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Wyszukujesz frazę ""CD8 Antigens"" wg kryterium: Temat


Tytuł :
PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition.
Autorzy :
Li K; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.; Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.
Yuan Z; Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Lyu J; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.; Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.
Ahn E; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Davis SJ; Radcliffe Department of Medicine and Medical Research Council Human Immunology Unit, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK.
Ahmed R; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Zhu C; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. .; Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA. .; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 12; Vol. 12 (1), pp. 2746. Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
CD8 Antigens/*immunology
Programmed Cell Death 1 Receptor/*immunology
Receptors, Antigen, T-Cell/*immunology
T-Lymphocytes/*immunology
Animals ; B7-H1 Antigen/immunology ; CD8 Antigens/metabolism ; Calcium/metabolism ; Humans ; Lymphocyte Activation ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Major Histocompatibility Complex/immunology ; Mice ; Mice, Transgenic ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/metabolism ; Protein Binding ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
WT1-specific CD8 + cytotoxic T cells with the capacity for antigen-specific expansion accumulate in the bone marrow in MDS.
Autorzy :
Suwabe T; Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan.
Shibasaki Y; Department of Hematopoietic Cell Transplantation, Niigata University Medical and Dental Hospital, Niigata, Japan.
Sato H; Laboratory of Hematology and Oncology, Graduate School of Health Sciences, Niigata University, Niigata, Japan.
Tamura S; Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan.
Katagiri T; Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan.
Nemoto H; Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan.; Department of Hematology, Niigata Minami Hospital, Niigata, Japan.
Kasami T; Department of Hematology, Niigata Minami Hospital, Niigata, Japan.
Kozakai T; Department of Hematology, Niigata Minami Hospital, Niigata, Japan.
Nanba A; Department of Hematology, Saiseikai Niigata Hospital, Niigata, Japan.
Kitajima T; Department of Hematology, Saiseikai Niigata Hospital, Niigata, Japan.
Fuse K; Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan.
Ushiki T; Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan.
Sone H; Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan.
Narita M; Laboratory of Hematology and Oncology, Graduate School of Health Sciences, Niigata University, Niigata, Japan.
Masuko M; Department of Hematopoietic Cell Transplantation, Niigata University Medical and Dental Hospital, Niigata, Japan. .
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Źródło :
International journal of hematology [Int J Hematol] 2021 May; Vol. 113 (5), pp. 723-734. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Marrow/*immunology
CD8 Antigens/*analysis
Myelodysplastic Syndromes/*immunology
T-Lymphocytes, Cytotoxic/*immunology
WT1 Proteins/*analysis
Adult ; Aged ; Aged, 80 and over ; CD8 Antigens/immunology ; Humans ; Middle Aged ; WT1 Proteins/immunology
Czasopismo naukowe
Tytuł :
Nivolumab for esophageal squamous cell carcinoma and the predictive role of PD-L1 or CD8 expression in its therapeutic effect.
Autorzy :
Lee J; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Kim B; Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Jung HA; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
La Choi Y; Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Sun JM; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 May; Vol. 70 (5), pp. 1203-1211. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Immunological/*therapeutic use
B7-H1 Antigen/*metabolism
CD8 Antigens/*metabolism
Esophageal Neoplasms/*drug therapy
Esophageal Squamous Cell Carcinoma/*drug therapy
Nivolumab/*therapeutic use
T-Lymphocytes/*immunology
Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen/genetics ; Biomarkers, Tumor/metabolism ; CD8 Antigens/genetics ; Esophageal Neoplasms/diagnosis ; Esophageal Neoplasms/mortality ; Esophageal Squamous Cell Carcinoma/diagnosis ; Esophageal Squamous Cell Carcinoma/mortality ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Programmed Cell Death 1 Receptor/immunology ; Retrospective Studies ; Survival Analysis
Czasopismo naukowe
Tytuł :
Association between CD8 and PD-L1 expression and outcomes after radical prostatectomy for localized prostate cancer.
Autorzy :
Vicier C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medical Oncology, Institut Paoli-Calmettes, Aix Marseille University, Marseille, France.
Ravi P; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Kwak L; Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
Werner L; Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
Huang Y; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Evan C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Loda M; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA.
Hamid AA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Sweeney CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
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Źródło :
The Prostate [Prostate] 2021 Jan; Vol. 81 (1), pp. 50-57. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B7-H1 Antigen/*biosynthesis
CD8 Antigens/*biosynthesis
Prostatic Neoplasms/*immunology
B7-H1 Antigen/immunology ; CD3 Complex/biosynthesis ; CD3 Complex/immunology ; CD8 Antigens/immunology ; Cohort Studies ; Forkhead Transcription Factors/biosynthesis ; Forkhead Transcription Factors/immunology ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Recurrence, Local/immunology ; Programmed Cell Death 1 Receptor/biosynthesis ; Programmed Cell Death 1 Receptor/immunology ; Proportional Hazards Models ; Prostatectomy ; Prostatic Neoplasms/surgery ; Retrospective Studies ; Tissue Array Analysis
Czasopismo naukowe
Tytuł :
IL-4Rα signaling by CD8α T cell responses.
Autorzy :
Wu X; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Brombacher F; Component & Division of Immunology, Faculty of Health Science, International Centre for Genetic Engineering and Biotechnology (ICGEB), University of Cape Town, Cape Town, South Africa.
Chroneos ZC; Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Norbury CC; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Gowda DC; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100615. Date of Electronic Publication: 2021 Mar 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8 Antigens/*immunology
CD8-Positive T-Lymphocytes/*immunology
Dendritic Cells/*immunology
Malaria, Cerebral/*immunology
Plasmodium berghei/*immunology
Receptors, Cell Surface/*immunology
Signal Transduction/*immunology
Th1 Cells/*immunology
Animals ; CD8 Antigens/genetics ; CD8-Positive T-Lymphocytes/pathology ; Dendritic Cells/pathology ; Interleukin-4/genetics ; Interleukin-4/immunology ; Malaria, Cerebral/genetics ; Malaria, Cerebral/pathology ; Mice ; Mice, Knockout ; Plasmodium berghei/genetics ; Receptors, Cell Surface/genetics ; Signal Transduction/genetics ; Th1 Cells/pathology ; Th2 Cells/immunology ; Th2 Cells/pathology
Czasopismo naukowe
Tytuł :
The Combination of CD8αα and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken γδT Cells Response.
Autorzy :
Liu Y; Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China.; Key Laboratory for Insect-Pollinator Biology of the Ministry of Agriculture, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, China.
Chen R; Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Liang R; Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Sun B; Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Wu Y; Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Zhang L; Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Kaufman J; Department of Pathology, University of Cambridge, Cambridge, United Kingdom.; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Xia C; Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Nov 23; Vol. 11, pp. 605085. Date of Electronic Publication: 2020 Nov 23 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8 Antigens/*metabolism
Histocompatibility Antigens Class I/*metabolism
Intraepithelial Lymphocytes/*metabolism
Animals ; Binding Sites ; CD8 Antigens/genetics ; CD8 Antigens/immunology ; Chickens ; Evolution, Molecular ; Histocompatibility Antigens Class I/immunology ; Intraepithelial Lymphocytes/immunology ; Models, Molecular ; Multiprotein Complexes ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Species Specificity
Czasopismo naukowe
Tytuł :
Zinc oxide nanoparticles augment CD4, CD8, and GLUT-4 expression and restrict inflammation response in streptozotocin-induced diabetic rats.
Autorzy :
Elassy N; Chemistry Department, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt.
El-Dafrawy S; Chemistry Department, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt.
Abd El-Azim AO; Zoology Department, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt.
El-Khawaga OAY; Chemistry Department, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt.
Negm A; Department of Chemistry, College of Science, King Faisal University, Al-Ahsa, 31982 Saudi Arabia. .
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Źródło :
IET nanobiotechnology [IET Nanobiotechnol] 2020 Oct; Vol. 14 (8), pp. 680-687.
Typ publikacji :
Journal Article
MeSH Terms :
CD4 Antigens/*biosynthesis
CD8 Antigens/*biosynthesis
Diabetes Mellitus, Experimental/*drug therapy
Glucose Transporter Type 4/*biosynthesis
Hypoglycemic Agents/*administration & dosage
Nanoparticles/*administration & dosage
Zinc Oxide/*chemistry
Animals ; CD4 Antigens/genetics ; CD4 Antigens/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD8 Antigens/immunology ; CD8 Antigens/metabolism ; CD8-Positive T-Lymphocytes/immunology ; Diabetes Mellitus, Experimental/immunology ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Glucose Transporter Type 4/genetics ; Glucose Transporter Type 4/metabolism ; Hypoglycemic Agents/chemistry ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Male ; Nanoparticles/chemistry ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
CD4, CD8b, and Cytokines Expression Profiles in Peripheral Blood Mononuclear Cells Infected with Different Subtypes of KoRV from Koalas ( Phascolarctos cinereus ) in a Japanese Zoo.
Autorzy :
Kayesh MEH; Transboundary Animal Diseases Centre, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan.; Department of Microbiology and Public Health, Faculty of Animal Science and Veterinary Medicine, Patuakhali Science and Technology University, Barishal 8210, Bangladesh.
Hashem MA; Transboundary Animal Diseases Centre, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan.; Department of Health, Chattogram City Corporation, Chattogram 4000, Bangladesh.
Maetani F; Hirakawa Zoological Park, Kagoshima 891-0133, Japan.
Eiei T; Hirakawa Zoological Park, Kagoshima 891-0133, Japan.
Mochizuki K; Hirakawa Zoological Park, Kagoshima 891-0133, Japan.
Ochiai S; Hirakawa Zoological Park, Kagoshima 891-0133, Japan.
Ito A; Hirakawa Zoological Park, Kagoshima 891-0133, Japan.
Ito N; Hirakawa Zoological Park, Kagoshima 891-0133, Japan.
Sakurai H; Hirakawa Zoological Park, Kagoshima 891-0133, Japan.
Asai T; Hirakawa Zoological Park, Kagoshima 891-0133, Japan.
Tsukiyama-Kohara K; Transboundary Animal Diseases Centre, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan.
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Źródło :
Viruses [Viruses] 2020 Dec 09; Vol. 12 (12). Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
Retroviridae*
CD4 Antigens/*metabolism
CD8 Antigens/*metabolism
Cytokines/*metabolism
Leukocytes, Mononuclear/*metabolism
Phascolarctidae/*virology
Retroviridae Infections/*veterinary
Animal Diseases/genetics ; Animal Diseases/virology ; Animals ; CD4 Antigens/genetics ; CD4-CD8 Ratio ; CD8 Antigens/genetics ; Child ; Child, Preschool ; Cytokines/genetics ; Female ; Gene Expression Profiling ; Humans ; Infant ; Lymphocyte Count ; Male ; Transcriptome
Czasopismo naukowe
Tytuł :
The Role of CD8 Downregulation during Thymocyte Differentiation.
Autorzy :
Nomura A; Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Taniuchi I; Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. Electronic address: .
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Źródło :
Trends in immunology [Trends Immunol] 2020 Nov; Vol. 41 (11), pp. 972-981. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
CD8 Antigens*/genetics
CD8-Positive T-Lymphocytes*/metabolism
Cell Differentiation*/genetics
Down-Regulation*
Thymocytes*/cytology
Animals ; Humans ; Mice
Czasopismo naukowe
Tytuł :
CD8 T cells drive anorexia, dysbiosis, and blooms of a commensal with immunosuppressive potential after viral infection.
Autorzy :
Labarta-Bajo L; Division of Biological Sciences, University of California San Diego, La Jolla, San Diego, CA 92093.
Gramalla-Schmitz A; Division of Biological Sciences, University of California San Diego, La Jolla, San Diego, CA 92093.
Gerner RR; Department of Pediatrics, University of California San Diego, La Jolla, CA 92093.; Division of Host-Microbe Systems & Therapeutics, University of California San Diego, La Jolla, CA 92093.
Kazane KR; Division of Biological Sciences, University of California San Diego, La Jolla, San Diego, CA 92093.
Humphrey G; Department of Pediatrics, University of California San Diego, La Jolla, CA 92093.
Schwartz T; Department of Pediatrics, University of California San Diego, La Jolla, CA 92093.
Sanders K; Department of Pediatrics, University of California San Diego, La Jolla, CA 92093.
Swafford A; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093.
Knight R; Department of Pediatrics, University of California San Diego, La Jolla, CA 92093.; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093.; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093.; Department of Computer Science & Engineering, University of California San Diego, La Jolla, CA 92093.
Raffatellu M; Department of Pediatrics, University of California San Diego, La Jolla, CA 92093.; Division of Host-Microbe Systems & Therapeutics, University of California San Diego, La Jolla, CA 92093.; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093.; Center for Mucosal Immunology, Allergy, and Vaccines, Chiba University-University of California San Diego, La Jolla, CA 92093.
Zúñiga EI; Division of Biological Sciences, University of California San Diego, La Jolla, San Diego, CA 92093; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 06; Vol. 117 (40), pp. 24998-25007. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Anorexia/*immunology
CD8 Antigens/*immunology
Immunologic Memory/*immunology
Lymphocytic Choriomeningitis/*immunology
Virus Diseases/*immunology
Akkermansia ; Animals ; Anorexia/microbiology ; Anorexia/virology ; CD8 Antigens/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/microbiology ; Dysbiosis/immunology ; Dysbiosis/microbiology ; Dysbiosis/virology ; Firmicutes/immunology ; Firmicutes/metabolism ; Gastrointestinal Microbiome/immunology ; Humans ; Lymphocytic Choriomeningitis/microbiology ; Lymphocytic Choriomeningitis/pathology ; Lymphocytic choriomeningitis virus/pathogenicity ; Mice ; T-Lymphocytes/immunology ; T-Lymphocytes/microbiology ; Verrucomicrobia/immunology ; Verrucomicrobia/pathogenicity ; Virus Diseases/microbiology ; Virus Diseases/pathology
SCR Organism :
Akkermansia muciniphila
Czasopismo naukowe
Tytuł :
TCR-α/β CD4 T cells.
Autorzy :
Rodríguez-Rodríguez N; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Current address: Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Flores-Mendoza G; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Apostolidis SA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.; Current address: Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Rosetti F; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Tsokos GC; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Crispín JC; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Mexico City, Mexico.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 Sep; Vol. 108 (3), pp. 851-857. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphopoiesis*
CD4 Antigens/*analysis
CD8 Antigens/*analysis
CD8-Positive T-Lymphocytes/*cytology
Receptors, Antigen, T-Cell, alpha-beta/*analysis
T-Lymphocyte Subsets/*cytology
Adoptive Transfer ; Animals ; CD8 Antigens/biosynthesis ; CD8 Antigens/genetics ; CD8-Positive T-Lymphocytes/classification ; Cell Lineage ; Lymphoid Tissue/cytology ; Lymphoid Tissue/immunology ; Mice ; Specific Pathogen-Free Organisms ; Up-Regulation
Czasopismo naukowe
Tytuł :
Immunotherapy response modeling by ex-vivo organ culture for lung cancer.
Autorzy :
Kamer I; Institute of Oncology, Sheba Medical Center, Tel Hashomer, 52620000, Ramat Gan, Israel.
Bab-Dinitz E; Institute of Oncology, Sheba Medical Center, Tel Hashomer, 52620000, Ramat Gan, Israel.
Zadok O; Institute of Oncology, Sheba Medical Center, Tel Hashomer, 52620000, Ramat Gan, Israel.
Ofek E; Pathology Department, Sheba Medical Center, Ramat Gan, Israel.
Gottfried T; Institute of Oncology, Sheba Medical Center, Tel Hashomer, 52620000, Ramat Gan, Israel.
Daniel-Meshulam I; Institute of Oncology, Sheba Medical Center, Tel Hashomer, 52620000, Ramat Gan, Israel.
Hout-Siloni G; Pathology Department, Sheba Medical Center, Ramat Gan, Israel.
Ben Nun A; Thoracic Surgery Department, Sheba Medical Center, Ramat Gan, Israel.; Affiliated with Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Thoracic Surgery Department, Assuta Medical Center, Tel Aviv, Israel.
Barshack I; Pathology Department, Sheba Medical Center, Ramat Gan, Israel.; Affiliated with Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Onn A; Pulmonology Institute, Sheba Medical Center, Ramat Gan, Israel.; Affiliated with Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Bar J; Institute of Oncology, Sheba Medical Center, Tel Hashomer, 52620000, Ramat Gan, Israel. .; Affiliated with Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Aug; Vol. 70 (8), pp. 2223-2234. Date of Electronic Publication: 2021 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Lung Neoplasms/*immunology
Lung Neoplasms/*therapy
B7-H1 Antigen/immunology ; Biomarkers, Tumor/immunology ; CD4 Antigens/immunology ; CD8 Antigens/immunology ; CTLA-4 Antigen/immunology ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/therapy ; Forkhead Transcription Factors/immunology ; Humans ; Immunohistochemistry/methods ; Immunologic Factors/immunology ; Immunotherapy/methods ; Interferon-gamma/immunology ; Organ Culture Techniques/methods ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Quantitative Multiplex Immunofluorescence Evaluation of the Tumor Microenvironment in Pretreatment Tumors of Patients with Metastatic Breast Cancer and Serous Ovarian Carcinoma Treated with Liposomal Eribulin.
Autorzy :
Marks DK; Perlmutter Cancer Center, NYU Langone Health, New York, New York, USA.; NYU Long Island School of Medicine, NYU Langone Health, New York, New York, USA.
Kucharczyk J; NYU Long Island School of Medicine, NYU Langone Health, New York, New York, USA.
Kim P; College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.
Chyong DI; Columbia College, Columbia University, New York, New York, USA.
Gartrell RD; Department of Pediatrics, Pediatric Hematology/Oncology and Medicine, Hematology/Oncology, Columbia University Irving Medical Center, New York, New York, USA.
Lu Y; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.
Hibshoosh H; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Guo H; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Evans TRJ; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
Lopez J; Institute of Cancer Research, London, UK.
Kristeleit R; Department of Oncology, Guys and St Thomas' NHS Foundation Trust, London, UK.
Connolly E; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.; Division of Radiation Oncology, Columbia University Irving Medical Center, New York, New York, USA.
Saenger Y; College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.
Kalinsky K; Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
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Źródło :
Cancer investigation [Cancer Invest] 2021 Jul-Aug; Vol. 39 (6-7), pp. 466-472. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*immunology
Breast Neoplasms/*drug therapy
Cystadenoma, Serous/*drug therapy
Furans/*therapeutic use
Ketones/*therapeutic use
Ovarian Neoplasms/*drug therapy
Breast Neoplasms/immunology ; CD3 Complex/metabolism ; CD8 Antigens ; Clinical Trials, Phase I as Topic ; Female ; Fluorescent Antibody Technique ; Humans ; Middle Aged ; Neoplasm Metastasis ; Phospholipids ; Survival Analysis ; T-Lymphocytes/metabolism ; Treatment Outcome ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Intestinal CD8αα IELs derived from two distinct thymic precursors have staggered ontogeny.
Autorzy :
Ruscher R; Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Lee ST; Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Salgado OC; Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Breed ER; Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Osum SH; Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Hogquist KA; Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2020 Aug 03; Vol. 217 (8).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Mucosal*
CD8 Antigens/*immunology
Cell Movement/*immunology
Intestinal Mucosa/*immunology
Intraepithelial Lymphocytes/*immunology
Thymocytes/*immunology
Animals ; CD8 Antigens/genetics ; Cell Movement/genetics ; Mice ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Brain metastasis PD-L1 and CD8 expression is dependent on primary tumor type and its PD-L1 and CD8 status.
Autorzy :
Camy F; Pathology, University Hospital of Saint-Etienne, Saint-Etienne, France.
Karpathiou G; Pathology, University Hospital of Saint-Etienne, Saint-Etienne, France .
Dumollard JM; Pathology, University Hospital of Saint-Etienne, Saint-Etienne, France.
Magne N; Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Etienne, France.
Perrot JL; Dermatology, University Hospital of Saint-Etienne, Saint-Etienne, France.
Vassal F; Neurosurgery, University Hospital of Saint-Eteinne, Saint-Etienne, France.
Picot T; Pathology, University Hospital of Saint-Etienne, Saint-Etienne, France.
Mobarki M; Pathology, University Hospital of Saint-Etienne, Saint-Etienne, France.; Faculty of Medicine, Jazan University, Jazan, Saudi Arabia.
Forest F; Pathology, University Hospital of Saint-Etienne, Saint-Etienne, France.
Casteillo F; Pathology, University Hospital of Saint-Etienne, Saint-Etienne, France.
Hathroubi S; Pathology, University Hospital of Saint-Etienne, Saint-Etienne, France.
Froudarakis M; Pneumology and Thoracic Oncology, University Hospital of Saint-Etienne, Saint-Etienne, France.
Peoc'h M; Pathology, University Hospital of Saint-Etienne, Saint-Etienne, France.
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Źródło :
Journal for immunotherapy of cancer [J Immunother Cancer] 2020 Aug; Vol. 8 (2).
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*biosynthesis
Brain Neoplasms/*immunology
Brain Neoplasms/*secondary
CD8 Antigens/*biosynthesis
CD8-Positive T-Lymphocytes/*immunology
Immunotherapy/*methods
Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen/immunology ; Biomarkers, Tumor/biosynthesis ; Biomarkers, Tumor/immunology ; CD8 Antigens/immunology ; CD8-Positive T-Lymphocytes/pathology ; Humans ; Immunohistochemistry ; Middle Aged ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Establishment and Characterization of Monoclonal Antibody Against Canine CD8 Alpha.
Autorzy :
Sakai O; Laboratory of Molecular Diagnostics and Therapeutics, Joint Graduate School of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
Ii T; Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Uchida K; Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Igase M; Laboratory of Molecular Diagnostics and Therapeutics, Joint Graduate School of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
Mizuno T; Laboratory of Molecular Diagnostics and Therapeutics, Joint Graduate School of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
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Źródło :
Monoclonal antibodies in immunodiagnosis and immunotherapy [Monoclon Antib Immunodiagn Immunother] 2020 Aug; Vol. 39 (4), pp. 129-134. Date of Electronic Publication: 2020 Jun 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal/*immunology
CD8 Antigens/*immunology
Immunohistochemistry/*methods
Animals ; CD8 Antigens/genetics ; Cats ; Cell Line ; Dogs ; Flow Cytometry ; Leukocytes, Mononuclear/immunology ; Mice ; NIH 3T3 Cells ; Paraffin Embedding ; Rats
Czasopismo naukowe
Tytuł :
Increased expression of CD8 marker on T-cells in COVID-19 patients.
Autorzy :
Ganji A; Molecular and Medicine Research Center, Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Farahani I; Molecular and Medicine Research Center, Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Khansarinejad B; Molecular and Medicine Research Center, Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Ghazavi A; Traditional and Complementary Medicine Research Center (TCMRC), Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Mosayebi G; Molecular and Medicine Research Center, Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran; Traditional and Complementary Medicine Research Center (TCMRC), Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran. Electronic address: .
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Źródło :
Blood cells, molecules & diseases [Blood Cells Mol Dis] 2020 Jul; Vol. 83, pp. 102437. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Immunity, Cellular*
Betacoronavirus/*immunology
CD8 Antigens/*immunology
CD8-Positive T-Lymphocytes/*immunology
Coronavirus Infections/*immunology
Pneumonia, Viral/*immunology
Betacoronavirus/isolation & purification ; Biomarkers/analysis ; CD4-CD8 Ratio ; CD8 Antigens/analysis ; CD8-Positive T-Lymphocytes/virology ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Female ; Humans ; Lymphocyte Count ; Male ; Pandemics ; Platelet Count ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APC mice.
Autorzy :
Szeponik L; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. .
Akeus P; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Rodin W; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Raghavan S; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Quiding-Järbrink M; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Jul; Vol. 69 (7), pp. 1279-1292. Date of Electronic Publication: 2020 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Adenomatous Polyposis Coli Protein/*physiology
CD8 Antigens/*immunology
CD8-Positive T-Lymphocytes/*immunology
Intestinal Neoplasms/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*immunology
T-Lymphocytes, Regulatory/*immunology
Animals ; CD8 Antigens/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Female ; Humans ; Intestinal Neoplasms/metabolism ; Intestinal Neoplasms/pathology ; Lymphocyte Activation ; Lymphocyte Depletion ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Antigen, T-Cell, alpha-beta/metabolism
Czasopismo naukowe
Tytuł :
CD8α conventional dendritic cells control Vβ T-cell immunity in response to Staphylococcus aureus infection in mice.
Autorzy :
Zhang W; Shanghai Public Health Clinical Center &, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Xu L; Shanghai Public Health Clinical Center &, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Zhang X; Shanghai Public Health Clinical Center &, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Xu J; Shanghai Public Health Clinical Center &, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Jin JO; Shanghai Public Health Clinical Center &, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Department of Medical Biotechnology, Yeungnam University, Gyeongsan, South Korea.
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Źródło :
Immunology [Immunology] 2020 Apr; Vol. 159 (4), pp. 404-412. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8 Antigens/*immunology
CD8-Positive T-Lymphocytes/*immunology
Dendritic Cells/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*immunology
Staphylococcal Infections/*immunology
Staphylococcus aureus/*immunology
Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/microbiology ; CD4-Positive T-Lymphocytes/pathology ; CD8 Antigens/deficiency ; CD8 Antigens/genetics ; CD8-Positive T-Lymphocytes/microbiology ; CD8-Positive T-Lymphocytes/pathology ; Cell Lineage/immunology ; Dendritic Cells/microbiology ; Gene Expression ; Host-Pathogen Interactions/immunology ; Immunity, Cellular ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Interleukin-17/genetics ; Interleukin-17/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Phagocytosis ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Spleen/immunology ; Spleen/microbiology ; Spleen/pathology ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/pathology ; Staphylococcus aureus/pathogenicity
Czasopismo naukowe
Tytuł :
Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling.
Autorzy :
Zareie P; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Szeto C; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Farenc C; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Gunasinghe SD; European Molecular Biology Laboratory (EMBL) Australia Node in Single Molecule Science and the ARC Centre of Excellence in Advanced Molecular Imaging, School of Medical Sciences, University of New South Wales, New South Wales, Australia.
Kolawole EM; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Nguyen A; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Blyth C; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Sng XYX; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Li J; Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Jones CM; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Fulcher AJ; Monash Micro Imaging, Monash University, Clayton, Victoria, Australia.
Jacobs JR; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Wei Q; Immunology Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545.
Wojciech L; Immunology Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545.
Petersen J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
Gascoigne NRJ; Immunology Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545.
Evavold BD; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Gaus K; European Molecular Biology Laboratory (EMBL) Australia Node in Single Molecule Science and the ARC Centre of Excellence in Advanced Molecular Imaging, School of Medical Sciences, University of New South Wales, New South Wales, Australia.
Gras S; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. .; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
Rossjohn J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. .; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.; Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
La Gruta NL; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. .
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jun 04; Vol. 372 (6546).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Histocompatibility Antigen H-2D/*metabolism
Nucleocapsid Proteins/*metabolism
Orthomyxoviridae Infections/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
Animals ; CD3 Complex/metabolism ; CD8 Antigens/immunology ; CD8 Antigens/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Epitopes, T-Lymphocyte ; Female ; Histocompatibility Antigen H-2D/chemistry ; Histocompatibility Antigen H-2D/immunology ; Influenza A virus ; Lymphocyte Activation ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Major Histocompatibility Complex ; Mice ; Mice, Inbred C57BL ; Models, Molecular ; Nucleocapsid Proteins/chemistry ; Nucleocapsid Proteins/immunology ; Peptide Fragments/immunology ; Peptide Fragments/metabolism ; Protein Binding ; Protein Conformation ; Receptors, Antigen, T-Cell, alpha-beta/chemistry ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Signal Transduction
Czasopismo naukowe

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