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Tytuł :
Linker Threonine-phosphorylated Smad2/3 Is a Biomarker of Colorectal Neoplastic Stem-like Cells that Correlates With Carcinogenesis.
Autorzy :
Miyamoto S; Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.
Fukui T; Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan .
Horitani S; Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.
Tanimura Y; Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.
Matsumoto Y; Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.
Suzuki R; Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.
Takahashi YU; Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.
Kishimoto M; Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.
Tomiyama T; Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.
Nishio A; Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.
Okazaki K; Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.
Naganuma M; Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Oct; Vol. 41 (10), pp. 4789-4799.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinogenesis/*metabolism
Colorectal Neoplasms/*metabolism
Neoplastic Stem Cells/*metabolism
Smad2 Protein/*metabolism
Smad3 Protein/*metabolism
Biomarkers, Tumor/metabolism ; Carcinogenesis/pathology ; Colorectal Neoplasms/pathology ; Humans ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Neoplastic Stem Cells/pathology ; Phosphorylation ; Threonine/metabolism ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity.
Autorzy :
Adhikari H; Department of Pharmacology & Cancer Biology, Duke University, Durham, NC, USA.
Kattan WE; Integrative Biology & Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at Houston, Houston, TX, USA.
Kumar S; Department of Biochemistry, Duke University, Durham, NC, USA.
Zhou P; Department of Biochemistry, Duke University, Durham, NC, USA.
Hancock JF; Integrative Biology & Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA. .; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at Houston, Houston, TX, USA. .
Counter CM; Department of Pharmacology & Cancer Biology, Duke University, Durham, NC, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 09; Vol. 12 (1), pp. 5248. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis/*genetics
Lung Neoplasms/*genetics
Membrane Proteins/*genetics
Minor Histocompatibility Antigens/*genetics
Pancreatic Neoplasms/*genetics
Phosphotransferases (Alcohol Group Acceptor)/*genetics
Proto-Oncogene Proteins p21(ras)/*genetics
Animals ; Antineoplastic Agents/pharmacology ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Dogs ; Enzyme Inhibitors/pharmacology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Female ; HEK293 Cells ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Madin Darby Canine Kidney Cells ; Membrane Proteins/metabolism ; Mice ; Mice, SCID ; Minor Histocompatibility Antigens/metabolism ; Mutation ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Phosphatidylinositol Phosphates/biosynthesis ; Phosphatidylserines/biosynthesis ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Piperazines/pharmacology ; Proto-Oncogene Proteins p21(ras)/metabolism ; Pyridines/pharmacology ; Pyrimidines/pharmacology ; Survival Analysis ; Tumor Burden/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Pharmacological inhibition of IRAK1 attenuates colitis-induced tumorigenesis in mice by inhibiting the inflammatory response and epithelial-mesenchymal transition.
Autorzy :
Feng Z; Department of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.; No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Duan Z; Department of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.; No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Shi G; No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Wang Q; Central Laboratory, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, China.
Zhou J; Central Laboratory, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, China.
Chen Y; Department of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 Sep; Vol. 35 (9), pp. e22838. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinogenesis/*drug effects
Colitis/*drug therapy
Colitis-Associated Neoplasms/*drug therapy
Epithelial-Mesenchymal Transition/*drug effects
Interleukin-1 Receptor-Associated Kinases/*antagonists & inhibitors
Neoplasm Proteins/*antagonists & inhibitors
Neoplasms, Experimental/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Animals ; Carcinogenesis/chemically induced ; Carcinogenesis/metabolism ; Colitis/chemically induced ; Colitis/enzymology ; Colitis-Associated Neoplasms/chemically induced ; Colitis-Associated Neoplasms/enzymology ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/enzymology ; Interleukin-1 Receptor-Associated Kinases/metabolism ; Male ; Mice ; Neoplasm Proteins/metabolism ; Neoplasms, Experimental/chemically induced ; Neoplasms, Experimental/enzymology
Czasopismo naukowe
Tytuł :
HOXB8 Counteracts MAPK/ERK Oncogenic Signaling in a Chicken Embryo Model of Neoplasia.
Autorzy :
Wilmerding A; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
Bouteille L; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
Rinaldi L; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.; Beth Israel Deaconess Medical Center, Department of Medicine and the Cancer Center, Division of Hematology, Harvard Initiative of RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.
Caruso N; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
Graba Y; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
Delfini MC; Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM-UMR 7288), 13288 Marseille, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 18; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*metabolism
Carcinogenesis/*pathology
Homeodomain Proteins/*metabolism
MAP Kinase Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
Neoplasms/*pathology
Animals ; Biomarkers, Tumor/genetics ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Chick Embryo ; Chickens ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/genetics ; Humans ; MAP Kinase Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; Neoplasms/etiology ; Neoplasms/metabolism ; Prognosis ; Survival Rate ; Transcriptome
Czasopismo naukowe
Tytuł :
Neutrophil in the Pancreatic Tumor Microenvironment.
Autorzy :
Jin L; Department of Pathology & Clinical Labs, Rogel Cancer Center and Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI 48109, USA.
Kim HS; Department of Pathology & Clinical Labs, Rogel Cancer Center and Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI 48109, USA.
Shi J; Department of Pathology & Clinical Labs, Rogel Cancer Center and Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI 48109, USA.
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Źródło :
Biomolecules [Biomolecules] 2021 Aug 07; Vol. 11 (8). Date of Electronic Publication: 2021 Aug 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Antineoplastic Agents, Immunological/*therapeutic use
Carcinogenesis/*drug effects
Carcinoma, Pancreatic Ductal/*immunology
Neutrophils/*immunology
Pancreatic Neoplasms/*immunology
Tumor Microenvironment/*drug effects
Carcinogenesis/genetics ; Carcinogenesis/immunology ; Carcinogenesis/pathology ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/mortality ; Cell Communication/drug effects ; Cytokines/genetics ; Cytokines/immunology ; Fibroblasts/drug effects ; Fibroblasts/immunology ; Fibroblasts/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/immunology ; Neutrophil Infiltration/drug effects ; Neutrophils/drug effects ; Neutrophils/pathology ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/mortality ; Prognosis ; Receptors, Cytokine/genetics ; Receptors, Cytokine/immunology ; Survival Analysis ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
TDO2 knockdown inhibits colorectal cancer progression via TDO2-KYNU-AhR pathway.
Autorzy :
Zhao L; Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, PR China; Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Beijing, PR China.
Wang B; Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, PR China; Laboratory of Surgical Oncology, Peking University People's Hospital, Beijing, PR China.
Yang C; Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, PR China; Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Beijing, PR China.
Lin Y; Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, PR China; Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Beijing, PR China.
Zhang Z; Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, PR China; Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Beijing, PR China.
Wang S; Laboratory of Surgical Oncology, Peking University People's Hospital, Beijing, PR China; Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Beijing, PR China.
Ye Y; Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, PR China.
Shen Z; Laboratory of Surgical Oncology, Peking University People's Hospital, Beijing, PR China; Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Beijing, PR China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Aug 05; Vol. 792, pp. 145736. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*genetics
Basic Helix-Loop-Helix Transcription Factors/*genetics
Carcinogenesis/*genetics
Colorectal Neoplasms/*genetics
Hydrolases/*genetics
Receptors, Aryl Hydrocarbon/*genetics
Tryptophan Oxygenase/*genetics
Adenocarcinoma/diagnosis ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Aged ; Atlases as Topic ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Humans ; Hydrolases/metabolism ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Protein Binding ; Protein Interaction Mapping ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; ROC Curve ; Receptors, Aryl Hydrocarbon/metabolism ; Signal Transduction ; Survival Analysis ; Tryptophan Oxygenase/antagonists & inhibitors ; Tryptophan Oxygenase/metabolism
Czasopismo naukowe
Tytuł :
Drosophila Larval Models of Invasive Tumorigenesis for In Vivo Studies on Tumour/Peripheral Host Tissue Interactions during Cancer Cachexia.
Autorzy :
Hodgson JA; CRUK Beatson Institute, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Parvy JP; CRUK Beatson Institute, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Yu Y; CRUK Beatson Institute, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Vidal M; CRUK Beatson Institute, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Cordero JB; CRUK Beatson Institute, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 02; Vol. 22 (15). Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Cachexia/*pathology
Carcinogenesis/*pathology
Larva/*growth & development
Neoplasms/*complications
Animals ; Cachexia/etiology ; Cachexia/metabolism ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Drosophila ; Gene Expression Profiling ; Humans ; Janus Kinases/genetics ; Janus Kinases/metabolism ; Larva/genetics ; Larva/metabolism ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Apoptosis - Fueling the oncogenic fire.
Autorzy :
Castillo Ferrer C; Cancer Target and Experimental Therapeutics, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenoble Alpes University, France.; EPHE, PSL Research University, Paris, France.
Berthenet K; Cancer Research Center of Lyon (CRCL) INSERM 1052, CNRS 5286, Lyon, France.; Cancer Cell Death Laboratory, part of LabEx DEVweCAN, Université de Lyon, France.
Ichim G; Cancer Research Center of Lyon (CRCL) INSERM 1052, CNRS 5286, Lyon, France.; Cancer Cell Death Laboratory, part of LabEx DEVweCAN, Université de Lyon, France.
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Źródło :
The FEBS journal [FEBS J] 2021 Aug; Vol. 288 (15), pp. 4445-4463. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Apoptosis*
Carcinogenesis/*metabolism
Animals ; Carcinogenesis/genetics ; Carcinogenesis/pathology ; Humans ; Mitochondria/metabolism
Czasopismo naukowe
Tytuł :
DYRK1A is required for maintenance of cancer stemness, contributing to tumorigenic potential in oral/oropharyngeal squamous cell carcinoma.
Autorzy :
Martin CE; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, 90095, USA.
Nguyen A; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, 90095, USA.
Kang MK; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, 90095, USA; UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA, 90095, USA.
Kim RH; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, 90095, USA; UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA, 90095, USA.
Park NH; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, 90095, USA; UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA, 90095, USA; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
Shin KH; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, 90095, USA; UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA, 90095, USA. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Aug 01; Vol. 405 (1), pp. 112656. Date of Electronic Publication: 2021 May 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Carcinogenesis/*pathology
Carcinoma, Squamous Cell/*pathology
Mouth Neoplasms/*pathology
Neoplastic Stem Cells/*pathology
Oropharyngeal Neoplasms/*pathology
Protein-Serine-Threonine Kinases/*metabolism
Protein-Tyrosine Kinases/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Cell Proliferation ; Humans ; Mice ; Mice, Nude ; Mouth Neoplasms/genetics ; Mouth Neoplasms/metabolism ; Neoplastic Stem Cells/metabolism ; Oropharyngeal Neoplasms/genetics ; Oropharyngeal Neoplasms/metabolism ; Protein-Serine-Threonine Kinases/genetics ; Protein-Tyrosine Kinases/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation.
Autorzy :
Magallón-Lorenz M; Hereditary Cancer Group, Germans Trias i Pujol Research Institute (IGTP)-PMPPC, Badalona, 08916, Barcelona, Spain.
Fernández-Rodríguez J; Hereditary Cancer Program, Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat, 08908, Barcelona, Spain.; Program in Molecular Mechanisms and Experimental Therapy in Oncology (ONCOBELL), L'Hospitalet de Llobregat, 08908, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain.
Terribas E; Hereditary Cancer Group, Germans Trias i Pujol Research Institute (IGTP)-PMPPC, Badalona, 08916, Barcelona, Spain.; Oncohematology Area, Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Illes Balears, Spain.
Creus-Batchiller E; Hereditary Cancer Program, Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat, 08908, Barcelona, Spain.; Program in Molecular Mechanisms and Experimental Therapy in Oncology (ONCOBELL), L'Hospitalet de Llobregat, 08908, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain.
Romagosa C; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain.; Pathology Department, Hospital Universitari Vall d'Hebron and Vall d'Hebron Research Institut (VHIR), 08035, Barcelona, Spain.; Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.
Estival A; B-ARGO Group, Catalan Institute of Oncology - Hospital Universitari Germans Tries i Pujol, Badalona, 08916, Barcelona, Spain.
Perez Sidelnikova D; Plastic Surgery Service, Functional Sarcoma Unit, ICO-HUB, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
Salvador H; Pediatric Oncology Department, Sant Joan de Déu Barcelona Children's Hospital, 08950, Barcelona, Spain.
Villanueva A; Program in Molecular Mechanisms and Experimental Therapy in Oncology (ONCOBELL), L'Hospitalet de Llobregat, 08908, Barcelona, Spain.; Group of Chemoresistance and Predictive Factors, Subprogram Against Cancer Therapeutic Resistance (ProCURE), ICO-IDIBELL, L'Hospitalet del Llobregat, 08908, Barcelona, Spain.
Blanco I; Programa d'Assessorament i Genètica Clínica, Hospital Universitari Germans Trias i Pujol, Badalona, 08916, Barcelona, Spain.
Carrió M; Hereditary Cancer Group, Germans Trias i Pujol Research Institute (IGTP)-PMPPC, Badalona, 08916, Barcelona, Spain.
Lázaro C; Hereditary Cancer Program, Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat, 08908, Barcelona, Spain.; Program in Molecular Mechanisms and Experimental Therapy in Oncology (ONCOBELL), L'Hospitalet de Llobregat, 08908, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain.
Serra E; Hereditary Cancer Group, Germans Trias i Pujol Research Institute (IGTP)-PMPPC, Badalona, 08916, Barcelona, Spain. .; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain. .
Gel B; Hereditary Cancer Group, Germans Trias i Pujol Research Institute (IGTP)-PMPPC, Badalona, 08916, Barcelona, Spain. .; Departament de Fonaments Clínics, Universitat de Barcelona, 08036, Barcelona, Spain. .
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Źródło :
Human genetics [Hum Genet] 2021 Aug; Vol. 140 (8), pp. 1241-1252. Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article
MeSH Terms :
Polymorphism, Single Nucleotide*
Translocation, Genetic*
Carcinogenesis/*genetics
Cyclin-Dependent Kinase Inhibitor p16/*genetics
Neurofibromatosis 1/*genetics
Neurofibrosarcoma/*genetics
Sarcoma/*genetics
Base Sequence ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Line, Tumor ; Chromosomes, Human, Pair 9 ; Cyclin-Dependent Kinase Inhibitor p16/deficiency ; Exons ; Genome, Human ; Humans ; Neurofibromatosis 1/complications ; Neurofibromatosis 1/metabolism ; Neurofibromatosis 1/pathology ; Neurofibrosarcoma/etiology ; Neurofibrosarcoma/metabolism ; Neurofibrosarcoma/pathology ; Sarcoma/etiology ; Sarcoma/metabolism ; Sarcoma/pathology ; Schwann Cells/metabolism ; Schwann Cells/pathology ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Oncogenic potential of human pluripotent stem cell-derived lung organoids with HER2 overexpression.
Autorzy :
Miura A; Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Yamada D; Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Nakamura M; Precision Health, Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Tomida S; Center for Comprehensive Genomic Medicine, Okayama University Hospital, Okayama, Japan.
Shimizu D; Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Jiang Y; Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Takao T; Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Yamamoto H; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Suzawa K; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Shien K; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Yamane M; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Sakaguchi M; Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Toyooka S; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Takarada T; Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Oct 15; Vol. 149 (8), pp. 1593-1604. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis*
Gene Expression Regulation, Neoplastic*
Adenocarcinoma of Lung/*pathology
Induced Pluripotent Stem Cells/*pathology
Lung Neoplasms/*pathology
Organoids/*pathology
Receptor, ErbB-2/*metabolism
Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Differentiation ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Organoids/metabolism ; Receptor, ErbB-2/genetics ; Transcriptome ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Human papillomavirus (HPV) types 16 and 18 infection and esophageal squamous cell carcinoma: a systematic review and meta-analysis.
Autorzy :
Petrelli F; Oncology Unit, ASST Bergamo Ovest, Treviglio, BG, Italy. .; Oncology Unit, Medical Sciences Department, ASST Bergamo Ovest, Piazzale Ospedale 1, 24047, Treviglio, BG, Italy. .
De Santi G; General Surgery 2, ASST Bergamo Ovest, Treviglio, BG, Italy.
Rampulla V; General Surgery 2, ASST Bergamo Ovest, Treviglio, BG, Italy.
Ghidini A; Oncology Unit, Casa di Cura Igea, Milano, Italy.
Mercurio P; Pathology Unit, ASST Bergamo Ovest, Treviglio, BG, Italy.
Mariani M; General Surgery 2, ASST Bergamo Ovest, Treviglio, BG, Italy.
Manara M; General Surgery 2, ASST Bergamo Ovest, Treviglio, BG, Italy.
Rausa E; General Surgery 1, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Lonati V; Oncology Unit, ASST Bergamo Ovest, Treviglio, BG, Italy.
Viti M; General Surgery 2, ASST Bergamo Ovest, Treviglio, BG, Italy.
Luciani A; Oncology Unit, ASST Bergamo Ovest, Treviglio, BG, Italy.
Celotti A; General Surgery 2, ASST Bergamo Ovest, Treviglio, BG, Italy.
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Oct; Vol. 147 (10), pp. 3011-3023. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Carcinogenesis*
Esophageal Neoplasms/*epidemiology
Esophageal Squamous Cell Carcinoma/*epidemiology
Human papillomavirus 16/*isolation & purification
Human papillomavirus 18/*isolation & purification
Papillomavirus Infections/*complications
Esophageal Neoplasms/virology ; Esophageal Squamous Cell Carcinoma/virology ; Humans ; Papillomavirus Infections/virology ; Risk Factors
Czasopismo naukowe
Tytuł :
RSPO2 silence inhibits tumorigenesis of nasopharyngeal carcinoma by ZNRF3/Hedgehog-Gli1 signal pathway.
Autorzy :
Wang Z; Department of Oncology and Radiotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wang Y; Department of Oncology and Radiotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Ma X; Department of Oncology and Radiotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Dang C; Tumor Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Oct 01; Vol. 282, pp. 119817. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Silencing*
Signal Transduction*
Carcinogenesis/*metabolism
Hedgehog Proteins/*metabolism
Intercellular Signaling Peptides and Proteins/*biosynthesis
Nasopharyngeal Carcinoma/*metabolism
Nasopharyngeal Neoplasms/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Zinc Finger Protein GLI1/*metabolism
Animals ; Carcinogenesis/genetics ; Cell Line, Tumor ; Hedgehog Proteins/genetics ; Humans ; Intercellular Signaling Peptides and Proteins/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nasopharyngeal Carcinoma/genetics ; Nasopharyngeal Neoplasms/genetics ; Ubiquitin-Protein Ligases/genetics ; Zinc Finger Protein GLI1/genetics
Czasopismo naukowe
Tytuł :
Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis.
Autorzy :
Del Poggetto E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Ho IL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Balestrieri C; Experimental Hematology Unit, San Raffaele Research Hospital, Milan 20132, Italy.; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.
Yen EY; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Zhang S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Citron F; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Shah R; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Corti D; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Diaferia GR; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan 20139, Italy.
Li CY; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Loponte S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Carbone F; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hayakawa Y; Department of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY 10032, USA.
Valenti G; Department of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY 10032, USA.
Jiang S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sapio L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jiang H; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Dey P; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Gao S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Deem AK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Rose-John S; Department of Biochemistry, Christian-Albrechts-Universität zu Kiel, Kiel 24098, Germany.
Yao W; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Ying H; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Rhim AD; Department of Gastroenterology Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Genovese G; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Heffernan TP; TRACTION, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Maitra A; Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Wang TC; Department of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY 10032, USA.
Wang L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Draetta GF; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Carugo A; TRACTION, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Natoli G; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan 20139, Italy.; Humanitas University, Pieve Emanuele, Milan 20089, Italy.
Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Sep 17; Vol. 373 (6561), pp. eabj0486. Date of Electronic Publication: 2021 Sep 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis*
Genes, ras*
Acinar Cells/*pathology
Carcinoma, Pancreatic Ductal/*pathology
Pancreas/*pathology
Pancreatitis/*physiopathology
Animals ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/immunology ; Carcinoma, Pancreatic Ductal/physiopathology ; Cell Transformation, Neoplastic ; Cells, Cultured ; Cellular Reprogramming ; Chromatin/metabolism ; Early Growth Response Protein 1/genetics ; Early Growth Response Protein 1/metabolism ; Enzyme Precursors/metabolism ; Epigenesis, Genetic ; Epithelial Cells/pathology ; Epithelial Cells/physiology ; Female ; MAP Kinase Signaling System ; Male ; Metaplasia ; Mice ; Mutation ; Pancreas/metabolism ; Pancreatitis/genetics ; Pancreatitis/immunology ; Spheroids, Cellular ; Transcriptome
Czasopismo naukowe
Tytuł :
The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.
Autorzy :
Martin TD; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Patel RS; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Cook DR; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Choi MY; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Patil A; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Liang AC; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Li MZ; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Haigis KM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Elledge SJ; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Sep 17; Vol. 373 (6561), pp. 1327-1335. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis*
Gene Silencing*
Genes, Tumor Suppressor*
Immune Evasion*/genetics
Neoplasms, Experimental/*genetics
Neoplasms, Experimental/*immunology
Animals ; CRISPR-Cas Systems ; Cell Line, Tumor ; Chemokine CCL2/metabolism ; Female ; GTP-Binding Protein alpha Subunits, G12-G13/genetics ; GTP-Binding Protein alpha Subunits, G12-G13/metabolism ; Humans ; Mammary Neoplasms, Experimental/genetics ; Mammary Neoplasms, Experimental/immunology ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, SCID ; Neoplasm Transplantation ; Neoplasms, Experimental/pathology ; Selection, Genetic ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Oral cancer stem cells drive tumourigenesis through activation of stromal fibroblasts.
Autorzy :
Al-Magsoosi MJN; College of Dentistry, University of Basra, Basra, Republic of Iraq.
Lambert DW; School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Ali Khurram S; School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Whawell SA; School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
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Źródło :
Oral diseases [Oral Dis] 2021 Sep; Vol. 27 (6), pp. 1383-1393. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinogenesis*
Fibroblasts*
Cell Line, Tumor ; Cell Transformation, Neoplastic ; Culture Media, Conditioned ; Humans ; Neoplastic Stem Cells ; Stromal Cells
Czasopismo naukowe
Tytuł :
The role of PD-1/PD-L1 checkpoint in arsenic lung tumorigenesis.
Autorzy :
Xu W; Department Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Department of Neurology, the First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, China.
Cui J; Department Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Department of Biochemistry, College of Medicine, Yichun University, Yichun, Jiangxi 336000, China.
Wu L; Department Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, FuZhou, Fujian 350003, China.
He C; Department Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Department of Histology and Embryology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 361000, China.
Chen G; Department Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USA. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Sep 01; Vol. 426, pp. 115633. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Arsenic/*toxicity
B7-H1 Antigen/*immunology
Carcinogenesis/*immunology
Lung Neoplasms/*chemically induced
Programmed Cell Death 1 Receptor/*immunology
Animals ; CD8-Positive T-Lymphocytes/immunology ; Carcinogenesis/drug effects ; Female ; Immunoglobulin G/therapeutic use ; Lung Neoplasms/drug therapy ; Lung Neoplasms/immunology ; Male ; Mice ; T-Lymphocytes, Regulatory/immunology
Czasopismo naukowe
Tytuł :
The transcription factor RUNX2 fuels YAP1 signaling and gastric cancer tumorigenesis.
Autorzy :
Guo Z; Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhou K; Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Wang Q; Pathology Department, Navy 971 Hospital of PLA, Qindao, China.
Huang Y; Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ji J; Department of Neurosurgery, Chongqing University Cancer Hospital, Chongqing, China.
Peng Y; Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhang X; Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zheng T; Department of Oncology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
Zhang Z; Department of Plastic and Aesthetic Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Chong D; Pathology Department, Navy 971 Hospital of PLA, Qindao, China.
Yang Z; Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3533-3544. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Carcinogenesis/*metabolism
Core Binding Factor Alpha 1 Subunit/*metabolism
Signal Transduction/*genetics
Stomach Neoplasms/*metabolism
Transcription Factors/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Self Renewal/genetics ; Core Binding Factor Alpha 1 Subunit/genetics ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Oncogenes ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Transcription Factors/genetics ; Transfection ; Tumor Burden/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The Duality of Caspases in Cancer, as Told through the Fly.
Autorzy :
Hounsell C; School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK.
Fan Y; School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 19; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Apoptosis*
Carcinogenesis*
Caspases/*metabolism
Neoplasms/*pathology
Animals ; Drosophila ; Humans ; Neoplasms/enzymology ; Neoplasms/etiology ; Neoplasms/prevention & control
Czasopismo naukowe

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