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Tytuł :
Distinct viral reservoirs in individuals with spontaneous control of HIV-1.
Autorzy :
Jiang C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
Lian X; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
Gao C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Sun X; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Einkauf KB; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
Chevalier JM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
Chen SMY; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Hua S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Rhee B; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
Chang K; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Blackmer JE; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Osborn M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Peluso MJ; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Hoh R; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Somsouk M; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Milush J; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Bertagnolli LN; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sweet SE; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Varriale JA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Burbelo PD; Dental Clinical Research Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Chun TW; National Institute of Allergies and Infectious Diseases, Bethesda, MD, USA.
Laird GM; Accelevir Diagnostics, Baltimore, MD, USA.
Serrao E; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Carrington M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Siliciano RF; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Siliciano JM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Deeks SG; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Lichterfeld M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Yu XG; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. .; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA. .
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Źródło :
Nature [Nature] 2020 Sep; Vol. 585 (7824), pp. 261-267. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Silencing*
HIV Infections/*genetics
HIV Infections/*virology
HIV-1/*genetics
Heterochromatin/*genetics
Proviruses/*genetics
Virus Integration/*genetics
Virus Latency/*genetics
Adult ; Aged ; Centromere/genetics ; Chromosomes, Human, Pair 19/genetics ; DNA, Satellite/genetics ; Female ; Genome, Viral/genetics ; HIV Infections/blood ; HIV-1/isolation & purification ; Heterochromatin/metabolism ; Humans ; Male ; Middle Aged ; Proviruses/isolation & purification ; Repressor Proteins/genetics ; Transcription Initiation Site
Czasopismo naukowe
Tytuł :
CD8 T cells in HIV control, cure and prevention.
Autorzy :
Collins DR; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Gaiha GD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Gastrointestinal Unit, Department of Medicine, MGH, Boston, MA, USA.
Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. .; Howard Hughes Medical Institute, Chevy Chase, MD, USA. .; Institute for Medical Engineering and Sciences and Department of Biology, MIT, Cambridge, MA, USA. .
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Źródło :
Nature reviews. Immunology [Nat Rev Immunol] 2020 Aug; Vol. 20 (8), pp. 471-482. Date of Electronic Publication: 2020 Feb 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
AIDS Vaccines/*immunology
CD8-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*transplantation
HIV Infections/*immunology
HIV Infections/*prevention & control
Adoptive Transfer/methods ; Anti-Retroviral Agents/therapeutic use ; Antibodies, Neutralizing/immunology ; CD4-Positive T-Lymphocytes/immunology ; Humans ; Immunity, Cellular/immunology ; Immunization
Czasopismo naukowe
Tytuł :
Envelope characteristics in individuals who developed neutralizing antibodies targeting different epitopes in HIV-1 subtype C infection.
Autorzy :
Ndlovu B; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. Electronic address: .
Gounder K; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, Durban, South Africa. Electronic address: .
Muema D; Africa Health Research Institute, Durban, South Africa. Electronic address: .
Raju N; Vanderbilt Vaccine Center and Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: .
Hermanus T; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa. Electronic address: .
Mthethwa Q; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. Electronic address: .
Robertson K; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. Electronic address: .
Walker BD; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. Electronic address: .
Georgiev IS; Vanderbilt Vaccine Center and Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: .
Morris L; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa; University of the Witwatersrand, Johannesburg, South Africa. Electronic address: .
Moore PL; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa; University of the Witwatersrand, Johannesburg, South Africa. Electronic address: .
Ndung'u T; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, Durban, South Africa; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA; Max Planck Institute for Infection Biology, Berlin, Germany; Division of Infection and Immunity, University College London, UK. Electronic address: .
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Źródło :
Virology [Virology] 2020 Jul; Vol. 546, pp. 1-12. Date of Electronic Publication: 2020 Mar 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*immunology
HIV Antibodies/*immunology
HIV Infections/*immunology
HIV-1/*immunology
env Gene Products, Human Immunodeficiency Virus/*immunology
Amino Acid Sequence ; Epitope Mapping ; HIV Infections/blood ; HIV Infections/virology ; HIV-1/chemistry ; HIV-1/classification ; HIV-1/genetics ; Humans ; env Gene Products, Human Immunodeficiency Virus/chemistry ; env Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection.
Autorzy :
Kazer SW; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Aicher TP; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Muema DM; African Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Carroll SL; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Ordovas-Montanes J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.
Miao VN; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Health Sciences and Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA, USA.
Tu AA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ziegler CGK; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Health Sciences and Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA, USA.
Nyquist SK; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Wong EB; African Health Research Institute, Durban, South Africa.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Division of Infection and Immunity, University College London, London, UK.; Harvard Medical School, Boston, MA, USA.
Ismail N; HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Dong M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Moodley A; HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Berger B; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Love JC; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Dong KL; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Leslie A; African Health Research Institute, Durban, South Africa.; Division of Infection and Immunity, University College London, London, UK.
Ndhlovu ZM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; African Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Ndung'u T; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; African Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Division of Infection and Immunity, University College London, London, UK.; Max Planck Institute for Infection Biology, Berlin, Germany.
Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. .; HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa. .; Howard Hughes Medical Institute, Chevy Chase, MD, USA. .
Shalek AK; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. .; Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA. .; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. .; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Program in Health Sciences and Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA, USA. .; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. .; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. .
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Źródło :
Nature medicine [Nat Med] 2020 Apr; Vol. 26 (4), pp. 511-518. Date of Electronic Publication: 2020 Mar 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Communication*/genetics
Cell Communication*/immunology
HIV Infections/*genetics
HIV Infections/*immunology
Immunity, Cellular/*physiology
Single-Cell Analysis/*methods
Acute Disease ; Acute-Phase Reaction/genetics ; Acute-Phase Reaction/immunology ; Acute-Phase Reaction/pathology ; Adolescent ; Adult ; Female ; Gene Expression Profiling ; Gene Regulatory Networks/immunology ; HIV Infections/pathology ; HIV-1/genetics ; HIV-1/pathogenicity ; Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/pathology ; Longitudinal Studies ; Sequence Analysis, RNA/methods ; Systems Integration ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism ; Viral Load/genetics ; Viral Load/immunology ; Young Adult
Czasopismo naukowe
Tytuł :
Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection.
Autorzy :
Muema DM; Africa Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Akilimali NA; Africa Health Research Institute, Durban, South Africa.
Ndumnego OC; Africa Health Research Institute, Durban, South Africa.
Rasehlo SS; Africa Health Research Institute, Durban, South Africa.
Durgiah R; Africa Health Research Institute, Durban, South Africa.
Ojwach DBA; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Ismail N; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Dong M; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Moodley A; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Dong KL; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA, USA.
Ndhlovu ZM; Africa Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA, USA.
Mabuka JM; Africa Health Research Institute, Durban, South Africa.
Walker BD; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA, USA.
Mann JK; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Ndung'u T; Africa Health Research Institute, Durban, South Africa. .; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa. .; Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA, USA. .; Max Planck Institute for Infection Biology, Berlin, Germany. .; Division of Infection and Immunity, University College London, London, UK. .
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Źródło :
BMC medicine [BMC Med] 2020 Mar 25; Vol. 18 (1), pp. 81. Date of Electronic Publication: 2020 Mar 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytokines/*therapeutic use
HIV Infections/*immunology
Viral Load/*methods
Viremia/*immunology
Adolescent ; Adult ; Cytokines/pharmacology ; Female ; HIV Infections/drug therapy ; Humans ; Male ; Young Adult
Czasopismo naukowe
Tytuł :
Immunological Fingerprints of Controllers Developing Neutralizing HIV-1 Antibodies.
Autorzy :
Martin-Gayo E; Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA; Universidad Autónoma de Madrid, Hospital de la Princesa, Madrid, Spain. Electronic address: .
Gao C; Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA.
Chen HR; Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA.
Ouyang Z; Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA.
Kim D; Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA.
Kolb KE; Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA; Department of Chemistry, MIT Institute for Medical Engineering and Science (IMES), MIT, Cambridge, MA, USA; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Shalek AK; Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA; Department of Chemistry, MIT Institute for Medical Engineering and Science (IMES), MIT, Cambridge, MA, USA; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Walker BD; Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Lichterfeld M; Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.
Yu XG; Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2020 Jan 28; Vol. 30 (4), pp. 984-996.e4.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Neutralizing/*immunology
CD4-Positive T-Lymphocytes/*immunology
Dendritic Cells/*immunology
HIV Antibodies/*immunology
HIV Infections/*immunology
HIV-1/*immunology
Monocytes/*immunology
T-Lymphocytes, Helper-Inducer/*immunology
Adult ; Aged ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; Cell Line ; Cell Survival/immunology ; Dendritic Cells/metabolism ; Female ; Gene Expression Regulation/immunology ; Humans ; Interleukin-12/metabolism ; Male ; Middle Aged ; Monocytes/metabolism ; RNA-Seq ; STAT4 Transcription Factor/genetics ; STAT4 Transcription Factor/metabolism ; T-Lymphocytes, Helper-Inducer/metabolism ; Th1 Cells/immunology ; Th1 Cells/metabolism
Czasopismo naukowe
Tytuł :
Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity.
Autorzy :
Jin SW; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Alsahafi N; Centre de Recherche du CHUM, Montreal, QC, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
Kuang XT; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Swann SA; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Toyoda M; Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
Göttlinger H; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Walker BD; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Cambridge, MA, USA.
Ueno T; Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
Finzi A; Centre de Recherche du CHUM, Montreal, QC, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada; Department of Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.
Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Brockman MA; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2019 Nov 05; Vol. 29 (6), pp. 1449-1457.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV Infections/*metabolism
HIV-1/*genetics
Host-Pathogen Interactions/*genetics
Membrane Proteins/*metabolism
T-Lymphocytes/*virology
nef Gene Products, Human Immunodeficiency Virus/*genetics
Alleles ; CD4 Antigens/metabolism ; Cell Line, Tumor ; Down-Regulation ; Gene Knockout Techniques ; HIV Infections/genetics ; HIV-1/metabolism ; HIV-1/pathogenicity ; HLA-A Antigens/metabolism ; Humans ; Membrane Proteins/antagonists & inhibitors ; Membrane Proteins/genetics ; Mutation ; Polymorphism, Genetic ; T-Lymphocytes/metabolism ; Virion/metabolism ; Virulence/genetics ; Virus Internalization ; Virus Replication/genetics ; nef Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
Toward T Cell-Mediated Control or Elimination of HIV Reservoirs: Lessons From Cancer Immunology.
Autorzy :
Mylvaganam G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.
Yanez AG; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.
Maus M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.; MGH Cancer Center, Boston, MA, United States.
Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.; Howard Hughes Medical Institute, Chevy Chase, MD, United States.; Institute for Medical Engineering and Sciences, MIT, Cambridge, MA, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2019 Sep 10; Vol. 10, pp. 2109. Date of Electronic Publication: 2019 Sep 10 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
HIV Infections/*immunology
HIV-1/*physiology
Immunotherapy, Adoptive/*methods
Lymphoid Tissue/*virology
Neoplasms/*immunology
Animals ; CD4-Positive T-Lymphocytes/transplantation ; HIV Infections/therapy ; Humans ; Immune Tolerance ; Immunity, Cellular ; Neoplasms/therapy ; Programmed Cell Death 1 Receptor/metabolism ; Remission, Spontaneous ; Tumor Microenvironment ; Virus Latency
Czasopismo naukowe
Tytuł :
Boosting of Markers of Fcγ Receptor Function in Anti-HIV Antibodies During Structured Treatment Interruption.
Autorzy :
Billings H; Immune Therapies Group, Life Sciences, Burnet Institute, Melbourne, Australia.
Wines BD; Immune Therapies Group, Life Sciences, Burnet Institute, Melbourne, Australia.; Department of Immunology, Monash University Central Clinical School, Melbourne, Australia.; Department of Pathology, The University of Melbourne, Melbourne, Australia.
Dyer WB; Australian Red Cross Blood Service, Alexandria, Australia.; School of Medical Science, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Center RJ; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.; Disease Elimination, Life Sciences, Burnet Institute, Melbourne, Australia.
Trist HM; Immune Therapies Group, Life Sciences, Burnet Institute, Melbourne, Australia.
Kent SJ; Disease Elimination, Life Sciences, Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases, Melbourne Sexual Health Centre, Alfred Health, Central Clinical School, Monash University, Melbourne, Australia.
Hogarth PM; Immune Therapies Group, Life Sciences, Burnet Institute, Melbourne, Australia.; Department of Immunology, Monash University Central Clinical School, Melbourne, Australia.; Department of Pathology, The University of Melbourne, Melbourne, Australia.
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Źródło :
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2019 Sep; Vol. 35 (9), pp. 842-852. Date of Electronic Publication: 2019 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV Antibodies/*immunology
HIV Infections/*immunology
HIV Seropositivity/*drug therapy
Immunoglobulin G/*immunology
Receptors, IgG/*immunology
Antigens, Viral/immunology ; Binding Sites, Antibody ; Epitopes ; HIV Infections/drug therapy ; HIV-1 ; Humans ; Immunity, Humoral ; Longitudinal Studies
Czasopismo naukowe
Tytuł :
HIV-1 DNA sequence diversity and evolution during acute subtype C infection.
Autorzy :
Lee GQ; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.; Brigham and Women's Hospital, Boston, 02115, MA, USA.; Harvard Medical School, Boston, MA, 02115, USA.
Reddy K; HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4001, South Africa.; Africa Health Research Institute, Durban, 4001, South Africa.
Einkauf KB; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.; Brigham and Women's Hospital, Boston, 02115, MA, USA.
Gounder K; HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4001, South Africa.; Africa Health Research Institute, Durban, 4001, South Africa.
Chevalier JM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.
Dong KL; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.; Harvard Medical School, Boston, MA, 02115, USA.
Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.; Brigham and Women's Hospital, Boston, 02115, MA, USA.; Harvard Medical School, Boston, MA, 02115, USA.; HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4001, South Africa.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA.
Yu XG; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.; Brigham and Women's Hospital, Boston, 02115, MA, USA.; Harvard Medical School, Boston, MA, 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Ndung'u T; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.; HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4001, South Africa.; Africa Health Research Institute, Durban, 4001, South Africa.; Max Planck Institute for Infection Biology, 10117, Berlin, Germany.
Lichterfeld M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA. .; Brigham and Women's Hospital, Boston, 02115, MA, USA. .; Harvard Medical School, Boston, MA, 02115, USA. .; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. .
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Źródło :
Nature communications [Nat Commun] 2019 Jun 21; Vol. 10 (1), pp. 2737. Date of Electronic Publication: 2019 Jun 21.
Typ publikacji :
Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Evolution, Molecular*
DNA, Viral/*genetics
Genome, Viral/*genetics
HIV Infections/*virology
HIV-1/*genetics
Acute Disease ; Adult ; Anti-HIV Agents/therapeutic use ; DNA Mutational Analysis ; Female ; Follow-Up Studies ; HIV Infections/blood ; HIV Infections/drug therapy ; High-Throughput Nucleotide Sequencing ; Humans ; Longitudinal Studies ; Mutation ; Prospective Studies ; South Africa ; Viral Load ; Young Adult
Czasopismo naukowe
Tytuł :
Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection.
Autorzy :
Ndhlovu ZM; Africa Health Research Institute, 4036 Durban, South Africa. .; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, 4013 Durban, South Africa.
Kazer SW; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.; Institute for Medical Engineering and Science (IMES), MIT, Cambridge, MA 02139, USA.; Department of Chemistry and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.
Nkosi T; Africa Health Research Institute, 4036 Durban, South Africa.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, 4013 Durban, South Africa.
Ogunshola F; Africa Health Research Institute, 4036 Durban, South Africa.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, 4013 Durban, South Africa.
Muema DM; Africa Health Research Institute, 4036 Durban, South Africa.
Anmole G; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Swann SA; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Moodley A; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, 4013 Durban, South Africa.
Dong K; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Reddy T; South Africa Medical Research Council, 4091 Durban, South Africa.
Brockman MA; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Shalek AK; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.; Institute for Medical Engineering and Science (IMES), MIT, Cambridge, MA 02139, USA.; Department of Chemistry and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.
Ndung'u T; Africa Health Research Institute, 4036 Durban, South Africa.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, 4013 Durban, South Africa.
Walker BD; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. .; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, 4013 Durban, South Africa.; Institute for Medical Engineering and Science (IMES), MIT, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.
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Źródło :
Science translational medicine [Sci Transl Med] 2019 May 22; Vol. 11 (493).
Typ publikacji :
Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
HIV Infections/*drug therapy
HIV Infections/*immunology
HIV-1/*immunology
T-Lymphocytes/*immunology
Acute Disease ; Adolescent ; Anti-Retroviral Agents/therapeutic use ; Antigens, Viral/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Differentiation ; Cell Proliferation ; Drug Therapy, Combination ; HIV Infections/genetics ; Humans ; Immunologic Memory ; Interferon-gamma/metabolism ; Interleukin-7 Receptor alpha Subunit/metabolism ; Phenotype ; Transcriptional Activation/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members.
Autorzy :
Gonzalo-Gil E; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, United States.
Rapuano PB; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, United States.
Ikediobi U; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, United States.
Leibowitz R; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, United States.
Mehta S; Yale Center for Genome Analysis Bioinformatics group, Yale University School of Medicine, New Haven, United States.
Coskun AK; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, United States.
Porterfield JZ; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, United States.
Lampkin TD; Infectious Diseases Section, Dallas VA Medical Center, Dallas, United States.
Marconi VC; Atlanta VA Medical Center, Emory University School of Medicine, Atlanta, United States.
Rimland D; Atlanta VA Medical Center, Emory University School of Medicine, Atlanta, United States.
Walker BD; Ragon Institute of MGH, MIT and Harvard University, Cambridge, United States.
Deeks S; Department of Medicine, University of California San Francisco, San Francisco, United States.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, United States.
Sutton RE; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, United States.
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Źródło :
ELife [Elife] 2019 Apr 09; Vol. 8. Date of Electronic Publication: 2019 Apr 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Resistance*
Down-Regulation*
Family*
HIV Long-Term Survivors*
HIV Infections/*immunology
Receptors, CCR5/*biosynthesis
Adult ; Aged ; CD4-Positive T-Lymphocytes/chemistry ; CD4-Positive T-Lymphocytes/virology ; Cells, Cultured ; Female ; HIV-1/growth & development ; Humans ; Macrophages/chemistry ; Macrophages/virology ; Male ; Middle Aged ; Receptors, CCR2/biosynthesis ; Viral Tropism ; Young Adult
Czasopismo naukowe
Tytuł :
HIV Controllers Exhibit Effective CD8 T Cells.
Autorzy :
Monel B; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
McKeon A; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
Lamothe-Molina P; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Jani P; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
Boucau J; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
Pacheco Y; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA; Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Jones RB; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA; Division of Infectious Diseases, Weill Cornell Medicine, New York, NY 10065, USA.
Le Gall S; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
Walker BD; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2019 Apr 02; Vol. 27 (1), pp. 142-153.e4.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
CD4-Positive T-Lymphocytes/*virology
CD8-Positive T-Lymphocytes/*immunology
HIV Infections/*immunology
HIV Infections/*pathology
HIV-1/*immunology
Immunity, Cellular/*physiology
CD8-Positive T-Lymphocytes/pathology ; Cells, Cultured ; Disease Progression ; HEK293 Cells ; HIV Infections/therapy ; HIV Infections/virology ; HIV-1/physiology ; HeLa Cells ; Humans ; Lymphocyte Activation/physiology ; Viral Load/drug effects ; Viral Load/immunology ; Virus Replication/physiology
Czasopismo naukowe
Tytuł :
Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting.
Autorzy :
Julg B; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA. Electronic address: .
Dee L; AIDS Action Baltimore, Baltimore, MD, USA.
Ananworanich J; US Military HIV Research Program, Henry Jackson Foundation, Bethesda, MD, USA.
Barouch DH; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA.
Bar K; Department of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Caskey M; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.
Colby DJ; Thai Red Cross AIDS Research Center, Bangkok, Thailand.
Dawson L; National Institute of Allergy and Infectious Diseases, Fishers ln Rockville, MD, USA.
Dong KL; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; University of KwaZulu Natal, Durban, South Africa.
Dubé K; Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Eron J; Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
Frater J; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford National Institute of Health Research Biomedical Research Centre, Oxford, UK.
Gandhi RT; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.
Geleziunas R; Gilead Sciences, Foster City, CA, USA.
Goulder P; Department of Paediatrics, University of Oxford, Oxford, UK.
Hanna GJ; Merck, Kenilworth, NJ, USA.
Jefferys R; Treatment Action Group, New York, NY, USA.
Johnston R; amfAR, New York, NY, USA.
Kuritzkes D; Division of Infectious Diseases, Brigham and Women's Hospital, Cambridge, MA, USA.
Li JZ; Division of Infectious Diseases, Brigham and Women's Hospital, Cambridge, MA, USA.
Likhitwonnawut U; AVAC: Global Advocacy for HIV Prevention, New York, NY, USA.
van Lunzen J; ViiV Healthcare, Brentford, UK.
Martinez-Picado J; AIDS Research Institute IrsiCaixa, Barcelona, Spain; Catalan Institution for Research and Advanced Studies, Barcelona, Spain; University of Vic-Central University of Catalonia, Barcelona, Spain.
Miller V; Forum for Collaborative Research, Washington, DC, USA.
Montaner LJ; The Montaner Laboratory, The Wistar Institute, Philadelphia, PA, USA.
Nixon DF; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York City, NY, USA.
Palm D; Global HIV Prevention, and Treatment Clinical Trials Unit, University of North Carolina, Chapel Hill, NC, USA.
Pantaleo G; Service Immunology and Allergy, and Swiss Vaccine Research Institute, Centre Hospitalier Universitaire, Lausanne, Switzerland.
Peay H; Research Triangle Institute, Research Triangle Park, NC, USA.
Persaud D; Pediatrics Infectious Disease, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Salzwedel J; AVAC: Global Advocacy for HIV Prevention, New York, NY, USA.
Salzwedel K; National Institute of Allergy and Infectious Diseases, Fishers ln Rockville, MD, USA.
Schacker T; Division of Infectious Disease and International Medicine, University of Minnesota, Minneapolis, MN, USA.
Sheikh V; Division of Antiviral Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
Søgaard OS; Department of Infectious Diseases, Aarhus University, Aarhus, Denmark.
Spudich S; Department of Neurology, Yale University, New Haven, CT, USA.
Stephenson K; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA.
Sugarman J; Berman Institute of Bioethics, University of North Carolina, Chapel Hill, NC, USA.
Taylor J; Collaboratory for AIDS Researchers for Eradication, University of North Carolina, Chapel Hill, NC, USA.
Tebas P; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Tiemessen CT; Cell Biology Research Laboratory, Centre for HIV and STIs, National Institute for Communicable Diseases, Johannesburg, South Africa; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Tressler R; National Institute of Allergy and Infectious Diseases, Fishers ln Rockville, MD, USA.
Weiss CD; Division of Antiviral Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
Zheng L; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Robb ML; US Military HIV Research Program, Henry Jackson Foundation, Bethesda, MD, USA.
Michael NL; US Military HIV Research Program, Henry Jackson Foundation, Bethesda, MD, USA.
Mellors JW; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Deeks SG; School of Medicine, University of California San Francisco, San Francisco, CA, USA.
Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
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Źródło :
The lancet. HIV [Lancet HIV] 2019 Apr; Vol. 6 (4), pp. e259-e268. Date of Electronic Publication: 2019 Mar 15.
Typ publikacji :
Consensus Development Conference; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Retroviral Agents/*administration & dosage
HIV Infections/*drug therapy
Withholding Treatment/*standards
Humans ; Sustained Virologic Response ; Viral Load
Czasopismo naukowe
Tytuł :
Two Families of Env Antibodies Efficiently Engage Fc-Gamma Receptors and Eliminate HIV-1-Infected Cells.
Autorzy :
Anand SP; Centre de Recherche du CHUM, Montreal, QC, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
Prévost J; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.
Baril S; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.
Richard J; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.
Medjahed H; Centre de Recherche du CHUM, Montreal, QC, Canada.
Chapleau JP; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.
Tolbert WD; Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Kirk S; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Smith AB 3rd; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Wines BD; Immune Therapies Group Burnet Institute, Melbourne, Victoria, Australia.; Department of Clinical Pathology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia.
Kent SJ; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.
Hogarth PM; Immune Therapies Group Burnet Institute, Melbourne, Victoria, Australia.; Department of Clinical Pathology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia.
Parsons MS; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.
Pazgier M; Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Finzi A; Centre de Recherche du CHUM, Montreal, QC, Canada .; Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.
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Źródło :
Journal of virology [J Virol] 2019 Jan 17; Vol. 93 (3). Date of Electronic Publication: 2019 Jan 17 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epitopes/*immunology
HIV Antibodies/*immunology
HIV Infections/*prevention & control
HIV-1/*immunology
Receptors, IgG/*metabolism
T-Lymphocytes/*immunology
env Gene Products, Human Immunodeficiency Virus/*immunology
Antibody-Dependent Cell Cytotoxicity ; Binding Sites ; HIV Antibodies/metabolism ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Protein Binding ; Receptors, IgG/immunology ; Recombinant Proteins/immunology
Czasopismo naukowe
Tytuł :
Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques.
Autorzy :
Parsons MS; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, and.
Lee WS; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, and.
Kristensen AB; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, and.
Amarasena T; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, and.
Khoury G; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, and.
Wheatley AK; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, and.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Melbourne, Parkville, Victoria, Australia.
Reynaldi A; Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Wines BD; Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia.
Hogarth PM; Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia.
Davenport MP; Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Kent SJ; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, and.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Melbourne, Parkville, Victoria, Australia.; Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Health, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2019 Jan 02; Vol. 129 (1), pp. 182-191. Date of Electronic Publication: 2018 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing*/immunology
Antibodies, Neutralizing*/pharmacology
HIV Antibodies*/immunology
HIV Antibodies*/pharmacology
HIV Infections*/immunology
HIV Infections*/pathology
HIV Infections*/therapy
Immunoglobulin Fc Fragments*/immunology
Immunoglobulin Fc Fragments*/pharmacology
HIV-1/*immunology
Simian Immunodeficiency Virus/*growth & development
Animals ; Female ; HIV-1/genetics ; Macaca nemestrina ; Male ; Simian Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Metabolic pathway activation distinguishes transcriptional signatures of CD8+ T cells from HIV-1 elite controllers.
Autorzy :
Chowdhury FZ; Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Cambridge, Massachusetts.
Ouyang Z; Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Cambridge, Massachusetts.
Buzon M; Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Cambridge, Massachusetts.
Walker BD; Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Cambridge, Massachusetts.; Howard Hughes Medical Institute, Chevy Chase, Maryland.
Lichterfeld M; Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Cambridge, Massachusetts.; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Yu XG; Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Cambridge, Massachusetts.; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
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Źródło :
AIDS (London, England) [AIDS] 2018 Nov 28; Vol. 32 (18), pp. 2669-2677.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV Long-Term Survivors*
CD8-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*metabolism
HIV Infections/*immunology
HIV Infections/*pathology
Metabolic Networks and Pathways/*genetics
Adult ; Aged ; Female ; Gene Expression Profiling ; Humans ; Male ; Microarray Analysis ; Middle Aged ; Signal Transduction ; Young Adult
Czasopismo naukowe
Tytuł :
The Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical Studies.
Autorzy :
Namazi G; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Fajnzylber JM; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Aga E; Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Bosch RJ; Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Acosta EP; University of Alabama, Birmingham.
Sharaf R; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Hartogensis W; University of California, San Francisco.
Jacobson JM; Temple University, Philadelphia, Pennsylvania.
Connick E; University of Arizona, Tucson.
Volberding P; University of California, San Francisco.
Skiest D; Tufts University, Boston, Massachusetts.
Margolis D; University of North Carolina, Chapel Hill.
Sneller MC; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
Little SJ; University of California, San Diego.
Gianella S; University of California, San Diego.
Smith DM; University of California, San Diego.
Kuritzkes DR; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Gulick RM; Weill Cornell Medicine, New York, NewYork.
Mellors JW; University of Pittsburgh, Pennsylvania.
Mehraj V; McGill University Health Centre, Montreal, Quebec, Canada.
Gandhi RT; Massachusetts General Hospital, Harvard Medical School, Boston.
Mitsuyasu R; University of California, Los Angeles.
Schooley RT; University of California, San Diego.
Henry K; University of Minnesota, Minneapolis.
Tebas P; University of Pennsylvania, Philadelphia.
Deeks SG; University of California, San Francisco.
Chun TW; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
Collier AC; University of Washington, Seattle.
Routy JP; McGill University Health Centre, Montreal, Quebec, Canada.
Hecht FM; University of California, San Francisco.
Walker BD; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge.
Li JZ; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2018 Nov 05; Vol. 218 (12), pp. 1954-1963.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV-1*
Anti-HIV Agents/*administration & dosage
Anti-HIV Agents/*therapeutic use
HIV Infections/*drug therapy
Adult ; CD4 Lymphocyte Count ; Drug Administration Schedule ; Female ; Humans ; Male ; Middle Aged ; Viral Load
Czasopismo naukowe
Tytuł :
Correlates of Serodiscordant Condomless Anal Intercourse Among Virologically Detectable HIV-Positive Young Men Who Have Sex with Men.
Autorzy :
Bruce D; Department of Health Sciences, DePaul University, Chicago, IL, USA. .; Department of Health Sciences, DePaul University, 1110 W. Belden, Suite 411, Chicago, IL, 60614, USA. .
Bauermeister JA; University of Pennsylvania School of Nursing, Philadelphia, PA, USA.
Kahana SY; National Institutes of Health, Bethesda, MD, USA.
Mendoza E; Department of Health Sciences, DePaul University, Chicago, IL, USA.
Fernández MI; College of Osteopathic Medicine, Nova Southeastern University, Davie, FL, USA.
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Corporate Authors :
Adolescent Trials Network for HIV/AIDS Interventions (ATN)
Źródło :
AIDS and behavior [AIDS Behav] 2018 Nov; Vol. 22 (11), pp. 3535-3539.
Typ publikacji :
Journal Article
MeSH Terms :
Risk-Taking*
Sexual Partners*/psychology
Unsafe Sex*
HIV Infections/*psychology
Homosexuality, Male/*psychology
Sexual Behavior/*psychology
Adolescent ; Adult ; Cross-Sectional Studies ; HIV ; HIV Infections/transmission ; HIV Infections/virology ; HIV-1/physiology ; Homosexuality, Male/statistics & numerical data ; Humans ; Male ; Risk Reduction Behavior ; Sexual Behavior/statistics & numerical data ; Viral Load ; Young Adult
Czasopismo naukowe
Tytuł :
A FRESH approach: Combining basic science and social good.
Autorzy :
Ndung'u T; Thumbi Ndung'u is a professor and the scientific director of the HIV Pathogenesis Programme and Doris Duke Medical Research Institute, University of KwaZulu-Natal (UKZN), and an investigator at the Africa Health Research Institute, Durban 4001, South Africa; an investigator at the Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA; and a group leader at the Max Planck Institute for Infection Biology, Berlin, Germany.; Krista L. Dong is a lecturer at Harvard Medical School; an assistant in Immunology at the Ragon Institute of MGH, MIT, and Harvard University, Cambridge, MA 02139, USA; and a lecturer in the Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA.; Douglas S. Kwon is an assistant professor at Harvard Medical School, Boston MA 021145, USA; a group leader at the Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA 02139, USA; and an associate physician in the Infectious Disease Division, MGH, Boston, MA 02114, USA.; Bruce D. Walker is the director of the Ragon Institute of MGH, MIT, and Harvard University, Cambridge, MA 02139, USA; an adjunct professor at the HIV Pathogenesis Programme and the Doris Duke Medical Research Institute, UKZN, and an associate of the Center for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4001, South Africa; a physician in the Infectious Disease Division, MGH, Boston, MA 02114, USA; a professor in the Institute for Medical Sciences and Engineering, MIT, Cambridge, MA 02139, USA; and an investigator of the Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Email: .
Dong KL; Thumbi Ndung'u is a professor and the scientific director of the HIV Pathogenesis Programme and Doris Duke Medical Research Institute, University of KwaZulu-Natal (UKZN), and an investigator at the Africa Health Research Institute, Durban 4001, South Africa; an investigator at the Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA; and a group leader at the Max Planck Institute for Infection Biology, Berlin, Germany.; Krista L. Dong is a lecturer at Harvard Medical School; an assistant in Immunology at the Ragon Institute of MGH, MIT, and Harvard University, Cambridge, MA 02139, USA; and a lecturer in the Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA.; Douglas S. Kwon is an assistant professor at Harvard Medical School, Boston MA 021145, USA; a group leader at the Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA 02139, USA; and an associate physician in the Infectious Disease Division, MGH, Boston, MA 02114, USA.; Bruce D. Walker is the director of the Ragon Institute of MGH, MIT, and Harvard University, Cambridge, MA 02139, USA; an adjunct professor at the HIV Pathogenesis Programme and the Doris Duke Medical Research Institute, UKZN, and an associate of the Center for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4001, South Africa; a physician in the Infectious Disease Division, MGH, Boston, MA 02114, USA; a professor in the Institute for Medical Sciences and Engineering, MIT, Cambridge, MA 02139, USA; and an investigator of the Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Email: .
Kwon DS; Thumbi Ndung'u is a professor and the scientific director of the HIV Pathogenesis Programme and Doris Duke Medical Research Institute, University of KwaZulu-Natal (UKZN), and an investigator at the Africa Health Research Institute, Durban 4001, South Africa; an investigator at the Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA; and a group leader at the Max Planck Institute for Infection Biology, Berlin, Germany.; Krista L. Dong is a lecturer at Harvard Medical School; an assistant in Immunology at the Ragon Institute of MGH, MIT, and Harvard University, Cambridge, MA 02139, USA; and a lecturer in the Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA.; Douglas S. Kwon is an assistant professor at Harvard Medical School, Boston MA 021145, USA; a group leader at the Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA 02139, USA; and an associate physician in the Infectious Disease Division, MGH, Boston, MA 02114, USA.; Bruce D. Walker is the director of the Ragon Institute of MGH, MIT, and Harvard University, Cambridge, MA 02139, USA; an adjunct professor at the HIV Pathogenesis Programme and the Doris Duke Medical Research Institute, UKZN, and an associate of the Center for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4001, South Africa; a physician in the Infectious Disease Division, MGH, Boston, MA 02114, USA; a professor in the Institute for Medical Sciences and Engineering, MIT, Cambridge, MA 02139, USA; and an investigator of the Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Email: .
Walker BD; Thumbi Ndung'u is a professor and the scientific director of the HIV Pathogenesis Programme and Doris Duke Medical Research Institute, University of KwaZulu-Natal (UKZN), and an investigator at the Africa Health Research Institute, Durban 4001, South Africa; an investigator at the Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA; and a group leader at the Max Planck Institute for Infection Biology, Berlin, Germany.; Krista L. Dong is a lecturer at Harvard Medical School; an assistant in Immunology at the Ragon Institute of MGH, MIT, and Harvard University, Cambridge, MA 02139, USA; and a lecturer in the Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA.; Douglas S. Kwon is an assistant professor at Harvard Medical School, Boston MA 021145, USA; a group leader at the Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA 02139, USA; and an associate physician in the Infectious Disease Division, MGH, Boston, MA 02114, USA.; Bruce D. Walker is the director of the Ragon Institute of MGH, MIT, and Harvard University, Cambridge, MA 02139, USA; an adjunct professor at the HIV Pathogenesis Programme and the Doris Duke Medical Research Institute, UKZN, and an associate of the Center for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4001, South Africa; a physician in the Infectious Disease Division, MGH, Boston, MA 02114, USA; a professor in the Institute for Medical Sciences and Engineering, MIT, Cambridge, MA 02139, USA; and an investigator of the Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Email: .
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Źródło :
Science immunology [Sci Immunol] 2018 Sep 14; Vol. 3 (27).
Typ publikacji :
Editorial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV Infections/*prevention & control
Poverty/*prevention & control
Adolescent ; Adult ; Cohort Studies ; Female ; HIV Infections/drug therapy ; HIV Infections/transmission ; HIV Infections/virology ; Health Education ; Humans ; Peer Group ; Power, Psychological ; Sociological Factors ; South Africa ; Viremia/drug therapy ; Viremia/immunology ; Young Adult
Raport

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