Proteins*/metabolism
Smad3 Protein*/genetics
Smad3 Protein*/metabolism
Acid Anhydride Hydrolases ; Cell Line, Tumor ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Novel Mutation in Brain Tumor Causes Both Neural Over-Proliferation and Neurodegeneration in Adult Drosophila .
Autorzy:
Loewen C; Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706.
Boekhoff-Falk G; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705 .
Ganetzky B; Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706.
Chtarbanova S; Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706 .; Department of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487.
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Źródło:
G3 (Bethesda, Md.) [G3 (Bethesda)] 2018 Oct 03; Vol. 8 (10), pp. 3331-3346. Date of Electronic Publication: 2018 Oct 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Association Studies*
Genetic Predisposition to Disease*
Mutation*
Brain Neoplasms/*genetics
Drosophila/*genetics
Drosophila Proteins/*genetics
Neurodegenerative Diseases/*genetics
Animals ; Biomarkers ; Brain/metabolism ; Brain/pathology ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Differentiation/genetics ; Cell Proliferation ; Disease Progression ; Drosophila Proteins/chemistry ; Gene Expression ; Immunohistochemistry ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Neuroglia/cytology ; Neuroglia/metabolism ; Neurons/cytology ; Neurons/metabolism ; Phenotype ; Protein Domains
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Whole-Genome Multi-omic Study of Survival in Patients with Glioblastoma Multiforme.
Autorzy:
Bernal Rubio YL; Department of Epidemiology and Biostatistics.
González-Reymúndez A; Department of Epidemiology and Biostatistics.; Institute for Quantitative Health Science and Engineering.
Wu KH; Department of Epidemiology and Biostatistics.; Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan, 48202.
Griguer CE; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama, 35294.
Steibel JP; Department of Animal Science and Department of Fisheries and Wildlife.
de Los Campos G; Department of Epidemiology and Biostatistics.; Institute for Quantitative Health Science and Engineering.; Department of Statistics and Probability.
Doseff A; Department of Physiology.; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, 48823.
Gallo K; Department of Physiology.
Vazquez AI; Department of Epidemiology and Biostatistics .; Institute for Quantitative Health Science and Engineering.
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Źródło:
G3 (Bethesda, Md.) [G3 (Bethesda)] 2018 Nov 06; Vol. 8 (11), pp. 3627-3636. Date of Electronic Publication: 2018 Nov 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Brain Neoplasms/*genetics
Glioblastoma/*genetics
Aged ; Antineoplastic Agents, Alkylating/therapeutic use ; Brain Neoplasms/drug therapy ; DNA Copy Number Variations ; DNA Methylation ; Female ; Genomics ; Glioblastoma/drug therapy ; Humans ; Male ; Middle Aged ; Prognosis ; Survival Analysis ; Temozolomide/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Incidence of brain metastasis from esophageal cancer.
Autorzy:
Welch G; Department of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Ross HJ; Division of Hematology and Medical Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Patel NP; Department of Neurologic Surgery, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Jaroszewski DE; Division of Cardiovascular and Thoracic Surgery Mayo Clinic Hospital, Phoenix, Arizona, USA.
Fleischer DE; Divisions of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Rule WG
Paripati HR; Division of Hematology and Medical Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Ramirez FC; Divisions of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Ashman JB
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Źródło:
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus [Dis Esophagus] 2017 Sep 01; Vol. 30 (9), pp. 1-6.
Typ publikacji:
Journal Article
MeSH Terms:
Adenocarcinoma/*epidemiology
Adenocarcinoma/*secondary
Brain Neoplasms/*epidemiology
Brain Neoplasms/*secondary
Carcinoma, Squamous Cell/*epidemiology
Carcinoma, Squamous Cell/*secondary
Esophageal Neoplasms/*pathology
Adenocarcinoma/therapy ; Adult ; Aged ; Aged, 80 and over ; Brain Neoplasms/therapy ; Carcinoma, Squamous Cell/therapy ; Esophageal Neoplasms/therapy ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Survival Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Treatment strategies in recurrent esophageal or junctional cancer.
Autorzy:
Butter R; Department of Surgery.; Medical Oncology.
Lagarde SM; Department of Surgery.; Department of Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
van Oijen MGH; Medical Oncology.
Anderegg MCJ; Department of Surgery.
Gisbertz SS; Department of Surgery.
Meijer SL; Pathology.
Hulshof MCCM; Radiotherapy.
Bergman JJGHM; Gastroenterology, Academic Medical Center, Amsterdam, Erasmus Medical Center, Rotterdam, the Netherlands.
van Berge Henegouwen MI; Department of Surgery.
van Laarhoven HWM; Medical Oncology.
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Źródło:
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus [Dis Esophagus] 2017 Sep 01; Vol. 30 (9), pp. 1-9.
Typ publikacji:
Journal Article
MeSH Terms:
Bone Neoplasms/*therapy
Brain Neoplasms/*therapy
Esophageal Neoplasms/*pathology
Esophageal Neoplasms/*therapy
Esophagogastric Junction/*surgery
Lung Neoplasms/*therapy
Neoplasm Recurrence, Local/*therapy
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Bone Neoplasms/secondary ; Brain Neoplasms/secondary ; Chemoradiotherapy, Adjuvant ; Esophagectomy/methods ; Female ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/secondary ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoadjuvant Therapy ; Palliative Care ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Survival Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
COVID-19-induced toxic epidermal necrolysis.
Autorzy:
Narang I; Department of, Department of, Dermatology, University Hospitals of Derby and Burton, Derby, UK.
Panthagani AP; Department of, Department of, Dermatology, University Hospitals of Derby and Burton, Derby, UK.
Lewis M; Department of, Palliative Medicine, University Hospitals of Derby and Burton, Derby, UK.
Chohan B; Department of, Pathology, University Hospitals of Derby and Burton, Derby, UK.
Ferguson A; Department of, Department of, Dermatology, University Hospitals of Derby and Burton, Derby, UK.
Nambi R; Department of, Department of, Dermatology, University Hospitals of Derby and Burton, Derby, UK.
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Źródło:
Clinical and experimental dermatology [Clin Exp Dermatol] 2021 Jul; Vol. 46 (5), pp. 927-929. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji:
Case Reports; Letter
MeSH Terms:
COVID-19/*diagnosis
Stevens-Johnson Syndrome/*diagnosis
Adrenal Cortex Hormones/therapeutic use ; Androstadienes/therapeutic use ; Aromatase Inhibitors/therapeutic use ; Body Surface Area ; Bone Neoplasms/complications ; Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Brain Neoplasms/complications ; Brain Neoplasms/drug therapy ; Brain Neoplasms/secondary ; Breast Neoplasms/complications ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; COVID-19/complications ; Dexamethasone/therapeutic use ; Emollients/therapeutic use ; Female ; Hospitalization ; Humans ; Liver Neoplasms/complications ; Liver Neoplasms/drug therapy ; Liver Neoplasms/secondary ; Middle Aged ; Palliative Care ; SARS-CoV-2 ; Stevens-Johnson Syndrome/drug therapy ; Stevens-Johnson Syndrome/etiology ; Stevens-Johnson Syndrome/pathology
Raport
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Copy Number Profiling of Brazilian Astrocytomas.
Autorzy:
Bidinotto LT; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, 14784 400, Brazil Barretos School of Health Sciences, Dr. Paulo Prata - FACISB, São Paulo, 14785 002, Brazil.
Torrieri R; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, 14784 400, Brazil.
Mackay A; Division of Molecular Pathology, The Institute of Cancer Research, London, SM2 5NG, UK Division of Cancer Therapeutics, The Institute of Cancer Research, London, SM2 5NG, UK.
Almeida GC; Department of Pathology, Barretos Cancer Hospital, São Paulo, 14784 400, Brazil.
Viana-Pereira M; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, 4704 553, Portugal 3B's - PT Government Associate Laboratory, Braga/Guimarães, 4704 553, Portugal.
Cruvinel-Carloni A; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, 14784 400, Brazil.
Spina ML; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, 14784 400, Brazil Barretos School of Health Sciences, Dr. Paulo Prata - FACISB, São Paulo, 14785 002, Brazil.
Campanella NC; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, 14784 400, Brazil.
Pereira de Menezes W; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, 14784 400, Brazil.
Clara CA; Department of Neurosurgery, Barretos Cancer Hospital, São Paulo, 14784 400, Brazil.
Becker AP; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, 14784 400, Brazil.
Jones C; Division of Molecular Pathology, The Institute of Cancer Research, London, SM2 5NG, UK Division of Cancer Therapeutics, The Institute of Cancer Research, London, SM2 5NG, UK.
Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, 14784 400, Brazil Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, 4704 553, Portugal 3B's - PT Government Associate Laboratory, Braga/Guimarães, 4704 553, Portugal .
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Źródło:
G3 (Bethesda, Md.) [G3 (Bethesda)] 2016 Jul 07; Vol. 6 (7), pp. 1867-78. Date of Electronic Publication: 2016 Jul 07.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Dosage*
Gene Expression Regulation, Neoplastic*
Astrocytoma/*genetics
Brain Neoplasms/*genetics
Glioblastoma/*genetics
Neoplasm Proteins/*genetics
Adolescent ; Adult ; Aged ; Astrocytoma/diagnosis ; Astrocytoma/metabolism ; Astrocytoma/pathology ; Brain Neoplasms/diagnosis ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Brazil ; Child ; Comparative Genomic Hybridization ; Cyclin-Dependent Kinase Inhibitor p16 ; Cyclin-Dependent Kinase Inhibitor p18/genetics ; Cyclin-Dependent Kinase Inhibitor p18/metabolism ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Female ; Glioblastoma/diagnosis ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; Male ; Microsatellite Instability ; Middle Aged ; Neoplasm Grading ; Neoplasm Proteins/metabolism ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Proto-Oncogene Proteins c-met/genetics ; Proto-Oncogene Proteins c-met/metabolism ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; Telomerase/genetics ; Telomerase/metabolism ; Tissue Array Analysis ; Vascular Endothelial Growth Factor Receptor-2/genetics ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Isolated local recurrence or solitary solid organ metastasis after esophagectomy for cancer is not the end of the road.
Autorzy:
Depypere L; Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.
Lerut T; Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.
Moons J; Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.
Coosemans W; Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.
Decker G; Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.
Van Veer H; Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.
De Leyn P; Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.
Nafteux P; Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.
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Źródło:
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus [Dis Esophagus] 2017 Jan 01; Vol. 30 (1), pp. 1-8.
Typ publikacji:
Journal Article
MeSH Terms:
Adenocarcinoma/*therapy
Adrenal Gland Neoplasms/*therapy
Brain Neoplasms/*therapy
Carcinoma, Squamous Cell/*therapy
Esophageal Neoplasms/*surgery
Liver Neoplasms/*therapy
Lung Neoplasms/*therapy
Neoplasm Recurrence, Local/*therapy
Adenocarcinoma/pathology ; Adenocarcinoma/secondary ; Adrenal Gland Neoplasms/secondary ; Brain Neoplasms/secondary ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/secondary ; Chemoradiotherapy ; Drugs, Chinese Herbal ; Esophageal Neoplasms/pathology ; Esophagectomy ; Esophagogastric Junction/pathology ; Esophagogastric Junction/surgery ; Female ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/secondary ; Lung Neoplasms/secondary ; Lymph Node Excision ; Lymph Nodes/pathology ; Male ; Metastasectomy ; Middle Aged ; Neoplasm Staging ; Prognosis ; Radiotherapy ; Retrospective Studies ; Salvage Therapy ; Survival Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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