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Wyszukujesz frazę ""CD4-Positive T-Lymphocytes"" wg kryterium: Temat


Tytuł :
Maturation of T and B Lymphocytes in the Assessment of the Immune Status in COVID-19 Patients.
Autorzy :
Kwiecień I; Laboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Rutkowska E; Laboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Kłos K; Department of Infectious Diseases and Allergology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Więsik-Szewczyk E; Department of Internal Medicine, Pulmonology, Allergology and Clinical Immunology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Jahnz-Różyk K; Department of Internal Medicine, Pulmonology, Allergology and Clinical Immunology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Rzepecki P; Department of Internal Medicine and Hematology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Chciałowski A; Department of Infectious Diseases and Allergology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
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Źródło :
Cells [Cells] 2020 Dec 05; Vol. 9 (12). Date of Electronic Publication: 2020 Dec 05.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes/*cytology
CD4-Positive T-Lymphocytes/*cytology
CD8-Positive T-Lymphocytes/*cytology
COVID-19/*pathology
Adult ; Aged ; Aged, 80 and over ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; COVID-19/immunology ; COVID-19/virology ; Case-Control Studies ; Female ; Flow Cytometry ; Humans ; Immunophenotyping ; Male ; Middle Aged ; SARS-CoV-2/isolation & purification
Czasopismo naukowe
Tytuł :
Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4 cell reservoir.
Autorzy :
Patasic L; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany.
Seifried J; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany. .; Department for Infectious Disease Epidemiology, Robert Koch-Institute, Berlin, Germany. .
Bezler V; Regensburg Center for Interventional Immunology (RCI), Department of Genetic Immunotherapy, University Hospital Regensburg, Regensburg, Germany.
Kaljanac M; Regensburg Center for Interventional Immunology (RCI), Department of Genetic Immunotherapy, University Hospital Regensburg, Regensburg, Germany.
Schneider IC; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Schmitz H; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany.
Tondera C; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany.
Hartmann J; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Hombach A; Center for Molecular Medicine Cologne, University of Cologne, and Department I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Buchholz CJ; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Abken H; Center for Molecular Medicine Cologne, University of Cologne, and Department I of Internal Medicine, University Hospital Cologne, Cologne, Germany.; Regensburg Center for Interventional Immunology (RCI), Department of Genetic Immunotherapy, University Hospital Regensburg, Regensburg, Germany.
König R; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany.; German Center for Infection Research (DZIF), Langen, Germany.; Immunity and Pathogenesis Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Cichutek K; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany. .; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany. .; German Center for Infection Research (DZIF), Langen, Germany. .
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Źródło :
Medical microbiology and immunology [Med Microbiol Immunol] 2020 Dec; Vol. 209 (6), pp. 681-691. Date of Electronic Publication: 2020 Sep 12.
Typ publikacji :
Journal Article
MeSH Terms :
Ankyrin Repeat*
Immunotherapy, Adoptive*
CD4-Positive T-Lymphocytes/*virology
HIV/*isolation & purification
HIV Infections/*immunology
Lymphocyte Depletion/*methods
Peptides/*pharmacology
CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; Dose-Response Relationship, Immunologic ; Drug Evaluation, Preclinical ; Gammaretrovirus/genetics ; Genetic Vectors/genetics ; HEK293 Cells ; HIV Infections/virology ; Humans ; Lymphocyte Activation ; Peptides/chemistry ; Single-Chain Antibodies/immunology ; Transduction, Genetic
Czasopismo naukowe
Tytuł :
Cytotoxic cell populations developed during treatment with tyrosine kinase inhibitors protect autologous CD4+ T cells from HIV-1 infection.
Autorzy :
Vigón L; AIDS Immunopathology Unit, National Center of Microbiology (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Rodríguez-Mora S; AIDS Immunopathology Unit, National Center of Microbiology (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Luna A; Clinical Hematology Service, Hospital Universitario Ramón y Cajal, YRICIS, Madrid, Spain.
Sandonís V; Viral Isolation and Detection, CIBER Epidemiology and Public Health (CNM, ISCIII), Madrid, Spain.
Mateos E; AIDS Immunopathology Unit, National Center of Microbiology (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Bautista G; Clinical Hematology Service, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
Steegmann JL; Hematology and Hemotherapy Service, Hospital Universitario de La Princesa, Madrid, Spain.
Climent N; Retrovirology and Viral Immunopathology Laboratory, AIDS Research Group, Hospital Clínic, IDIBAPS, Barcelona, Spain.
Plana M; Retrovirology and Viral Immunopathology Laboratory, AIDS Research Group, Hospital Clínic, IDIBAPS, Barcelona, Spain.
Pérez-Romero P; Viral Isolation and Detection, CIBER Epidemiology and Public Health (CNM, ISCIII), Madrid, Spain.
de Ory F; Serology Service, CIBER Epidemiology and Public Health (CNM, ISCIII), Madrid, Spain.
Alcamí J; AIDS Immunopathology Unit, National Center of Microbiology (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
García-Gutierrez V; Clinical Hematology Service, Hospital Universitario Ramón y Cajal, YRICIS, Madrid, Spain.
Planelles V; Microbiology and Immunology Lab, University of Utah, Salt Lake City, USA.
López-Huertas MR; AIDS Immunopathology Unit, National Center of Microbiology (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Electronic address: .
Coiras M; AIDS Immunopathology Unit, National Center of Microbiology (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114203. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*metabolism
Cytoprotection/*drug effects
HIV Infections/*metabolism
HIV-1/*metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*metabolism
Protein Kinase Inhibitors/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; Cytoprotection/physiology ; Female ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV-1/drug effects ; HIV-1/immunology ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology ; Male ; Middle Aged ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
CD4 and CD8 Lymphocyte Counts as Surrogate Early Markers for Progression in SARS-CoV-2 Pneumonia: A Prospective Study.
Autorzy :
Calvet J; Rheumatology Department, Parc Taulí University Hospital, I3PT Research Institute (UAB), Universitat Autónoma de Barcelona (UAB), 08208 Sabadell, Spain.
Gratacós J; Rheumatology Department, Parc Taulí University Hospital, I3PT Research Institute (UAB), Universitat Autónoma de Barcelona (UAB), 08208 Sabadell, Spain.
Amengual MJ; Immunology Unit UDIAT, Parc Taulí University Hospital. I3PT Research Institute (UAB), 08208 Sabadell, Spain.
Llop M; Rheumatology Department, Parc Taulí University Hospital, I3PT Research Institute (UAB), Universitat Autónoma de Barcelona (UAB), 08208 Sabadell, Spain.
Navarro M; Infectious Disease Department, Parc Taulí University Hospital. I3PT Research Institute (UAB), 08208 Sabadell, Spain.
Moreno A; Pneumology Department, Parc Taulí University Hospital, I3PT Research Institute (UAB), 08208 Sabadell, Spain.
Berenguer-Llergo A; Biostatistics and Bioinformatics Unit, Institute for Research in Biomedicine Barcelona (IRB Barcelona), 08028 Barcelona, Spain.
Serrano A; Research Biology Unit, I3PT Research Institute (UAB), 08208 Sabadell, Spain.
Orellana C; Rheumatology Department, Parc Taulí University Hospital, I3PT Research Institute (UAB), Universitat Autónoma de Barcelona (UAB), 08208 Sabadell, Spain.
Cervantes M; Infectious Disease Department, Parc Taulí University Hospital. I3PT Research Institute (UAB), 08208 Sabadell, Spain.
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Źródło :
Viruses [Viruses] 2020 Nov 09; Vol. 12 (11). Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
CD4-Positive T-Lymphocytes/*pathology
CD8-Positive T-Lymphocytes/*pathology
COVID-19/*diagnosis
Lymphocyte Subsets/*pathology
SARS-CoV-2/*pathogenicity
Aged ; Area Under Curve ; Biomarkers/analysis ; CD4-CD8 Ratio/statistics & numerical data ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/virology ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/virology ; Disease Progression ; Female ; Humans ; Lung ; Lymphocyte Count ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/virology ; Male ; Middle Aged ; Patient Discharge/statistics & numerical data ; Prognosis ; Prospective Studies ; ROC Curve ; SARS-CoV-2/immunology ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus.
Autorzy :
Karimi MM; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Guo Y; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Cui X; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Pallikonda HA; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Horková V; Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Wang YF; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Gil SR; CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Rodriguez-Esteban G; CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Robles-Rebollo I; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Bruno L; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Georgieva R; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Patel B; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Elliott J; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Dore MH; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Dauphars D; Department of Immunology, Duke University Medical Center, Durham, NC, USA.
Krangel MS; Department of Immunology, Duke University Medical Center, Durham, NC, USA.
Lenhard B; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Heyn H; CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Fisher AG; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Štěpánek O; Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Merkenschlager M; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 04; Vol. 12 (1), pp. 99. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*cytology
CD8-Positive T-Lymphocytes/*cytology
Cell Differentiation/*immunology
Cell Lineage/*immunology
Thymus Gland/*cytology
Thymus Gland/*immunology
Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Core Binding Factor Alpha 3 Subunit/metabolism ; Cytokines/metabolism ; DNA-Binding Proteins/metabolism ; Gene Expression Regulation ; Histocompatibility Antigens/metabolism ; Lymphocyte Activation/genetics ; Mice, Inbred C57BL ; Principal Component Analysis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19.
Autorzy :
Leonardi AJ; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Proenca RB; Department of Biology, Johns Hopkins University, Baltimore, MD, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Dec 21; Vol. 11, pp. 600405. Date of Electronic Publication: 2020 Dec 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Apoptosis/*immunology
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
Cell Differentiation/*immunology
Proto-Oncogene Proteins c-akt/*immunology
SARS-CoV-2/*immunology
fas Receptor/*immunology
CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/pathology ; COVID-19/pathology ; Humans
Czasopismo naukowe
Tytuł :
Biomodulina T (InmunyVital ) Restores T Cells and Helps Contain COVID-19.
Autorzy :
Rodriguez Martin RR; BIOLONG Corporation, Miami, FL, United States.
Gonzalez Gonzalez O; BIOLONG Corporation, Miami, FL, United States.
Rodriguez Gonzalez C; BIOLONG Corporation, Miami, FL, United States.
Rodriguez Gonzalez RR; BIOLONG Corporation, Miami, FL, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Dec 09; Vol. 11, pp. 606447. Date of Electronic Publication: 2020 Dec 09 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*drug therapy
Immunologic Factors/*therapeutic use
SARS-CoV-2/*immunology
CD4-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/drug effects ; COVID-19/immunology ; Humans ; Immunotherapy/methods ; SARS-CoV-2/drug effects ; Thymus Gland/metabolism
Czasopismo naukowe
Tytuł :
Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals.
Autorzy :
Gong F; Department of Laboratory Medicine, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.; Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Dai Y; Department of Laboratory Medicine, The Fifth People's Hospital of Wuxi, Wuxi, Jiangsu, China.
Zheng T; Qilu University of Technology, Shandong Academy of Sciences, Shandong Analysis and Test Center, Laboratory of Immunology for Environment and Health, Jinan, China.
Cheng L; Department of Respiration, The Fifth People's Hospital of Wuxi, Wuxi, Jiangsu, China.
Zhao D; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Wang H; Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Liu M; Department of Laboratory Medicine, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Pei H; Department of Laboratory Medicine, The Fifth People's Hospital of Wuxi, Wuxi, Jiangsu, China.
Jin T; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Yu D; Qilu University of Technology, Shandong Academy of Sciences, Shandong Analysis and Test Center, Laboratory of Immunology for Environment and Health, Jinan, China.; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.
Zhou P; Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Dec 01; Vol. 130 (12), pp. 6588-6599.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibody Formation*
Convalescence*
Antibodies, Viral/*immunology
CD4-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
T-Lymphocyte Subsets/*immunology
Adult ; Aged ; Antibodies, Viral/blood ; CD4-Positive T-Lymphocytes/metabolism ; COVID-19/blood ; Female ; Humans ; Male ; Middle Aged ; SARS-CoV-2/metabolism ; T-Lymphocyte Subsets/metabolism
Czasopismo naukowe
Tytuł :
Divergent SARS-CoV-2-specific T- and B-cell responses in severe but not mild COVID-19 patients.
Autorzy :
Oja AE; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Saris A; Centre for Experimental and Molecular Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Amsterdam UMC COVID Study Group, Amsterdam UMC, Amsterdam, The Netherlands.
Ghandour CA; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Kragten NAM; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Hogema BM; Sanquin Diagnostic Services and Sanquin Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Nossent EJ; Amsterdam UMC COVID Study Group, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Pulmonary Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
Heunks LMA; Amsterdam UMC COVID Study Group, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Intensive Care Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
Cuvalay S; Unit of Transfusion Medicine, Sanquin Blood Supply, Amsterdam, The Netherlands.
Slot E; Laboratory of Blood-borne Infections, Sanquin Blood Supply, Amsterdam, The Netherlands.
Linty F; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Swaneveld FH; Unit of Transfusion Medicine, Sanquin Blood Supply, Amsterdam, The Netherlands.
Vrielink H; Unit of Transfusion Medicine, Sanquin Blood Supply, Amsterdam, The Netherlands.
Vidarsson G; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Rispens T; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
van der Schoot E; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
van Lier RAW; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Ten Brinke A; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Hombrink P; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
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Źródło :
European journal of immunology [Eur J Immunol] 2020 Dec; Vol. 50 (12), pp. 1998-2012. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Antibodies, Viral/*immunology
B-Lymphocytes/*immunology
CD4-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
Immunoglobulin G/*immunology
SARS-CoV-2/*immunology
Adult ; Aged ; B-Lymphocytes/pathology ; CD4-Positive T-Lymphocytes/pathology ; COVID-19/pathology ; Female ; Humans ; Male ; Middle Aged ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Negative Clinical Evolution in COVID-19 Patients Is Frequently Accompanied With an Increased Proportion of Undifferentiated Th Cells and a Strong Underrepresentation of the Th1 Subset.
Autorzy :
Gutiérrez-Bautista JF; Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Rodriguez-Nicolas A; Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Rosales-Castillo A; Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Jiménez P; Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Garrido F; Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.; Departamento Bioquímica, Biología Molecular e Inmunología III, University of Granada, Granada, Spain.
Anderson P; Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.
Ruiz-Cabello F; Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.; Departamento Bioquímica, Biología Molecular e Inmunología III, University of Granada, Granada, Spain.
López-Ruz MÁ; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.; Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen de las Nieves, Granada, Spain.; Departamento de Medicina, University of Granada, Granada, Spain.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Nov 26; Vol. 11, pp. 596553. Date of Electronic Publication: 2020 Nov 26 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
T-Lymphocytes, Helper-Inducer/*immunology
Th1 Cells/*immunology
ADP-ribosyl Cyclase 1/immunology ; ADP-ribosyl Cyclase 1/metabolism ; Aged ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; COVID-19/virology ; Cell Differentiation/immunology ; Female ; HLA-DR Antigens/immunology ; HLA-DR Antigens/metabolism ; Humans ; Lymphocyte Activation/immunology ; Male ; Middle Aged ; Prospective Studies ; SARS-CoV-2/physiology ; T-Lymphocytes, Helper-Inducer/metabolism ; Th1 Cells/metabolism ; Th17 Cells/immunology ; Th17 Cells/metabolism
Czasopismo naukowe
Tytuł :
Circulating Cytokines and Lymphocyte Subsets in Patients Who Have Recovered from COVID-19.
Autorzy :
Hasichaolu; Department of Laboratory Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Zhang X; Department of Respiratory and Critical Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Li X; Department of Cardiology, Cardiovascular Hospital of Shanxi Province, China.
Li X; Department of Laboratory Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Li D; Department of Respiratory and Critical Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
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Źródło :
BioMed research international [Biomed Res Int] 2020 Nov 26; Vol. 2020, pp. 7570981. Date of Electronic Publication: 2020 Nov 26 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
CD4-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
COVID-19*/blood
COVID-19*/immunology
Cytokines*/blood
Cytokines*/immunology
Killer Cells, Natural*/immunology
Killer Cells, Natural*/metabolism
Lymphocyte Subsets*/immunology
Lymphocyte Subsets*/metabolism
SARS-CoV-2*/immunology
SARS-CoV-2*/metabolism
Adult ; Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression.
Autorzy :
Srinivasachar Badarinarayan S; Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
Shcherbakova I; Molecular Biology Division, Biomedical Center, Ludwig-Maximilians-University Munich, Planegg-Martinsried 82152, Germany.
Langer S; Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Koepke L; Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
Preising A; Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
Hotter D; Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
Kirchhoff F; Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
Sparrer KMJ; Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
Schotta G; Molecular Biology Division, Biomedical Center, Ludwig-Maximilians-University Munich, Planegg-Martinsried 82152, Germany.
Sauter D; Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 04; Vol. 48 (19), pp. 10890-10908.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Promoter Regions, Genetic*
CD4-Positive T-Lymphocytes/*immunology
Endogenous Retroviruses/*genetics
Gene Expression Regulation/*immunology
HIV Infections/*genetics
T-Lymphocyte Subsets/*immunology
Animals ; CD4-Positive T-Lymphocytes/cytology ; GTP-Binding Proteins/genetics ; GTP-Binding Proteins/immunology ; HEK293 Cells ; HIV Infections/immunology ; HIV-1 ; Humans ; Macaca mulatta ; T-Lymphocyte Subsets/cytology
Czasopismo naukowe
Tytuł :
Cell composition and expansion strategy can reduce the beneficial effect of AKT-inhibition on functionality of CD8 T cells.
Autorzy :
Mousset CM; Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.
Hobo W; Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.
de Ligt A; Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.
Baardman S; Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.
Schaap NPM; Department of Hematology, Radboud university medical center, Nijmegen, The Netherlands.
Jansen JH; Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.
van der Waart AB; Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.
Dolstra H; Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Nov; Vol. 69 (11), pp. 2259-2273. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Benzimidazoles/*pharmacology
CD4-Positive T-Lymphocytes/*drug effects
CD8-Positive T-Lymphocytes/*drug effects
Cell Differentiation/*drug effects
Quinoxalines/*pharmacology
CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Culture Techniques/methods ; Cell Differentiation/immunology ; Cells, Cultured ; Humans
Czasopismo naukowe
Tytuł :
Immune responses and pathogenesis in persistently PCR-positive patients with SARS-CoV-2 infection.
Autorzy :
Yu HB; Department Three of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Wang WJ; Beijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Tang S; Department Three of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Chen DX; Beijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Xu B; Department Two of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
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Źródło :
Journal of medical virology [J Med Virol] 2021 Feb; Vol. 93 (2), pp. 760-765. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Variation, Individual*
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*pathology
Natural Killer T-Cells/*immunology
SARS-CoV-2/*pathogenicity
Adult ; Aged ; Antigens, CD/genetics ; Antigens, CD/immunology ; CD4-Positive T-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/virology ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Testing ; Female ; Gene Expression ; HLA-DR Antigens/genetics ; HLA-DR Antigens/immunology ; Humans ; Immunity, Innate ; Immunophenotyping ; Lymphocyte Count ; Male ; Middle Aged ; Natural Killer T-Cells/virology ; Phenotype ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/genetics ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Severe Human Lassa Fever Is Characterized by Nonspecific T-Cell Activation and Lymphocyte Homing to Inflamed Tissues.
Autorzy :
Port JR; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
Wozniak DM; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Oestereich L; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
Pallasch E; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
Becker-Ziaja B; Robert Koch Institute, Berlin, Germany.
Müller J; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Rottstegge M; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
Olal C; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
Gómez-Medina S; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
Oyakhliome J; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Ighodalo Y; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Omomoh E; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Olokor T; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Adomeh DI; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Asogun D; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Ogbani-Emovon E; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Hartmann K; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Krasemann S; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nelson EV; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
Escudero-Pérez B; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
McElroy AK; Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Günther S; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
Muñoz-Fontela C; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany .; German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
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Źródło :
Journal of virology [J Virol] 2020 Oct 14; Vol. 94 (21). Date of Electronic Publication: 2020 Oct 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Outbreaks*
Lymphocyte Activation*
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Intestinal Mucosa/*immunology
Lassa Fever/*immunology
Lassa virus/*pathogenicity
Adolescent ; Adult ; Aged ; Animals ; CD4-Positive T-Lymphocytes/pathology ; CD4-Positive T-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/virology ; Child ; Child, Preschool ; Female ; Gene Expression Regulation ; HLA-DR Antigens/genetics ; HLA-DR Antigens/immunology ; Humans ; Infant ; Infant, Newborn ; Integrin beta1/genetics ; Integrin beta1/immunology ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Intestinal Mucosa/pathology ; Intestinal Mucosa/virology ; Lassa Fever/genetics ; Lassa Fever/mortality ; Lassa Fever/virology ; Lassa virus/growth & development ; Lassa virus/immunology ; Lysosomal-Associated Membrane Protein 1/genetics ; Lysosomal-Associated Membrane Protein 1/immunology ; Male ; Mice ; Middle Aged ; Nigeria/epidemiology ; Retrospective Studies ; Severity of Illness Index ; Skin/immunology ; Skin/pathology ; Skin/virology ; Survival Analysis ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology
Czasopismo naukowe
Tytuł :
Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses.
Autorzy :
Zhou R; AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), People's Republic of China; Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
To KK; Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Wong YC; AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), People's Republic of China; Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Liu L; AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), People's Republic of China; Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Zhou B; AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), People's Republic of China; Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Li X; AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), People's Republic of China.
Huang H; AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), People's Republic of China.
Mo Y; AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), People's Republic of China; Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Luk TY; AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), People's Republic of China.
Lau TT; AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), People's Republic of China.
Yeung P; Department of Intensive Care, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Chan WM; Department of Adult Intensive Care, Queen Mary Hospital, Hong Kong SAR, People's Republic of China.
Wu AK; Department of Microbiology, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, People's Republic of China.
Lung KC; Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, People's Republic of China.
Tsang OT; Department of Medicine, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.
Leung WS; Department of Medicine, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.
Hung IF; Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Yuen KY; Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China. Electronic address: .
Chen Z; AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), People's Republic of China; Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China. Electronic address: .
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Źródło :
Immunity [Immunity] 2020 Oct 13; Vol. 53 (4), pp. 864-877.e5. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Betacoronavirus/*pathogenicity
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Coronavirus Infections/*immunology
Dendritic Cells/*immunology
Diabetes Mellitus/*immunology
Hypertension/*immunology
Pneumonia, Viral/*immunology
Adult ; Aged ; Antibodies, Neutralizing/biosynthesis ; Antibodies, Viral/biosynthesis ; Betacoronavirus/immunology ; CD4-Positive T-Lymphocytes/pathology ; CD4-Positive T-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/virology ; COVID-19 ; Convalescence ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Dendritic Cells/pathology ; Dendritic Cells/virology ; Diabetes Complications ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/virology ; Disease Progression ; Female ; Humans ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/virology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/pathology ; Killer Cells, Natural/virology ; Lymphocyte Activation ; Lymphocyte Count ; Male ; Middle Aged ; Monocytes/immunology ; Monocytes/pathology ; Monocytes/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Impaired virus-specific T cell responses in patients with myeloproliferative neoplasms treated with ruxolitinib.
Autorzy :
Rumi E; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Sant'Antonio E; UOC Ematologia Aziendale, Azienda USL Toscana Nord Ovest, Lucca, Italy.
Cavalloni C; Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Comolli G; Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Experimental Research Laboratories, Biotechnology Area, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Ferretti VV; Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Cassaniti I; Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Pietra D; Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Trotti C; Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Ciboddo M; Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Furione M; Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Vanni D; Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Casetti IC; Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Favaron C; Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Baldanti F; Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Arcaini L; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Cazzola M; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
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Źródło :
Hematological oncology [Hematol Oncol] 2020 Oct; Vol. 38 (4), pp. 554-559. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Cytomegalovirus Infections/*immunology
Epstein-Barr Virus Infections/*immunology
Myeloproliferative Disorders/*immunology
Pyrazoles/*pharmacology
Virus Activation/*immunology
Adult ; Aged ; Aged, 80 and over ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/virology ; Cytomegalovirus/drug effects ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/virology ; Epstein-Barr Virus Infections/drug therapy ; Epstein-Barr Virus Infections/virology ; Female ; Follow-Up Studies ; Herpesvirus 4, Human/drug effects ; Herpesvirus 4, Human/immunology ; Humans ; Interferon-gamma/metabolism ; Male ; Middle Aged ; Myeloproliferative Disorders/drug therapy ; Myeloproliferative Disorders/virology ; Prognosis ; Survival Rate ; Viral Load ; Virus Activation/drug effects
Czasopismo naukowe
Tytuł :
Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection.
Autorzy :
Macharia GN; Department of Medicine, Imperial College London, London, United Kingdom.; IAVI Human Immunology Laboratory, London, United Kingdom.
Yue L; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.
Staller E; Department of Medicine, Imperial College London, London, United Kingdom.; IAVI Human Immunology Laboratory, London, United Kingdom.
Dilernia D; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.
Wilkins D; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.
Song H; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.
McGowan E; Department of Medicine, Imperial College London, London, United Kingdom.; IAVI Human Immunology Laboratory, London, United Kingdom.
King D; Department of Medicine, Imperial College London, London, United Kingdom.; IAVI Human Immunology Laboratory, London, United Kingdom.
Fast P; IAVI, New York, NY, United States of America.
Imami N; Department of Medicine, Imperial College London, London, United Kingdom.
Price MA; IAVI, New York, NY, United States of America.; Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, United States of America.
Sanders EJ; Kenya Medical Research Institute-Wellcome Trust, Kilifi, Kenya.; Nuffield Department of Clinical Medicine, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Headington, United Kingdom.
Hunter E; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States of America.
Gilmour J; Department of Medicine, Imperial College London, London, United Kingdom.; IAVI Human Immunology Laboratory, London, United Kingdom.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 04; Vol. 16 (9), pp. e1008853. Date of Electronic Publication: 2020 Sep 04 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Founder Effect*
HIV Infections*/genetics
HIV Infections*/immunology
HIV Infections*/pathology
Virus Replication*/genetics
Virus Replication*/immunology
gag Gene Products, Human Immunodeficiency Virus*/genetics
gag Gene Products, Human Immunodeficiency Virus*/immunology
CD4-Positive T-Lymphocytes/*immunology
HIV-1/*physiology
Acute Disease ; Adolescent ; Adult ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; CD4-Positive T-Lymphocytes/pathology ; CD4-Positive T-Lymphocytes/virology ; Female ; Humans ; Male ; Middle Aged ; Viremia/genetics ; Viremia/immunology ; Viremia/pathology
Czasopismo naukowe
Tytuł :
Cells producing residual viremia during antiretroviral treatment appear to contribute to rebound viremia following interruption of treatment.
Autorzy :
Aamer HA; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America.; Department of Global Health, University of Washington, Seattle, Washington, United States of America.
McClure J; Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America.
Ko D; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America.
Maenza J; Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Collier AC; Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Coombs RW; Department of Global Health, University of Washington, Seattle, Washington, United States of America.; Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America.; Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Mullins JI; Department of Global Health, University of Washington, Seattle, Washington, United States of America.; Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America.; Department of Medicine, University of Washington, Seattle, Washington, United States of America.; Department of Microbiology, University of Washington, Seattle, Washington, United States of America.
Frenkel LM; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America.; Department of Global Health, University of Washington, Seattle, Washington, United States of America.; Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America.; Department of Medicine, University of Washington, Seattle, Washington, United States of America.; Department of Pediatrics, University of Washington, Seattle, Washington, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Aug 25; Vol. 16 (8), pp. e1008791. Date of Electronic Publication: 2020 Aug 25 (Print Publication: 2020).
Typ publikacji :
Journal Article; Observational Study; Research Support, N.I.H., Extramural
MeSH Terms :
Virus Replication*
Anti-Retroviral Agents/*therapeutic use
CD4-Positive T-Lymphocytes/*immunology
HIV Infections/*immunology
HIV-1/*immunology
Plasma/*virology
Viremia/*epidemiology
CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/virology ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/genetics ; Humans ; Incidence ; Plasma/drug effects ; Plasma/immunology ; Retrospective Studies ; United States/epidemiology ; Viral Load ; Viremia/virology ; Virus Latency ; Withholding Treatment
Czasopismo naukowe
Tytuł :
Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells.
Autorzy :
Elsner C; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hanover, Germany.; Institute for Virology, University of Duisburg-Essen, University Hospital Essen, 45147 Essen, Germany.
Ponnurangam A; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hanover, Germany.
Kazmierski J; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hanover, Germany.; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Berlin Institute of Health, 10178 Berlin, Germany.
Zillinger T; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany.
Jansen J; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Berlin Institute of Health, 10178 Berlin, Germany.
Todt D; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.; European Virus Bioinformatics Center, 07743 Jena, Germany.
Döhner K; Institute of Virology, Hanover Medical School, 30625 Hanover, Germany.
Xu S; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hanover, Germany.
Ducroux A; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hanover, Germany.
Kriedemann N; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hanover, Germany.
Malassa A; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hanover, Germany.
Larsen PK; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hanover, Germany.
Hartmann G; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany.
Barchet W; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany.; German Center for Infection Research, 50935 Cologne-Bonn, Germany.
Steinmann E; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.
Kalinke U; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hanover, Germany.
Sodeik B; Institute of Virology, Hanover Medical School, 30625 Hanover, Germany.; Cluster of Excellence Resolving Infection Susceptibility (Excellence Cluster 2155), Hanover Medical School, 30625 Hanover, Germany.
Goffinet C; Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hanover, Germany; .; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Berlin Institute of Health, 10178 Berlin, Germany.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 11; Vol. 117 (32), pp. 19475-19486. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*virology
HIV-1/*physiology
Interferon Type I/*metabolism
Nucleotidyltransferases/*metabolism
Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cells, Cultured ; DNA, Viral/physiology ; Exodeoxyribonucleases/genetics ; Exodeoxyribonucleases/metabolism ; Herpesvirus 1, Human/physiology ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Interferon Regulatory Factor-3/metabolism ; Mice ; Nucleotidyltransferases/genetics ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Phosphorylation ; Species Specificity ; Virus Replication
Czasopismo naukowe

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