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Wyświetlanie 1-10 z 10
Tytuł :
Adhesion of T Cells to Endothelial Cells Facilitates Blinatumomab-Associated Neurologic Adverse Events.
Autorzy :
Klinger M; Amgen Research (Munich) GmbH, Munich, Germany. .
Zugmaier G; Amgen Research (Munich) GmbH, Munich, Germany.
Nägele V; Amgen Research (Munich) GmbH, Munich, Germany.
Goebeler ME; Comprehensive Cancer Center Mainfranken, University Würzburg, Würzburg, Germany.
Brandl C; Amgen Research (Munich) GmbH, Munich, Germany.
Stelljes M; Medizinische Klinik A, University Münster, Münster, Germany.
Lassmann H; Department of Neuroimmunology, Medical University of Vienna, Vienna, Austria.
von Stackelberg A; Department of Pediatrics, Division of Oncology and Hematology, Charité, Berlin, Germany.
Bargou RC; Comprehensive Cancer Center Mainfranken, University Würzburg, Würzburg, Germany.
Kufer P; Amgen Research (Munich) GmbH, Munich, Germany.
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Źródło :
Cancer research [Cancer Res] 2020 Jan 01; Vol. 80 (1), pp. 91-101. Date of Electronic Publication: 2019 Oct 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*adverse effects
Cell Adhesion/*drug effects
Endothelial Cells/*immunology
Neurotoxicity Syndromes/*immunology
T-Lymphocytes/*immunology
Adult ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; Brain/blood supply ; Brain/immunology ; Brain/pathology ; Cell Adhesion/immunology ; Cell Line ; Child ; Clinical Trials, Phase I as Topic ; Clinical Trials, Phase II as Topic ; Endothelial Cells/drug effects ; Endothelium, Vascular/cytology ; Endothelium, Vascular/immunology ; Endothelium, Vascular/pathology ; Female ; Humans ; Incidence ; Lymphoma, Non-Hodgkin/blood ; Lymphoma, Non-Hodgkin/drug therapy ; Lymphoma, Non-Hodgkin/immunology ; Male ; Microvessels/cytology ; Microvessels/immunology ; Microvessels/pathology ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/immunology ; Neurotoxicity Syndromes/epidemiology ; Neurotoxicity Syndromes/pathology ; Neurotoxicity Syndromes/prevention & control ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/blood ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/immunology ; T-Lymphocytes/drug effects
Czasopismo naukowe
Tytuł :
Blinatumomab Pharmacodynamics and Exposure-Response Relationships in Relapsed/Refractory Acute Lymphoblastic Leukemia.
Autorzy :
Zhu M; Clinical Pharmacology, Modeling and Simulation, Amgen Inc., Thousand Oaks, CA, USA.
Kratzer A; Pharmacokinetics and Drug Metabolism, Amgen Research (Munich) GmbH, Munich, Germany.
Johnson J; Clinical Pharmacology, Modeling and Simulation, Amgen Inc., Thousand Oaks, CA, USA.
Holland C; Department of Global Biostatistical Science, Amgen Inc., Washington, DC, USA.
Brandl C; Pharmacokinetics and Drug Metabolism, Amgen Research (Munich) GmbH, Munich, Germany.
Singh I; Clinical Pharmacology, Modeling and Simulation, Amgen Inc., Thousand Oaks, CA, USA.
Wolf A; Pharmacokinetics and Drug Metabolism, Amgen Research (Munich) GmbH, Munich, Germany.
Doshi S; Clinical Pharmacology, Modeling and Simulation, Amgen Inc., Thousand Oaks, CA, USA.
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Źródło :
Journal of clinical pharmacology [J Clin Pharmacol] 2018 Feb; Vol. 58 (2), pp. 168-179. Date of Electronic Publication: 2017 Sep 18.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific*/pharmacology
Antibodies, Bispecific*/therapeutic use
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/metabolism
Adolescent ; Adult ; Aged ; B-Lymphocytes/drug effects ; Cytokines/blood ; Dose-Response Relationship, Drug ; Female ; Humans ; Leukocyte Count ; Male ; Middle Aged ; Recurrence ; Remission Induction ; T-Lymphocytes/drug effects ; Young Adult
Czasopismo naukowe
Tytuł :
Blinatumomab, a Bispecific T-cell Engager (BiTE(®)) for CD-19 Targeted Cancer Immunotherapy: Clinical Pharmacology and Its Implications.
Autorzy :
Zhu M; Amgen Inc., Thousand Oaks, CA, 91320, USA. .
Wu B; Amgen Inc., Thousand Oaks, CA, 91320, USA.
Brandl C; Amgen Research Munich, Munich, Germany.
Johnson J; Amgen Inc., Thousand Oaks, CA, 91320, USA.
Wolf A; Amgen Research Munich, Munich, Germany.
Chow A; Amgen Inc., Thousand Oaks, CA, 91320, USA.
Doshi S; Amgen Inc., Thousand Oaks, CA, 91320, USA.
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Źródło :
Clinical pharmacokinetics [Clin Pharmacokinet] 2016 Oct; Vol. 55 (10), pp. 1271-1288.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*pharmacokinetics
Antibodies, Bispecific/*therapeutic use
Antineoplastic Agents/*pharmacokinetics
Antineoplastic Agents/*therapeutic use
Lymphoma, Non-Hodgkin/*drug therapy
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Age Factors ; B-Lymphocytes/immunology ; Body Weight ; Cytokines/drug effects ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Half-Life ; Humans ; Male ; Metabolic Clearance Rate ; Renal Insufficiency/metabolism ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-Bispecific BiTE antibody cross-reactive with non-human primate antigens.
Autorzy :
Friedrich M; Baeuerle, Amgen Research GmbH, Munich, Germany.
Raum T
Lutterbuese R
Voelkel M
Deegen P
Rau D
Kischel R
Hoffmann P
Brandl C
Schuhmacher J
Mueller P
Finnern R
Fuergut M
Zopf D
Slootstra JW
Baeuerle PA
Rattel B
Kufer P
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Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2012 Dec; Vol. 11 (12), pp. 2664-73. Date of Electronic Publication: 2012 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Bispecific/*pharmacology
Antigens, Surface/*immunology
CD3 Complex/*immunology
Glutamate Carboxypeptidase II/*immunology
Prostatic Neoplasms/*immunology
Prostatic Neoplasms/*therapy
Animals ; Antibodies, Bispecific/genetics ; Antibodies, Bispecific/immunology ; CD3 Complex/genetics ; CHO Cells ; Cricetinae ; Cross Reactions ; Female ; Haplorhini ; Humans ; Immunization, Passive/methods ; Macaca fascicularis ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred NOD ; Mice, SCID ; Prostatic Neoplasms/pathology ; Transfection ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab.
Autorzy :
Klinger M; Amgen Research (Munich) GmbH, Munich, Germany.
Brandl C
Zugmaier G
Hijazi Y
Bargou RC
Topp MS
Gökbuget N
Neumann S
Goebeler M
Viardot A
Stelljes M
Brüggemann M
Hoelzer D
Degenhard E
Nagorsen D
Baeuerle PA
Wolf A
Kufer P
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Źródło :
Blood [Blood] 2012 Jun 28; Vol. 119 (26), pp. 6226-33. Date of Electronic Publication: 2012 May 16.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study
MeSH Terms :
Antibodies, Bispecific/*administration & dosage
Antigens, CD19/*immunology
CD3 Complex/*immunology
Immune System/*drug effects
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*therapy
Adult ; Antibodies, Bispecific/adverse effects ; Antibodies, Bispecific/pharmacokinetics ; Antilymphocyte Serum/administration & dosage ; Antilymphocyte Serum/adverse effects ; Antilymphocyte Serum/metabolism ; Cytotoxicity, Immunologic/drug effects ; Humans ; Immunologic Factors/administration & dosage ; Immunologic Factors/adverse effects ; Immunologic Factors/pharmacokinetics ; Immunotherapy/adverse effects ; Immunotherapy/methods ; Infusion Pumps ; Lymphocyte Activation/drug effects ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Combination of rituximab with blinatumomab (MT103/MEDI-538), a T cell-engaging CD19-/CD3-bispecific antibody, for highly efficient lysis of human B lymphoma cells.
Autorzy :
d'Argouges S; Micromet AG, Staffelseestr. 2, 81477 Munich, Germany.
Wissing S
Brandl C
Prang N
Lutterbuese R
Kozhich A
Suzich J
Locher M
Kiener P
Kufer P
Hofmeister R
Baeuerle PA
Bargou RC
Pokaż więcej
Źródło :
Leukemia research [Leuk Res] 2009 Mar; Vol. 33 (3), pp. 465-73. Date of Electronic Publication: 2008 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*pharmacology
Antibodies, Monoclonal/*pharmacology
Cytotoxicity, Immunologic/*drug effects
Antibodies, Monoclonal, Murine-Derived ; Antigens, CD19/immunology ; Antineoplastic Combined Chemotherapy Protocols ; CD3 Complex/immunology ; Caspase 3/metabolism ; Caspase 7/metabolism ; Drug Synergism ; Granzymes ; Humans ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/pathology ; Rituximab ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct.
Autorzy :
Brandl C; Micromet AG, Staffelseestr. 2, 814777, Munich, Germany.
Haas C
d'Argouges S
Fisch T
Kufer P
Brischwein K
Prang N
Bargou R
Suzich J
Baeuerle PA
Hofmeister R
Pokaż więcej
Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2007 Oct; Vol. 56 (10), pp. 1551-63. Date of Electronic Publication: 2007 Feb 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Bispecific/*pharmacology
CD4-Positive T-Lymphocytes/*drug effects
CD8-Positive T-Lymphocytes/*drug effects
Dexamethasone/*pharmacology
Glucocorticoids/*pharmacology
Neoplasms/*immunology
Antigens, CD/metabolism ; Antigens, CD19/immunology ; CD3 Complex/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Line, Tumor ; Cytokines/metabolism ; Cytotoxicity, Immunologic/drug effects ; Humans ; Lymphocyte Activation/drug effects ; Lymphocyte Function-Associated Antigen-1/metabolism ; Neoplasms/therapy
Czasopismo naukowe
Tytuł :
T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct.
Autorzy :
Schlereth B; Micromet AG, Staffelseestr. 2, 81477, Munich, Germany.
Quadt C
Dreier T
Kufer P
Lorenczewski G
Prang N
Brandl C
Lippold S
Cobb K
Brasky K
Leo E
Bargou R
Murthy K
Baeuerle PA
Pokaż więcej
Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2006 May; Vol. 55 (5), pp. 503-14. Date of Electronic Publication: 2005 Jul 20.
Typ publikacji :
Journal Article
MeSH Terms :
Lymphocyte Depletion*
Antibodies, Bispecific/*pharmacokinetics
B-Lymphocytes/*drug effects
Lymphocyte Activation/*drug effects
T-Lymphocytes/*drug effects
Animals ; Antigens, CD19/immunology ; B-Lymphocytes/immunology ; CD3 Complex/immunology ; Cell Line, Tumor ; Cells, Cultured ; Cytotoxicity Tests, Immunologic ; Female ; Flow Cytometry ; Humans ; Immunotherapy ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/immunology ; Lymphocyte Activation/immunology ; Male ; Pan troglodytes ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody.
Autorzy :
Dreier T; Micromet AG, Am Klopferspitz 19, 82152 Martinsried, Germany.
Lorenczewski G
Brandl C
Hoffmann P
Syring U
Hanakam F
Kufer P
Riethmuller G
Bargou R
Baeuerle PA
Pokaż więcej
Źródło :
International journal of cancer [Int J Cancer] 2002 Aug 20; Vol. 100 (6), pp. 690-7.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Bispecific/*metabolism
Antigens, CD19/*metabolism
CD3 Complex/*metabolism
Lymphoma/*metabolism
T-Lymphocytes, Cytotoxic/*metabolism
Animals ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Murine-Derived ; CHO Cells ; Cell Separation ; Cricetinae ; Dose-Response Relationship, Immunologic ; Flow Cytometry ; Humans ; Interleukin-2/metabolism ; Kinetics ; Lymphocyte Activation ; Mice ; Rituximab ; Time Factors ; Tumor Cells, Cultured
Czasopismo naukowe
    Wyświetlanie 1-10 z 10

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