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Tytuł :
Indolent T-cell prolymphocytic leukemia with no expression of surface T-cell receptors or surface CD3.
Autorzy :
Wang HY; Division of Laboratory and Genomic Medicine, Department of Pathology, University of California San Diego Health System, La Jolla, CA, USA.
Murray SS; Division of Laboratory and Genomic Medicine, Department of Pathology, University of California San Diego Health System, La Jolla, CA, USA.
Bejar R; Division of Hematology and Oncology, Department of Medicine, University of California San Diego Health System, La Jolla, CA, USA.
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Źródło :
International journal of laboratory hematology [Int J Lab Hematol] 2021 Aug; Vol. 43 (4), pp. O224-O226. Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Letter
MeSH Terms :
CD3 Complex/*metabolism
Leukemia, Prolymphocytic, T-Cell/*metabolism
Receptors, Antigen, T-Cell/*metabolism
CD3 Complex/genetics ; Gene Expression ; Humans ; Immunophenotyping ; Leukemia, Prolymphocytic, T-Cell/etiology ; Receptors, Antigen, T-Cell/genetics
Opinia redakcyjna
Tytuł :
CD3E as a new predictive biomarker of response to omalizumab treatment in asthma patients: Evidence from bioinformatic analysis.
Autorzy :
Zhang Q; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100730, China; Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
Li H; Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China.
Gao S; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100730, China; Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
Wang J; Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China.
Li C; Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China.
Shu J; Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China.
Lin J; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100730, China; Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2021 Apr; Vol. 93, pp. 107423. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
Asthma/*diagnosis
Biomarkers, Pharmacological/*metabolism
CD3 Complex/*metabolism
Computational Biology/*methods
T-Lymphocytes/*immunology
Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; CD3 Complex/genetics ; Humans ; Nitric Oxide/metabolism ; Omalizumab/therapeutic use ; Phenotype ; Predictive Value of Tests ; Prognosis ; ROC Curve ; Transcriptome ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Protein functionality as a potential bottleneck for somatic revertant variants.
Autorzy :
Kaiser FMP; Department of Immunology, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Pediatrics, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Reisli I; Department of Pediatric Immunology and Allergy, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.
Pico-Knijnenburg I; Laboratory for Pediatric Immunology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Langerak AW; Department of Immunology, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Kavelaars FG; Department of Hematology, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Artac H; Department of Pediatric Immunology and Allergy, Selçuk University Medical Faculty, Konya, Turkey.
IJspeert H; Department of Immunology, University Medical Center Rotterdam, Rotterdam, The Netherlands.
van der Burg M; Department of Immunology, University Medical Center Rotterdam, Rotterdam, The Netherlands; Laboratory for Pediatric Immunology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: .
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Jan; Vol. 147 (1), pp. 391-393.e8. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Case Reports; Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Base Sequence*
CD3 Complex*/genetics
CD3 Complex*/immunology
Germ-Line Mutation*
Sequence Deletion*
Humans ; Infant ; Male
Raport
Tytuł :
Calcium signaling on Jurkat T cells induced by microbeads coated with novel peptide ligands specific to human CD3ε.
Autorzy :
Ahmadi A; Department of Chemical & Materials Engineering, University of Alabama in Huntsville, 301 Sparkman Drive NW, Huntsville, AL 35899, USA. .
Ayyadevara VSSA; Biotechnology Science and Engineering, University of Alabama in Huntsville, Huntsville, AL 35899, USA.
Baudry J; Biotechnology Science and Engineering, University of Alabama in Huntsville, Huntsville, AL 35899, USA and Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899, USA.
Roh KH; Department of Chemical & Materials Engineering, University of Alabama in Huntsville, 301 Sparkman Drive NW, Huntsville, AL 35899, USA. and Biotechnology Science and Engineering, University of Alabama in Huntsville, Huntsville, AL 35899, USA.
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Źródło :
Journal of materials chemistry. B [J Mater Chem B] 2021 Feb 14; Vol. 9 (6), pp. 1661-1675. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
CD3 Complex/*metabolism
Calcium Signaling/*drug effects
Coated Materials, Biocompatible/*pharmacology
Peptides/*pharmacology
Animals ; CD3 Complex/chemistry ; Cells, Cultured ; Coated Materials, Biocompatible/chemistry ; Humans ; Jurkat Cells ; Ligands ; Mice ; Particle Size ; Peptides/chemistry ; Surface Properties
Czasopismo naukowe
Tytuł :
Extensive proteomic and transcriptomic changes quench the TCR/CD3 activation signal of latently HIV-1 infected T cells.
Autorzy :
Carlin E; Department of Medicine, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Greer B; Department of Medicine, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Lowman K; Department of Medicine, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Duverger A; Department of Medicine, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Wagner F; Department of Medicine, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Moylan D; Department of Medicine, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Dalecki A; Department of Medicine, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Samuel S; Department of Medicine, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Perez M; Department of Medicine, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Sabbaj S; Department of Medicine, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Kutsch O; Department of Medicine, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2021 Jan 19; Vol. 17 (1), pp. e1008748. Date of Electronic Publication: 2021 Jan 19 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Proteome*
Transcriptome*
Virus Latency*
CD3 Complex/*metabolism
CD4-Positive T-Lymphocytes/*immunology
HIV Infections/*immunology
Receptors, Antigen, T-Cell/*metabolism
CD3 Complex/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/virology ; Gene Expression Regulation, Viral ; Gene Regulatory Networks ; HIV Infections/genetics ; HIV Infections/metabolism ; HIV Infections/virology ; HIV-1/physiology ; Humans ; Lymphocyte Activation ; Receptors, Antigen, T-Cell/immunology ; Signal Transduction ; Virus Activation ; Virus Replication
Czasopismo naukowe
Tytuł :
Summary of a workshop on preclinical and translational safety assessment of CD3 bispecifics.
Autorzy :
Kamperschroer C; Pfizer Worldwide Research and Development, Groton, CT, USA.
Shenton J; Nonclinical Safety, Janssen R&D, Spring House, PA, USA.
Lebrec H; Translational Safety, Amgen Research, South San Francisco, CA, USA.
Leighton JK; U. S. Food and Drug Administration, Silver Spring, MD, USA.
Moore PA; MacroGenics, Rockville, MD, USA.
Thomas O; Translational Safety, Amgen Research, Munich, Germany.
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Źródło :
Journal of immunotoxicology [J Immunotoxicol] 2020 Dec; Vol. 17 (1), pp. 67-85.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Bispecific/*toxicity
Antigens, Neoplasm/*metabolism
Antineoplastic Agents/*toxicity
CD3 Complex/*antagonists & inhibitors
Cytokine Release Syndrome/*prevention & control
Animals ; Antibodies, Bispecific/administration & dosage ; Antigens, Neoplasm/immunology ; Antineoplastic Agents/administration & dosage ; CD3 Complex/immunology ; CD3 Complex/metabolism ; Consensus ; Consensus Development Conferences as Topic ; Cytokine Release Syndrome/chemically induced ; Cytokine Release Syndrome/immunology ; Cytokines/metabolism ; Drug Screening Assays, Antitumor/standards ; Europe ; Humans ; Japan ; Neoplasms/drug therapy ; Neoplasms/immunology ; Receptors, Antigen, T-Cell/antagonists & inhibitors ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Translational Medical Research/standards ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Tytuł :
Peripheral blood CD4+ cell counts but not CD3+ and CD8+ cell counts are reduced in SARS-CoV-2 infection.
Autorzy :
Huang ZX; Department of Neurology, Guangdong Second Provincial General Hospital, Southern Medical University, 466 Middle Xingang Road, Guangzhou 510317, Guangdong, China. Electronic address: .
Li W; Department of Infectious Diseases, Guangdong Second Provincial General Hospital, 466 Middle Xingang Road, Guangzhou 510317, Guangdong, China.
Lu E; Department of Infectious Diseases, Guangdong Second Provincial General Hospital, 466 Middle Xingang Road, Guangzhou 510317, Guangdong, China.
Yan X; P3 Biosafety Laboratory, Guangdong Second Provincial General Hospital, 466 Middle Xingang Road, Guangzhou 510317, Guangdong, China.
Lin J; P3 Biosafety Laboratory, Guangdong Second Provincial General Hospital, 466 Middle Xingang Road, Guangzhou 510317, Guangdong, China. Electronic address: .
Zhuo L; Department of Infectious Diseases, Guangdong Second Provincial General Hospital, 466 Middle Xingang Road, Guangzhou 510317, Guangdong, China. Electronic address: .
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Źródło :
Journal of affective disorders [J Affect Disord] 2020 Dec 01; Vol. 277, pp. 375-378. Date of Electronic Publication: 2020 Aug 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD3 Complex*
CD4 Lymphocyte Count*
CD8-Positive T-Lymphocytes*
Lymphocyte Count*
Coronavirus Infections/*blood
Pneumonia, Viral/*blood
Adult ; Blood Cell Count ; COVID-19 ; Ethnic Groups ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia/blood ; Polymerase Chain Reaction ; Prospective Studies ; ROC Curve
Czasopismo naukowe
Tytuł :
CD3-CD20-positive nodal lymphoma with cross-lineage rearrangement in a dog.
Autorzy :
Nicoletti A; School of Agriculture and Veterinary Medicine, University of Turin, Grugliasco, Turin, Italy.
Aresu L; School of Agriculture and Veterinary Medicine, University of Turin, Grugliasco, Turin, Italy.
Marino M; Laboratorio La Vallonea, Passirana di Rho, Milano, Italy.
Massaro M; Laboratorio La Vallonea, Passirana di Rho, Milano, Italy.
Martignani E; School of Agriculture and Veterinary Medicine, University of Turin, Grugliasco, Turin, Italy.
Caporali E; Clinica Veterinaria San Rocco, Foiana della Chiana, Arezzo, Italy.
Capuccini S; Clinica Veterinaria San Rocco, Foiana della Chiana, Arezzo, Italy.
Bonfanti U; Laboratorio La Vallonea, Passirana di Rho, Milano, Italy.
Gola C; School of Agriculture and Veterinary Medicine, University of Turin, Grugliasco, Turin, Italy.
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Źródło :
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc [J Vet Diagn Invest] 2020 Nov; Vol. 32 (6), pp. 964-967. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Gene Rearrangement*
Antigens, CD20/*genetics
CD3 Complex/*genetics
Dog Diseases/*diagnosis
Dog Diseases/*genetics
Lymphoma, Large B-Cell, Diffuse/*veterinary
Animals ; Antigens, CD20/metabolism ; CD3 Complex/metabolism ; Dog Diseases/physiopathology ; Dogs ; Fluorescent Antibody Technique/veterinary ; Immunohistochemistry ; Lymph Nodes/pathology ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/physiopathology ; Male
Czasopismo naukowe
Tytuł :
Immunological analysis of the murine anti-CD3-induced cytokine release syndrome model and therapeutic efficacy of anti-cytokine antibodies.
Autorzy :
Nouveau L; Light Chain Bioscience-Novimmune S.A., Geneva, Switzerland.
Buatois V; Light Chain Bioscience-Novimmune S.A., Geneva, Switzerland.
Cons L; Light Chain Bioscience-Novimmune S.A., Geneva, Switzerland.
Chatel L; Light Chain Bioscience-Novimmune S.A., Geneva, Switzerland.
Pontini G; Light Chain Bioscience-Novimmune S.A., Geneva, Switzerland.
Pleche N; Light Chain Bioscience-Novimmune S.A., Geneva, Switzerland.
Ferlin WG; Light Chain Bioscience-Novimmune S.A., Geneva, Switzerland.
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Źródło :
European journal of immunology [Eur J Immunol] 2021 Aug; Vol. 51 (8), pp. 2074-2085. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies/*immunology
Antibodies, Monoclonal/*pharmacology
CD3 Complex/*antagonists & inhibitors
Cytokine Release Syndrome/*etiology
Cytokine Release Syndrome/*metabolism
Cytokines/*antagonists & inhibitors
Cytokines/*metabolism
Animals ; Antibodies/adverse effects ; Antibodies, Monoclonal/therapeutic use ; Cytokine Release Syndrome/diagnosis ; Cytokine Release Syndrome/drug therapy ; Cytokines/blood ; Disease Models, Animal ; Drug Therapy, Combination ; Inflammation Mediators/blood ; Inflammation Mediators/metabolism ; Lymphocyte Activation/immunology ; Mice ; Phenotype ; Severity of Illness Index ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
PD-L1 Expression, T-lymphocyte Subpopulations and Langerhans Cells in Cutaneous Squamous Cell Carcinoma and Precursor Lesions.
Autorzy :
Stravodimou A; Department of Pathology, School of Medicine, University of Patras, Patras, Greece.
Tzelepi V; Department of Pathology, School of Medicine, University of Patras, Patras, Greece.
Balasis S; Department of Orthopaedics, University of Patras Hospital, Patras, Greece.
Georgiou S; Department of Dermatology, School of Medicine, University of Patras, Patras, Greece.
Papadaki H; Department of Anatomy, School of Medicine, University of Patras, Patras, Greece.
Mouzaki A; Division of Hematology, Department of Internal Medicine, School of Medicine, University of Patras, Patras, Greece.
Melachrinou M; Department of Pathology, School of Medicine, University of Patras, Patras, Greece.
Kourea EP; Department of Pathology, School of Medicine, University of Patras, Patras, Greece; .
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Źródło :
Anticancer research [Anticancer Res] 2021 Jul; Vol. 41 (7), pp. 3439-3448.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*metabolism
Carcinoma, Squamous Cell/*immunology
Carcinoma, Squamous Cell/*metabolism
Langerhans Cells/*metabolism
Skin Neoplasms/*immunology
Skin Neoplasms/*metabolism
T-Lymphocyte Subsets/*metabolism
Adult ; Aged ; Aged, 80 and over ; CD3 Complex/immunology ; CD8-Positive T-Lymphocytes/immunology ; Carcinoma, Squamous Cell/pathology ; Female ; Humans ; Immunohistochemistry/methods ; Langerhans Cells/immunology ; Langerhans Cells/pathology ; Male ; Middle Aged ; Skin Neoplasms/pathology ; T-Lymphocyte Subsets/immunology ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Immunohistochemistry patterns of SARS-CoV-2 deaths in forensic autopsies.
Autorzy :
Lupariello F; Dipartimento di Scienze della Sanità Pubblica e Pediatriche, Sezione di Medicina Legale, 'Università degli Studi di Torino', corso Galileo Galilei 22, 10126 Torino, Italy. Electronic address: .
Godio L; A.O.U. Città della Salute e della Scienza, Anatomia Patologica U, corso Bramante 88, 10126 Torino, Italy.
Di Vella G; Dipartimento di Scienze della Sanità Pubblica e Pediatriche, Sezione di Medicina Legale, 'Università degli Studi di Torino', corso Galileo Galilei 22, 10126 Torino, Italy.
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Źródło :
Legal medicine (Tokyo, Japan) [Leg Med (Tokyo)] 2021 Jul; Vol. 51, pp. 101894. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Case Reports
MeSH Terms :
Forensic Pathology*
Immunohistochemistry*
COVID-19/*immunology
COVID-19/*metabolism
SARS-CoV-2/*immunology
Aged ; Aged, 80 and over ; Antigens, CD20 ; Autopsy ; CD3 Complex ; COVID-19/physiopathology ; Female ; Humans ; Integrin beta3 ; Male ; Platelet Aggregation ; T-Cell Intracellular Antigen-1 ; T-Lymphocytes, Cytotoxic
Raport
Tytuł :
Quantitative Multiplex Immunofluorescence Evaluation of the Tumor Microenvironment in Pretreatment Tumors of Patients with Metastatic Breast Cancer and Serous Ovarian Carcinoma Treated with Liposomal Eribulin.
Autorzy :
Marks DK; Perlmutter Cancer Center, NYU Langone Health, New York, New York, USA.; NYU Long Island School of Medicine, NYU Langone Health, New York, New York, USA.
Kucharczyk J; NYU Long Island School of Medicine, NYU Langone Health, New York, New York, USA.
Kim P; College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.
Chyong DI; Columbia College, Columbia University, New York, New York, USA.
Gartrell RD; Department of Pediatrics, Pediatric Hematology/Oncology and Medicine, Hematology/Oncology, Columbia University Irving Medical Center, New York, New York, USA.
Lu Y; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.
Hibshoosh H; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Guo H; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Evans TRJ; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
Lopez J; Institute of Cancer Research, London, UK.
Kristeleit R; Department of Oncology, Guys and St Thomas' NHS Foundation Trust, London, UK.
Connolly E; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.; Division of Radiation Oncology, Columbia University Irving Medical Center, New York, New York, USA.
Saenger Y; College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.
Kalinsky K; Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
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Źródło :
Cancer investigation [Cancer Invest] 2021 Jul-Aug; Vol. 39 (6-7), pp. 466-472. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*immunology
Breast Neoplasms/*drug therapy
Cystadenoma, Serous/*drug therapy
Furans/*therapeutic use
Ketones/*therapeutic use
Ovarian Neoplasms/*drug therapy
Breast Neoplasms/immunology ; CD3 Complex/metabolism ; CD8 Antigens ; Clinical Trials, Phase I as Topic ; Female ; Fluorescent Antibody Technique ; Humans ; Middle Aged ; Neoplasm Metastasis ; Phospholipids ; Survival Analysis ; T-Lymphocytes/metabolism ; Treatment Outcome ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Serum-soluble PD-L1 may be a potential diagnostic biomarker in sepsis.
Autorzy :
Sun S; Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen Y; Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu Z; Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tian R; Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu J; Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen E; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mao E; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Pan T; Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qu H; Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Źródło :
Scandinavian journal of immunology [Scand J Immunol] 2021 Jul; Vol. 94 (1), pp. e13049. Date of Electronic Publication: 2021 May 16.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*blood
Biomarkers/*blood
Sepsis/*blood
Acute Disease ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; B7-H1 Antigen/immunology ; CD3 Complex/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Female ; Humans ; Male ; Middle Aged ; Organ Dysfunction Scores ; Pancreatitis/blood ; Pancreatitis/immunology ; Prognosis ; ROC Curve ; Sepsis/immunology ; Young Adult
Czasopismo naukowe
Tytuł :
A template to quantify the location and density of CD3 + and CD8 + tumor-infiltrating lymphocytes in colon cancer by digital pathology on whole slides for an objective, standardized immune score assessment.
Autorzy :
Lea D; Gastrointestinal Translational Research Unit, Molecular Laboratory, Hillevåg, Stavanger University Hospital, Stavanger, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway.; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.
Watson M; Gastrointestinal Translational Research Unit, Molecular Laboratory, Hillevåg, Stavanger University Hospital, Stavanger, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway.; Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway.
Skaland I; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.
Hagland HR; Gastrointestinal Translational Research Unit, Molecular Laboratory, Hillevåg, Stavanger University Hospital, Stavanger, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.
Lillesand M; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.
Gudlaugsson E; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.
Søreide K; Gastrointestinal Translational Research Unit, Molecular Laboratory, Hillevåg, Stavanger University Hospital, Stavanger, Norway. .; Department of Clinical Medicine, University of Bergen, Bergen, Norway. .; Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Jul; Vol. 70 (7), pp. 2049-2057. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article
MeSH Terms :
Microsatellite Instability*
CD3 Complex/*metabolism
CD8-Positive T-Lymphocytes/*immunology
Colonic Neoplasms/*immunology
Colonic Neoplasms/*pathology
Lymphocytes, Tumor-Infiltrating/*immunology
Colonic Neoplasms/metabolism ; Follow-Up Studies ; Humans ; Prognosis ; Prospective Studies
Czasopismo naukowe
Tytuł :
Preclinical efficacy of humanized, non-FcγR-binding anti-CD3 antibodies in T-cell acute lymphoblastic leukemia.
Autorzy :
Tran Quang C; Institut Curie, Orsay, France.; Centre National de la Recherche Scientifique UMR3348, Centre Universitaire, Orsay, France.; UMR3348, University Paris Sud-Paris-Saclay, Orsay, France.; UMR3348, PSL Research University, Paris, France.
Zaniboni B; Institut Curie, Orsay, France.; Centre National de la Recherche Scientifique UMR3348, Centre Universitaire, Orsay, France.; UMR3348, University Paris Sud-Paris-Saclay, Orsay, France.; UMR3348, PSL Research University, Paris, France.
Humeau R; Institut Curie, Orsay, France.; Centre National de la Recherche Scientifique UMR3348, Centre Universitaire, Orsay, France.; UMR3348, University Paris Sud-Paris-Saclay, Orsay, France.; UMR3348, PSL Research University, Paris, France.
Lengliné E; Adult Leukemia Unit, Department of Hematology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, University of Paris, Paris, France.; EA3518, Saint-Louis Research Institute, University of Paris, Paris, France.
Dourthe ME; Department of Pediatric Hematology and Immunology, Hôpital Universitaire Robert-Debré, Assistance Publique-Hôpitaux de Paris, Paris, France.; INSERM U1151, Institut Necker-Enfants Malades, Université Paris Descartes Sorbonne Cité, Paris, France.
Ganesan R; Janssen Biotherapeutics, Spring House, PA; and.
Singh S; Janssen Biotherapeutics, Spring House, PA; and.
Scheer JM; Boehringer-Ingelheim Pharmaceuticals, Inc, Ridgefield, CT.
Asnafi V; INSERM U1151, Institut Necker-Enfants Malades, Université Paris Descartes Sorbonne Cité, Paris, France.
Ghysdael J; Institut Curie, Orsay, France.; Centre National de la Recherche Scientifique UMR3348, Centre Universitaire, Orsay, France.; UMR3348, University Paris Sud-Paris-Saclay, Orsay, France.; UMR3348, PSL Research University, Paris, France.
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Źródło :
Blood [Blood] 2020 Sep 10; Vol. 136 (11), pp. 1298-1302.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Antibodies, Monoclonal, Humanized/*therapeutic use
Antineoplastic Agents, Immunological/*therapeutic use
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
CD3 Complex/*immunology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal, Humanized/immunology ; Antineoplastic Agents, Immunological/immunology ; CD3 Complex/antagonists & inhibitors ; Combined Modality Therapy ; Dexamethasone/administration & dosage ; Dose-Response Relationship, Immunologic ; Female ; Humans ; Mice ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Specific Pathogen-Free Organisms ; Vincristine/administration & dosage ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy.
Autorzy :
Wu W; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Zhou Q; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Masubuchi T; Section of Cell & Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093-0347, USA.
Shi X; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; Center for Precision Medicine Multi-omics Research, Peking University Health Science Center, Peking University First Hospital, Beijing 100191, China.
Li H; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Xu X; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Huang M; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Meng L; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
He X; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Zhu H; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Gao S; Center for Precision Medicine Multi-omics Research, Peking University Health Science Center, Peking University First Hospital, Beijing 100191, China.
Zhang N; Center for Precision Medicine Multi-omics Research, Peking University Health Science Center, Peking University First Hospital, Beijing 100191, China.
Jing R; Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China; Institute of Hematology, Zhejiang University & Laboratory of Stem Cell and Immunotherapy Engineering, Hangzhou 310058, Zhejiang, China.
Sun J; Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China; Institute of Hematology, Zhejiang University & Laboratory of Stem Cell and Immunotherapy Engineering, Hangzhou 310058, Zhejiang, China.
Wang H; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Hui E; Section of Cell & Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093-0347, USA. Electronic address: .
Wong CC; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; Center for Precision Medicine Multi-omics Research, Peking University Health Science Center, Peking University First Hospital, Beijing 100191, China; School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. Electronic address: .
Xu C; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, Zhejiang, China. Electronic address: .
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Źródło :
Cell [Cell] 2020 Aug 20; Vol. 182 (4), pp. 855-871.e23. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
CD3 Complex/*metabolism
Immunotherapy, Adoptive/*methods
Receptors, Chimeric Antigen/*metabolism
Amino Acid Motifs ; Animals ; CD3 Complex/chemistry ; CSK Tyrosine-Protein Kinase/metabolism ; Cell Line ; Cytokines/metabolism ; Humans ; Lymphocyte Activation/drug effects ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Mice ; Mice, Inbred NOD ; Neoplasms/mortality ; Neoplasms/pathology ; Neoplasms/therapy ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Survival Analysis ; Vanadates/pharmacology
Czasopismo naukowe
Tytuł :
GLP toxicology study of a fully-human T cell redirecting CD3:EGFRvIII binding immunotherapeutic bispecific antibody.
Autorzy :
Gedeon PC; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, NC, United States of America.; Department of Biomedical Engineering, Duke University, Durham, NC, United States of America.; The Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery, Duke University Medical Center, Durham, NC, United States of America.
Streicker MA; Integrated Laboratory Systems, Inc., Research Triangle Park, NC, United States of America.
Schaller TH; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, NC, United States of America.; The Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery, Duke University Medical Center, Durham, NC, United States of America.; Department of Pathology, Duke University Medical Center, Durham, NC, United States of America.
Archer GE; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, NC, United States of America.; The Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery, Duke University Medical Center, Durham, NC, United States of America.
Jokinen MP; Integrated Laboratory Systems, Inc., Research Triangle Park, NC, United States of America.
Sampson JH; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, NC, United States of America.; Department of Biomedical Engineering, Duke University, Durham, NC, United States of America.; The Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery, Duke University Medical Center, Durham, NC, United States of America.; Department of Pathology, Duke University Medical Center, Durham, NC, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Jul 31; Vol. 15 (7), pp. e0236374. Date of Electronic Publication: 2020 Jul 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antibodies, Bispecific/*pharmacology
CD3 Complex/*immunology
ErbB Receptors/*immunology
Glioma/*immunology
Animals ; Antibodies, Bispecific/immunology ; Body Weight/drug effects ; Body Weight/immunology ; CD3 Complex/pharmacology ; Disease Models, Animal ; ErbB Receptors/pharmacology ; Female ; Glioma/pathology ; Glioma/therapy ; Humans ; Immunotherapy/adverse effects ; Male ; Mice ; Single-Chain Antibodies/immunology ; Single-Chain Antibodies/pharmacology ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Nanovesicles released by OKT3 hybridoma express fully active antibodies.
Autorzy :
Logozzi M; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Di Raimo R; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Properzi F; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
Barca S; FARVA - National Centre for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy.
Angelini DF; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, Italy.
Mizzoni D; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Falchi M; National AIDS Center, Istituto Superiore di Sanità, Rome, Italy.
Battistini L; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, Italy.
Fais S; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 175-182.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes/*immunology
Exosomes/*immunology
Hybridomas/*immunology
Immunoglobulin G/*biosynthesis
Muromonab-CD3/*immunology
T-Lymphocytes/*immunology
Animals ; Antigens, Surface/genetics ; Antigens, Surface/immunology ; B-Lymphocytes/cytology ; CD3 Complex/genetics ; CD3 Complex/immunology ; Cell Line, Tumor ; Cytokines/biosynthesis ; Cytokines/immunology ; Exosomes/chemistry ; Exosomes/genetics ; Gene Expression ; Humans ; Hybridomas/chemistry ; Immunoglobulin G/immunology ; Lymphocyte Activation ; Macrophages/cytology ; Macrophages/immunology ; Mice ; Multiple Myeloma/immunology ; Muromonab-CD3/genetics ; Neoplasms, Experimental/immunology ; Primary Cell Culture ; Spleen/cytology ; Spleen/immunology ; T-Lymphocytes/cytology
Czasopismo naukowe
Tytuł :
αβ and γδ T cell receptors: Similar but different.
Autorzy :
Morath A; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Institute of Biology III, Faculty of Biology, University of Freiburg, Freiburg, Germany.; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany.
Schamel WW; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Institute of Biology III, Faculty of Biology, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center Freiburg and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 Jun; Vol. 107 (6), pp. 1045-1055. Date of Electronic Publication: 2020 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
CD3 Complex/*immunology
Cell Lineage/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*immunology
Receptors, Antigen, T-Cell, gamma-delta/*immunology
T-Lymphocytes/*immunology
Amino Acid Sequence ; Animals ; Antibodies/pharmacology ; CD3 Complex/antagonists & inhibitors ; CD3 Complex/chemistry ; CD3 Complex/genetics ; Cell Differentiation ; Cell Lineage/genetics ; Gene Expression ; Glycosylation ; Humans ; Ligands ; Mice ; Protein Binding/drug effects ; Receptors, Antigen, T-Cell, alpha-beta/chemistry ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, gamma-delta/chemistry ; Receptors, Antigen, T-Cell, gamma-delta/genetics ; Signal Transduction ; T-Lymphocytes/classification ; T-Lymphocytes/cytology ; T-Lymphocytes/drug effects ; Thymus Gland/cytology ; Thymus Gland/immunology
Czasopismo naukowe
Tytuł :
Blockade of VLA4 sensitizes leukemic and myeloma tumor cells to CD3 redirection in the bone marrow microenvironment.
Autorzy :
Nair-Gupta P; Janssen Research & Development LLC, Spring House, PA, USA.
Rudnick SI; Janssen Research & Development LLC, Spring House, PA, USA.
Luistro L; Janssen Research & Development LLC, Spring House, PA, USA.
Smith M; Janssen Research & Development LLC, Spring House, PA, USA.
McDaid R; Janssen Research & Development LLC, Spring House, PA, USA.
Li Y; Janssen Research & Development LLC, Spring House, PA, USA.
Pillarisetti K; Janssen Research & Development LLC, Spring House, PA, USA.
Joseph J; Janssen Research & Development LLC, Spring House, PA, USA.
Heidrich B; Janssen Research & Development LLC, Spring House, PA, USA.
Packman K; Janssen Research & Development LLC, Spring House, PA, USA.
Attar R; Janssen Research & Development LLC, Spring House, PA, USA.
Gaudet F; Janssen Research & Development LLC, Spring House, PA, USA. .
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Źródło :
Blood cancer journal [Blood Cancer J] 2020 Jun 01; Vol. 10 (6), pp. 65. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Immunological/*pharmacology
Bone Marrow/*drug effects
CD3 Complex/*immunology
Integrin alpha4beta1/*antagonists & inhibitors
Leukemia, Myeloid, Acute/*drug therapy
Multiple Myeloma/*drug therapy
Animals ; Antibodies, Bispecific/pharmacology ; Antibodies, Bispecific/therapeutic use ; Antineoplastic Agents, Immunological/therapeutic use ; B-Cell Maturation Antigen/antagonists & inhibitors ; B-Cell Maturation Antigen/immunology ; Bone Marrow/immunology ; Bone Marrow/pathology ; CD3 Complex/antagonists & inhibitors ; Cell Line, Tumor ; Female ; Humans ; Integrin alpha4beta1/immunology ; Interleukin-3 Receptor alpha Subunit/antagonists & inhibitors ; Interleukin-3 Receptor alpha Subunit/immunology ; Leukemia, Myeloid, Acute/immunology ; Leukemia, Myeloid, Acute/pathology ; Mice ; Multiple Myeloma/immunology ; Multiple Myeloma/pathology ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; Tumor Microenvironment/drug effects
Czasopismo naukowe

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