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Tytuł:
Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody.
Autorzy:
Esparza TJ; National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.
Su S; National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Francescutti CM; National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Rodionova E; National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Kim JH; National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.
Brody DL; National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. david.brody@nih.gov.; Center for Neuroscience and Regenerative Medicine, Bethesda, MD, USA. david.brody@nih.gov.; Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. david.brody@nih.gov.
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Źródło:
Fluids and barriers of the CNS [Fluids Barriers CNS] 2023 Aug 24; Vol. 20 (1), pp. 64. Date of Electronic Publication: 2023 Aug 24.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*
Hypothermia*
Animals ; Mice ; Histidine ; Neurotensin ; Transcytosis ; Hydrogen-Ion Concentration
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Individualized precision targeting of dorsal attention and default mode networks with rTMS in traumatic brain injury-associated depression.
Autorzy:
Siddiqi SH; Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA. .; Center for Brain Circuit Therapeutics, Brigham & Women's Hospital, 60 Fenwood Rd, Boston, MA, 02115, USA. .; Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD, 20814, USA. .
Kandala S; Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA.
Hacker CD; Department of Neurosurgery, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA.
Trapp NT; Department of Psychiatry, University of Iowa Carver College of Medicine, 500 Newton Rd, Iowa City, IA, 52246, USA.
Leuthardt EC; Department of Neurosurgery, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA.
Carter AR; Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA.
Brody DL; Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD, 20814, USA.; Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO, 63110, USA.
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 11; Vol. 13 (1), pp. 4052. Date of Electronic Publication: 2023 Mar 11.
Typ publikacji:
Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Depression*/therapy
Brain Injuries, Traumatic*/complications
Humans ; Reproducibility of Results ; Magnetic Resonance Imaging ; Transcranial Magnetic Stimulation/methods ; Brain Mapping
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Selection of single domain anti-transferrin receptor antibodies for blood-brain barrier transcytosis using a neurotensin based assay and histological assessment of target engagement in a mouse model of Alzheimer's related amyloid-beta pathology.
Autorzy:
Su S; National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America.
Esparza TJ; National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America.; Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, Maryland, United States of America.
Brody DL; National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America.; Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.; Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.
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Źródło:
PloS one [PLoS One] 2022 Oct 18; Vol. 17 (10), pp. e0276107. Date of Electronic Publication: 2022 Oct 18 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Alzheimer Disease*/metabolism
Hypothermia*/metabolism
Camelids, New World*
Animals ; Mice ; Blood-Brain Barrier/metabolism ; Neurotensin/metabolism ; Contrast Media/metabolism ; Fluorescent Dyes/metabolism ; Brain/metabolism ; Amyloid beta-Peptides/metabolism ; Plaque, Amyloid/pathology ; Mice, Transgenic ; Disease Models, Animal ; Transcytosis ; Body Weight
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unbiased high-content screening reveals Aβ- and tau-independent synaptotoxic activities in human brain homogenates from Alzheimer's patients and high-pathology controls.
Autorzy:
Jiang H; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, United States of America.
Esparza TJ; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, United States of America.; Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.; National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America.
Kummer TT; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, United States of America.
Brody DL; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, United States of America.; National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America.; Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Nov 08; Vol. 16 (11), pp. e0259335. Date of Electronic Publication: 2021 Nov 08 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Alzheimer Disease/*pathology
Brain/*pathology
Neurons/*pathology
Synapses/*pathology
Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Animals ; Brain/metabolism ; Case-Control Studies ; Female ; High-Throughput Screening Assays ; Humans ; Male ; Mice ; Neurons/metabolism ; Primary Cell Culture ; Synapses/metabolism ; tau Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Pharmacokinetics of Single Domain Antibodies and Conjugated Nanoparticles Using a Hybrid near Infrared Method.
Autorzy:
Su S; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MI 63130, USA.
Esparza TJ; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20892, USA.
Nguyen D; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Mastrogiacomo S; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Kim JH; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20892, USA.
Brody DL; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MI 63130, USA.; Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20892, USA.; Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 13; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 13.
Typ publikacji:
Journal Article
MeSH Terms:
Camelids, New World/*immunology
Kidney/*chemistry
Liver/*chemistry
Magnetic Iron Oxide Nanoparticles/*chemistry
Single-Domain Antibodies/*administration & dosage
Administration, Intravenous ; Animals ; Brain Chemistry ; Female ; Fluorometry ; Humans ; Mice ; Models, Theoretical ; Particle Size ; Single-Domain Antibodies/blood ; Single-Domain Antibodies/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Sensitive detection of extremely small iron oxide nanoparticles in living mice using MP2RAGE with advanced image co-registration.
Autorzy:
Kim JH; Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, MD, USA.; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Dodd S; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Ye FQ; Neurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, and National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Knutsen AK; Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, MD, USA.
Nguyen D; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Wu H; Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Su S; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Mastrogiacomo S; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Esparza TJ; Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, MD, USA.; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Swenson RE; Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Brody DL; Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, MD, USA. david.brody@usuhs.edu.; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. david.brody@usuhs.edu.; Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. david.brody@usuhs.edu.
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Źródło:
Scientific reports [Sci Rep] 2021 Jan 08; Vol. 11 (1), pp. 106. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji:
Evaluation Study; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain/*diagnostic imaging
Contrast Media/*chemistry
Magnetic Iron Oxide Nanoparticles/*chemistry
Magnetic Resonance Imaging/*methods
Animals ; Female ; Magnetic Resonance Imaging/instrumentation ; Mice ; Mice, Inbred C57BL ; Sensitivity and Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme.
Autorzy:
Esparza TJ; Laboratory of Functional and Molecular Imaging, The National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD, 20892, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20892, USA.
Martin NP; Viral Vector Core, National Institute of Environmental Health Sciences, NIH/DHHS, Research Triangle Park, NC, 27709, USA.; Neurobiology Laboratory, National Institute of Environmental Health Sciences, NIH/DHHS, Research Triangle Park, NC, 27709, USA.
Anderson GP; Center for Biomolecular Science and Engineering, US Naval Research Laboratory, Washington, DC, 20375, USA.
Goldman ER; Center for Biomolecular Science and Engineering, US Naval Research Laboratory, Washington, DC, 20375, USA.
Brody DL; Laboratory of Functional and Molecular Imaging, The National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD, 20892, USA. david.brody@nih.gov.; Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. david.brody@nih.gov.
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Źródło:
Scientific reports [Sci Rep] 2020 Dec 22; Vol. 10 (1), pp. 22370. Date of Electronic Publication: 2020 Dec 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Antibody Affinity*
Angiotensin-Converting Enzyme 2/*metabolism
Antibodies, Viral/*immunology
COVID-19/*metabolism
Drug Discovery/*methods
Protein Interaction Domains and Motifs/*immunology
SARS-CoV-2/*chemistry
Single-Domain Antibodies/*immunology
Spike Glycoprotein, Coronavirus/*chemistry
Angiotensin-Converting Enzyme 2/genetics ; Animals ; Antibodies, Neutralizing/immunology ; Binding Sites, Antibody/immunology ; COVID-19/therapy ; COVID-19/virology ; Camelids, New World ; HEK293 Cells ; Humans ; Immunization/methods ; Male ; Protein Binding ; Signal Transduction/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Transduction, Genetic ; Transfection
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates.
Autorzy:
Jiang H; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, Missouri, 63110, USA.
Esparza TJ; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, Missouri, 63110, USA.; Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, 20817, USA.; National Institute of Neurological Disorders and Stroke, 10 Center Drive, Bethesda, Maryland, 20892, USA.
Kummer TT; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, Missouri, 63110, USA.
Zhong H; Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon, 97239, USA.
Rettig J; Department of Physiology, Saarland University, Center for Integrative Physiology and Molecular Medicine (CIPMM), Building 48, Homburg, 66421, Germany.
Brody DL; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, Missouri, 63110, USA. David.brody@usuhs.edu.; National Institute of Neurological Disorders and Stroke, 10 Center Drive, Bethesda, Maryland, 20892, USA. David.brody@usuhs.edu.; Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20814, USA. David.brody@usuhs.edu.
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Źródło:
Scientific reports [Sci Rep] 2020 Feb 25; Vol. 10 (1), pp. 3412. Date of Electronic Publication: 2020 Feb 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*metabolism
Amyloid beta-Peptides/*metabolism
Disks Large Homolog 4 Protein/*metabolism
Neurons/*metabolism
Vesicle-Associated Membrane Protein 2/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Animals ; Disease Models, Animal ; Disks Large Homolog 4 Protein/genetics ; Mice ; Mice, Knockout ; Neurons/pathology ; Vesicle-Associated Membrane Protein 2/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Novel Gradient Echo Plural Contrast Imaging Method Detects Brain Tissue Abnormalities in Patients With TBI Without Evident Anatomical Changes on Clinical MRI: A Pilot Study.
Autorzy:
Astafiev SV; Department of Radiology, Washington University in St. Louis, 660 S. Euclid Ave, Campus Box 8225, St. Louis, MO.; Department of Psychiatry, Washington University in St. Louis, 660 S. Euclid Ave, Campus Box 8134, St. Louis, MO.
Wen J; Department of Radiology, Washington University in St. Louis, 660 S. Euclid Ave, Campus Box 8225, St. Louis, MO.
Brody DL; Department of Neurology, Washington University in St. Louis, 660 S. Euclid Ave, Campus Box 8111, St. Louis, MO.; Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD.
Cross AH; Department of Neurology, Washington University in St. Louis, 660 S. Euclid Ave, Campus Box 8111, St. Louis, MO.
Anokhin AP; Department of Psychiatry, Washington University in St. Louis, 660 S. Euclid Ave, Campus Box 8134, St. Louis, MO.
Zinn KL; Department of Neurology, Washington University in St. Louis, 660 S. Euclid Ave, Campus Box 8111, St. Louis, MO.
Corbetta M; Department of Neurology, Washington University in St. Louis, 660 S. Euclid Ave, Campus Box 8111, St. Louis, MO.; Department of Neuroscience and Padova Neuroscience Center (PNC), University of Padova, Palazzina Neuroscienze, Via Giustiniani, 2, Padova, Italy.
Yablonskiy DA; Department of Radiology, Washington University in St. Louis, 660 S. Euclid Ave, Campus Box 8225, St. Louis, MO.
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Źródło:
Military medicine [Mil Med] 2019 Mar 01; Vol. 184 (Suppl 1), pp. 218-227.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Contrast Media/*therapeutic use
Gray Matter/*injuries
Magnetic Resonance Imaging/*methods
Adult ; Aged ; Brain/abnormalities ; Brain/diagnostic imaging ; Brain/physiopathology ; Female ; Gray Matter/diagnostic imaging ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Pilot Projects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 29

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