- Tytuł:
- Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking.
- Autorzy:
- Źródło:
- Scientific reports [Sci Rep] 2015 May 07; Vol. 5, pp. 9705. Date of Electronic Publication: 2015 May 07.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Models, Molecular*
Quantitative Structure-Activity Relationship*
Antiprotozoal Agents/*chemistryEnzyme Inhibitors /*chemistry
Leishmania major/*drug effects
Leishmania major/*enzymology
Peroxidases/*antagonists & inhibitors
Peroxidases/*chemistry
Protozoan Proteins/*antagonists & inhibitors
Protozoan Proteins/*chemistry
Antiprotozoal Agents/pharmacology ; Binding Sites ; Crystallography, X-Ray ; Drug Design ;Enzyme Inhibitors /pharmacology ; Molecular Conformation ; Molecular Docking Simulation ; Protein Binding ; Surface Plasmon Resonance
Czasopismo naukowe