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Wyszukujesz frazę ""CD8-Positive T-Lymphocytes"" wg kryterium: Temat


Tytuł :
IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice.
Autorzy :
Song Q; Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, CA, USA.; Hematologic Malignancies and Stem Cell Transplantation Institute, The Beckman Research Institute of City of Hope, Duarte, CA, USA.; Fujian Medical University Center of Translational Hematology, Fujian Institute of Hematology, and Fujian Medical University Union Hospital, Fuzhou, China.
Wang X; Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, CA, USA.; Hematologic Malignancies and Stem Cell Transplantation Institute, The Beckman Research Institute of City of Hope, Duarte, CA, USA.; Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wu X; Department of Integrative Genomics Core, The Beckman Research Institute of City of Hope, Duarte, CA, USA.
Kang TH; Department of Integrative Genomics Core, The Beckman Research Institute of City of Hope, Duarte, CA, USA.
Qin H; Department of Integrative Genomics Core, The Beckman Research Institute of City of Hope, Duarte, CA, USA.
Zhao D; The Tisch Cancer Institute and Division of Hematology/Medical Oncology, The Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.
Jenq RR; Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
van den Brink MRM; Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Riggs AD; Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, CA, USA.
Martin PJ; Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
Chen YZ; Fujian Medical University Center of Translational Hematology, Fujian Institute of Hematology, and Fujian Medical University Union Hospital, Fuzhou, China. .
Zeng D; Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, CA, USA. .; Hematologic Malignancies and Stem Cell Transplantation Institute, The Beckman Research Institute of City of Hope, Duarte, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 05; Vol. 12 (1), pp. 805. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Dysbiosis/*immunology
Graft vs Host Disease/*immunology
Interferon-gamma/*immunology
Interleukins/*immunology
Phagocytes/*immunology
Animals ; CD8-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/transplantation ; CX3C Chemokine Receptor 1/genetics ; CX3C Chemokine Receptor 1/immunology ; Disease Models, Animal ; Dysbiosis/genetics ; Dysbiosis/microbiology ; Dysbiosis/pathology ; Gastrointestinal Microbiome/immunology ; Gene Expression Regulation ; Graft vs Host Disease/genetics ; Graft vs Host Disease/microbiology ; Graft vs Host Disease/pathology ; Interferon-gamma/deficiency ; Interferon-gamma/genetics ; Interleukin-17/deficiency ; Interleukin-17/genetics ; Interleukin-17/immunology ; Interleukins/genetics ; Intestines/immunology ; Intestines/microbiology ; Intestines/pathology ; Lymphocyte Depletion ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Pancreatitis-Associated Proteins/genetics ; Pancreatitis-Associated Proteins/immunology ; Phagocytes/cytology ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/immunology ; Signal Transduction ; T-Lymphocytes, Helper-Inducer ; T-Lymphocytes, Regulatory ; Whole-Body Irradiation
Czasopismo naukowe
Tytuł :
The Cytokine Profiles and Immune Response Are Increased in COVID-19 Patients with Type 2 Diabetes Mellitus.
Autorzy :
Zheng M; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
Wang X; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230031, China.
Guo H; Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China.
Fan Y; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
Song Z; Department of Pathophysiology, Anhui Medical University, Hefei, Anhui 230032, China.
Lu Z; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
Wang J; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
Zheng C; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
Dong L; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
Ma Y; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
Zhu Y; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
Fang H; Department of Pathophysiology, Anhui Medical University, Hefei, Anhui 230032, China.
Ye S; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
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Źródło :
Journal of diabetes research [J Diabetes Res] 2021 Jan 02; Vol. 2021, pp. 9526701. Date of Electronic Publication: 2021 Jan 02 (Print Publication: 2021).
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
Cytokines/*immunology
Diabetes Mellitus, Type 2/*immunology
Inflammation Mediators/*immunology
SARS-CoV-2/*immunology
Adult ; Aged ; Biomarkers/blood ; Blood Glucose/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/virology ; COVID-19/blood ; COVID-19/epidemiology ; COVID-19/virology ; Cytokines/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Host-Pathogen Interactions ; Humans ; Inflammation Mediators/blood ; Length of Stay ; Male ; Middle Aged ; Prognosis ; Time Factors
Czasopismo naukowe
Tytuł :
Maturation of T and B Lymphocytes in the Assessment of the Immune Status in COVID-19 Patients.
Autorzy :
Kwiecień I; Laboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Rutkowska E; Laboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Kłos K; Department of Infectious Diseases and Allergology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Więsik-Szewczyk E; Department of Internal Medicine, Pulmonology, Allergology and Clinical Immunology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Jahnz-Różyk K; Department of Internal Medicine, Pulmonology, Allergology and Clinical Immunology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Rzepecki P; Department of Internal Medicine and Hematology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Chciałowski A; Department of Infectious Diseases and Allergology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
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Źródło :
Cells [Cells] 2020 Dec 05; Vol. 9 (12). Date of Electronic Publication: 2020 Dec 05.
Typ publikacji :
Journal Article
MeSH Terms :
B-Lymphocytes/*cytology
CD4-Positive T-Lymphocytes/*cytology
CD8-Positive T-Lymphocytes/*cytology
COVID-19/*pathology
Adult ; Aged ; Aged, 80 and over ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; COVID-19/immunology ; COVID-19/virology ; Case-Control Studies ; Female ; Flow Cytometry ; Humans ; Immunophenotyping ; Male ; Middle Aged ; SARS-CoV-2/isolation & purification
Czasopismo naukowe
Tytuł :
Naive CD8 T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity.
Autorzy :
Padgett LE; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.).
Dinh HQ; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.).
Wu R; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.).
Gaddis DE; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.).
Araujo DJ; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.).
Winkels H; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.).
Nguyen A; Cardiovascular Research Center and Division of Cardiovascular Medicine, University of Virginia, Charlottesville (A.N., C.A.M.).
McNamara CA; Cardiovascular Research Center and Division of Cardiovascular Medicine, University of Virginia, Charlottesville (A.N., C.A.M.).
Hedrick CC; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Dec; Vol. 40 (12), pp. 2845-2859. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aortic Diseases/*metabolism
Atherosclerosis/*metabolism
CD8-Positive T-Lymphocytes/*metabolism
Cardiovascular Diseases/*metabolism
fas Receptor/*metabolism
Adoptive Transfer ; Adult ; Aged ; Aged, 80 and over ; Animals ; Aortic Diseases/immunology ; Aortic Diseases/pathology ; Atherosclerosis/immunology ; Atherosclerosis/pathology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/transplantation ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/immunology ; Case-Control Studies ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Heart Disease Risk Factors ; Humans ; Lymphocyte Activation ; Male ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; Middle Aged ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
CD39 T cells mediate metastatic dormancy in breast cancer.
Autorzy :
Tallón de Lara P; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland.; Department of Medicine, Mount Sinai St. Luke's & Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Castañón H; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland.
Vermeer M; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland.
Núñez N; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland.
Silina K; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland.
Sobottka B; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Urdinez J; Department of Orthopaedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.; Cutiss AG, Schlieren, Switzerland.
Cecconi V; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland.
Yagita H; Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
Movahedian Attar F; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland.
Hiltbrunner S; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland.; Department of Hematology and Oncology, University Hospital Zurich, Zurich, Switzerland.
Glarner I; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland.
Moch H; Comprehensive Cancer Center Zurich, Zurich, Switzerland.; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Tugues S; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland.
Becher B; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland.
van den Broek M; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. .; Comprehensive Cancer Center Zurich, Zurich, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 03; Vol. 12 (1), pp. 769. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD/*immunology
Apyrase/*immunology
Breast Neoplasms/*immunology
CD8-Positive T-Lymphocytes/*immunology
Mammary Neoplasms, Experimental/*immunology
Programmed Cell Death 1 Receptor/*immunology
Animals ; Antigens, CD/metabolism ; Apyrase/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; CD8-Positive T-Lymphocytes/metabolism ; Cell Line, Tumor ; Humans ; Immunotherapy ; Lung/immunology ; Lung/pathology ; Mammary Neoplasms, Experimental/pathology ; Mammary Neoplasms, Experimental/therapy ; Mice, Inbred BALB C ; Mice, Inbred NOD ; Mice, Knockout ; Neoplasm Metastasis ; Programmed Cell Death 1 Receptor/metabolism
Czasopismo naukowe
Tytuł :
Immune responses and pathogenesis in persistently PCR-positive patients with SARS-CoV-2 infection.
Autorzy :
Yu HB; Department Three of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Wang WJ; Beijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Tang S; Department Three of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Chen DX; Beijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Xu B; Department Two of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
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Źródło :
Journal of medical virology [J Med Virol] 2021 Feb; Vol. 93 (2), pp. 760-765. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Variation, Individual*
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*pathology
Natural Killer T-Cells/*immunology
SARS-CoV-2/*pathogenicity
Adult ; Aged ; Antigens, CD/genetics ; Antigens, CD/immunology ; CD4-Positive T-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/virology ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Testing ; Female ; Gene Expression ; HLA-DR Antigens/genetics ; HLA-DR Antigens/immunology ; Humans ; Immunity, Innate ; Immunophenotyping ; Lymphocyte Count ; Male ; Middle Aged ; Natural Killer T-Cells/virology ; Phenotype ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/genetics ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Influences of CD8 Tregs on Peripheral Blood Mononuclear Cells from Allergic Rhinitis Patients.
Autorzy :
Lin L; Department of Otorhinolaryngology-Head and Neck Surgery, Huashan Hospital of Fudan University, Shanghai, China.
Dai F; Department of Otorhinolaryngology-Head and Neck Surgery, Huashan Hospital of Fudan University, Shanghai, China.
Wei J; Department of Otorhinolaryngology-Head and Neck Surgery, Huashan Hospital of Fudan University, Shanghai, China.
Chen Z; Department of Otorhinolaryngology-Head and Neck Surgery, Huashan Hospital of Fudan University, Shanghai, China.
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Źródło :
The Laryngoscope [Laryngoscope] 2021 Feb; Vol. 131 (2), pp. E316-E323. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Rhinitis, Allergic/*immunology
T-Lymphocytes, Regulatory/*immunology
Adult ; CD8-Positive T-Lymphocytes/metabolism ; Case-Control Studies ; Cells, Cultured ; Female ; Healthy Volunteers ; Humans ; Interleukin-10/metabolism ; Interleukin-4/metabolism ; Interleukin-5/metabolism ; Male ; Middle Aged ; Primary Cell Culture ; Rhinitis, Allergic/blood ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
A CD8 NK cell transcriptomic signature associated with clinical outcome in relapsing remitting multiple sclerosis.
Autorzy :
McKinney EF; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK. .; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK. .
Cuthbertson I; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Harris KM; Biomarker Discovery Research, ITN, Bethesda, MD, USA.
Smilek DE; Biomarker Discovery Research, ITN, Bethesda, MD, USA.
Connor C; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Manferrari G; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Carr EJ; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Zamvil SS; Department of Neurology and Program in Immunology, University of California, San Francisco, CA, USA.
Smith KGC; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
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Źródło :
Nature communications [Nat Commun] 2021 Jan 27; Vol. 12 (1), pp. 635. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Killer Cells, Natural/*immunology
Multiple Sclerosis, Relapsing-Remitting/*genetics
Multiple Sclerosis, Relapsing-Remitting/*immunology
Transcriptome/*genetics
CD8-Positive T-Lymphocytes/ultrastructure ; Gene Expression Regulation ; Gene Regulatory Networks ; HLA-G Antigens/metabolism ; Humans ; Killer Cells, Natural/ultrastructure ; Lymphocyte Activation/genetics ; Reproducibility of Results ; Risk Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus.
Autorzy :
Karimi MM; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Guo Y; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Cui X; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Pallikonda HA; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Horková V; Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Wang YF; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Gil SR; CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Rodriguez-Esteban G; CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Robles-Rebollo I; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Bruno L; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Georgieva R; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Patel B; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Elliott J; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Dore MH; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Dauphars D; Department of Immunology, Duke University Medical Center, Durham, NC, USA.
Krangel MS; Department of Immunology, Duke University Medical Center, Durham, NC, USA.
Lenhard B; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Heyn H; CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Fisher AG; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Štěpánek O; Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Merkenschlager M; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 04; Vol. 12 (1), pp. 99. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*cytology
CD8-Positive T-Lymphocytes/*cytology
Cell Differentiation/*immunology
Cell Lineage/*immunology
Thymus Gland/*cytology
Thymus Gland/*immunology
Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Core Binding Factor Alpha 3 Subunit/metabolism ; Cytokines/metabolism ; DNA-Binding Proteins/metabolism ; Gene Expression Regulation ; Histocompatibility Antigens/metabolism ; Lymphocyte Activation/genetics ; Mice, Inbred C57BL ; Principal Component Analysis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Characterising the immune microenvironment in liposarcoma, its impact on prognosis and the impact of radiotherapy.
Autorzy :
Snow H; Peter MacCallum Cancer Centre, Melbourne, Australia.
Mitchell C; Peter MacCallum Cancer Centre, Melbourne, Australia.
Hendry S; Peter MacCallum Cancer Centre, Melbourne, Australia.
McKinley M; Peter MacCallum Cancer Centre, Melbourne, Australia.
Byrne D; Peter MacCallum Cancer Centre, Melbourne, Australia.
Ngan S; Peter MacCallum Cancer Centre, Melbourne, Australia.
Chander S; Peter MacCallum Cancer Centre, Melbourne, Australia.
Chu J; Peter MacCallum Cancer Centre, Melbourne, Australia.
Desai J; Peter MacCallum Cancer Centre, Melbourne, Australia.
Bae S; Peter MacCallum Cancer Centre, Melbourne, Australia.
Henderson M; Peter MacCallum Cancer Centre, Melbourne, Australia.
Choong P; Peter MacCallum Cancer Centre, Melbourne, Australia.
Gyorki D; Peter MacCallum Cancer Centre, Melbourne, Australia.
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Źródło :
Journal of surgical oncology [J Surg Oncol] 2021 Jan; Vol. 123 (1), pp. 117-126. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Liposarcoma/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Neoplasm Recurrence, Local/*immunology
Radiotherapy/*methods
Tumor Microenvironment/*immunology
Adolescent ; Adult ; Aged ; CD8-Positive T-Lymphocytes/radiation effects ; Female ; Follow-Up Studies ; Humans ; Liposarcoma/pathology ; Liposarcoma/radiotherapy ; Lymphocytes, Tumor-Infiltrating/radiation effects ; Male ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/radiotherapy ; Prognosis ; Retrospective Studies ; Tumor Microenvironment/radiation effects ; Young Adult
Czasopismo naukowe
Tytuł :
Compartmental immunophenotyping in COVID-19 ARDS: A case series.
Autorzy :
Ronit A; Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Berg RMG; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine and PET and Centre for Physical Activity Research, University of Copenhagen, Copenhagen, Denmark; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, United Kingdom.
Bay JT; Department of Clinical Immunology, University of Copenhagen, Copenhagen, Denmark.
Haugaard AK; Department of Clinical Immunology, University of Copenhagen, Copenhagen, Denmark.
Ahlström MG; Department of Clinical Microbiology, University of Copenhagen, Copenhagen, Denmark.
Burgdorf KS; Department of Clinical Immunology, University of Copenhagen, Copenhagen, Denmark.
Ullum H; Department of Clinical Immunology, University of Copenhagen, Copenhagen, Denmark.
Rørvig SB; Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Tjelle K; Department of Anesthesiology and Intensive Care, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Foss NB; Department of Anesthesiology and Intensive Care, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Benfield T; Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Marquart HV; Department of Clinical Immunology, University of Copenhagen, Copenhagen, Denmark.
Plovsing RR; Department of Anesthesiology and Intensive Care, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark. Electronic address: .
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Jan; Vol. 147 (1), pp. 81-91. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
Lung/*immunology
Lymphopenia/*immunology
Respiratory Distress Syndrome/*immunology
SARS-CoV-2/*immunology
Th17 Cells/*immunology
Adult ; Aged ; CD8-Positive T-Lymphocytes/pathology ; COVID-19/pathology ; Cross-Sectional Studies ; Cytokines/immunology ; Female ; Humans ; Immunophenotyping ; Lung/pathology ; Lymphopenia/pathology ; Male ; Middle Aged ; Respiratory Distress Syndrome/pathology ; Th17 Cells/pathology
Czasopismo naukowe
Tytuł :
[Changes of different cell subsets in thymus and spleen of mice at different growth stages and the facilitating effect of ROCK inhibitor on thymus regeneration in aged mice].
Autorzy :
Zeng Y; Department of Pathology and Immunology, Medical College, Institute of Infection and Inflammation, China Three Gorges University, Yichang 443002, China.
Chen C; Department of Pathology and Immunology, Medical College, Institute of Infection and Inflammation, China Three Gorges University, Yichang 443002, China.
Jiang X; Department of Pathology and Immunology, Medical College, Institute of Infection and Inflammation, China Three Gorges University, Yichang 443002, China.
Liu M; Department of Pathology and Immunology, Medical College, Institute of Infection and Inflammation, China Three Gorges University, Yichang 443002, China.
Tong C; Department of Pathology and Immunology, Medical College, Institute of Infection and Inflammation, China Three Gorges University, Yichang 443002, China.
Zhu X; Department of Pathology and Immunology, Medical College, Institute of Infection and Inflammation, China Three Gorges University, Yichang 443002, China.
Song Y; Department of Pathology and Immunology, Medical College, Institute of Infection and Inflammation, China Three Gorges University, Yichang 443002, China. *Corresponding author, E-mail: .
DU D; Institute of Infection and Inflammation, China Three Gorges University, Yichang 443002; Department of Lung Diseases, The Third People Hospital of Yichang City, Yichang 443003, China.
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Źródło :
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2021 Jan; Vol. 37 (1), pp. 16-23.
Typ publikacji :
Journal Article
MeSH Terms :
CD8-Positive T-Lymphocytes*
Spleen*
Animals ; Female ; Mice ; Mice, Inbred C57BL ; Regeneration ; T-Lymphocyte Subsets ; Thymus Gland ; rho-Associated Kinases
Czasopismo naukowe
Tytuł :
Impact of histamine H4 receptor deficiency on the modulation of T cells in a murine breast cancer model.
Autorzy :
Nicoud MB; Laboratory of Tumour Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Táquez Delgado MA; Laboratory of Tumour Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Sarasola MP; Laboratory of Tumour Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Vidal A; Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Speisky D; Pathology Department, British Hospital, Buenos Aires, Argentina.
Cremaschi GA; Neuroimmunomodulation and Molecular Oncology Division, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Sterle HA; Neuroimmunomodulation and Molecular Oncology Division, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Medina VA; Laboratory of Tumour Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Jan; Vol. 70 (1), pp. 233-244. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*immunology
Breast Neoplasms/*metabolism
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Receptors, Histamine H4/*deficiency
Receptors, Histamine H4/*immunology
T-Lymphocytes, Regulatory/*immunology
Animals ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Disease Models, Animal ; Female ; Histamine/immunology ; Interleukin-2 Receptor alpha Subunit/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; T-Lymphocytes, Regulatory/metabolism ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity.
Autorzy :
Érsek B; Department of Genetics, Cell and Immunobiology, Semmelweis University, 4 Nagyvarad ter, VII/709, Budapest, 1089, Hungary.; Office for Research Groups Attached to Universities and Other Institutions of the Hungarian Academy of Sciences, Budapest, 1051, Hungary.
Silló P; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
Cakir U; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
Molnár V; Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, 1083, Hungary.
Bencsik A; Department of Genetics, Cell and Immunobiology, Semmelweis University, 4 Nagyvarad ter, VII/709, Budapest, 1089, Hungary.
Mayer B; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
Mezey E; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 20815, USA.
Kárpáti S; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
Pós Z; Department of Genetics, Cell and Immunobiology, Semmelweis University, 4 Nagyvarad ter, VII/709, Budapest, 1089, Hungary. .
Németh K; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Jan; Vol. 78 (2), pp. 661-673. Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article
MeSH Terms :
Arginase/*immunology
CD8-Positive T-Lymphocytes/*immunology
Cancer-Associated Fibroblasts/*immunology
Immune Checkpoint Proteins/*immunology
Melanoma/*immunology
Skin Neoplasms/*immunology
Arginase/genetics ; CD8-Positive T-Lymphocytes/metabolism ; Cancer-Associated Fibroblasts/metabolism ; Cells, Cultured ; Gene Expression Regulation, Neoplastic ; Humans ; Immune Checkpoint Proteins/genetics ; Lymphocyte Activation ; Melanoma/genetics ; Skin Neoplasms/genetics ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism
Czasopismo naukowe
Tytuł :
Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19.
Autorzy :
Leonardi AJ; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Proenca RB; Department of Biology, Johns Hopkins University, Baltimore, MD, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Dec 21; Vol. 11, pp. 600405. Date of Electronic Publication: 2020 Dec 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Apoptosis/*immunology
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
Cell Differentiation/*immunology
Proto-Oncogene Proteins c-akt/*immunology
SARS-CoV-2/*immunology
fas Receptor/*immunology
CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/pathology ; COVID-19/pathology ; Humans
Czasopismo naukowe
Tytuł :
Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer.
Autorzy :
Krishna S; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Lowery FJ; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Copeland AR; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Bahadiroglu E; Immunodynamics Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Mukherjee R; Immunodynamics Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Jia L; National Institutes of Health Library, National Institutes of Health, Bethesda, MD 20892, USA.
Anibal JT; Immunodynamics Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Sachs A; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Adebola SO; Immunodynamics Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Gurusamy D; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Yu Z; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Hill V; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Gartner JJ; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Li YF; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Parkhurst M; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Paria B; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Kvistborg P; Division of Immunology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Kelly MC; Single Cell Analysis Facility, Cancer Research Technology Program, Frederick National Laboratory, Bethesda, MD 20892, USA.
Goff SL; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Altan-Bonnet G; Immunodynamics Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Robbins PF; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. .
Rosenberg SA; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Dec 11; Vol. 370 (6522), pp. 1328-1334.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Immunotherapy, Adoptive/*methods
Lymphocytes, Tumor-Infiltrating/*transplantation
Melanoma/*therapy
Skin Neoplasms/*therapy
Animals ; Antigens, CD/analysis ; Antigens, Differentiation, T-Lymphocyte/analysis ; Apyrase/analysis ; CD8-Positive T-Lymphocytes/chemistry ; Female ; Humans ; Lectins, C-Type/analysis ; Melanoma/immunology ; Mice ; Mice, Mutant Strains ; Skin Neoplasms/immunology
Czasopismo naukowe
Tytuł :
Biomodulina T (InmunyVital ) Restores T Cells and Helps Contain COVID-19.
Autorzy :
Rodriguez Martin RR; BIOLONG Corporation, Miami, FL, United States.
Gonzalez Gonzalez O; BIOLONG Corporation, Miami, FL, United States.
Rodriguez Gonzalez C; BIOLONG Corporation, Miami, FL, United States.
Rodriguez Gonzalez RR; BIOLONG Corporation, Miami, FL, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Dec 09; Vol. 11, pp. 606447. Date of Electronic Publication: 2020 Dec 09 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*drug therapy
Immunologic Factors/*therapeutic use
SARS-CoV-2/*immunology
CD4-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/drug effects ; COVID-19/immunology ; Humans ; Immunotherapy/methods ; SARS-CoV-2/drug effects ; Thymus Gland/metabolism
Czasopismo naukowe
Tytuł :
CD103 T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.
Autorzy :
Kuhn NF; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.
Lopez AV; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Li X; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cai W; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Daniyan AF; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Brentjens RJ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 02; Vol. 11 (1), pp. 6171. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD40 Ligand/*genetics
CD8-Positive T-Lymphocytes/*immunology
Dendritic Cells/*immunology
Immunotherapy, Adoptive/*methods
Lymphoma, B-Cell/*therapy
Receptors, Chimeric Antigen/*genetics
Adaptive Immunity ; Animals ; Antigen Presentation ; Antigens, CD/genetics ; Antigens, CD/immunology ; Basic-Leucine Zipper Transcription Factors/deficiency ; Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/immunology ; CD11b Antigen/deficiency ; CD11b Antigen/genetics ; CD11b Antigen/immunology ; CD40 Ligand/immunology ; CD8-Positive T-Lymphocytes/cytology ; Dendritic Cells/cytology ; Female ; Gene Expression ; Immunity, Innate ; Immunophenotyping ; Integrin alpha Chains/deficiency ; Integrin alpha Chains/genetics ; Integrin alpha Chains/immunology ; Lymphoma, B-Cell/genetics ; Lymphoma, B-Cell/immunology ; Lymphoma, B-Cell/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Neoplasm Transplantation ; Receptors, Chimeric Antigen/immunology ; Repressor Proteins/deficiency ; Repressor Proteins/genetics ; Repressor Proteins/immunology
Czasopismo naukowe
Tytuł :
CD8 T Cells: Exacting a Toll in Viral Pneumonia.
Autorzy :
Ballinger MN; Department of Internal Medicine The Ohio State University Columbus, Ohio and.
Davis IC; Department of Veterinary Biosciences The Ohio State University Columbus, Ohio.
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Źródło :
American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2020 Dec; Vol. 63 (6), pp. 717-718.
Typ publikacji :
Editorial; Comment
MeSH Terms :
CD8-Positive T-Lymphocytes*
Pneumonia, Viral*
Animals ; Mice
Opinia redakcyjna

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