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Wyświetlanie 1-20 z 33
Tytuł:
The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study.
Autorzy:
Squier K; Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
Scott A; Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
Hunt MA; Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
Brunham LR; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.
Wilson DR; Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.; Department of Orthopaedics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Screen H; School of Engineering & Materials Science, Queen Mary University of London, London, United Kingdom.
Waugh CM; Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
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Źródło:
PloS one [PLoS One] 2021 Sep 16; Vol. 16 (9), pp. e0257269. Date of Electronic Publication: 2021 Sep 16 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Achilles Tendon/*drug effects
Achilles Tendon/*physiology
Cholesterol/*metabolism
Hyperlipoproteinemia Type II/*complications
Xanthomatosis/*complications
Adult ; Biomechanical Phenomena ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Humans ; Hypercholesterolemia ; Imaging, Three-Dimensional ; Male ; Motion ; Ultrasonography ; Walking
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cell-derived cardiomyocytes.
Autorzy:
Christidi E; Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, Canada.
Huang H; Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, Canada.
Shafaattalab S; Molecular Cardiac Physiology Group, Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.; Department of Cardiovascular Science, British Columbia Children's Hospital, Vancouver, Canada.
Maillet A; Astellas Pharma Europe B.V., Leiden, Netherlands.
Lin E; Molecular Cardiac Physiology Group, Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.
Huang K; Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, Canada.
Laksman Z; Heart Rhythm Services, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, Canada.; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Davis MK; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Tibbits GF; Molecular Cardiac Physiology Group, Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.; Department of Cardiovascular Science, British Columbia Children's Hospital, Vancouver, Canada.
Brunham LR; Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, Canada. liam.brunham@ubc.ca.; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. liam.brunham@ubc.ca.; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada. liam.brunham@ubc.ca.
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Źródło:
Scientific reports [Sci Rep] 2020 Jun 25; Vol. 10 (1), pp. 10363. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation*
Cardiotoxicity/*pathology
Doxorubicin/*adverse effects
Induced Pluripotent Stem Cells/*pathology
Myocytes, Cardiac/*pathology
Neoplasms/*drug therapy
Receptors, Retinoic Acid/*genetics
Adult ; Aged ; Aged, 80 and over ; Antibiotics, Antineoplastic/adverse effects ; CRISPR-Cas Systems ; Cardiotoxicity/etiology ; Cardiotoxicity/metabolism ; Case-Control Studies ; Female ; Follow-Up Studies ; Humans ; Induced Pluripotent Stem Cells/drug effects ; Male ; Middle Aged ; Myocytes, Cardiac/drug effects ; Neoplasms/pathology ; Receptors, Retinoic Acid/antagonists & inhibitors ; Receptors, Retinoic Acid/metabolism ; Tumor Cells, Cultured ; Retinoic Acid Receptor gamma
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CETP genetic variant rs1800777 (allele A) is associated with abnormally low HDL-C levels and increased risk of AKI during sepsis.
Autorzy:
Genga KR; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.; Experimental Medicine Program, University of British Columbia, Vancouver, British Columbia, Canada.
Trinder M; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.; Experimental Medicine Program, University of British Columbia, Vancouver, British Columbia, Canada.
Kong HJ; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
Li X; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
Leung AKK; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
Shimada T; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
Walley KR; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Russell JA; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Francis GA; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Brunham LR; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.; Experimental Medicine Program, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Boyd JH; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada. .; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2018 Nov 13; Vol. 8 (1), pp. 16764. Date of Electronic Publication: 2018 Nov 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alleles*
Polymorphism, Single Nucleotide*
Acute Kidney Injury/*complications
Cholesterol Ester Transfer Proteins/*genetics
Cholesterol, HDL/*blood
Sepsis/*blood
Sepsis/*genetics
Adult ; Aged ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Sepsis/complications
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genotype-guided versus traditional clinical dosing of warfarin in patients of Asian ancestry: a randomized controlled trial.
Autorzy:
Syn NL; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Wong AL; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Lee SC; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Teoh HL; Division of Neurology, Department of Medicine, National University Health System, Singapore, Singapore.
Yip JWL; Department of Cardiology, National University Heart Centre, Singapore, Singapore.
Seet RC; Division of Neurology, Department of Medicine, National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Yeo WT; Department of Cardiology, National University Heart Centre, Singapore, Singapore.
Kristanto W; Department of Cardiology, National University Heart Centre, Singapore, Singapore.
Bee PC; Department of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
Poon LM; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Marban P; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Wu TS; Department of Pharmacy, National University Hospital, Singapore, Singapore.
Winther MD; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Brunham LR; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Medicine, Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada.
Soong R; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Pathology, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore.
Tai BC; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Goh BC; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore. .; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. .; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore, 119228, Singapore. .
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Źródło:
BMC medicine [BMC Med] 2018 Jul 10; Vol. 16 (1), pp. 104. Date of Electronic Publication: 2018 Jul 10.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Maximum Tolerated Dose*
Anticoagulants/*therapeutic use
Warfarin/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Anticoagulants/administration & dosage ; Anticoagulants/pharmacology ; Asian People ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Warfarin/administration & dosage ; Warfarin/pharmacology ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients.
Autorzy:
Chan SL; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore and the National University of Singapore, Singapore.
Chua APG; Department of Respiratory Medicine, Tan Tock Seng Hospital, Singapore.
Aminkeng F; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore and the National University of Singapore, Singapore.
Chee CBE; Department of Respiratory Medicine, Tan Tock Seng Hospital, Singapore.
Jin S; School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.
Loh M; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore and the National University of Singapore, Singapore.
Gan SH; Department of Respiratory Medicine, Tan Tock Seng Hospital, Singapore.
Wang YT; Department of Respiratory Medicine, Tan Tock Seng Hospital, Singapore.
Brunham LR; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore and the National University of Singapore, Singapore.; Department of Medicine, Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada.
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Źródło:
PloS one [PLoS One] 2017 Oct 16; Vol. 12 (10), pp. e0186200. Date of Electronic Publication: 2017 Oct 16 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Antitubercular Agents/*toxicity
Arylamine N-Acetyltransferase/*genetics
Chemical and Drug Induced Liver Injury/*genetics
Isoniazid/*toxicity
Antitubercular Agents/therapeutic use ; Biomarkers, Pharmacological ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Humans ; Isoniazid/therapeutic use ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Prognosis ; Singapore ; Tuberculosis/complications ; Tuberculosis/drug therapy ; Tuberculosis/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes.
Autorzy:
Maillet A; Translational Laboratory in Genetic Medicine, National University of Singapore and the Agency for Science Technology and Research (A*STAR), Singapore.
Tan K; Translational Laboratory in Genetic Medicine, National University of Singapore and the Agency for Science Technology and Research (A*STAR), Singapore.
Chai X; Center for Computational Biology, Duke-NUS Graduate Medical School, Singapore.
Sadananda SN; Translational Laboratory in Genetic Medicine, National University of Singapore and the Agency for Science Technology and Research (A*STAR), Singapore.
Mehta A; National Heart Research Institute, National Heart Centre Singapore, Singapore.; Cardiovascular Academic Clinical Program, DUKE-NUS Graduate Medical School, Singapore.
Ooi J; Translational Laboratory in Genetic Medicine, National University of Singapore and the Agency for Science Technology and Research (A*STAR), Singapore.
Hayden MR; Translational Laboratory in Genetic Medicine, National University of Singapore and the Agency for Science Technology and Research (A*STAR), Singapore.; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.
Pouladi MA; Translational Laboratory in Genetic Medicine, National University of Singapore and the Agency for Science Technology and Research (A*STAR), Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ghosh S; Center for Computational Biology, Duke-NUS Graduate Medical School, Singapore.; Program in Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School, Singapore.
Shim W; National Heart Research Institute, National Heart Centre Singapore, Singapore.; Cardiovascular Academic Clinical Program, DUKE-NUS Graduate Medical School, Singapore.
Brunham LR; Translational Laboratory in Genetic Medicine, National University of Singapore and the Agency for Science Technology and Research (A*STAR), Singapore.; Department of Medicine, Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada.
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Źródło:
Scientific reports [Sci Rep] 2016 May 04; Vol. 6, pp. 25333. Date of Electronic Publication: 2016 May 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cardiotoxicity*
Models, Biological*
Antibiotics, Antineoplastic/*adverse effects
Doxorubicin/*adverse effects
Myocytes, Cardiac/*drug effects
Myocytes, Cardiac/*physiology
Cell Survival/drug effects ; Cells, Cultured ; Electrophysiological Phenomena/drug effects ; Gene Expression Profiling ; Humans ; Pluripotent Stem Cells/drug effects ; Pluripotent Stem Cells/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.
Autorzy:
Aminkeng F; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; Child and Family Research Institute, Vancouver, British Columbia, Canada.
Bhavsar AP; Child and Family Research Institute, Vancouver, British Columbia, Canada.; Department of Pediatrics, Division of Translational Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.
Visscher H; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pediatrics, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, the Netherlands.
Rassekh SR; Child and Family Research Institute, Vancouver, British Columbia, Canada.; Department of Pediatrics, Division of Pediatric Hematology/Oncology/Blood and Marrow Transplantation, University of British Columbia, Vancouver, British Columbia, Canada.
Li Y; Child and Family Research Institute, Vancouver, British Columbia, Canada.; Department of Pediatrics, Division of Translational Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.
Lee JW; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; Child and Family Research Institute, Vancouver, British Columbia, Canada.
Brunham LR; Translational Laboratory in Genetic Medicine, National University of Singapore and Association for Science, Technology and Research (A*STAR), Singapore.
Caron HN; Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, the Netherlands.
van Dalen EC; Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, the Netherlands.
Kremer LC; Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, the Netherlands.
van der Pal HJ; Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, the Netherlands.; Department of Medical Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, the Netherlands.
Amstutz U; Child and Family Research Institute, Vancouver, British Columbia, Canada.; Department of Pediatrics, Division of Translational Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.
Rieder MJ; Department of Pediatrics, University of Western Ontario, London, Ontario, Canada.
Bernstein D; Division of Pediatric Cardiology, Stanford University, Palo Alto, California, USA.
Carleton BC; Child and Family Research Institute, Vancouver, British Columbia, Canada.; Department of Pediatrics, Division of Translational Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.
Hayden MR; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; Child and Family Research Institute, Vancouver, British Columbia, Canada.; Translational Laboratory in Genetic Medicine, National University of Singapore and Association for Science, Technology and Research (A*STAR), Singapore.
Ross CJ; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; Child and Family Research Institute, Vancouver, British Columbia, Canada.; Department of Pediatrics, Division of Translational Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.; Pharmaceutical Outcomes Programme, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.
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Corporate Authors:
Canadian Pharmacogenomics Network for Drug Safety Consortium
Źródło:
Nature genetics [Nat Genet] 2015 Sep; Vol. 47 (9), pp. 1079-84. Date of Electronic Publication: 2015 Aug 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Anthracyclines/*adverse effects
Antibiotics, Antineoplastic/*adverse effects
Receptors, Retinoic Acid/*genetics
Ventricular Dysfunction, Left/*genetics
Adolescent ; Anthracyclines/therapeutic use ; Antibiotics, Antineoplastic/therapeutic use ; Bone Neoplasms/drug therapy ; Bone Neoplasms/genetics ; Case-Control Studies ; Child ; Child, Preschool ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Polymorphism, Single Nucleotide ; Rhabdomyosarcoma/drug therapy ; Rhabdomyosarcoma/genetics ; Sarcoma, Ewing/drug therapy ; Sarcoma, Ewing/genetics ; Ventricular Dysfunction, Left/chemically induced ; Retinoic Acid Receptor gamma
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 33

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