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    Wyświetlanie 1-11 z 11
    Tytuł:
    Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys.
    Autorzy:
    Blessing NA; Rammelkamp Center for Education and Research, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
    Wu Z; Department of Inflammation & Immunity, Cleveland Clinic, Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
    Madhavan SM; Department of Medicine, Ohio State University, Columbus, OH, United States of America.
    Choy JW; Merck & Company, Inc., Kenilworth, NJ, United States of America.
    Chen M; Merck & Company, Inc., Kenilworth, NJ, United States of America.
    Shin MK; Merck & Company, Inc., Kenilworth, NJ, United States of America.
    Hoek M; Maze Therapeutics, South San Francisco, CA, United States of America.
    Sedor JR; Department of Inflammation & Immunity, Cleveland Clinic, Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.; Department of Nephrology, Cleveland Clinic, Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.; Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
    O'Toole JF; Department of Inflammation & Immunity, Cleveland Clinic, Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.; Department of Nephrology, Cleveland Clinic, Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
    Bruggeman LA; Department of Inflammation & Immunity, Cleveland Clinic, Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.; Department of Nephrology, Cleveland Clinic, Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
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    Źródło:
    PloS one [PLoS One] 2021 Jun 17; Vol. 16 (6), pp. e0253197. Date of Electronic Publication: 2021 Jun 17 (Print Publication: 2021).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Apolipoprotein L1/*metabolism
    Kidney Tubules, Proximal/*metabolism
    Proteinuria/*metabolism
    Alleles ; Animals ; Apolipoprotein L1/genetics ; Endothelial Cells/metabolism ; Humans ; Kidney ; Liver/metabolism ; Mice ; Mice, Transgenic ; Podocytes/metabolism ; Proteinuria/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Podocyte density is reduced in kidney allografts with high-risk APOL1 genotypes at transplantation.
    Autorzy:
    Chen DP; Division of Nephrology, UNC Kidney Center, University of North Carolina, Chapel Hill, NC, USA.
    Zaky ZS; Glickman Urology and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
    Schold JD; Glickman Urology and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.; Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
    Herlitz LC; Pathology and Lab Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
    El-Rifai R; Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN, USA.
    Drawz PE; Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN, USA.
    Bruggeman LA; Glickman Urology and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
    Barisoni L; Departments of Pathology and Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC, USA.
    Hogan SL; Division of Nephrology, UNC Kidney Center, University of North Carolina, Chapel Hill, NC, USA.
    Hu Y; Division of Nephrology, UNC Kidney Center, University of North Carolina, Chapel Hill, NC, USA.
    O'Toole JF; Glickman Urology and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
    Poggio ED; Glickman Urology and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
    Sedor JR; Glickman Urology and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
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    Źródło:
    Clinical transplantation [Clin Transplant] 2021 Apr; Vol. 35 (4), pp. e14234. Date of Electronic Publication: 2021 Feb 10.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Apolipoprotein L1*/genetics
    Kidney Transplantation*
    Podocytes*
    Allografts ; Genotype ; Graft Survival ; Humans ; Kidney
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Association of preeclampsia with infant APOL1 genotype in African Americans.
    Autorzy:
    Miller AK; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, USA.
    Azhibekov T; Division of Neonatology, Department of Pediatrics, Metro Health Medical Center, Case Western Reserve University School of Medicine, Cleveland, USA.
    O'Toole JF; Departments of Inflammation and Immunity and Nephrology, Cleveland Clinic, Case Western Reserve University School of Medicine, Cleveland, USA.
    Sedor JR; Departments of Inflammation and Immunity and Nephrology, Cleveland Clinic, Case Western Reserve University School of Medicine, Cleveland, USA.; Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, USA.
    Williams SM; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, USA.
    Redline RW; Departments of Pathology and Reproductive Biology, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
    Bruggeman LA; Departments of Inflammation and Immunity and Nephrology, Cleveland Clinic, Case Western Reserve University School of Medicine, Cleveland, USA. leslie.bruggeman@case.edu.
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    Źródło:
    BMC medical genetics [BMC Med Genet] 2020 May 20; Vol. 21 (1), pp. 110. Date of Electronic Publication: 2020 May 20.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genetic Predisposition to Disease*
    Genetic Variation*
    Genotype*
    Black or African American/*genetics
    Apolipoprotein L1/*genetics
    Pre-Eclampsia/*diagnosis
    Pre-Eclampsia/*genetics
    Alleles ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Testing ; Humans ; Logistic Models ; Male ; Models, Genetic ; Odds Ratio ; Placenta/metabolism ; Pregnancy
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy.
    Autorzy:
    Bruggeman LA; Departments of Inflammation & Immunity and Nephrology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
    Wu Z; Departments of Inflammation & Immunity and Nephrology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
    Luo L; Departments of Inflammation & Immunity and Nephrology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
    Madhavan S; Department of Medicine, Ohio State University, Columbus, Ohio, United States of America.
    Drawz PE; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America.
    Thomas DB; Departments of Pathology, University of Miami, Miami, Florida, United States of America.
    Barisoni L; Departments of Pathology and Medicine, Duke University, Durham, North Carolina, United States of America.
    O'Toole JF; Departments of Inflammation & Immunity and Nephrology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
    Sedor JR; Departments of Inflammation & Immunity and Nephrology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.; Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
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    Źródło:
    PloS one [PLoS One] 2019 Oct 29; Vol. 14 (10), pp. e0224408. Date of Electronic Publication: 2019 Oct 29 (Print Publication: 2019).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    AIDS-Associated Nephropathy/*physiopathology
    Apolipoprotein L1/*metabolism
    Animals ; Apolipoprotein L1/genetics ; Apolipoprotein L1/physiology ; Apolipoproteins/genetics ; Disease Models, Animal ; Genetic Predisposition to Disease/genetics ; Genetic Variation/genetics ; Humans ; Kidney Glomerulus/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Podocytes/metabolism ; Podocytes/physiology ; Polymorphism, Genetic/genetics ; Renal Insufficiency, Chronic/pathology ; Transcriptome/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Fyn-binding protein ADAP supports actin organization in podocytes.
    Autorzy:
    Wu Z; Department of Medicine and Rammelkamp Center for Education and Research, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
    Blessing NA; Department of Medicine and Rammelkamp Center for Education and Research, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
    Simske JS; Department of Medicine and Rammelkamp Center for Education and Research, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
    Bruggeman LA; Department of Medicine and Rammelkamp Center for Education and Research, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
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    Źródło:
    Physiological reports [Physiol Rep] 2017 Dec; Vol. 5 (23).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Actin Cytoskeleton/*metabolism
    Adaptor Proteins, Signal Transducing/*metabolism
    Podocytes/*metabolism
    Adaptor Proteins, Signal Transducing/genetics ; Animals ; Cell Line ; Female ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Podocytes/ultrastructure ; Proteinuria/genetics ; Proteinuria/metabolism ; Proteinuria/pathology ; Proto-Oncogene Proteins c-fyn/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Biochemical and Cellular Determinants of Renal Glomerular Elasticity.
    Autorzy:
    Embry AE; Nephrology and Medicine, U.T. Southwestern Medical School, Dallas, Texas, United States of America.
    Mohammadi H; Center for Matrix Biology, University of Toronto, Toronto, Ontario, Canada.
    Niu X; Nephrology and Medicine, U.T. Southwestern Medical School, Dallas, Texas, United States of America.
    Liu L; Nephrology and Medicine, U.T. Southwestern Medical School, Dallas, Texas, United States of America.
    Moe B; Nephrology and Medicine, U.T. Southwestern Medical School, Dallas, Texas, United States of America.
    Miller-Little WA; Nephrology and Medicine, U.T. Southwestern Medical School, Dallas, Texas, United States of America.
    Lu CY; Nephrology and Medicine, U.T. Southwestern Medical School, Dallas, Texas, United States of America.
    Bruggeman LA; Nephrology, MetroHealth Medical Center, Case-Western Reserve University, Cleveland, Ohio, United States of America.
    McCulloch CA; Center for Matrix Biology, University of Toronto, Toronto, Ontario, Canada.
    Janmey PA; Physiology and Biophysics, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
    Miller RT; Nephrology and Medicine, U.T. Southwestern Medical School, Dallas, Texas, United States of America.; Medicine, Dallas VAMC, Dallas, Texas, United States of America.
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    Źródło:
    PloS one [PLoS One] 2016 Dec 12; Vol. 11 (12), pp. e0167924. Date of Electronic Publication: 2016 Dec 12 (Print Publication: 2016).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Elastic Modulus*
    Actin Cytoskeleton/*metabolism
    Kidney Glomerulus/*metabolism
    Actin Cytoskeleton/drug effects ; Adenosine Triphosphate/metabolism ; Animals ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cell Line ; Integrins/metabolism ; Kidney Glomerulus/cytology ; Mesangial Cells/metabolism ; Mice ; Mice, Inbred C57BL ; Podocytes/metabolism ; Thiazolidines/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Microarray analyses of glucocorticoid and vitamin D3 target genes in differentiating cultured human podocytes.
    Autorzy:
    Cheng X; Department of Biochemistry, School of Medicine, Case Western Reserve University (CWRU) and the Comprehensive Cancer Center of CWRU, Cleveland, Ohio, United States of America.
    Zhao X
    Khurana S
    Bruggeman LA
    Kao HY
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    Źródło:
    PloS one [PLoS One] 2013 Apr 04; Vol. 8 (4), pp. e60213. Date of Electronic Publication: 2013 Apr 04 (Print Publication: 2013).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Gene Expression Profiling*/methods
    Cholecalciferol/*pharmacology
    Gene Expression Regulation/*drug effects
    Glucocorticoids/*pharmacology
    Podocytes/*drug effects
    Podocytes/*metabolism
    Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Cell Line, Tumor ; Cells, Cultured ; Cluster Analysis ; Gene Regulatory Networks ; Humans ; Molecular Sequence Annotation ; Podocytes/cytology ; Transcriptome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-11 z 11

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