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    Wyświetlanie 1-18 z 18
    Tytuł:
    Pharmacodynamic characterization of gemcitabine cytotoxicity in an in vitro cell culture bioreactor system.
    Autorzy:
    Kirstein MN
    Brundage RC
    Moore MM
    Williams BW
    Hillman LA
    Dagit JW
    Fisher JE
    Marker PH
    Kratzke RA
    Yee D
    Kirstein, Mark N
    Brundage, Richard C
    Moore, Megan M
    Williams, Brent W
    Hillman, Lisa A
    Dagit, Jason W
    Fisher, James E
    Marker, Paul H
    Kratzke, Robert A
    Yee, Douglas
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    Źródło:
    Cancer Chemotherapy & Pharmacology; Feb2008, Vol. 61 Issue 2, p291-299, 9p
    Czasopismo naukowe
    Szczegóły
    Tytuł:
    A pharmacokinetic simulation study to assess the performance of a sparse blood sampling approach to quantify early drug exposure.
    Autorzy:
    Sathe AG; Department of Experimental and Clinical Pharmacology, College of Pharmacy, Minneapolis, Minnesota, USA.
    Brundage RC; Department of Experimental and Clinical Pharmacology, College of Pharmacy, Minneapolis, Minnesota, USA.
    Ivaturi V; Center for Translational Medicine, University of Maryland, College Park, Maryland, USA.
    Cloyd JC; Department of Experimental and Clinical Pharmacology, College of Pharmacy, Minneapolis, Minnesota, USA.
    Chamberlain JM; Division of Emergency Medicine, Children's National Hospital, Washington, DC, USA.
    Elm JJ; Department of Public Health Science, Medical University of South Carolina, Charleston, South Carolina, USA.
    Silbergleit R; Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA.
    Kapur J; Department of Neurology and Department of Neuroscience, Brain Institute, University of Virginia, Charlottesville, Virginia, USA.
    Coles LD; Department of Experimental and Clinical Pharmacology, College of Pharmacy, Minneapolis, Minnesota, USA.
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    Źródło:
    Clinical and translational science [Clin Transl Sci] 2021 Jul; Vol. 14 (4), pp. 1444-1451. Date of Electronic Publication: 2021 May 01.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Models, Biological*
    Blood Specimen Collection/*methods
    Drug Monitoring/*methods
    Adolescent ; Adult ; Area Under Curve ; Biological Variation, Population ; Child ; Child, Preschool ; Computer Simulation ; Emergency Treatment ; Female ; Healthy Volunteers ; Humans ; Levetiracetam/administration & dosage ; Levetiracetam/blood ; Levetiracetam/pharmacokinetics ; Male ; Middle Aged ; Phenytoin/administration & dosage ; Phenytoin/blood ; Phenytoin/pharmacokinetics ; Valproic Acid/administration & dosage ; Valproic Acid/blood ; Valproic Acid/pharmacokinetics ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Application of Deep Neural Networks as a Prescreening Tool to Assign Individualized Absorption Models in Pharmacokinetic Analysis.
    Autorzy:
    Jaber MM; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
    Yaman B; Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
    Sarafoglou K; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, MN 55454, USA.
    Brundage RC; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
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    Źródło:
    Pharmaceutics [Pharmaceutics] 2021 May 26; Vol. 13 (6). Date of Electronic Publication: 2021 May 26.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Evaluation of bias in weighted residual calculations when handling below the limit of quantification data using Beal's M3 method.
    Autorzy:
    Jaber MM; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
    Cheng S; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
    Brundage RC; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
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    Źródło:
    CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 Apr; Vol. 10 (4), pp. 275-278.
    Typ publikacji:
    Address; Journal Article; Research Support, U.S. Gov't, P.H.S.
    MeSH Terms:
    Computer Simulation/*statistics & numerical data
    Data Science/*statistics & numerical data
    Research Design/*statistics & numerical data
    Bias ; Evaluation Studies as Topic ; Humans ; Models, Theoretical ; Pharmacokinetics ; Radiotherapy Planning, Computer-Assisted
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Individualized Absorption Models in Population Pharmacokinetic Analyses.
    Autorzy:
    Jaber MM; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
    Al-Kofahi M; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
    Sarafoglou K; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
    Brundage RC; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
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    Źródło:
    CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2020 Jun; Vol. 9 (6), pp. 307-309. Date of Electronic Publication: 2020 May 21.
    Typ publikacji:
    Journal Article; Research Support, U.S. Gov't, P.H.S.
    MeSH Terms:
    Gastrointestinal Absorption*
    Models, Biological*
    Adrenal Hyperplasia, Congenital/*drug therapy
    Hydrocortisone/*pharmacokinetics
    Administration, Oral ; Adrenal Hyperplasia, Congenital/blood ; Humans ; Hydrocortisone/administration & dosage ; Hydrocortisone/blood
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A hierarchical Bayesian approach for combining pharmacokinetic/pharmacodynamic modeling and Phase IIa trial design in orphan drugs: Treating adrenoleukodystrophy with Lorenzo's oil.
    Autorzy:
    Basu C; a Division of Biostatistics , School of Public Health, University of Minnesota , Minneapolis , Minnesota , USA.
    Ahmed MA; b Experimental and Clinical Pharmacology, College of Pharmacy , University of Minnesota , Minneapolis , Minnesota , USA.; c College of Pharmacy , Helwan University , Helwan , Egypt.
    Kartha RV; d Center for Orphan Drug Research, College of Pharmacy , University of Minnesota , Minneapolis , Minnesota , USA.
    Brundage RC; b Experimental and Clinical Pharmacology, College of Pharmacy , University of Minnesota , Minneapolis , Minnesota , USA.
    Raymond GV; e Department of Neurology , University of Minnesota Medical School , Minneapolis , Minnesota , USA.
    Cloyd JC; d Center for Orphan Drug Research, College of Pharmacy , University of Minnesota , Minneapolis , Minnesota , USA.
    Carlin BP; a Division of Biostatistics , School of Public Health, University of Minnesota , Minneapolis , Minnesota , USA.
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    Źródło:
    Journal of biopharmaceutical statistics [J Biopharm Stat] 2016; Vol. 26 (6), pp. 1025-1039. Date of Electronic Publication: 2016 Aug 22.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Bayes Theorem*
    Clinical Trials, Phase II as Topic*
    Research Design*
    Adrenoleukodystrophy/*drug therapy
    Erucic Acids/*pharmacokinetics
    Triolein/*pharmacokinetics
    Dose-Response Relationship, Drug ; Drug Combinations ; Erucic Acids/blood ; Erucic Acids/therapeutic use ; Humans ; Male ; Orphan Drug Production ; Triolein/therapeutic use
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    SLC28A3 genotype and gemcitabine rate of infusion affect dFdCTP metabolite disposition in patients with solid tumours.
    Autorzy:
    Khatri A; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA.
    Williams BW; 1] Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA [2] Clinical Pharmacology Shared Resource of Masonic Comprehensive Cancer Center, University of Minnesota, Minneapolis, MN 55414, USA.
    Fisher J; 1] Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA [2] Clinical Pharmacology Shared Resource of Masonic Comprehensive Cancer Center, University of Minnesota, Minneapolis, MN 55414, USA.
    Brundage RC; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA.
    Gurvich VJ; 1] Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA [2] Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA [3] Masonic Comprehensive Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
    Lis LG; Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA.
    Skubitz KM; 1] Masonic Comprehensive Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA [2] Department of Medicine, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
    Dudek AZ; 1] Masonic Comprehensive Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA [2] Department of Medicine, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
    Greeno EW; 1] Masonic Comprehensive Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA [2] Department of Medicine, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
    Kratzke RA; 1] Masonic Comprehensive Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA [2] Department of Medicine, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
    Lamba JK; 1] Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA [2] Masonic Comprehensive Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA [3] PUMA-Institute of Personalized Medicine, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
    Kirstein MN; 1] Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA [2] Clinical Pharmacology Shared Resource of Masonic Comprehensive Cancer Center, University of Minnesota, Minneapolis, MN 55414, USA [3] Masonic Comprehensive Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA [4] PUMA-Institute of Personalized Medicine, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
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    Źródło:
    British journal of cancer [Br J Cancer] 2014 Jan 21; Vol. 110 (2), pp. 304-12. Date of Electronic Publication: 2013 Dec 03.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antimetabolites, Antineoplastic/*administration & dosage
    Antimetabolites, Antineoplastic/*pharmacokinetics
    Deoxycytidine/*analogs & derivatives
    Membrane Transport Proteins/*genetics
    Neoplasms/*genetics
    Neoplasms/*metabolism
    5'-Nucleotidase/genetics ; 5'-Nucleotidase/metabolism ; Adult ; Aged ; Aged, 80 and over ; Alleles ; Antimetabolites, Antineoplastic/blood ; Cytidine Deaminase/genetics ; Cytidine Deaminase/metabolism ; Deoxycytidine/administration & dosage ; Deoxycytidine/blood ; Deoxycytidine/pharmacokinetics ; Female ; Genotype ; Humans ; Infusions, Intravenous ; Leukocytes, Mononuclear/metabolism ; Male ; Membrane Transport Proteins/metabolism ; Middle Aged ; Neoplasms/blood ; Neoplasms/drug therapy ; Young Adult ; Gemcitabine
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Population pharmacokinetics of rifampicin in Mexican patients with tuberculosis.
    Autorzy:
    Milán Segovia RC; Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, México. />Domínguez Ramírez AM
    Jung Cook H
    Magaña Aquino M
    Vigna Pérez M
    Brundage RC
    Romano Moreno S
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    Źródło:
    Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2013 Feb; Vol. 38 (1), pp. 56-61. Date of Electronic Publication: 2012 Nov 20.
    Typ publikacji:
    Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Validation Study
    MeSH Terms:
    Models, Biological*
    Antibiotics, Antitubercular/*pharmacokinetics
    Rifampin/*pharmacokinetics
    Tuberculosis/*drug therapy
    Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibiotics, Antitubercular/administration & dosage ; Antibiotics, Antitubercular/therapeutic use ; Biological Availability ; Female ; Humans ; Male ; Mexico ; Middle Aged ; Nonlinear Dynamics ; Prospective Studies ; Rifampin/administration & dosage ; Rifampin/therapeutic use ; Sex Factors ; Tissue Distribution ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Quantitative Epstein-Barr virus shedding and its correlation with the risk of post-transplant lymphoproliferative disorder.
    Autorzy:
    Holman CJ; Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Minneapolis, MN 55455, USA.
    Karger AB
    Mullan BD
    Brundage RC
    Balfour HH Jr
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    Źródło:
    Clinical transplantation [Clin Transplant] 2012 Sep-Oct; Vol. 26 (5), pp. 741-7. Date of Electronic Publication: 2012 Mar 04.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Postoperative Complications*
    Virus Shedding*
    Epstein-Barr Virus Infections/*virology
    Lymphoproliferative Disorders/*diagnosis
    Organ Transplantation/*adverse effects
    Adult ; Child ; DNA, Viral/genetics ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/genetics ; Female ; Follow-Up Studies ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/pathogenicity ; Humans ; Lymphoproliferative Disorders/etiology ; Male ; Polymerase Chain Reaction ; Prognosis ; Viral Load
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-18 z 18

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