Temat: "CD8-Positive T-Lymphocytes" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: An IL-7 fusion protein targeting EDA fibronectin upregulates TCF1 on CD8+ T-cells, preferentially accumulates to neoplastic lesions, and boosts PD-1 blockade.
Autorzy:: Di Nitto C; Philochem AG, Otelfingen, Switzerland.
Ravazza D; Philochem AG, Otelfingen, Switzerland.
Gilardoni E; Philochem AG, Otelfingen, Switzerland.
Look T; Department of Neurology and Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland.
Sun M; Department of Neurology and Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland.
Prodi E; Philochem AG, Otelfingen, Switzerland.
Moisoiu V; Department of Neurology and Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland.
Pellegrino C; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.
Manz MG; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.
Puca E; Philochem AG, Otelfingen, Switzerland.
Weller M; Department of Neurology and Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland.; University of Zurich, Zurich, Switzerland.
Weiss T; Department of Neurology and Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland.; University of Zurich, Zurich, Switzerland.
Neri D; Philogen SpA, Siena, Italy.; Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.
De Luca R; Philochem AG, Otelfingen, Switzerland .; Pokaż więcej
Źródło:: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Aug 13; Vol. 12 (8). Date of Electronic Publication: 2024 Aug 13.
Typ publikacji:: Journal Article
MeSH Terms:: Fibronectins*/metabolism
Fibronectins*/genetics
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
Interleukin-7*/metabolism
Interleukin-7*/pharmacology
Humans ; Animals ; Mice ; Recombinant Fusion Proteins/pharmacology ; Recombinant Fusion Proteins/therapeutic use ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/metabolism ; Neoplasms/drug therapy ; Neoplasms/immunology ; Hepatocyte Nuclear Factor 1-alpha/metabolism ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Up-Regulation ; Female ; Cell Line, Tumor

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Tytuł:: NPRL2 promotes TRIM16-mediated ubiquitination degradation of Galectin-3 to prevent CD8 T lymphocyte cuproptosis in glioma.
Autorzy:: Wang F; Department of Neurosurgery, The Second Affiliated Hospital of Chongqing, Medical University, 74 Linjiang Rd, Yuzhong, Chongqing, 400010, China.
Yue J; Department of Neurosurgery, The Second Affiliated Hospital of Chongqing, Medical University, 74 Linjiang Rd, Yuzhong, Chongqing, 400010, China.
Zhang M; Department of Neurosurgery, The Second Affiliated Hospital of Chongqing, Medical University, 74 Linjiang Rd, Yuzhong, Chongqing, 400010, China.
Sun M; Department of Neurosurgery, The Second Affiliated Hospital of Chongqing, Medical University, 74 Linjiang Rd, Yuzhong, Chongqing, 400010, China.
Luo X; Department of Neurosurgery, The Second Affiliated Hospital of Chongqing, Medical University, 74 Linjiang Rd, Yuzhong, Chongqing, 400010, China.
Zhang H; Department of Neurosurgery, The Second Affiliated Hospital of Chongqing, Medical University, 74 Linjiang Rd, Yuzhong, Chongqing, 400010, China.
Wu Y; Department of Health Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Cheng Y; Department of Neurosurgery, The Second Affiliated Hospital of Chongqing, Medical University, 74 Linjiang Rd, Yuzhong, Chongqing, 400010, China.
Chen J; Department of Neurosurgery, The Second Affiliated Hospital of Chongqing, Medical University, 74 Linjiang Rd, Yuzhong, Chongqing, 400010, China. .
Huang N; Department of Neurosurgery, The Second Affiliated Hospital of Chongqing, Medical University, 74 Linjiang Rd, Yuzhong, Chongqing, 400010, China. .; Pokaż więcej
Źródło:: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2024 Oct 05; Vol. 81 (1), pp. 424. Date of Electronic Publication: 2024 Oct 05.
Typ publikacji:: Journal Article
MeSH Terms:: CD8-Positive T-Lymphocytes*/metabolism
CD8-Positive T-Lymphocytes*/immunology
Galectin 3*/metabolism
Galectin 3*/genetics
Glioma*/metabolism
Glioma*/pathology
Glioma*/immunology
Glioma*/genetics
Tripartite Motif Proteins*/metabolism
Tripartite Motif Proteins*/genetics
Ubiquitin-Protein Ligases*/metabolism
Ubiquitin-Protein Ligases*/genetics
Ubiquitination*
Animals ; Female ; Humans ; Male ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Brain Neoplasms/immunology ; Cell Line, Tumor ; Tumor Suppressor Proteins/metabolism ; Tumor Suppressor Proteins/genetics

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Tytuł:: Activation of NOD1 on tumor-associated macrophages augments CD8 T cell-mediated antitumor immunity in hepatocellular carcinoma.
Autorzy:: Zhang F; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China.; Shanghai Institute of Liver Disease, 180 Fenglin Road, Shanghai, 200032, P.R. China.
Jiang Q; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China.; Shanghai Institute of Liver Disease, 180 Fenglin Road, Shanghai, 200032, P.R. China.
Cai J; Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China.
Meng F; Shanghai Institute of Liver Disease, 180 Fenglin Road, Shanghai, 200032, P.R. China.
Tang W; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China.; Shanghai Institute of Liver Disease, 180 Fenglin Road, Shanghai, 200032, P.R. China.
Liu Z; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China.; Shanghai Institute of Liver Disease, 180 Fenglin Road, Shanghai, 200032, P.R. China.
Lin X; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China.; Shanghai Institute of Liver Disease, 180 Fenglin Road, Shanghai, 200032, P.R. China.
Liu W; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China.; Shanghai Institute of Liver Disease, 180 Fenglin Road, Shanghai, 200032, P.R. China.
Zhou Y; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China.; Shanghai Institute of Liver Disease, 180 Fenglin Road, Shanghai, 200032, P.R. China.
Shen X; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China.; Shanghai Institute of Liver Disease, 180 Fenglin Road, Shanghai, 200032, P.R. China.
Xue R; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China.; Shanghai Institute of Liver Disease, 180 Fenglin Road, Shanghai, 200032, P.R. China.
Dong L; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China.; Shanghai Institute of Liver Disease, 180 Fenglin Road, Shanghai, 200032, P.R. China.
Zhang S; NHC Key Laboratory of Glycoconjugates Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, 130 Dongan Road, Shanghai, 200030, P.R. China.; Pokaż więcej
Źródło:: Science advances [Sci Adv] 2024 Oct 04; Vol. 10 (40), pp. eadp8266. Date of Electronic Publication: 2024 Oct 02.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Hepatocellular*/immunology
Carcinoma, Hepatocellular*/pathology
Carcinoma, Hepatocellular*/metabolism
Carcinoma, Hepatocellular*/therapy
Liver Neoplasms*/immunology
Liver Neoplasms*/pathology
Liver Neoplasms*/metabolism
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
Nod1 Signaling Adaptor Protein*/metabolism
Tumor-Associated Macrophages*/immunology
Tumor-Associated Macrophages*/metabolism
Animals ; Humans ; Mice ; Cell Line, Tumor ; Immunotherapy/methods ; Male ; Tumor Microenvironment/immunology

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Tytuł:: Energy demanding RNA and protein metabolism drive dysfunctionality of HIV-specific T cell changes during chronic HIV infection.
Autorzy:: van Pul L; Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.
Stunnenberg M; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.
Kroeze S; Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.
van Dort KA; Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.
Boeser-Nunnink BDM; Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.
Harskamp AM; Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.
Geijtenbeek TBH; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.
Kootstra NA; Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2024 Oct 02; Vol. 19 (10), pp. e0298472. Date of Electronic Publication: 2024 Oct 02 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
HIV Infections*/immunology
HIV Infections*/genetics
HIV Infections*/virology
Humans ; Male ; Energy Metabolism ; Adult ; HIV-1/immunology ; RNA/genetics ; RNA/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Female ; Chronic Disease ; HLA-B Antigens/genetics ; HLA-B Antigens/metabolism ; Middle Aged

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Tytuł:: T-cell specific in vivo gene delivery with DART-AAVs targeted to CD8.
Autorzy:: Demircan MB; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Zinser LJ; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Michels A; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Guaza-Lasheras M; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany.
John F; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany; Frankfurt Cancer Institute, Goethe University, 60596 Frankfurt, Germany.
Gorol JM; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany; Frankfurt Cancer Institute, Goethe University, 60596 Frankfurt, Germany; Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt, Germany.
Theuerkauf SA; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Günther DM; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany; Ernst Strüngmann Institute for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany.
Grimm D; Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty and Faculty of Engineering Sciences, Heidelberg University, BioQuant, 69120 Heidelberg, Germany.
Greten FR; Frankfurt Cancer Institute, Goethe University, 60596 Frankfurt, Germany; Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt, Germany.
Chlanda P; Schaller Research Groups, Department of Infectious Diseases/Virology, Medical Faculty, Heidelberg University, BioQuant, 69120 Heidelberg, Germany.
Thalheimer FB; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany; HZG Hematology, Cell and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Buchholz CJ; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany; Frankfurt Cancer Institute, Goethe University, 60596 Frankfurt, Germany. Electronic address: .; Pokaż więcej
Źródło:: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Oct 02; Vol. 32 (10), pp. 3470-3484. Date of Electronic Publication: 2024 Aug 08.
Typ publikacji:: Journal Article
MeSH Terms:: Dependovirus*/genetics
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
Genetic Vectors*/administration & dosage
Genetic Vectors*/genetics
Gene Transfer Techniques*
Genetic Therapy*/methods
Animals ; Mice ; Humans ; Transduction, Genetic ; Capsid Proteins/genetics

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Tytuł:: Advanced machine learning unveils CD8 + T cell genetic markers enhancing prognosis and immunotherapy efficacy in breast cancer.
Autorzy:: Ma H; Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China.
Shi L; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan University of Science and Technology, Luoyang, China.
Zheng J; Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China.
Zeng L; Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China.
Chen Y; Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China.
Zhang S; Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China.
Tang S; Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China.
Qu Z; Radiology Department, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
Xiong X; Department of Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Zheng X; Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China. .; School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China. .
Yin Q; Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China. .; School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China. .; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2024 Oct 01; Vol. 24 (1), pp. 1222. Date of Electronic Publication: 2024 Oct 01.
Typ publikacji:: Journal Article
MeSH Terms:: CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
Machine Learning*
Breast Neoplasms*/genetics
Breast Neoplasms*/therapy
Breast Neoplasms*/immunology
Breast Neoplasms*/pathology
Tumor Microenvironment*/immunology
Tumor Microenvironment*/genetics
Biomarkers, Tumor*/genetics
Humans ; Female ; Prognosis ; Immunotherapy/methods ; Genetic Markers ; Gene Expression Regulation, Neoplastic ; Single-Cell Analysis/methods

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Tytuł:: Caspase-1-dependent spatiality in triple-negative breast cancer and response to immunotherapy.
Autorzy:: Zheng W; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Marini W; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Murakami K; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Sotov V; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Butler M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medicine, Division of Medical Oncology, University of Toronto, Toronto, ON, Canada.
Gorrini C; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; School of Molecular and Cellular Biology, University of Leeds, Leeds, UK.
Ohashi PS; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Reedijk M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. .; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. .; Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. .; Pokaż więcej
Źródło:: Nature communications [Nat Commun] 2024 Oct 01; Vol. 15 (1), pp. 8514. Date of Electronic Publication: 2024 Oct 01.
Typ publikacji:: Journal Article
MeSH Terms:: Triple Negative Breast Neoplasms*/immunology
Triple Negative Breast Neoplasms*/therapy
Triple Negative Breast Neoplasms*/metabolism
Triple Negative Breast Neoplasms*/genetics
Tumor Microenvironment*/immunology
Immunotherapy*/methods
Caspase 1*/metabolism
Estrogen Receptor alpha*/metabolism
Proto-Oncogene Protein c-ets-1*/metabolism
Proto-Oncogene Protein c-ets-1*/genetics
Interleukin-1beta*/metabolism
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
Tumor-Associated Macrophages*/immunology
Tumor-Associated Macrophages*/metabolism
Animals ; Female ; Humans ; Mice ; Cell Line, Tumor ; Immune Checkpoint Inhibitors/therapeutic use ; Immune Checkpoint Inhibitors/pharmacology ; Gene Expression Regulation, Neoplastic

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Tytuł:: SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8 T cell activation.
Autorzy:: Liu W; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Endocrinology, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
You D; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Lin J; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zou H; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhang L; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Luo S; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yuan Y; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wang Z; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Qi J; Department of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Wang W; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ye X; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yang X; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Deng Y; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Teng F; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zheng X; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Lin Y; Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Huang Z; Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Huang Y; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yang Z; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhou X; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhang Y; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chen R; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xu L; Department of Endocrinology, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
Li J; Division of Endocrinology, Department of Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, China. Electronic address: .
Yang W; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China; Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. Electronic address: .
Zhang H; Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China; Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China; State Key Laboratory of Organ Failure Research, Guangzhou, China; Guangdong Provincial Key Laboratory of Cell Metabolic Homeostasis and Major Chronic Diseases, Guangzhou, China. Electronic address: .; Pokaż więcej
Źródło:: Cell metabolism [Cell Metab] 2024 Oct 01; Vol. 36 (10), pp. 2245-2261.e6. Date of Electronic Publication: 2024 Sep 06.
Typ publikacji:: Journal Article
MeSH Terms:: CD8-Positive T-Lymphocytes*/drug effects
CD8-Positive T-Lymphocytes*/metabolism
CD8-Positive T-Lymphocytes*/immunology
Sodium-Glucose Transporter 2 Inhibitors*/pharmacology
Mice, Inbred C57BL*
Benzhydryl Compounds*/pharmacology
Fatty Liver*/drug therapy
Fatty Liver*/metabolism
Animals ; Mice ; Male ; Lymphocyte Activation/drug effects ; Glucosides/pharmacology ; Glucosides/therapeutic use ; Humans ; 3-Hydroxybutyric Acid/pharmacology

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Tytuł:: Investigating immune-modulatory function of α-glucopyranose-rich compound polysaccharides by MC38-N4/OT-I co-culture system.
Autorzy:: Xu Y; School of Food Sciences and Engineering, South China University of Technology, Guangzhou, Guangdong 510641, PR China.
Xu T; School of Food Sciences and Engineering, South China University of Technology, Guangzhou, Guangdong 510641, PR China.
Huang C; School of Food Sciences and Engineering, South China University of Technology, Guangzhou, Guangdong 510641, PR China.
Amakye WK; School of Food Sciences and Engineering, South China University of Technology, Guangzhou, Guangdong 510641, PR China.
Liu L; School of Food Sciences and Engineering, South China University of Technology, Guangzhou, Guangdong 510641, PR China.
Fan J; School of Food Sciences and Engineering, South China University of Technology, Guangzhou, Guangdong 510641, PR China.
Zhu Y; Infinitus (China) Ltd., Guangzhou, Guangdong 510665, PR China.
Yao M; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, PR China. Electronic address: .
Ren J; School of Food Sciences and Engineering, South China University of Technology, Guangzhou, Guangdong 510641, PR China. Electronic address: .; Pokaż więcej
Źródło:: International journal of biological macromolecules [Int J Biol Macromol] 2024 Oct; Vol. 278 (Pt 3), pp. 134941. Date of Electronic Publication: 2024 Aug 20.
Typ publikacji:: Journal Article
MeSH Terms:: Coculture Techniques*
Polysaccharides*/pharmacology
Polysaccharides*/chemistry
CD8-Positive T-Lymphocytes*/drug effects
CD8-Positive T-Lymphocytes*/immunology
Animals ; Mice ; Immunologic Factors/pharmacology ; Immunologic Factors/chemistry ; Cell Line, Tumor ; Lymphocyte Activation/drug effects ; Agaricus/chemistry ; Grifola/chemistry

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Tytuł:: Tumor-derived exosomal ICAM1 promotes bone metastasis of triple-negative breast cancer by inducing CD8+ T cell exhaustion.
Autorzy:: Chen M; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China; Metabolic Disease Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Fu Z; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China. Electronic address: .
Wu C; Department of Breast Surgery (Integrated Traditional and Western Medicine), Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .; Pokaż więcej
Źródło:: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2024 Oct; Vol. 175, pp. 106637. Date of Electronic Publication: 2024 Aug 13.
Typ publikacji:: Journal Article
MeSH Terms:: Triple Negative Breast Neoplasms*/pathology
Triple Negative Breast Neoplasms*/immunology
Triple Negative Breast Neoplasms*/metabolism
Exosomes*/metabolism
Exosomes*/immunology
Intercellular Adhesion Molecule-1*/metabolism
Intercellular Adhesion Molecule-1*/genetics
Intercellular Adhesion Molecule-1*/immunology
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
Bone Neoplasms*/secondary
Bone Neoplasms*/immunology
Bone Neoplasms*/pathology
Bone Neoplasms*/metabolism
Tumor Microenvironment*/immunology
Humans ; Female ; Animals ; Mice ; Cell Line, Tumor ; Cell Proliferation ; Mice, Inbred BALB C ; T-Cell Exhaustion

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Tytuł:: IRG1/Itaconate inhibits proliferation and promotes apoptosis of CD69 tissue-resident memory T cells in autoimmune hepatitis by regulating the JAK3/STAT3/P53 signalling pathway.
Autorzy:: Zhou P; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Tao K; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Zeng L; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Zeng X; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Wan Y; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Xie G; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Liu X; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China.
Zhang P; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, China. zhangpeng_.; Pokaż więcej
Źródło:: Apoptosis : an international journal on programmed cell death [Apoptosis] 2024 Oct; Vol. 29 (9-10), pp. 1738-1756. Date of Electronic Publication: 2024 Apr 19.
Typ publikacji:: Journal Article
MeSH Terms:: Antigens, Differentiation, T-Lymphocyte*/genetics
Antigens, Differentiation, T-Lymphocyte*/metabolism
Apoptosis*/drug effects
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/drug effects
Cell Proliferation*/drug effects
Hepatitis, Autoimmune*/immunology
Hepatitis, Autoimmune*/pathology
Hepatitis, Autoimmune*/genetics
Hepatitis, Autoimmune*/drug therapy
Integrin alpha Chains*/genetics
Integrin alpha Chains*/metabolism
Janus Kinase 3*/genetics
Janus Kinase 3*/metabolism
Janus Kinase 3*/antagonists & inhibitors
STAT3 Transcription Factor*/metabolism
STAT3 Transcription Factor*/genetics
Tumor Suppressor Protein p53*/metabolism
Tumor Suppressor Protein p53*/genetics
Animals ; Mice ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Disease Models, Animal ; Lectins, C-Type/genetics ; Lectins, C-Type/metabolism ; Liver/pathology ; Liver/drug effects ; Liver/metabolism ; Liver/immunology ; Memory T Cells/immunology ; Memory T Cells/metabolism ; Memory T Cells/drug effects ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction/drug effects

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Tytuł:: Follicular CD8 T cells promote immunoglobulin production and demyelination in multiple sclerosis and a murine model.
Autorzy:: Ding JQ; Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China; Department of Neurology, Tangdu Hospital, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Zhang JQ; Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Zhao SJ; Department of Neurology, Tangdu Hospital, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Jiang DB; Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Lu JR; Department of Neurology, Tangdu Hospital, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Yang SY; Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Wang J; Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Sun YJ; Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Huang YN; Department of Emergency, the Second Affiliated Hospital (Xixian New District Central Hospital), Shaanxi University of Chinese Medicine, Shaanxi, China.
Hu CC; Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Zhang XY; Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Zhang JX; Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Liu TY; Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Han CY; Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Qiao XP; Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China.
Guo J; Department of Neurology, Tangdu Hospital, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China. Electronic address: guojun_.
Zhao C; Department of Neurology, Air Force Medical Center of PLA, Beijing, China. Electronic address: .
Yang K; Department of Immunology, Basic Medicine School, Air Force Medical University (the Fourth Military Medical University), Shaanxi, China. Electronic address: .; Pokaż więcej
Źródło:: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Oct; Vol. 1870 (7), pp. 167303. Date of Electronic Publication: 2024 Jun 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
Encephalomyelitis, Autoimmune, Experimental*/immunology
Encephalomyelitis, Autoimmune, Experimental*/pathology
Multiple Sclerosis*/immunology
Multiple Sclerosis*/pathology
Animals ; Mice ; Humans ; Female ; Receptors, CXCR5/metabolism ; Male ; Disease Models, Animal ; Mice, Inbred C57BL ; Adult ; Middle Aged ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Immunoglobulins/metabolism ; Immunoglobulins/immunology ; Demyelinating Diseases/immunology ; Demyelinating Diseases/pathology

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Tytuł:: Targeting OXCT1-mediated ketone metabolism reprograms macrophages to promote antitumor immunity via CD8 T cells in hepatocellular carcinoma.
Autorzy:: Zhu CX; School of Medicine, South China University of Technology, Guangzhou, China.
Yan K; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Chen L; School of Medicine, South China University of Technology, Guangzhou, China.
Huang RR; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Bian ZH; School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, China.
Wei HR; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Gu XM; School of Medicine, South China University of Technology, Guangzhou, China.
Zhao YY; School of Medicine, South China University of Technology, Guangzhou, China; Biomedical Engineering Cockrell School of Engineering, University of Texas at Austin, Austin, United States.
Liu MC; School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, China.
Suo CX; Department of Colorectal Surgery, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Li ZK; School of Medicine, South China University of Technology, Guangzhou, China.
Yang ZY; School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, China.
Lu MQ; Department of Hepatobiliary Surgery, Guangzhou First People's Hospital, Guangzhou, China.
Hua XF; Department of Hepatobiliary Surgery, Guangzhou First People's Hospital, Guangzhou, China.
Li L; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Zhao ZB; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Sun LC; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Zhang HF; The Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China.
Gao P; School of Medicine, South China University of Technology, Guangzhou, China; Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. Electronic address: .
Lian ZX; Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. Electronic address: .; Pokaż więcej
Źródło:: Journal of hepatology [J Hepatol] 2024 Oct; Vol. 81 (4), pp. 690-703. Date of Electronic Publication: 2024 May 15.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Hepatocellular*/immunology
Carcinoma, Hepatocellular*/metabolism
Carcinoma, Hepatocellular*/pathology
Carcinoma, Hepatocellular*/genetics
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
Liver Neoplasms*/immunology
Liver Neoplasms*/pathology
Liver Neoplasms*/metabolism
Liver Neoplasms*/genetics
Ketones*
Animals ; Mice ; Humans ; Coenzyme A-Transferases/metabolism ; Coenzyme A-Transferases/genetics ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/metabolism ; Macrophages/metabolism ; Macrophages/immunology ; Mice, Knockout

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Tytuł:: Vimentin, inversely correlating with infiltration of CD8 + T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma.
Autorzy:: Liang Y; State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, PR China.
He S; State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, PR China.
Liu Q; State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, PR China.
Liu T; Department of Clinical Laboratory, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, PR China.
Tan Y; State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, PR China.
Peng T; State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, PR China.
Huang C; Department of Pathology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Lu X; State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, PR China. Electronic address: .
Zheng S; State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, PR China. Electronic address: .; Pokaż więcej
Źródło:: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2024 Oct; Vol. 1871 (7), pp. 119781. Date of Electronic Publication: 2024 Jun 18.
Typ publikacji:: Journal Article
MeSH Terms:: B7-H1 Antigen*/metabolism
B7-H1 Antigen*/genetics
CD8-Positive T-Lymphocytes*/metabolism
CD8-Positive T-Lymphocytes*/immunology
Esophageal Neoplasms*/metabolism
Esophageal Neoplasms*/pathology
Esophageal Neoplasms*/genetics
Esophageal Squamous Cell Carcinoma*/metabolism
Esophageal Squamous Cell Carcinoma*/pathology
Esophageal Squamous Cell Carcinoma*/genetics
Esophageal Squamous Cell Carcinoma*/immunology
Mice, Inbred C57BL*
Vimentin*/metabolism
Animals ; Female ; Humans ; Male ; Mice ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Gene Expression Regulation, Neoplastic ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Middle Aged

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Tytuł:: Mediator complex subunit 1 promotes oral squamous cell carcinoma progression by activating MMP9 transcription and suppressing CD8 T cell antitumor immunity.
Autorzy:: Li Z; Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin Medical University Institute of Stomatology, 12 Qixiangtai Road, Tianjin, 300070, China.
Sun M; Immunology Department, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, China.
Yang R; Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin Medical University Institute of Stomatology, 12 Qixiangtai Road, Tianjin, 300070, China.
Wang Z; Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin Medical University Institute of Stomatology, 12 Qixiangtai Road, Tianjin, 300070, China.
Zhu Q; Immunology Department, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, China.
Zhang Y; Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin Medical University Institute of Stomatology, 12 Qixiangtai Road, Tianjin, 300070, China.
Yang H; Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin Medical University Institute of Stomatology, 12 Qixiangtai Road, Tianjin, 300070, China.
Meng Z; Department of Oral and Maxillofacial Surgery, Tianjin Medical University School and Hospital of Stomatology, Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin Medical University Institue of Stomatology, 12 Qixiangtai Road, Tianjin, 300070, China. .
Hu L; Immunology Department, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, China. .
Sui L; Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin Medical University Institute of Stomatology, 12 Qixiangtai Road, Tianjin, 300070, China. .; Pokaż więcej
Źródło:: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Sep 30; Vol. 43 (1), pp. 270. Date of Electronic Publication: 2024 Sep 30.
Typ publikacji:: Journal Article
MeSH Terms:: Mouth Neoplasms*/pathology
Mouth Neoplasms*/genetics
Mouth Neoplasms*/immunology
Mouth Neoplasms*/metabolism
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
Matrix Metalloproteinase 9*/metabolism
Matrix Metalloproteinase 9*/genetics
Disease Progression*
Mediator Complex Subunit 1*/metabolism
Mediator Complex Subunit 1*/genetics
Carcinoma, Squamous Cell*/genetics
Carcinoma, Squamous Cell*/pathology
Carcinoma, Squamous Cell*/immunology
Carcinoma, Squamous Cell*/metabolism
Humans ; Mice ; Animals ; Cell Line, Tumor ; Male ; Female ; Gene Expression Regulation, Neoplastic ; Cell Proliferation ; Prognosis

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Tytuł:: Apigenin ameliorates lupus nephritis by inhibiting SAT3 signaling in CD8 T cells.
Autorzy:: Liu J; The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Wang N; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China. .
Wu Z; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China. .
Gan Y; The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Ji J; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China. .
Huang Z; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Du Y; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China. .
Wen C; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China. .
Tian F; The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Fan Y; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Xu L; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China. .; Pokaż więcej
Źródło:: Food & function [Food Funct] 2024 Sep 30; Vol. 15 (19), pp. 10020-10036. Date of Electronic Publication: 2024 Sep 30.
Typ publikacji:: Journal Article
MeSH Terms:: Apigenin*/pharmacology
CD8-Positive T-Lymphocytes*/drug effects
CD8-Positive T-Lymphocytes*/immunology
Lupus Nephritis*/drug therapy
Lupus Nephritis*/immunology
Mice, Inbred MRL lpr*
Signal Transduction*/drug effects
Animals ; Mice ; Female ; Humans ; STAT3 Transcription Factor/metabolism ; STAT3 Transcription Factor/genetics ; Disease Models, Animal ; Cytokines/metabolism

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Tytuł:: Dihydroartemisinin remodels tumor micro-environment and improves cancer immunotherapy through inhibiting cyclin-dependent kinases.
Autorzy:: Zhou Z; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.
Lei J; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China; Department of Laboratory Medicine, Xixi Hospital of Hangzhou, Hangzhou, Zhejiang 310023, China. Electronic address: .
Fang J; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.
Chen P; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.
Zhou J; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.
Wang H; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.
Sun Z; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.
Chen Y; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China. Electronic address: .
Yin L; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China; Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Electronic address: .; Pokaż więcej
Źródło:: International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112637. Date of Electronic Publication: 2024 Jul 20.
Typ publikacji:: Journal Article
MeSH Terms:: Tumor Microenvironment*/drug effects
Tumor Microenvironment*/immunology
Artemisinins*/pharmacology
Artemisinins*/therapeutic use
Carcinoma, Hepatocellular*/therapy
Carcinoma, Hepatocellular*/immunology
Carcinoma, Hepatocellular*/drug therapy
Liver Neoplasms*/immunology
Liver Neoplasms*/drug therapy
Liver Neoplasms*/therapy
Cyclin-Dependent Kinases*/antagonists & inhibitors
Cyclin-Dependent Kinases*/metabolism
Mice, Inbred C57BL*
Immunotherapy*/methods
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/drug effects
Animals ; Mice ; Cell Line, Tumor ; Humans ; Reactive Oxygen Species/metabolism ; Myeloid-Derived Suppressor Cells/drug effects ; Myeloid-Derived Suppressor Cells/immunology ; Male

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Tytuł:: The significance of T-BET-positive CD8 T-cells with diminished CD5 expression in Kikuchi-Fujimoto disease.
Autorzy:: Yamashita T; Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Momose S; Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Imada H; Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Takayanagi N; Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Murakami C; Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Nagata M; Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Sawada K; Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Yamazaki M; Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Shimizu T; Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Kikuchi Y; Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Yamamoto W; Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Higashi M; Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.; Pokaż więcej
Źródło:: Journal of clinical and experimental hematopathology : JCEH [J Clin Exp Hematop] 2024 Sep 28; Vol. 64 (3), pp. 183-190. Date of Electronic Publication: 2024 Jul 31.
Typ publikacji:: Journal Article
MeSH Terms:: Histiocytic Necrotizing Lymphadenitis*/pathology
Histiocytic Necrotizing Lymphadenitis*/diagnosis
Histiocytic Necrotizing Lymphadenitis*/metabolism
CD5 Antigens*/metabolism
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/pathology
CD8-Positive T-Lymphocytes*/metabolism
T-Box Domain Proteins*/metabolism
Humans ; Adult ; Male ; Female ; Middle Aged ; Aged

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Tytuł:: Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy.
Autorzy:: Maliah A; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Santana-Magal N; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Parikh S; The Ragon Institute of Mass General, MIT and Harvard 600/625 Main Street, Cambridge, MA, USA.
Gordon S; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Reshef K; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sade Y; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Khateeb A; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Richter A; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Gutwillig A; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Parikh R; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Golan T; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Krissi M; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Na M; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Binshtok G; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Manich P; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Elkoshi N; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Grisaru-Tal S; Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Zemser-Werner V; Institute of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Brenner R; Institute of Oncology, E. Wolfson Medical Center, Holon, Israel.
Vaknine H; Institute of Pathology, E. Wolfson Medical Center, Holon, Israel.
Nizri E; Peritoneal Surface Malignancies and Melanoma Unit, Department of Surgery A, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
Moyal L; Felsenstein Medical Research Center, Tel-Aviv University and the Division of Dermatology, Rabin Medical Center, Petach Tikva, Israel.
Amitay-Laish I; Felsenstein Medical Research Center, Tel-Aviv University and the Division of Dermatology, Rabin Medical Center, Petach Tikva, Israel.
Rosemberg L; School of Zoology, Tel Aviv University, Tel Aviv-Yafo, Israel.
Munitz A; Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Kronfeld-Schor N; School of Zoology, Tel Aviv University, Tel Aviv-Yafo, Israel.
Shifrut E; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Faculty of Life Sciences, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv, Israel.; Dotan Center for Advanced Therapies, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Kobiler O; Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Madi A; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Geiger T; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Carmi Y; Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. .
Levy C; Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. .; Pokaż więcej
Źródło:: Nature communications [Nat Commun] 2024 Sep 27; Vol. 15 (1), pp. 8354. Date of Electronic Publication: 2024 Sep 27.
Typ publikacji:: Journal Article
MeSH Terms:: CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
Antigens, Ly*/metabolism
Antigens, Ly*/immunology
Immunotherapy*/methods
Tumor Microenvironment*/immunology
Animals ; Mice ; Mice, Inbred C57BL ; Cell Line, Tumor ; Humans ; Melanoma, Experimental/immunology ; Melanoma, Experimental/therapy ; Melanoma, Experimental/pathology ; Female ; Programmed Cell Death 1 Receptor/metabolism ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Skin Neoplasms/immunology ; Skin Neoplasms/therapy ; Skin Neoplasms/pathology ; Mitochondria/metabolism ; Melanoma/immunology ; Melanoma/therapy ; Interferon Type I/metabolism

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Tytuł:: Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion.
Autorzy:: Fiorenza S; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. .
Zheng Y; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Bioinformatics and Computational Biology Department, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Purushe J; Clinical Research Division, Fred Hutchinson Cancer Cente, Seattle, WA, USA.
Bock TJ; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Sarthy J; Clinical Research Division, Fred Hutchinson Cancer Cente, Seattle, WA, USA.
Janssens DH; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.
Sheih AS; Clinical Research Division, Fred Hutchinson Cancer Cente, Seattle, WA, USA.
Kimble EL; Clinical Research Division, Fred Hutchinson Cancer Cente, Seattle, WA, USA.
Kirchmeier D; Clinical Research Division, Fred Hutchinson Cancer Cente, Seattle, WA, USA.
Phi TD; Clinical Research Division, Fred Hutchinson Cancer Cente, Seattle, WA, USA.
Gauthier J; Clinical Research Division, Fred Hutchinson Cancer Cente, Seattle, WA, USA.
Hirayama AV; Clinical Research Division, Fred Hutchinson Cancer Cente, Seattle, WA, USA.
Riddell SR; Clinical Research Division, Fred Hutchinson Cancer Cente, Seattle, WA, USA.
Wu Q; Clinical Research Division, Fred Hutchinson Cancer Cente, Seattle, WA, USA.
Gottardo R; Biomedical Data Sciences, Lausanne University Hospital, Lausanne, Switzerland.
Maloney DG; Clinical Research Division, Fred Hutchinson Cancer Cente, Seattle, WA, USA.
Yang JYH; Sydney Precision Data Science Centre, The University of Sydney, Sydney, NSW, Australia.
Henikoff S; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Turtle CJ; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Royal North Shore Hospital, St. Leonards, NSW, Australia.; Pokaż więcej
Źródło:: Nature communications [Nat Commun] 2024 Sep 27; Vol. 15 (1), pp. 8309. Date of Electronic Publication: 2024 Sep 27.
Typ publikacji:: Journal Article
MeSH Terms:: Receptors, Chimeric Antigen*/metabolism
Receptors, Chimeric Antigen*/genetics
Receptors, Chimeric Antigen*/immunology
Immunotherapy, Adoptive*/methods
Histone Code*
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
Humans ; Kruppel-Like Transcription Factors/metabolism ; Kruppel-Like Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Histones/metabolism ; Lymphoma/genetics ; Lymphoma/metabolism ; Lymphoma/therapy ; Cell Proliferation/genetics ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Immunologic Memory

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