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Wyszukujesz frazę ""CD3 Complex"" wg kryterium: Temat


Tytuł:
Integrative temporal multi-omics reveals uncoupling of transcriptome and proteome during human T cell activation.
Autorzy:
Weerakoon H; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia.; Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka.
Mohamed A; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Wong Y; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.; Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.
Chen J; Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Senadheera B; School of Computing, University of Colombo, Colombo, Sri Lanka.
Haigh O; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Watkins TS; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Kazakoff S; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Mukhopadhyay P; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Mulvenna J; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Miles JJ; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Hill MM; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.; Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Lepletier A; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. .; Institute for Glycomics, Griffith Univeristy, Gold Coast, QLD, Australia. .
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Źródło:
NPJ systems biology and applications [NPJ Syst Biol Appl] 2024 Feb 28; Vol. 10 (1), pp. 21. Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Proteome*/genetics
Transcriptome*/genetics
Humans ; CD3 Complex ; Multiomics ; Proteomics ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism
Czasopismo naukowe
Tytuł:
Integrative analysis of single-cell and bulk RNA-sequencing data revealed T cell marker genes based molecular sub-types and a prognostic signature in lung adenocarcinoma.
Autorzy:
Peng Y; Shanxi Provincial Key Laboratory of Kidney Disease, Shanxi Provincial People's Hospital of Shanxi Medical University, Taiyuan, 030012, Shanxi, China.; Department of Nephrology, Shanxi Provincial People's Hospital (Fifth Hospital of Shanxi Medical University), Taiyuan, 030012, China.
Dong Y; Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, 030001, China.
Sun Q; South China University of Technology, Guangzhou, 510006, China.
Zhang Y; Shanxi Provincial Key Laboratory of Kidney Disease, Shanxi Provincial People's Hospital of Shanxi Medical University, Taiyuan, 030012, Shanxi, China.; Department of Nephrology, Shanxi Provincial People's Hospital (Fifth Hospital of Shanxi Medical University), Taiyuan, 030012, China.
Zhou X; Shanxi Provincial Key Laboratory of Kidney Disease, Shanxi Provincial People's Hospital of Shanxi Medical University, Taiyuan, 030012, Shanxi, China.; Department of Cell Biology, School of Basic Medicine, Shanxi Medical University, Taiyuan, 030001, China.
Li X; Shanxi Provincial Key Laboratory of Kidney Disease, Shanxi Provincial People's Hospital of Shanxi Medical University, Taiyuan, 030012, Shanxi, China.; Department of Nephrology, Shanxi Provincial People's Hospital (Fifth Hospital of Shanxi Medical University), Taiyuan, 030012, China.
Ma Y; Shanxi Provincial Key Laboratory of Kidney Disease, Shanxi Provincial People's Hospital of Shanxi Medical University, Taiyuan, 030012, Shanxi, China.; Department of Nephrology, Shanxi Provincial People's Hospital (Fifth Hospital of Shanxi Medical University), Taiyuan, 030012, China.
Liu X; Shanxi Provincial Key Laboratory of Kidney Disease, Shanxi Provincial People's Hospital of Shanxi Medical University, Taiyuan, 030012, Shanxi, China.; Department of Nephrology, Shanxi Provincial People's Hospital (Fifth Hospital of Shanxi Medical University), Taiyuan, 030012, China.
Li R; Shanxi Provincial Key Laboratory of Kidney Disease, Shanxi Provincial People's Hospital of Shanxi Medical University, Taiyuan, 030012, Shanxi, China.; Department of Nephrology, Shanxi Provincial People's Hospital (Fifth Hospital of Shanxi Medical University), Taiyuan, 030012, China.
Guo F; South China University of Technology, Guangzhou, 510006, China. .; Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China. .
Guo L; Shanxi Provincial Key Laboratory of Kidney Disease, Shanxi Provincial People's Hospital of Shanxi Medical University, Taiyuan, 030012, Shanxi, China. .; Department of Nephrology, Shanxi Provincial People's Hospital (Fifth Hospital of Shanxi Medical University), Taiyuan, 030012, China. .; Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 10; Vol. 14 (1), pp. 964. Date of Electronic Publication: 2024 Jan 10.
Typ publikacji:
Journal Article
MeSH Terms:
Adenocarcinoma of Lung*/genetics
Lung Neoplasms*/genetics
Humans ; Prognosis ; RNA ; Base Sequence ; CD3 Complex ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł:
Teclistamab: Mechanism of action, clinical, and translational science.
Autorzy:
Guo Y; Janssen Research & Development, Spring House, Pennsylvania, USA.
Quijano Cardé NA; Janssen Research & Development, Spring House, Pennsylvania, USA.
Kang L; Janssen Research & Development, Spring House, Pennsylvania, USA.
Verona R; Janssen Research & Development, Spring House, Pennsylvania, USA.
Banerjee A; Janssen Research & Development, Spring House, Pennsylvania, USA.
Kobos R; Janssen Research & Development, Spring House, Pennsylvania, USA.
Chastain K; Janssen Research & Development, Spring House, Pennsylvania, USA.
Uhlar C; Janssen Research & Development, Spring House, Pennsylvania, USA.
Pillarisetti K; Janssen Research & Development, Spring House, Pennsylvania, USA.
Doyle M; Janssen Sciences Ireland, Dublin, Ireland.
Smit J; Janssen Research & Development, Spring House, Pennsylvania, USA.
Haddish-Berhane N; Janssen Research & Development, Spring House, Pennsylvania, USA.
Ouellet D; Janssen Research & Development, Spring House, Pennsylvania, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2024 Jan; Vol. 17 (1), pp. e13717.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Multiple Myeloma*/drug therapy
Antibodies, Bispecific*
Antineoplastic Agents*
Humans ; Translational Science, Biomedical ; B-Cell Maturation Antigen ; CD3 Complex
Czasopismo naukowe
Tytuł:
Comprehensive Analysis of MICALL2 Reveals Its Potential Roles in EGFR Stabilization and Ovarian Cancer Cell Invasion.
Autorzy:
Xia T; Department of Physiology, Nanjing Medical University, Nanjing 211166, China.
Ye F; Department of Physiology, Nanjing Medical University, Nanjing 211166, China.
Zhao W; Department of Physiology, Nanjing Medical University, Nanjing 211166, China.
Min P; Department of Physiology, Nanjing Medical University, Nanjing 211166, China.
Qi C; Department of Physiology, Nanjing Medical University, Nanjing 211166, China.
Wang Q; Department of Physiology, Nanjing Medical University, Nanjing 211166, China.
Zhao M; Department of Physiology, Nanjing Medical University, Nanjing 211166, China.
Zhang Y; Department of Physiology, Nanjing Medical University, Nanjing 211166, China.
Du J; Department of Physiology, Nanjing Medical University, Nanjing 211166, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 30; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 30.
Typ publikacji:
Journal Article
MeSH Terms:
Matrix Metalloproteinase 9*/genetics
Ovarian Neoplasms*/genetics
Female ; Humans ; Carcinoma, Ovarian Epithelial ; CD3 Complex ; ErbB Receptors/genetics ; Neoplasm Invasiveness ; Proto-Oncogene Proteins c-akt ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł:
Development and characterization of NILK-2301, a novel CEACAM5xCD3 κλ bispecific antibody for immunotherapy of CEACAM5-expressing cancers.
Autorzy:
Seckinger A; LamKap Bio Alpha AG, Bahnhofstrasse 1, 8808, Pfäffikon, SZ, Switzerland.
Majocchi S; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Moine V; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Nouveau L; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Ngoc H; Institute of Anatomy, Leipzig University, Liebigstrasse 13, 04103, Leipzig, Germany.
Daubeuf B; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Ravn U; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Pleche N; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Calloud S; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Broyer L; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Cons L; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Lesnier A; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Chatel L; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Papaioannou A; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Salgado-Pires S; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Krämer S; Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Gockel I; Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Lordick F; Department of Medicine II, University Cancer Center Leipzig (UCCL), Leipzig University Medical Center, Liebigstrasse 22, 04103, Leipzig, Germany.
Masternak K; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Poitevin Y; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Magistrelli G; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Malinge P; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Shang L; Light Chain Bioscience - Novimmune SA, Chemin du Pré-Fleuri 15, 1228, Plan-les-Ouates, Switzerland.
Kallendrusch S; Institute of Anatomy, Leipzig University, Liebigstrasse 13, 04103, Leipzig, Germany.; Institute of Clinical Research and System Medicine, Health and Medical University Potsdam, Schiffbauergasse 14, 14467, Potsdam, Germany.
Strein K; LamKap Bio Alpha AG, Bahnhofstrasse 1, 8808, Pfäffikon, SZ, Switzerland.
Hose D; LamKap Bio Alpha AG, Bahnhofstrasse 1, 8808, Pfäffikon, SZ, Switzerland. .
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Źródło:
Journal of hematology & oncology [J Hematol Oncol] 2023 Dec 12; Vol. 16 (1), pp. 117. Date of Electronic Publication: 2023 Dec 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Bispecific*/pharmacology
Antibodies, Bispecific*/therapeutic use
Adenocarcinoma*/drug therapy
Pancreatic Neoplasms*/drug therapy
Humans ; Animals ; Mice ; Cell Line, Tumor ; Immunotherapy ; CD3 Complex ; Carcinoembryonic Antigen ; GPI-Linked Proteins
Czasopismo naukowe
Tytuł:
Identification and validation of a T cell marker gene-based signature to predict prognosis and immunotherapy response in gastric cancer.
Autorzy:
Zhong J; Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
Pan R; Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
Gao M; Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
Mo Y; Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
Peng X; Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
Liang G; Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
Chen Z; Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
Du J; Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
Huang Z; Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, People's Republic of China. .; Key Laboratory of Noncommunicable Diseases Control and Health Data Statistics of Guangdong Medical University, Dongguan, Guangdong, People's Republic of China. .
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Źródło:
Scientific reports [Sci Rep] 2023 Dec 04; Vol. 13 (1), pp. 21357. Date of Electronic Publication: 2023 Dec 04.
Typ publikacji:
Journal Article
MeSH Terms:
Stomach Neoplasms*/genetics
Stomach Neoplasms*/therapy
Adenocarcinoma*
Humans ; Prognosis ; Immunotherapy ; Nomograms ; CD3 Complex ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł:
CD3Z polymorphisms and promoter hypermethylation in dermatomyositis - the role of cytosine-phosphate-guanine-related single nucleotide polymorphisms.
Autorzy:
Saraeva R; Medical University Sofia, Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Sofia, Bulgaria.
Kamenarska Z; Medical University Sofia, Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Sofia, Bulgaria.
Dourmishev L; Medical University Sofia, Department of Dermatology and Venereology, University Hospital Alexandrovska, Clinic of Dermatology and Venereology, Sofia, Bulgaria.
Vinkov A; Department of Neurology, Hôpitaux Drôme Nord, Romans-sur-Isère, France.
Dzhebir G; Medical University Sofia, Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Sofia, Bulgaria.
Kachakova D; Medical University Sofia, Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Sofia, Bulgaria.
Ivanova N; Medical University Sofia, Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Sofia, Bulgaria.
Pozharashka J; Medical University Sofia, Department of Dermatology and Venereology, University Hospital Alexandrovska, Clinic of Dermatology and Venereology, Sofia, Bulgaria.
Kaneva R; Medical University Sofia, Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Sofia, Bulgaria.
Hristova M; Department of Internal Medicine, University Hospital St. Ivan Rilski, Clinic of Nephrology, Sofia, Bulgaria.
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Źródło:
Immunological investigations [Immunol Invest] 2022 May; Vol. 51 (4), pp. 817-825. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji:
Journal Article
MeSH Terms:
CD3 Complex*/genetics
Dermatomyositis*/genetics
Polymorphism, Single Nucleotide*
Cytosine ; DNA Methylation ; Genotype ; Guanine ; Humans ; Phosphates
Czasopismo naukowe
Tytuł:
Single-cell transcriptomics identify TNFRSF1B as a novel T-cell exhaustion marker for ovarian cancer.
Autorzy:
Gao Y; Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Shi H; School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Human Brain Protection, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China.; Joint Graduate Program of Peking-Tsinghua-NIBS, School of Life Sciences, Tsinghua University, Beijing, China.
Zhao H; Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Yao M; Bioinformatics department, Annoroad Gene Technology Co., Ltd, Beijing, China.
He Y; Department of Gynecology and Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Jiang M; Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Li J; Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Li Z; Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Su S; Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Liu T; Bioinformatics department, Annoroad Gene Technology Co., Ltd, Beijing, China.
Yin C; Department of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Liao X; School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Human Brain Protection, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China.
Yue W; Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2023 Sep; Vol. 13 (9), pp. e1416.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ovarian Neoplasms*/genetics
Transcriptome*
Animals ; Female ; Humans ; Mice ; CD3 Complex ; CD8-Positive T-Lymphocytes ; Ecosystem ; Receptors, Tumor Necrosis Factor, Type II ; T-Cell Exhaustion ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł:
Targeting NKG2DL with Bispecific NKG2D-CD16 and NKG2D-CD3 Fusion Proteins on Triple-Negative Breast Cancer.
Autorzy:
Kaidun P; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tuebingen, 72076 Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tuebingen, 72074 Tuebingen, Germany.
Holzmayer SJ; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tuebingen, 72076 Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tuebingen, 72074 Tuebingen, Germany.
Greiner SM; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tuebingen, 72076 Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tuebingen, 72074 Tuebingen, Germany.; Department of Obstetrics and Gynecology, University Hospital Tuebingen, 72076 Tuebingen, Germany.
Seller A; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tuebingen, 72076 Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tuebingen, 72074 Tuebingen, Germany.; Department of Obstetrics and Gynecology, University Hospital Tuebingen, 72076 Tuebingen, Germany.
Tegeler CM; Department of Obstetrics and Gynecology, University Hospital Tuebingen, 72076 Tuebingen, Germany.
Hagelstein I; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tuebingen, 72076 Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tuebingen, 72074 Tuebingen, Germany.
Mauermann J; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tuebingen, 72076 Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tuebingen, 72074 Tuebingen, Germany.
Engler T; Department of Obstetrics and Gynecology, University Hospital Tuebingen, 72076 Tuebingen, Germany.
Koch A; Department of Obstetrics and Gynecology, University Hospital Tuebingen, 72076 Tuebingen, Germany.
Hartkopf AD; Department of Obstetrics and Gynecology, University Hospital Tuebingen, 72076 Tuebingen, Germany.
Salih HR; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tuebingen, 72076 Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tuebingen, 72074 Tuebingen, Germany.
Märklin M; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tuebingen, 72076 Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tuebingen, 72074 Tuebingen, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 24; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 24.
Typ publikacji:
Journal Article
MeSH Terms:
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/genetics
Recombinant Fusion Proteins*/therapeutic use
Humans ; Administration, Cutaneous ; Aggression ; Ligands ; NK Cell Lectin-Like Receptor Subfamily K/genetics ; Receptors, IgG ; CD3 Complex
Czasopismo naukowe
Tytuł:
Identification and validation of tumor microenvironment-related signature for predicting prognosis and immunotherapy response in patients with lung adenocarcinoma.
Autorzy:
Li C; Department of Oncology, Suining Central Hospital, Suining, 629000, Sichuan, China.
Yuan Y; Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jiang X; Department of Oncology, Suining Central Hospital, Suining, 629000, Sichuan, China. .
Wang Q; Gastrointestinal Surgical Unit, Suining Central Hospital, Suining, 629000, Sichuan, China. .
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Źródło:
Scientific reports [Sci Rep] 2023 Aug 21; Vol. 13 (1), pp. 13568. Date of Electronic Publication: 2023 Aug 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenocarcinoma of Lung*/genetics
Adenocarcinoma of Lung*/therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/therapy
Humans ; Tumor Microenvironment/genetics ; Prognosis ; CD3 Complex ; Immunotherapy ; Carrier Proteins ; Microfilament Proteins
Czasopismo naukowe
Tytuł:
Endotoxemia Associated with Liver Disease Correlates with Systemic Inflammation and T Cell Exhaustion in Hepatitis C Virus Infection.
Autorzy:
Shive CL; Cleveland VA Medical Center, Cleveland, OH 44106, USA.; Pathology Department, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Kowal CM; Cleveland VA Medical Center, Cleveland, OH 44106, USA.
Desotelle AF; Cleveland VA Medical Center, Cleveland, OH 44106, USA.
Nguyen Y; Cleveland VA Medical Center, Cleveland, OH 44106, USA.
Carbone S; Cleveland VA Medical Center, Cleveland, OH 44106, USA.
Kostadinova L; Cleveland VA Medical Center, Cleveland, OH 44106, USA.
Davitkov P; Cleveland VA Medical Center, Cleveland, OH 44106, USA.
O'Mara M; Cleveland VA Medical Center, Cleveland, OH 44106, USA.
Reihs A; Cleveland VA Medical Center, Cleveland, OH 44106, USA.
Siddiqui H; Cleveland VA Medical Center, Cleveland, OH 44106, USA.
Wilson BM; Cleveland VA Medical Center, Cleveland, OH 44106, USA.; Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Anthony DD; Cleveland VA Medical Center, Cleveland, OH 44106, USA.; Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
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Źródło:
Cells [Cells] 2023 Aug 10; Vol. 12 (16). Date of Electronic Publication: 2023 Aug 10.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Endotoxemia*/complications
Hepatitis C, Chronic*/complications
Hepatitis C*
Humans ; Hepacivirus ; Chemokine CXCL10 ; Interleukin-6 ; Programmed Cell Death 1 Receptor ; T-Cell Exhaustion ; Inflammation ; CD3 Complex ; Antiviral Agents
Czasopismo naukowe
Tytuł:
Indolent T-cell prolymphocytic leukemia with no expression of surface T-cell receptors or surface CD3.
Autorzy:
Wang HY; Division of Laboratory and Genomic Medicine, Department of Pathology, University of California San Diego Health System, La Jolla, CA, USA.
Murray SS; Division of Laboratory and Genomic Medicine, Department of Pathology, University of California San Diego Health System, La Jolla, CA, USA.
Bejar R; Division of Hematology and Oncology, Department of Medicine, University of California San Diego Health System, La Jolla, CA, USA.
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Źródło:
International journal of laboratory hematology [Int J Lab Hematol] 2021 Aug; Vol. 43 (4), pp. O224-O226. Date of Electronic Publication: 2021 Apr 14.
Typ publikacji:
Letter
MeSH Terms:
CD3 Complex/*metabolism
Leukemia, Prolymphocytic, T-Cell/*metabolism
Receptors, Antigen, T-Cell/*metabolism
CD3 Complex/genetics ; Gene Expression ; Humans ; Immunophenotyping ; Leukemia, Prolymphocytic, T-Cell/etiology ; Receptors, Antigen, T-Cell/genetics
Opinia redakcyjna
Tytuł:
Evaluation of Immune Infiltrates in Ovarian Endometriosis and Endometriosis-Associated Ovarian Cancer: Relationship with Histological and Clinical Features.
Autorzy:
Spagnolo E; Department of Gynecology, La Paz University Hospital, 28046 Madrid, Spain.; Research Institute 'IdiPaz', La Paz University Hospital, 28046 Madrid, Spain.
Martinez A; Department of Surgical Oncology, Institut Claudius Regaud-Institut Universitaire du Cancer du Toulouse (IUCT) Oncopole, 31059 Toulouse, France.; Centre de Recherches en Cancérologie de Toulouse, UMR 1037 INSERM, 31100 Toulouse, France.
Mascarós-Martínez A; Department of Pathology, General University Hospital of Valencia, 46014 Valencia, Spain.
Marí-Alexandre J; Department of Pathology, General University Hospital of Valencia, 46014 Valencia, Spain.; Research Laboratory in Biomarkers in Reproduction, Obstetrics and Gynecology, Research Foundation, General University Hospital of Valencia, 46014 Valencia, Spain.
Carbonell M; Department of Gynecology, La Paz University Hospital, 28046 Madrid, Spain.; Research Institute 'IdiPaz', La Paz University Hospital, 28046 Madrid, Spain.
González-Cantó E; Research Laboratory in Biomarkers in Reproduction, Obstetrics and Gynecology, Research Foundation, General University Hospital of Valencia, 46014 Valencia, Spain.
Pena-Burgos EM; Department of Pathology, La Paz University Hospital, 28046 Madrid, Spain.
Mc Cormack BA; Research Laboratory in Biomarkers in Reproduction, Obstetrics and Gynecology, Research Foundation, General University Hospital of Valencia, 46014 Valencia, Spain.
Tomás-Pérez S; Research Laboratory in Biomarkers in Reproduction, Obstetrics and Gynecology, Research Foundation, General University Hospital of Valencia, 46014 Valencia, Spain.
Gilabert-Estellés J; Research Laboratory in Biomarkers in Reproduction, Obstetrics and Gynecology, Research Foundation, General University Hospital of Valencia, 46014 Valencia, Spain.; Department of Obstetrics and Gynecology, General University Hospital of Valencia, 46014 Valencia, Spain.; Department of Paediatrics, Obstetrics and Gynaecology, University of Valencia, 46010 Valencia, Spain.
López-Carrasco A; Department of Gynecology, La Paz University Hospital, 28046 Madrid, Spain.; Research Institute 'IdiPaz', La Paz University Hospital, 28046 Madrid, Spain.
Hidalgo P; Department of Radiology, La Paz University Hospital, 28046 Madrid, Spain.
Ángeles MA; Department of Surgical Oncology, Institut Claudius Regaud-Institut Universitaire du Cancer du Toulouse (IUCT) Oncopole, 31059 Toulouse, France.
Redondo A; Department of Medical Oncology, La Paz University Hospital, 28046 Madrid, Spain.
Gallego A; Department of Medical Oncology, La Paz University Hospital, 28046 Madrid, Spain.
Hernández A; Department of Gynecology, La Paz University Hospital, 28046 Madrid, Spain.; Research Institute 'IdiPaz', La Paz University Hospital, 28046 Madrid, Spain.; Department of Obstetrics and Gynaecology, Universidad Autónoma Madrid, 28049 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 28; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 28.
Typ publikacji:
Journal Article
MeSH Terms:
Endometriosis*/complications
Endometriosis*/pathology
Ovarian Neoplasms*/pathology
Humans ; Female ; Hepatitis A Virus Cellular Receptor 2 ; Programmed Cell Death 1 Receptor ; CD3 Complex ; Lymphocytes, Tumor-Infiltrating/pathology ; Forkhead Transcription Factors
Czasopismo naukowe
Tytuł:
A simplified function-first method for the discovery and optimization of bispecific immune engaging antibodies.
Autorzy:
Shepherd A; Human Health Therapeutics Research Centre, National Research Council, Ottawa, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada.
Bennychen B; Human Health Therapeutics Research Centre, National Research Council, Ottawa, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada.
Marcil A; Human Health Therapeutics Research Centre, National Research Council, Ottawa, Canada.
Bloemberg D; Human Health Therapeutics Research Centre, National Research Council, Ottawa, Canada.
Pon RA; Human Health Therapeutics Research Centre, National Research Council, Ottawa, Canada.
Weeratna RD; Human Health Therapeutics Research Centre, National Research Council, Ottawa, Canada.
McComb S; Human Health Therapeutics Research Centre, National Research Council, Ottawa, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Canada.
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Źródło:
PloS one [PLoS One] 2023 Jun 22; Vol. 18 (6), pp. e0273884. Date of Electronic Publication: 2023 Jun 22 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neoplasm Recurrence, Local*
Antibodies, Bispecific*/pharmacology
Humans ; CD3 Complex/metabolism ; Jurkat Cells ; Antigens, Neoplasm ; B-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł:
CAR T-Cell Therapy for Cancer: Latest Updates and Challenges, with a Focus on B-Lymphoid Malignancies and Selected Solid Tumours.
Autorzy:
Tang HKC; Department of Oncology, Nottingham University Hospitals, Nottingham NG5 1PB, UK.
Wang B; University of Cambridge, Trinity Hall, Cambridge CB3 9DP, UK.
Tan HX; Department of Oncology, Nottingham University Hospitals, Nottingham NG5 1PB, UK.
Sarwar MA; Department of Oncology, Nottingham University Hospitals, Nottingham NG5 1PB, UK.
Baraka B; Department of Oncology, Nottingham University Hospitals, Nottingham NG5 1PB, UK.
Shafiq T; Department of Oncology, Nottingham University Hospitals, Nottingham NG5 1PB, UK.
Rao AR; Department of Oncology, Nottingham University Hospitals, Nottingham NG5 1PB, UK.
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Źródło:
Cells [Cells] 2023 Jun 08; Vol. 12 (12). Date of Electronic Publication: 2023 Jun 08.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Immunotherapy, Adoptive*/adverse effects
Neuroblastoma*/pathology
Humans ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes ; Immunotherapy ; CD3 Complex/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
Focusing on scRNA-seq-Derived T Cell-Associated Genes to Identify Prognostic Signature and Immune Microenvironment Status in Low-Grade Glioma.
Autorzy:
Wen J; Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100020, China.; Graduate College, Beijing University of Chinese Medicine, Beijing 100020, China.; Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100089, China.
Huang Q; Graduate College, Beijing University of Chinese Medicine, Beijing 100020, China.; Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100089, China.
Yao J; First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan 250011, China.
Wei W; Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100020, China.
Li Z; Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100089, China.
Zhang H; Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100089, China.
Chang S; Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100089, China.
Pei H; Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100089, China.
Cao Y; Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100089, China.
Li H; Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100020, China.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2023 May 31; Vol. 2023, pp. 3648946. Date of Electronic Publication: 2023 May 31 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Single-Cell Gene Expression Analysis*
Glioma*/genetics
Humans ; Prognosis ; Transcription Factors ; CD4-Positive T-Lymphocytes ; CD3 Complex ; Tumor Microenvironment/genetics ; SEC Translocation Channels
Czasopismo naukowe
Tytuł:
Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning.
Autorzy:
Haber L; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA. .
Olson K; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Kelly MP; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Crawford A; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
DiLillo DJ; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Tavaré R; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Ullman E; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Mao S; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Canova L; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Sineshchekova O; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Finney J; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Pawashe A; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Patel S; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
McKay R; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Rizvi S; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Damko E; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Chiu D; AstraZeneca, Cambridge, UK.
Vazzana K; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Ram P; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Mohrs K; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
D'Orvilliers A; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Xiao J; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Makonnen S; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Hickey C; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Arnold C; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Giurleo J; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Chen YP; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Thwaites C; Lonza, Slough, UK.
Dudgeon D; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Bray K; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Rafique A; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Huang T; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Delfino F; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Hermann A; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Kirshner JR; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Retter MW; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Babb R; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
MacDonald D; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Chen G; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Olson WC; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Thurston G; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Davis S; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Lin JC; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Smith E; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
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Źródło:
Scientific reports [Sci Rep] 2021 Jul 13; Vol. 11 (1), pp. 14397. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Bispecific*
CD3 Complex*
Cytokines*/metabolism
Lymphocyte Activation ; Tissue Distribution
Czasopismo naukowe
Tytuł:
Summary of a workshop on preclinical and translational safety assessment of CD3 bispecifics.
Autorzy:
Kamperschroer C; Pfizer Worldwide Research and Development, Groton, CT, USA.
Shenton J; Nonclinical Safety, Janssen R&D, Spring House, PA, USA.
Lebrec H; Translational Safety, Amgen Research, South San Francisco, CA, USA.
Leighton JK; U. S. Food and Drug Administration, Silver Spring, MD, USA.
Moore PA; MacroGenics, Rockville, MD, USA.
Thomas O; Translational Safety, Amgen Research, Munich, Germany.
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Źródło:
Journal of immunotoxicology [J Immunotoxicol] 2020 Dec; Vol. 17 (1), pp. 67-85.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Bispecific/*toxicity
Antigens, Neoplasm/*metabolism
Antineoplastic Agents/*toxicity
CD3 Complex/*antagonists & inhibitors
Cytokine Release Syndrome/*prevention & control
Animals ; Antibodies, Bispecific/administration & dosage ; Antigens, Neoplasm/immunology ; Antineoplastic Agents/administration & dosage ; CD3 Complex/immunology ; CD3 Complex/metabolism ; Consensus ; Consensus Development Conferences as Topic ; Cytokine Release Syndrome/chemically induced ; Cytokine Release Syndrome/immunology ; Cytokines/metabolism ; Drug Screening Assays, Antitumor/standards ; Europe ; Humans ; Japan ; Neoplasms/drug therapy ; Neoplasms/immunology ; Receptors, Antigen, T-Cell/antagonists & inhibitors ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Translational Research, Biomedical/standards ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Tytuł:
Expansion of mixed immune cells using CD3/CD161 co-stimulation for the treatment of cancer.
Autorzy:
Tsumura R; Division of Developmental Therapeutics, EPOC, National Cancer Center, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
Haruta M; Dojin institute of cancer immunology, Co., Ltd. Kumamoto, Kumamoto, 862-0967, Japan.
Kuwano M; Dojin institute of cancer immunology, Co., Ltd. Kumamoto, Kumamoto, 862-0967, Japan.
Yasunaga M; Division of Developmental Therapeutics, EPOC, National Cancer Center, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2023 Apr 26; Vol. 13 (1), pp. 6803. Date of Electronic Publication: 2023 Apr 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Natural Killer T-Cells*
Neoplasms*/therapy
Neoplasms*/metabolism
Humans ; CD3 Complex ; CD8-Positive T-Lymphocytes ; Killer Cells, Natural ; T-Lymphocytes, Cytotoxic/metabolism ; NK Cell Lectin-Like Receptor Subfamily B/metabolism
Czasopismo naukowe
Tytuł:
Single-cell and bulk RNA sequencing identifies T cell marker genes score to predict the prognosis of pancreatic ductal adenocarcinoma.
Autorzy:
Zheng H; Department of Medical Oncology, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, 711018, Shaanxi, People's Republic of China. .
Li Y; Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
Zhao Y; Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
Jiang A; Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 06; Vol. 13 (1), pp. 3684. Date of Electronic Publication: 2023 Mar 06.
Typ publikacji:
Journal Article
MeSH Terms:
Pancreatic Neoplasms*/genetics
Carcinoma, Pancreatic Ductal*/genetics
Humans ; Prognosis ; RNA-Seq ; CD3 Complex ; T-Lymphocytes ; Pancreatic Neoplasms
Czasopismo naukowe

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