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Tytuł :
YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity
Autorzy :
Yui, OM
Benitez, JA
Plouffe, SW
Ryback, D
Klein, A
Smith, J
Greenbaum, J
Delatte, B
Rao, A
Guan, K-L
Furnari, FB
Chaim, OM
Miyamoto, S
Brown, JH
Pokaż więcej
Temat :
Phosphoproteins
rhoA GTP-Binding Protein
glioblastoma multiforme
Oncology & Carcinogenesis
Signal Transducing
Heterografts
YAP
Brain Neoplasms
Neoplastic
Adaptor Proteins
Trans-Activators
Mice
patient derived xenograft
Article
Gene Expression Regulation
Oncology and Carcinogenesis
Glioblastoma
MRTF-A
sphingosine-1-phosphate
Animals
Nude
Clinical Sciences
Humans
RhoA
Źródło :
Yui, OM; Benitez, JA; Plouffe, SW; Ryback, D; Klein, A; Smith, J; et al.(2018). YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. ONCOGENE, 37(41), 5492 - 5507. doi: 10.1038/s41388-018-0301-5. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/09f4x8r8
Opis pliku :
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Tytuł :
BioTIME: A database of biodiversity time series for the Anthropocene
Autorzy :
Dornelas, M
Antão, LH
Moyes, F
Bates, AE
Magurran, AE
Adam, D
Akhmetzhanova, AA
Appeltans, W
Arcos, JM
Arnold, H
Ayyappan, N
Badihi, G
Baird, AH
Barbosa, M
Barreto, TE
Bässler, C
Bellgrove, A
Belmaker, J
Benedetti-Cecchi, L
Bett, BJ
Bjorkman, AD
Błażewicz, M
Blowes, SA
Bloch, CP
Bonebrake, TC
Boyd, S
Bradford, M
Brooks, AJ
Brown, JH
Bruelheide, H
Budy, P
Carvalho, F
Castañeda-Moya, E
Chen, CA
Chamblee, JF
Chase, TJ
Siegwart Collier, L
Collinge, SK
Condit, R
Cooper, EJ
Cornelissen, JHC
Cotano, U
Kyle Crow, S
Damasceno, G
Davies, CH
Davis, RA
Day, FP
Degraer, S
Doherty, TS
Dunn, TE
Durigan, G
Duffy, JE
Edelist, D
Edgar, GJ
Elahi, R
Elmendorf, SC
Enemar, A
Ernest, SKM
Escribano, R
Estiarte, M
Evans, BS
Fan, T-Y
Turini Farah, F
Loureiro Fernandes, L
Farneda, FZ
Fidelis, A
Fitt, R
Fosaa, AM
Daher Correa Franco, GA
Frank, GE
Fraser, WR
García, H
Cazzolla Gatti, R
Givan, O
Gorgone-Barbosa, E
Gould, WA
Gries, C
Grossman, GD
Gutierréz, JR
Hale, S
Harmon, ME
Harte, J
Haskins, G
Henshaw, DL
Hermanutz, L
Hidalgo, P
Higuchi, P
Hoey, A
Van Hoey, G
Hofgaard, A
Holeck, K
Hollister, RD
Holmes, R
Hoogenboom, M
Hsieh, C
Hubbell, SP
Huettmann, F
Huffard, CL
Hurlbert, AH
Macedo Ivanauskas, N
Janík, D
Jandt, U
Jażdżewska, A
Johannessen, T
Johnstone, J
Jones, J
Jones, FAM
Kang, J
Kartawijaya, T
Keeley, EC
Kelt, DA
Kinnear, R
Klanderud, K
Knutsen, H
Koenig, CC
Kortz, AR
Král, K
Kuhnz, LA
Kuo, C-Y
Kushner, DJ
Laguionie-Marchais, C
Lancaster, LT
Min Lee, C
Lefcheck, JS
Lévesque, E
Lightfoot, D
Lloret, F
Lloyd, JD
López-Baucells, A
Louzao, M
Madin, JS
Magnússon, B
Malamud, S
Matthews, I
McFarland, KP
McGill, B
McKnight, D
McLarney, WO
Meador, J
Meserve, PL
Metcalfe, DJ
Meyer, CFJ
Michelsen, A
Milchakova, N
Moens, T
Moland, E
Moore, J
Mathias Moreira, C
Müller, J
Murphy, G
Myers-Smith, IH
Myster, RW
Naumov, A
Neat, F
Nelson, JA
Paul Nelson, M
Newton, SF
Norden, N
Oliver, JC
Olsen, EM
Onipchenko, VG
Pabis, K
Pabst, RJ
Paquette, A
Pardede, S
Paterson, DM
Pélissier, R
Peñuelas, J
Pérez-Matus, A
Pizarro, O
Pomati, F
Post, E
Prins, HHT
Priscu, JC
Provoost, P
Prudic, KL
Pulliainen, E
Ramesh, BR
Mendivil Ramos, O
Rassweiler, A
Rebelo, JE
Reed, DC
Reich, PB
Remillard, SM
Richardson, AJ
Richardson, JP
van Rijn, I
Rocha, R
Rivera-Monroy, VH
Rixen, C
Robinson, KP
Ribeiro Rodrigues, R
de Cerqueira Rossa-Feres, D
Rudstam, L
Ruhl, H
Ruz, CS
Sampaio, EM
Rybicki, N
Rypel, A
Sal, S
Salgado, B
Santos, FAM
Savassi-Coutinho, AP
Scanga, S
Schmidt, J
Schooley, R
Setiawan, F
Shao, K-T
Shaver, GR
Sherman, S
Sherry, TW
Siciński, J
Sievers, C
da Silva, AC
Rodrigues da Silva, F
Silveira, FL
Slingsby, J
Smart, T
Snell, SJ
Soudzilovskaia, NA
Souza, GBG
Maluf Souza, F
Castro Souza, V
Stallings, CD
Stanforth, R
Stanley, EH
Mauro Sterza, J
Stevens, M
Stuart-Smith, R
Rondon Suarez, Y
Supp, S
Yoshio Tamashiro, J
Tarigan, S
Thiede, GP
Thorn, S
Tolvanen, A
Teresa Zugliani Toniato, M
Totland, Ø
Twilley, RR
Vaitkus, G
Valdivia, N
Vallejo, MI
Valone, TJ
Van Colen, C
Vanaverbeke, J
Venturoli, F
Verheye, HM
Vianna, M
Vieira, RP
Vrška, T
Quang Vu, C
Van Vu, L
Waide, RB
Waldock, C
Watts, D
Webb, S
Wesołowski, T
White, EP
Widdicombe, CE
Wilgers, D
Williams, R
Williams, SB
Williamson, M
Willig, MR
Willis, TJ
Wipf, S
Woods, KD
Woehler, EJ
Zawada, K
Zettler, ML
Pokaż więcej
Opis pliku :
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Tytuł :
C-terminal phosphorylation of Na(V)1.5 impairs FGF13-dependent regulation of channel inactivation
Autorzy :
Burel, S
Coyan, FC
Lorenzini, M
Meyer, MR
Lichti, CF
Brown, JH
Loussouarn, G
Charpentier, F
Nerbonne, JM
Townsend, RR
Maier, LS
Marionneau, C
Pokaż więcej
Temat :
Animals
Mice, Transgenic
Humans
Mice
Fibroblast Growth Factors
Amino Acid Substitution
Ion Channel Gating
Phosphorylation
Mutation, Missense
Heart Failure
Calcium-Calmodulin-Dependent Protein Kinase Type 2
HEK293 Cells
NAV1.5 Voltage-Gated Sodium Channel
Źródło :
Burel, S; Coyan, FC; Lorenzini, M; Meyer, MR; Lichti, CF; Brown, JH; et al.(2017). C-terminal phosphorylation of Na(V)1.5 impairs FGF13-dependent regulation of channel inactivation. JOURNAL OF BIOLOGICAL CHEMISTRY, 292(42), 17431 - 17448. doi: 10.1074/jbc.M117.787788. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2rz48167
Opis pliku :
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Tytuł :
Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes
Autorzy :
Dusaban, SS
Chun, J
Rosen, H
Purcell, NH
Brown, JH
Pokaż więcej
Temat :
rhoA GTP-Binding Protein
Biotechnology
Neurosciences
Neurology. Diseases of the nervous system
Cultured
Transfection
Mice
Research
S1P(3)
1.1 Normal biological development and functioning
S1P
Brain Disorders
Genetics
S1P3
Inflammation
Neurology & Neurosurgery
Transgenic
Small Interfering
Cytokines
Animals
Vascular Endothelial Growth Factor A
2.1 Biological and endogenous factors
Immunology
Receptors
RNA
Signal Transduction
Inbred C57BL
RC346-429
Newborn
Renilla
Neurological
Central nervous system
Cells
Messenger
Neurodegenerative
Cyclooxygenase 2
Astrocytes
Clinical Sciences
Lysosphingolipid
RhoA
Gene Expression
Źródło :
Journal of neuroinflammation, vol 14, iss 1
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-10 (2017)
Dusaban, SS; Chun, J; Rosen, H; Purcell, NH; & Brown, JH. (2017). Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes. JOURNAL OF NEUROINFLAMMATION, 14. doi: 10.1186/s12974-017-0882-x. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2bp9760n
Journal of Neuroinflammation
Opis pliku :
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Tytuł :
Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure.
Autorzy :
Dewenter, M
Neef, S
Vettel, C
Laemmle, S
Beushausen, C
Zelarayan, LC
Katz, S
von der Lieth, A
Meyer-Roxlau, S
Weber, S
Wieland, T
Sossalla, S
Backs, J
Brown, JH
Maier, LS
El-Armouche, A
Pokaż więcej
Temat :
heart failure
Biochemistry and Cell Biology
cardiovascular system
calcium
beta-adrenergic blockers
Echocardiography
Mice
Disease Models
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Medical Physiology
calmodulin-dependent protein kinase type 2
Cardiorespiratory Medicine and Haematology
Adrenergic beta-Antagonists
Metoprolol
calcium/calmodulin-dependent protein kinase type 2
Immunoblotting
Animal
Transgenic
Animals
Humans
Cardiovascular System & Hematology
Źródło :
Circulation. Heart failure, vol 10, iss 5
Dewenter, M; Neef, S; Vettel, C; Laemmle, S; Beushausen, C; Zelarayan, LC; et al.(2017). Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic -Adrenoceptor Blockade in Experimental and Human Heart Failure. CIRCULATION-HEART FAILURE, 10(5). doi: 10.1161/CIRCHEARTFAILURE.117.003840. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/46h9g99w
Opis pliku :
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Tytuł :
Exercise training reverses myocardial dysfunction induced by CaMKII delta(C) overexpression by restoring Ca2+ homeostasis
Autorzy :
Hoydal, MA
Stolen, TO
Kettlewell, S
Maier, LS
Brown, JH
Sowa, T
Catalucci, D
Condorelli, G
Kemi, OJ
Smith, GL
Wisloff, U
Pokaż więcej
Temat :
calcium handling
CaM kinase
exercise training
heart disease
Źródło :
Hoydal, MA; Stolen, TO; Kettlewell, S; Maier, LS; Brown, JH; Sowa, T; et al.(2016). Exercise training reverses myocardial dysfunction induced by CaMKII delta(C) overexpression by restoring Ca2+ homeostasis. JOURNAL OF APPLIED PHYSIOLOGY, 121(1), 212 - 220. doi: 10.1152/japplphysiol.00188.2016. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/25z3x6kx
Opis pliku :
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Tytuł :
Reductions in the Cardiac Transient Outward K+ Current I-to Caused by Chronic beta-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor kappa B
Autorzy :
Panama, BK
Korogyi, AS
Aschar-Sobbi, R
Oh, Y
Gray, CBB
Gang, H
Brown, JH
Kirshenbaum, LA
Backx, PH
Pokaż więcej
Temat :
adrenergic receptor
Ca2+
calmodulin-dependent protein kinase (CaMK)
cardiomyocyte
potassium channel
transcription
Źródło :
Panama, BK; Korogyi, AS; Aschar-Sobbi, R; Oh, Y; Gray, CBB; Gang, H; et al.(2016). Reductions in the Cardiac Transient Outward K+ Current I-to Caused by Chronic beta-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor kappa B. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(8), 4156 - 4165. doi: 10.1074/jbc.M115.694984. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6m02g50k
Opis pliku :
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Tytuł :
CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca2+leak and the pathophysiological response to chronic β-adrenergic stimulation
Autorzy :
Grimm, M
Ling, H
Willeford, A
Pereira, L
Gray, CBB
Erickson, JR
Sarma, S
Respress, JL
Wehrens, XHT
Bers, DM
Brown, JH
Pokaż więcej
Temat :
cardiovascular system
musculoskeletal system
Źródło :
Grimm, M; Ling, H; Willeford, A; Pereira, L; Gray, CBB; Erickson, JR; et al.(2015). CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca2+leak and the pathophysiological response to chronic β-adrenergic stimulation. Journal of Molecular and Cellular Cardiology, 85, 282 - 291. doi: 10.1016/j.yjmcc.2015.06.007. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/01d3x2zj
Opis pliku :
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Tytuł :
G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation.
Autorzy :
Yu, OM
Brown, JH
Pokaż więcej
Temat :
rhoA GTP-Binding Protein
Neurosciences
Biochemistry and Cell Biology
Receptors
Cell Proliferation
Signal Transduction
Special Issue Commemorating the 50th Anniversary of Molecular Pharmacology
Cardiovascular Diseases
G-Protein-Coupled
Gene Expression Regulation
Mucolipidoses
Inflammation
Pharmacology and Pharmaceutical Sciences
Animals
Neoplasms
Humans
Pharmacology & Pharmacy
Źródło :
Yu, OM; & Brown, JH. (2015). G protein-coupled receptor and RhoA-stimulated transcriptional responses: Links to inflammation, differentiation, and cell proliferation. Molecular Pharmacology, 88(1), 171 - 180. doi: 10.1124/mol.115.097857. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/10x818w6
Molecular pharmacology, vol 88, iss 1
Opis pliku :
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Tytuł :
Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes.
Autorzy :
Zhang, DM
Chai, Y
Erickson, JR
Brown, JH
Bers, DM
Lin, YF
Pokaż więcej
Temat :
Potassium
Cultured
Rabbits
Mice
Ion Channel Gating
Myocytes
1.1 Normal biological development and functioning
Heart Disease
KATP Channels
Animals
HEK293 Cells
2.1 Biological and endogenous factors
Sarcolemma
Knockout
Nitric Oxide
cardiovascular system
Signal Transduction
Physiology
Heart Ventricles
Cardiovascular
Biological Sciences
Medical and Health Sciences
Cells
Humans
Cardiac
Źródło :
Zhang, DM; Chai, Y; Erickson, JR; Brown, JH; Bers, DM; & Lin, YF. (2014). Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes. Journal of Physiology, 592(5), 971 - 990. doi: 10.1113/jphysiol.2013.264697. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/35z494dv
The Journal of physiology, vol 592, iss 5
Opis pliku :
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Tytuł :
Nonequilibrium reactivation of Na+current drives early afterdepolarizations in mouse ventricle
Autorzy :
Edwards, AG
Grandi, E
Hake, JE
Patel, S
Li, P
Miyamoto, S
Omens, JH
Brown, JH
Bers, DM
McCulloch, AD
Pokaż więcej
Źródło :
Edwards, AG; Grandi, E; Hake, JE; Patel, S; Li, P; Miyamoto, S; et al.(2014). Nonequilibrium reactivation of Na+current drives early afterdepolarizations in mouse ventricle. Circulation: Arrhythmia and Electrophysiology, 7(6), 1205 - 1213. doi: 10.1161/CIRCEP.113.001666. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/349749pm
Opis pliku :
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Tytuł :
Climate Change and the Integrity of Science
Autorzy :
Gleick, PH
Adams, RM
Amasino, RM
Anders, E
Anderson, DJ
Anderson, WW
Anselin, LE
Arroyo, MK
Asfaw, B
Ayala, FJ
Bax, A
Bebbington, AJ
Bell, G
Bennett, MVL
Bennetzen, JL
Berenbaum, MR
Berlin, OB
Bjorkman, PJ
Blackburn, E
Blamont, JE
Botchan, MR
Boyer, JS
Boyle, EA
Branton, D
Briggs, SP
Briggs, WR
Brill, WJ
Britten, RJ
Broecker, WS
Brown, JH
Brown, PO
Brunger, AT
Cairns, J
Canfield, DE
Carpenter, SR
Carrington, JC
Cashmore, AR
Castilla, JC
Cazenave, A
Chapin, FS
Ciechanover, AJ
Clapham, DE
Clark, WC
Clayton, RN
Coe, MD
Conwell, EM
Cowling, EB
Cowling, RM
Cox, CS
Croteau, RB
Crothers, DM
Crutzen, PJ
Daily, GC
Dalrymple, GB
Dangl, JL
Darst, SA
Davies, DR
Davis, MB
De Camilli, PV
Dean, C
Defries, RS
Deisenhofer, J
Delmer, DP
Delong, EF
Derosier, DJ
Diener, TO
Dirzo, R
Dixon, JE
Donoghue, MJ
Doolittle, RF
Dunne, T
Ehrlich, PR
Eisenstadt, SN
Eisner, T
Emanuel, KA
Englander, SW
Ernst, WG
Falkowski, PG
Feher, G
Ferejohn, JA
Fersht, A
Fischer, EH
Fischer, R
Flannery, KV
Frank, J
Frey, PA
Fridovich, I
Frieden, C
Futuyma, DJ
Gardner, WR
Garrett, CJR
Gilbert, W
Goldberg, RB
Goodenough, WH
Goodman, CS
Goodman, M
Greengard, P
Hake, S
Hammel, G
Hanson, S
Harrison, SC
Hart, SR
Hartl, DL
Haselkorn, R
Hawkes, K
Hayes, JM
Hille, B
Hökfelt, T
House, JS
Hout, M
Hunten, DM
Izquierdo, IA
Jagendorf, AT
Janzen, DH
Jeanloz, R
Jencks, CS
Jury, WA
Kaback, HR
Kailath, T
Kay, P
Kay, SA
Kennedy, D
Kerr, A
Kessler, RC
Khush, GS
Kieffer, SW
Kirch, PV
Kirk, K
Kivelson, MG
Klinman, JP
Klug, A
Knopoff, L
Kornberg, H
Kutzbach, JE
Lagarias, JC
Lambeck, K
Landy, A
Langmuir, CH
Larkins, BA
Le Pichon, XT
Lenski, RE
Leopold, EB
Levin, SA
Levitt, M
Likens, GE
Lippincott-Schwartz, J
Lorand, L
Lovejoy, CO
Lynch, M
Mabogunje, AL
Malone, TF
Manabe, S
Marcus, J
Massey, DS
McWilliams, JC
Medina, E
Melosh, HJ
Meltzer, DJ
Michener, CD
Miles, EL
Mooney, HA
Moore, PB
Morel, FMM
Mosley-Thompson, ES
Moss, B
Munk, WH
Myers, N
Nair, GB
Nathans, J
Nester, EW
Nicoll, RA
Novick, RP
O’Connell, JF
Olsen, PE
Opdyke, ND
Oster, GF
Ostrom, E
Pace, NR
Paine, RT
Palmiter, RD
Pedlosky, J
Petsko, GA
Pettengill, GH
Philander, SG
Piperno, DR
Pollard, TD
Price, PB
Reichard, PA
Reskin, BF
Ricklefs, RE
Rivest, RL
Roberts, JD
Romney, AK
Rossmann, MG
Russell, DW
Rutter, WJ
Sabloff, JA
Sagdeev, RZ
Sahlins, MD
Salmond, A
Sanes, JR
Schekman, R
Schellnhuber, J
Schindler, DW
Schmitt, J
Schneider, SH
Schramm, VL
Sederoff, RR
Shatz, CJ
Sherman, F
Sidman, RL
Sieh, K
Simons, EL
Singer, BH
Singer, MF
Skyrms, B
Sleep, NH
Smith, BD
Snyder, SH
Sokal, RR
Spencer, CS
Steitz, TA
Strier, KB
Südhof, TC
Taylor, SS
Terborgh, J
Thomas, DH
Thompson, LG
Jian, RTT
Turner, MG
Uyeda, S
Valentine, JW
Valentine, JS
Van Etten, JL
Van Holde, KE
Vaughan, M
Verba, S
Von Hippel, PH
Wake, DB
Walker, A
Walker, JE
Watson, EB
Watson, PJ
Weigel, D
Wessler, SR
West-Eberhard, MJ
White, TD
Wilson, WJ
Wolfenden, RV
Wood, JA
Woodwell, GM
Wright, HE
Wu, C
Wunsch, C
Zoback, ML
Pokaż więcej
Temat :
Article
Tytuł :
Akt regulates L-type Ca2+channel activity by modulating Cavα1 protein stability
Autorzy :
Catalucci, D
Zhang, DH
Desantiago, J
Aimond, F
Barbara, G
Chemin, J
Bonci, D
Picht, E
Rusconi, F
Dalton, ND
Peterson, KL
Richard, S
Bers, DM
Brown, JH
Condorelli, G
Pokaż więcej
Źródło :
Catalucci, D; Zhang, DH; Desantiago, J; Aimond, F; Barbara, G; Chemin, J; et al.(2009). Akt regulates L-type Ca2+channel activity by modulating Cavα1 protein stability. Journal of Cell Biology, 184(6), 923 - 933. doi: 10.1083/jcb.200805063. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7mk8j3s4
Opis pliku :
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