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Tytuł :
Single-Cell RNA Sequencing to Disentangle the Blood System.
Autorzy :
Acosta J; Division of Hematology, Brigham and Women's Hospital, Boston, MA. Department of Medicine, Harvard Medical School, Boston, MA. Broad Institute of MIT and Harvard, Cambridge, MA.
Ssozi D; Division of Hematology, Brigham and Women's Hospital, Boston, MA. Department of Medicine, Harvard Medical School, Boston, MA. Broad Institute of MIT and Harvard, Cambridge, MA.
van Galen P; Division of Hematology, Brigham and Women's Hospital, Boston, MA. Department of Medicine, Harvard Medical School, Boston, MA. Broad Institute of MIT and Harvard, Cambridge, MA.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Mar; Vol. 41 (3), pp. 1012-1018. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Hematopoiesis/*genetics
RNA-Seq/*methods
Single-Cell Analysis/*methods
Animals ; Computational Biology/methods ; Computational Biology/trends ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; RNA-Seq/statistics & numerical data ; RNA-Seq/trends ; Single-Cell Analysis/statistics & numerical data ; Single-Cell Analysis/trends
Czasopismo naukowe
Tytuł :
Dynamic blood single-cell immune responses in patients with COVID-19.
Autorzy :
Huang L; The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences, Chengdu, Sichuan, China.; Natural Products Research Center, Institute of Chengdu Biology, Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, Sichuan, China.
Shi Y; The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences, Chengdu, Sichuan, China.; Natural Products Research Center, Institute of Chengdu Biology, Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, Sichuan, China.
Gong B; The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences, Chengdu, Sichuan, China.; Natural Products Research Center, Institute of Chengdu Biology, Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, Sichuan, China.
Jiang L; The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences, Chengdu, Sichuan, China.
Zhang Z; Institute of Health Management, Health Management Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Liu X; The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences, Chengdu, Sichuan, China.; Natural Products Research Center, Institute of Chengdu Biology, Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, Sichuan, China.
Yang J; The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences, Chengdu, Sichuan, China.
He Y; The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Jiang Z; The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Zhong L; The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Tang J; Department of Infection Disease, Zigong First People's Hospital, Zigong, Sichuan, China.
You C; Department of Infection Disease, Zigong First People's Hospital, Zigong, Sichuan, China.
Jiang Q; Department of Infection Disease, Mianyang No. 404 Hospital, Mianyang, Sichuan, China.
Long B; Department of Infection Disease, Mianyang No. 404 Hospital, Mianyang, Sichuan, China.
Zeng T; Infectious diseases laboratory, Public Health and Clinical Center of Chengdu, Chengdu, Sichuan, China.
Luo M; Infectious diseases laboratory, Public Health and Clinical Center of Chengdu, Chengdu, Sichuan, China.
Zeng F; Sichuan Dazhou Central Hosptical, Dazhou, Sichuan, China.
Zeng F; Sichuan Dazhou Central Hosptical, Dazhou, Sichuan, China.
Wang S; Department of Infection Disease, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Yang X; Department of Infection Disease, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Yang Z; The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. .; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences, Chengdu, Sichuan, China. .; Natural Products Research Center, Institute of Chengdu Biology, Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, Sichuan, China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Mar 06; Vol. 6 (1), pp. 110. Date of Electronic Publication: 2021 Mar 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Single-Cell Analysis*
COVID-19/*immunology
Leukocytes/*immunology
Receptors, Antigen, B-Cell/*immunology
Receptors, Antigen, T-Cell/*immunology
SARS-CoV-2/*immunology
Adult ; COVID-19/genetics ; Female ; Ferroptosis/genetics ; Ferroptosis/immunology ; Humans ; MAP Kinase Signaling System/genetics ; MAP Kinase Signaling System/immunology ; Male ; Middle Aged ; RNA-Seq ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, T-Cell/genetics ; SARS-CoV-2/genetics
Czasopismo naukowe
Tytuł :
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Autorzy :
Muus C; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. .
Luecken MD; Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany. .
Eraslan G; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Sikkema L; Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.
Waghray A; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.; Departments of Internal Medicine and Pediatrics, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.
Heimberg G; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Kobayashi Y; Department of Cell Biology, Duke University Medical School, Durham, NC, USA.
Vaishnav ED; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Subramanian A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Smillie C; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jagadeesh KA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Duong ET; Division of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Fiskin E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Triglia ET; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ansari M; Comprehensive Pneumology Center (CPC)/Institute of Lung Biology and Disease (ILBD), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Computational Biology, Helmholtz Zentrum München, Munich, Germany.
Cai P; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lin B; Departments of Internal Medicine and Pediatrics, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Buchanan J; Center for Epigenomics, University of California San Diego School of Medicine, La Jolla, CA, USA.; Department of Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA.
Chen S; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Shu J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
Haber AL; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Chung H; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Montoro DT; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Adams T; Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
Aliee H; Institute of Computational Biology, Helmholtz Zentrum München, Munich, Germany.
Allon SJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science & Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Andrusivova Z; SciLifeLab, Department of Gene Technology, KTH Royal Institute of Technology, Stockolm, Sweden.
Angelidis I; Comprehensive Pneumology Center (CPC)/Institute of Lung Biology and Disease (ILBD), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Ashenberg O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Bassler K; Department for Genomics & Immunoregulation, LIMES-Institute, University of Bonn, Bonn, Germany.
Bécavin C; Université Côte d'Azur, CNRS, IPMC, Sophia-Antipolis, France.
Benhar I; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Bergenstråhle J; SciLifeLab, Department of Gene Technology, KTH Royal Institute of Technology, Stockolm, Sweden.
Bergenstråhle L; SciLifeLab, Department of Gene Technology, KTH Royal Institute of Technology, Stockolm, Sweden.
Bolt L; Wellcome Sanger Institute, Hinxton, UK.
Braun E; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Bui LT; Translational Genomics Research Institute, Phoenix, AZ, USA.
Callori S; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Bioinformatics Program, Boston University School of Medicine, Boston, MA, USA.
Chaffin M; Precision Cardiology Laboratory, The Broad Institute, Cambridge, MA, USA.
Chichelnitskiy E; Institute of Transplant Immunology, Hannover Medical School, MHH, Hannover, Germany.; German Center for Infectious Diseases (DZIF), Braunschweig, Germany.
Chiou J; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA.
Conlon TM; Comprehensive Pneumology Center (CPC)/Institute of Lung Biology and Disease (ILBD), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Cuoco MS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Cuomo ASE; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Deprez M; Université Côte d'Azur, CNRS, IPMC, Sophia-Antipolis, France.
Duclos G; Boston University School of Medicine, Boston, MA, USA.
Fine D; Boston University Medical Center, Boston, MA, USA.
Fischer DS; Institute of Computational Biology, Helmholtz Zentrum München, Munich, Germany.; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Ghazanfar S; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Gillich A; Department of Biochemistry and Wall Center for Pulmonary Vascular Disease, Stanford, CA, USA.
Giotti B; Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gould J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Guo M; Divisions of Pulmonary Biology; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Gutierrez AJ; Translational Genomics Research Institute, Phoenix, AZ, USA.
Habermann AC; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Harvey T; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
He P; Wellcome Sanger Institute, Hinxton, UK.
Hou X; Center for Epigenomics, University of California-San Diego School of Medicine, La Jolla, CA, USA.; Department of Cellular and Molecular Medicine, University of California-San Diego School of Medicine, La Jolla, CA, USA.
Hu L; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Hu Y; Division of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.
Jaiswal A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ji L; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, SAR, China.
Jiang P; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, SAR, China.
Kapellos TS; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Kuo CS; Division of Pulmonary Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Larsson L; SciLifeLab, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden.
Leney-Greene MA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Lim K; Gurdon Institute, University of Cambridge, Cambridge, UK.
Litviňuková M; Cellular Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Ludwig LS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Lukassen S; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; Berlin Institute of Health (BIH), Center for Digital Health, Berlin, Germany.
Luo W; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Maatz H; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Madissoon E; European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK.; Wellcome Sanger Institute, Cellular Genetics Programme Wellcome Genome Campus, Hinxton, UK.
Mamanova L; Wellcome Sanger Institute, Hinxton, UK.
Manakongtreecheep K; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, USA.
Leroy S; Pulmonology Department, Université Côte d'Azur, CHU Nice, Nice, France.; CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Sophia-Antipolis, France.
Mayr CH; Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Systems Medicine of Chronic Lung Disease, Member of the German Center for Lung Research (DZL), Munich, Germany.
Mbano IM; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of Kwazulu Natal, Durban, South Africa.
McAdams AM; Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA.
Nabhan AN; Department of Biochemistry and Wall Center for Pulmonary Vascular Disease, Stanford, CA, USA.
Nyquist SK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Computational and Systems Biology, CSAIL, Institute for Medical Engineering and Science & Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Penland L; Department of Biochemistry and Wall Center for Pulmonary Vascular Disease, Stanford, CA, USA.
Poirion OB; Center for Epigenomics, University of California-San Diego School of Medicine, La Jolla, CA, USA.; Department of Cellular and Molecular Medicine, University of California-San Diego School of Medicine, La Jolla, CA, USA.
Poli S; Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
Qi C; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Queen R; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Newcastle upon Tyne, UK.
Reichart D; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Cardiology, University Heart & Vascular Center, University of Hamburg, Hamburg, Germany.
Rosas I; Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
Schupp JC; Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
Shea CV; Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Shi X; Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Bioinformatics Program, Boston University, Boston, MA, USA.
Sinha R; Institute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA, USA.
Sit RV; Department of Biochemistry and Wall Center for Pulmonary Vascular Disease, Stanford, CA, USA.
Slowikowski K; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, USA.
Slyper M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Smith NP; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.
Sountoulidis A; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Strunz M; Comprehensive Pneumology Center (CPC) and Institute of Lung Biology and Disease (ILBD), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Sullivan TB; Lahey Hospital & Medical Center, Burlington, MA, USA.
Sun D; Gurdon Institute, University of Cambridge, Cambridge, UK.
Talavera-López C; Cellular Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Tan P; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Tantivit J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, USA.
Travaglini KJ; Department of Biochemistry and Wall Center for Pulmonary Vascular Disease, Stanford, CA, USA.
Tucker NR; Precision Cardiology Laboratory, The Broad Institute, Cambridge, MA, USA.; Masonic Medical Research Institute, Utica, NY, USA.
Vernon KA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Wadsworth MH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Department of Chemistry & Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Waldman J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Wang X; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Xu K; Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Yan W; Center for Brain Science, Harvard University, Cambridge, MA, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
Zhao W; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ziegler CGK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard-MIT Health Sciences and Technology, Institute for Medical Engineering and Science, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
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Corporate Authors :
NHLBI LungMap Consortium
Human Cell Atlas Lung Biological Network
Źródło :
Nature medicine [Nat Med] 2021 Mar; Vol. 27 (3), pp. 546-559. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Internalization*
COVID-19/*epidemiology
COVID-19/*genetics
Host-Pathogen Interactions/*genetics
SARS-CoV-2/*physiology
Sequence Analysis, RNA/*statistics & numerical data
Single-Cell Analysis/*statistics & numerical data
Adult ; Aged ; Aged, 80 and over ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/virology ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/pathology ; COVID-19/virology ; Cathepsin L/genetics ; Cathepsin L/metabolism ; Datasets as Topic/statistics & numerical data ; Demography ; Female ; Gene Expression Profiling/statistics & numerical data ; Humans ; Lung/metabolism ; Lung/virology ; Male ; Middle Aged ; Organ Specificity/genetics ; Respiratory System/metabolism ; Respiratory System/virology ; Sequence Analysis, RNA/methods ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Single-Cell Analysis/methods
Czasopismo naukowe
Tytuł :
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Autorzy :
Velten L; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain. .; Universitat Pompeu Fabra (UPF), Barcelona, Spain. .
Story BA; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.; Swiss Federal Institute of Technology (ETH) Zurich, Department of Biosystems Science and Engineering, Basel, Switzerland.
Hernández-Malmierca P; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
Raffel S; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Department of Internal Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Leonce DR; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
Milbank J; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
Paulsen M; European Molecular Biology Laboratory (EMBL), Flow Cytometry Core Facility, Heidelberg, Germany.
Demir A; Department of Internal Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Szu-Tu C; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Frömel R; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Lutz C; Department of Internal Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Nowak D; Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Jann JC; Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Pabst C; Department of Internal Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), University of Heidelberg and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Boch T; Swiss Federal Institute of Technology (ETH) Zurich, Department of Biosystems Science and Engineering, Basel, Switzerland.; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Hofmann WK; Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Müller-Tidow C; Department of Internal Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Trumpp A; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.
Haas S; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Berlin Institute of Health (BIH), Berlin, Germany.; Charité-Universitätsmedizin, Berlin, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Steinmetz LM; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany. .; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. .; Stanford Genome Technology Center, Palo Alto, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 01; Vol. 12 (1), pp. 1366. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Single-Cell Analysis*
Clone Cells/*pathology
Leukemia, Myeloid, Acute/*genetics
Leukemia, Myeloid, Acute/*pathology
Neoplastic Stem Cells/*metabolism
Neoplastic Stem Cells/*pathology
Transcriptome/*genetics
Biomarkers, Tumor/genetics ; Bone Marrow/pathology ; Cell Differentiation ; Gene Expression Regulation, Leukemic ; Genome ; Hematopoietic Stem Cells/pathology ; Humans ; K562 Cells ; Mitochondria/genetics ; Mutation/genetics
Czasopismo naukowe
Tytuł :
Comprehensive analysis of TCR repertoire in COVID-19 using single cell sequencing.
Autorzy :
Wang P; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Jin X; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Zhou W; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Luo M; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Xu Z; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Xu C; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Li Y; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Ma K; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Cao H; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Huang Y; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Xue G; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Jin S; School of Mathematics, Harbin Institute of Technology, Harbin 150000, China.
Nie H; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China. Electronic address: .
Jiang Q; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China; Key Laboratory of Biological Big Data (Harbin Institute of Technology), Ministry of Education, China. Electronic address: .
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Źródło :
Genomics [Genomics] 2021 Mar; Vol. 113 (2), pp. 456-462. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
High-Throughput Nucleotide Sequencing*
SARS-CoV-2*
Single-Cell Analysis*
COVID-19/*genetics
Receptors, Antigen, T-Cell/*genetics
COVID-19/immunology ; Female ; Humans ; Male ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
CHARTS: a web application for characterizing and comparing tumor subpopulations in publicly available single-cell RNA-seq data sets.
Autorzy :
Bernstein MN; Morgridge Institute for Research, Madison, WI, 53715, USA.
Ni Z; Department of Statistics, University of Wisconsin - Madison, Madison, WI, 53706, USA.
Collins M; Morgridge Institute for Research, Madison, WI, 53715, USA.
Burkard ME; Department of Medicine, Hematology/Oncology, University of Wisconsin - Madison, Madison, WI, 53705, USA.; University of Wisconsin Carbone Cancer Center, Madison, WI, 53705, USA.
Kendziorski C; Department of Biostatistics and Medical Informatics, University of Wisconsin - Madison, Madison, WI, 53792, USA. .
Stewart R; Morgridge Institute for Research, Madison, WI, 53715, USA. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Feb 23; Vol. 22 (1), pp. 83. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article
MeSH Terms :
Neoplasms*/genetics
Sequence Analysis, RNA*
Single-Cell Analysis*
Gene Expression Profiling ; Humans ; RNA-Seq ; Software ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos.
Autorzy :
Wang Y; Beijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China.; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
Yuan P; Beijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China.; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
Yan Z; Beijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China.; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
Yang M; Beijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China.; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Huo Y; Beijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China.; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
Nie Y; Beijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China.; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
Zhu X; Beijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China.; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
Qiao J; Beijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. .; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China. .; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China. .; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. .; National Clinical Research Center for Obstetrics and Gynecology, Beijing, China. .; Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Beijing, China. .
Yan L; Beijing Advanced Innovation Center for Genomics, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. .; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China. .; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China. .; National Clinical Research Center for Obstetrics and Gynecology, Beijing, China. .; Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Beijing, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 23; Vol. 12 (1), pp. 1247. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Developmental*
Genomics*
Single-Cell Analysis*
Blastocyst/*metabolism
Embryo, Mammalian/*metabolism
Alleles ; Animals ; Cell Lineage/genetics ; Chromatin/metabolism ; DNA Methylation/genetics ; Ectoderm/cytology ; Female ; Male ; Mice ; Phylogeny ; Promoter Regions, Genetic ; Zygote/metabolism
Czasopismo naukowe
Tytuł :
Fast and precise single-cell data analysis using a hierarchical autoencoder.
Autorzy :
Tran D; Department of Computer Science and Engineering, University of Nevada Reno, Reno, NV, USA.
Nguyen H; Department of Computer Science and Engineering, University of Nevada Reno, Reno, NV, USA.
Tran B; Department of Computer Science and Engineering, University of Nevada Reno, Reno, NV, USA.
La Vecchia C; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Luu HN; Division of Cancer Control and Population Sciences, Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
Nguyen T; Department of Computer Science and Engineering, University of Nevada Reno, Reno, NV, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 15; Vol. 12 (1), pp. 1029. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Neural Networks, Computer*
Sequence Analysis, RNA/*statistics & numerical data
Single-Cell Analysis/*statistics & numerical data
Unsupervised Machine Learning/*statistics & numerical data
Animals ; Bayes Theorem ; Benchmarking ; Cell Separation/methods ; Cerebellum/chemistry ; Cerebellum/cytology ; Embryo, Mammalian ; Humans ; Liver/chemistry ; Liver/cytology ; Lung/chemistry ; Lung/cytology ; Mice ; Mouse Embryonic Stem Cells/chemistry ; Mouse Embryonic Stem Cells/cytology ; Pancreas/chemistry ; Pancreas/cytology ; Retina/chemistry ; Retina/cytology ; Single-Cell Analysis/methods ; Visual Cortex/chemistry ; Visual Cortex/cytology ; Zygote/chemistry ; Zygote/cytology
Czasopismo naukowe
Tytuł :
Pairwise Proximity-Differentiated Visualization of Single-Cell DNA Epigenetic Marks.
Autorzy :
Xue J; Institute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xianning West Road, Xi'an, Shaanxi, 710049, China.
Chen F; Institute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xianning West Road, Xi'an, Shaanxi, 710049, China.
Su L; Institute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xianning West Road, Xi'an, Shaanxi, 710049, China.
Cao X; Institute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xianning West Road, Xi'an, Shaanxi, 710049, China.
Bai M; Institute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xianning West Road, Xi'an, Shaanxi, 710049, China.
Zhao Y; Institute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xianning West Road, Xi'an, Shaanxi, 710049, China.
Fan C; Institute of Molecular Medicine, Renji Hospital, School of Medicine and School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200127, China.
Zhao Y; Institute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xianning West Road, Xi'an, Shaanxi, 710049, China.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Feb 15; Vol. 60 (7), pp. 3428-3432. Date of Electronic Publication: 2020 Dec 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Single-Cell Analysis*
5-Methylcytosine/*analogs & derivatives
Cytosine/*analogs & derivatives
DNA/*chemistry
5-Methylcytosine/chemistry ; Cell Line ; Chromatin/chemistry ; Chromatin/metabolism ; Cytosine/chemistry ; Humans ; Molecular Structure
Czasopismo naukowe
Tytuł :
Immobilized Droplet Arrays in Thermosetting Oil for Dynamic Proteolytic Assays of Single Cells.
Autorzy :
Wu W; Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou 310027, P. R. China.; College of Life Sciences, Zhejiang University, Hangzhou 310058, P. R. China.
Zhang S; Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou 310027, P. R. China.; College of Life Sciences, Zhejiang University, Hangzhou 310058, P. R. China.
Zhang T; Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou 310027, P. R. China.
Mu Y; Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou 310027, P. R. China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Feb 10; Vol. 13 (5), pp. 6081-6090. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Microfluidic Analytical Techniques*/instrumentation
Single-Cell Analysis*/instrumentation
Temperature*
Matrix Metalloproteinases/*metabolism
Silicone Oils/*chemistry
A549 Cells ; Cell Survival ; Enzymes, Immobilized/chemistry ; Enzymes, Immobilized/metabolism ; Humans ; Matrix Metalloproteinases/chemistry ; Particle Size ; Proteolysis ; Surface Properties
Czasopismo naukowe
Tytuł :
Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy.
Autorzy :
Rabilloud T; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.
Potier D; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.
Pankaew S; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.
Nozais M; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France.
Loosveld M; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France. .; APHM, Hôpital La Timone, Laboratoire d'Hématologie, Marseille, France. .
Payet-Bornet D; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 08; Vol. 12 (1), pp. 865. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunotherapy, Adoptive*
Single-Cell Analysis*
Antigens, CD19/*metabolism
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*immunology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*therapy
Child ; Clone Cells ; Humans ; Recurrence
Czasopismo naukowe
Tytuł :
Single-cell metabolic profiling of human cytotoxic T cells.
Autorzy :
Hartmann FJ; Department of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Mrdjen D; Department of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
McCaffrey E; Department of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.; Immunology Graduate Program, Stanford University, Palo Alto, CA, USA.
Glass DR; Department of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.; Immunology Graduate Program, Stanford University, Palo Alto, CA, USA.
Greenwald NF; Department of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Bharadwaj A; Department of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Khair Z; Department of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Verberk SGS; Department of Molecular Cell Biology and Immunology, Amsterdam Cardiovascular Sciences, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Baranski A; Department of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Baskar R; Department of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Graf W; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Van Valen D; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Van den Bossche J; Department of Molecular Cell Biology and Immunology, Amsterdam Cardiovascular Sciences, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Angelo M; Department of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
Bendall SC; Department of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA. .
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Źródło :
Nature biotechnology [Nat Biotechnol] 2021 Feb; Vol. 39 (2), pp. 186-197. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Metabolome*
Single-Cell Analysis*
T-Lymphocytes, Cytotoxic/*cytology
T-Lymphocytes, Cytotoxic/*metabolism
Colorectal Neoplasms/immunology ; Colorectal Neoplasms/pathology ; Humans ; Lymphocyte Activation/immunology ; Lymphocyte Subsets/immunology ; Metabolic Flux Analysis
Czasopismo naukowe
Tytuł :
In-Depth Mass Spectrometry-Based Single-Cell and Nanoscale Proteomics.
Autorzy :
Liang Y; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Truong T; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Zhu Y; Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA.
Kelly RT; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA. .; Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2185, pp. 159-179.
Typ publikacji :
Journal Article
MeSH Terms :
Mass Spectrometry*
Proteomics*
Single-Cell Analysis*
Leukemia/*metabolism
Neoplastic Stem Cells/*metabolism
Humans
Czasopismo naukowe
Tytuł :
Single-Cell Analysis of Fungal Uptake in Cultured Airway Epithelial Cells Using Differential Fluorescent Staining and Imaging Flow Cytometry.
Autorzy :
Bertuzzi M; Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, Core Technology Facility Building, The University of Manchester, Manchester, UK. .; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. .
Howell GJ; Flow Cytometry Core Facility, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2260, pp. 83-109.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Flow Cytometry*
Microscopy, Fluorescence*
Single-Cell Analysis*
Alveolar Epithelial Cells/*microbiology
Aspergillus fumigatus/*pathogenicity
Fluorescent Dyes/*chemistry
A549 Cells ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/pathology ; Apoptosis ; Host-Pathogen Interactions ; Humans ; Image Processing, Computer-Assisted ; Necrosis ; Software
Czasopismo naukowe
Tytuł :
Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys.
Autorzy :
Speranza E; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.; Laboratory of Immune System Biology, Lymphocyte Biology Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Williamson BN; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Feldmann F; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Sturdevant GL; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Pérez-Pérez L; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Meade-White K; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Smith BJ; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Lovaglio J; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Martens C; Research Technologies Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Munster VJ; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Okumura A; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Shaia C; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Feldmann H; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Best SM; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
de Wit E; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. .
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Źródło :
Science translational medicine [Sci Transl Med] 2021 Jan 27; Vol. 13 (578). Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Sequence Analysis, RNA*
Single-Cell Analysis*
COVID-19/*epidemiology
COVID-19/*virology
Lung/*virology
SARS-CoV-2/*physiology
Alveolar Epithelial Cells/pathology ; Alveolar Epithelial Cells/virology ; Animals ; Bronchoalveolar Lavage Fluid/virology ; COVID-19/genetics ; Chlorocebus aethiops ; DNA, Viral/genetics ; Female ; Genome, Viral/genetics ; Inflammation/pathology ; Lung/pathology ; Lymph Nodes/pathology ; Macrophages/pathology ; Macrophages/virology ; Male ; Mediastinum/pathology ; Transcription, Genetic ; Viral Load ; Virus Replication
Czasopismo naukowe
Tytuł :
Characterization of Heterogeneity and Dynamics of Lysis of Single Bacillus subtilis Cells upon Prophage Induction During Spore Germination, Outgrowth, and Vegetative Growth Using Raman Tweezers and Live-Cell Phase-Contrast Microscopy.
Autorzy :
Wu MY; Department of Physics, East Carolina University, Greenville, North Carolina 27858-4353, United States.
Li WW
Christie G; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, U.K.
Setlow P; Department of Molecular Biology and Biophysics, UCONN Health, Farmington, Connecticut 06030-3305, United States.
Li YQ; Department of Physics, East Carolina University, Greenville, North Carolina 27858-4353, United States.; School of Electronic Engineering, Dongguan University of Technology, Dongguan, Guangdong 523808, P. R. China.
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Źródło :
Analytical chemistry [Anal Chem] 2021 Jan 26; Vol. 93 (3), pp. 1443-1450. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Single-Cell Analysis*
Bacillus subtilis/*cytology
Spores, Bacterial/*growth & development
Bacillus subtilis/metabolism ; Microscopy, Phase-Contrast ; Optical Tweezers ; Spectrum Analysis, Raman ; Spores, Bacterial/chemistry ; Spores, Bacterial/metabolism
Czasopismo naukowe
Tytuł :
Nonspecific Binding Correction for Single-Cell Mass Cytometric Analysis of Autophagy and Myoblast Differentiation.
Autorzy :
Brown HMG; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Kuhns MM; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Maxwell Z; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Arriaga EA; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Pokaż więcej
Źródło :
Analytical chemistry [Anal Chem] 2021 Jan 26; Vol. 93 (3), pp. 1401-1408. Date of Electronic Publication: 2020 Dec 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Autophagy*
Flow Cytometry*
Single-Cell Analysis*
Myoblasts/*pathology
Animals ; Cell Differentiation ; Cells, Cultured ; Mass Spectrometry ; Mice ; Microscopy, Fluorescence ; Rats
Czasopismo naukowe
Tytuł :
3D Imaging and Quantification of the Integrin at a Single-Cell Base on a Multisignal Nanoprobe and Synchrotron Radiation Soft X-ray Tomography Microscopy.
Autorzy :
Zhang C; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100090, China.; Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Yao S; School of Physical Science and Technology, Shanghai Tech University, Shanghai 201210, China.; Shandong Provincial Engineering and Technical Center of Light Manipulations & Shandong Provincial Key Laboratory of Optics and Photonic Device, School of Physics and Electronics, Shandong Normal University, Jinan 250358, China.
Xu C; College of Chemistry and Material Science, Shandong Agricultural University, Tai'an 271018, China.
Chang Y; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Zong Y; School of Physical Science and Technology, Shanghai Tech University, Shanghai 201210, China.
Zhang K; Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Zhang X; Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
Zhang L; Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
Chen C; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100090, China.
Zhao Y; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100090, China.
Jiang H; School of Physical Science and Technology, Shanghai Tech University, Shanghai 201210, China.
Gao X; Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Wang Y; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100090, China.
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Źródło :
Analytical chemistry [Anal Chem] 2021 Jan 26; Vol. 93 (3), pp. 1237-1241. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Imaging, Three-Dimensional*
Single-Cell Analysis*
Tomography, X-Ray Computed*
Integrins/*analysis
Nanoparticles/*chemistry
Cell Line, Tumor ; Gadolinium/chemistry ; Gold/chemistry ; Humans ; Serum Albumin, Bovine/chemistry ; Synchrotrons
Czasopismo naukowe
Tytuł :
Characterization of Single-Cell Osmotic Swelling Dynamics for New Physical Biomarkers.
Autorzy :
Fajrial AK; Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, 1111 Engineering Drive, UCB 427, Boulder, Colorado 80309, United States.
Liu K; Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, 1111 Engineering Drive, UCB 427, Boulder, Colorado 80309, United States.
Gao Y; Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, 1111 Engineering Drive, UCB 427, Boulder, Colorado 80309, United States.
Gu J; Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Lakerveld R; Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Ding X; Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, 1111 Engineering Drive, UCB 427, Boulder, Colorado 80309, United States.; Biomedical Engineering Program, University of Colorado Boulder, Boulder, Colorado 80309, United States.
Pokaż więcej
Źródło :
Analytical chemistry [Anal Chem] 2021 Jan 26; Vol. 93 (3), pp. 1317-1325. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lab-On-A-Chip Devices*
Single-Cell Analysis*
Biomarkers/analysis ; Cells, Cultured ; HEK293 Cells ; HeLa Cells ; Humans
Czasopismo naukowe

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