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Wyszukujesz frazę ""CELL death"" wg kryterium: Temat


Tytuł :
Tumor-treating fields (TTFields) induce immunogenic cell death resulting in enhanced antitumor efficacy when combined with anti-PD-1 therapy.
Autorzy :
Voloshin T; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Kaynan N; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Davidi S; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Porat Y; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Shteingauz A; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Schneiderman RS; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Zeevi E; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Munster M; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Blat R; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Tempel Brami C; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Cahal S; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Itzhaki A; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Giladi M; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel. .
Kirson ED; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Weinberg U; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
Kinzel A; Novocure GmbH, Munich, Germany.
Palti Y; Novocure Ltd., Topaz Building, MATAM Center, 31905, Haifa, Israel.
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Jul; Vol. 69 (7), pp. 1191-1204. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Immunogenic Cell Death*
Antineoplastic Agents, Immunological/*pharmacology
Carcinoma, Hepatocellular/*therapy
Carcinoma, Lewis Lung/*therapy
Electric Stimulation Therapy/*methods
Lymphocytes, Tumor-Infiltrating/*immunology
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Animals ; Apoptosis ; Carcinoma, Hepatocellular/immunology ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Lewis Lung/immunology ; Carcinoma, Lewis Lung/pathology ; Cell Proliferation ; Combined Modality Therapy ; Female ; Humans ; Liver Neoplasms/immunology ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
TNFR2 blockade alone or in combination with PD-1 blockade shows therapeutic efficacy in murine cancer models.
Autorzy :
Case K; Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Tran L; Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Yang M; Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Zheng H; Biostatistics Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Kuhtreiber WM; Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Faustman DL; Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 Jun; Vol. 107 (6), pp. 981-991. Date of Electronic Publication: 2020 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Antineoplastic Agents, Immunological/*pharmacology
Colonic Neoplasms/*therapy
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Receptors, Tumor Necrosis Factor, Type II/*antagonists & inhibitors
T-Lymphocytes, Regulatory/*drug effects
Animals ; Antineoplastic Agents, Immunological/chemistry ; Cell Death/drug effects ; Cell Death/immunology ; Cell Line, Tumor ; Cell Proliferation ; Colonic Neoplasms/genetics ; Colonic Neoplasms/immunology ; Colonic Neoplasms/pathology ; Combined Modality Therapy/methods ; Drug Administration Schedule ; Humans ; Immunotherapy/methods ; Mice ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/immunology ; Receptors, Tumor Necrosis Factor, Type II/genetics ; Receptors, Tumor Necrosis Factor, Type II/immunology ; T-Lymphocytes, Cytotoxic/cytology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/pathology ; Treatment Outcome ; Tumor Burden/drug effects ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Hydroxychloroquine can potentially interfere with immune function in COVID-19 patients: Mechanisms and insights.
Autorzy :
Devarajan A; UCLA Cardiac Arrhythmia Center, University of California, Los Angeles, CA, USA; Neurocardiology Research Center of Excellence, University of California, Los Angeles, CA, USA. Electronic address: .
Vaseghi M; UCLA Cardiac Arrhythmia Center, University of California, Los Angeles, CA, USA; Neurocardiology Research Center of Excellence, University of California, Los Angeles, CA, USA.
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Źródło :
Redox biology [Redox Biol] 2021 Jan; Vol. 38, pp. 101810. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Antiviral Agents*/adverse effects
Antiviral Agents*/therapeutic use
Autophagic Cell Death*/drug effects
Autophagic Cell Death*/immunology
COVID-19*/drug therapy
COVID-19*/epidemiology
COVID-19*/immunology
COVID-19*/pathology
Hydroxychloroquine*/adverse effects
Hydroxychloroquine*/therapeutic use
Pandemics*
Antigen Presentation/*drug effects
SARS-CoV-2/*immunology
Humans ; Oxidation-Reduction/drug effects
Czasopismo naukowe
Tytuł :
Molecular dynamics of the immune checkpoint programmed cell death protein I, PD-1: conformational changes of the BC-loop upon binding of the ligand PD-L1 and the monoclonal antibody nivolumab.
Autorzy :
Roither B; Institute of Biosimulation and Bioinformatics, Medical University of Vienna, Spitalgasse 23/88.04.510, 1090, Vienna, Austria.
Oostenbrink C; Institute of Molecular Modeling and Simulation, University of Natural Resources and Life Science, Vienna, Muthgasse 18, 1190, Vienna, Austria.
Schreiner W; Institute of Biosimulation and Bioinformatics, Medical University of Vienna, Spitalgasse 23/88.04.510, 1090, Vienna, Austria. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2020 Dec 14; Vol. 21 (Suppl 17), pp. 557. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Dynamics Simulation*
B7-H1 Antigen/*chemistry
Nivolumab/*immunology
Programmed Cell Death 1 Receptor/*chemistry
Antibodies, Monoclonal/immunology ; B7-H1 Antigen/metabolism ; Cluster Analysis ; Humans ; Hydrogen Bonding ; Ligands ; Programmed Cell Death 1 Receptor/immunology ; Programmed Cell Death 1 Receptor/metabolism ; Protein Binding ; Protein Domains
Czasopismo naukowe
Tytuł :
Dynamics of peripheral T cell clones during PD-1 blockade in non-small cell lung cancer.
Autorzy :
Zhang F; Beijing Advanced Innovation Center for Genomics, School of Life Sciences, BIOPIC, Peking University, Beijing, 100871, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
Bai H; State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China.
Gao R; Beijing Advanced Innovation Center for Genomics, School of Life Sciences, BIOPIC, Peking University, Beijing, 100871, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
Fei K; State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China.
Duan J; State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China.
Zhang Z; Beijing Advanced Innovation Center for Genomics, School of Life Sciences, BIOPIC, Peking University, Beijing, 100871, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
Wang J; State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China. .
Hu X; Beijing Advanced Innovation Center for Genomics, School of Life Sciences, BIOPIC, Peking University, Beijing, 100871, China. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Dec; Vol. 69 (12), pp. 2599-2611. Date of Electronic Publication: 2020 Jun 26.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Immunological/*therapeutic use
Carcinoma, Non-Small-Cell Lung/*drug therapy
Lung Neoplasms/*drug therapy
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
T-Lymphocyte Subsets/*drug effects
Aged ; Antineoplastic Agents, Immunological/pharmacology ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/immunology ; Clinical Trials, Phase III as Topic ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Lung Neoplasms/blood ; Lung Neoplasms/diagnosis ; Lung Neoplasms/immunology ; Male ; Middle Aged ; Multicenter Studies as Topic ; Nivolumab/pharmacology ; Nivolumab/therapeutic use ; Programmed Cell Death 1 Receptor/immunology ; Programmed Cell Death 1 Receptor/metabolism ; RNA-Seq ; Randomized Controlled Trials as Topic ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Single-Cell Analysis ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
Czasopismo naukowe
Tytuł :
The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma.
Autorzy :
Tervo S; Haartman Institute, University of Helsinki, Helsinki, Finland.; Department of Pathology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab laboratories Ltd., Tampere, Finland.
Seppälä M; Haartman Institute, University of Helsinki, Helsinki, Finland.
Rautiainen M; Department of Otorhinolaryngology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Huhtala H; Faculty of Social Sciences, Tampere University, Tampere, Finland.
Salo T; Department of Oral and Maxillofacial Diseases, Clincium, University of Helsinki, Helsinki, Finland.
Al-Samadi A; Department of Oral and Maxillofacial Diseases, Clincium, University of Helsinki, Helsinki, Finland.
Kuopio T; Department of Pathology, Central Finland Central Hospital, Jyväskylä, Finland.; Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland.
Ahtiainen M; Department of Education and Research, Central Finland Central Hospital, Jyväskylä, Finland.
Tommola S; Fimlab laboratories Ltd., Tampere, Finland.
Paavonen T; Department of Pathology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab laboratories Ltd., Tampere, Finland.
Toppila-Salmi S; Haartman Institute, University of Helsinki, Helsinki, Finland.; Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
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Źródło :
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2020 Dec; Vol. 128 (12), pp. 626-636. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Squamous Cell/*genetics
Programmed Cell Death 1 Receptor/*genetics
Tongue Neoplasms/*genetics
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Humans ; Middle Aged ; Prognosis ; Programmed Cell Death 1 Receptor/metabolism ; Survival ; Tongue Neoplasms/diagnosis ; Tongue Neoplasms/mortality ; Tongue Neoplasms/pathology ; Young Adult
Czasopismo naukowe
Tytuł :
Design, Synthesis, and Biological Evaluation of Linear Aliphatic Amine-Linked Triaryl Derivatives as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction with Promising Antitumor Effects In Vivo.
Autorzy :
Guo J; National Engineering Research Center for the Emergency Drug, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Luo L; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and ToxicologyBeijing 100850, China.
Wang Z; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and ToxicologyBeijing 100850, China.
Hu N; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and ToxicologyBeijing 100850, China.
Wang W; The Affiliated Hospital, Changchun University of Chinese Medicine, Changchun 130021, China.
Xie F; National Engineering Research Center for the Emergency Drug, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Liang E; National Engineering Research Center for the Emergency Drug, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Yan X; National Engineering Research Center for the Emergency Drug, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Xiao J; National Engineering Research Center for the Emergency Drug, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Li S; National Engineering Research Center for the Emergency Drug, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Nov 25; Vol. 63 (22), pp. 13825-13850. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Antineoplastic Agents/*chemical synthesis
B7-H1 Antigen/*antagonists & inhibitors
Fatty Acids/*chemical synthesis
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Animals ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; B7-H1 Antigen/chemistry ; B7-H1 Antigen/metabolism ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical/methods ; Fatty Acids/metabolism ; Fatty Acids/pharmacology ; Female ; Humans ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Programmed Cell Death 1 Receptor/chemistry ; Programmed Cell Death 1 Receptor/metabolism ; RAW 264.7 Cells ; Rats, Sprague-Dawley ; Treatment Outcome ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
"Janus" efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms.
Autorzy :
D'Amore C; Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, Padova, Italy. Electronic address: .
Moro E; Department of Molecular Medicine, University of Padova, Via U. Bassi 58/B, Padova, Italy.
Borgo C; Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, Padova, Italy.
Itami K; Institute of Transformative Bio-Molecules, Nagoya University, Nagoya 464-8601, Japan; Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya 464-8601, Japan.
Hirota T; Institute of Transformative Bio-Molecules, Nagoya University, Nagoya 464-8601, Japan.
Pinna LA; Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, Padova, Italy; CNR Institute of Neurosciences, Via U. Bassi 58/B, Padova, Italy.
Salvi M; Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, Padova, Italy. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2020 Nov; Vol. 1867 (11), pp. 118807. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Casein Kinase II/*genetics
Cell Death/*genetics
Neoplasms/*drug therapy
rac1 GTP-Binding Protein/*genetics
CRISPR-Cas Systems/genetics ; Casein Kinase II/antagonists & inhibitors ; Cell Death/drug effects ; Gene Editing ; Hep G2 Cells ; Humans ; Indoles/pharmacology ; Pinocytosis/drug effects ; Pinocytosis/genetics ; Pyrimidines/pharmacology ; Quinolines/pharmacology ; Vacuoles/drug effects ; Vacuoles/genetics ; rac1 GTP-Binding Protein/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
[The role of programmed death receptor-1/programmed death receptor-1 ligands pathway in autoimmune diseases].
Autorzy :
Zhang S; Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Wang L
Li MT
Zeng XF
Zhang FC
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Źródło :
Zhonghua nei ke za zhi [Zhonghua Nei Ke Za Zhi] 2019 Aug 01; Vol. 58 (8), pp. 620-624.
Typ publikacji :
Journal Article
MeSH Terms :
Programmed Cell Death 1 Receptor*
Receptors, Death Domain*
Autoimmune Diseases/*immunology
Autophagy ; Humans ; Programmed Cell Death 1 Ligand 2 Protein ; Signal Transduction
Czasopismo naukowe
Tytuł :
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy.
Autorzy :
Somasundaram R; The Wistar Institute, Philadelphia, PA, USA. .
Connelly T; The Wistar Institute, Philadelphia, PA, USA.
Choi R; The Wistar Institute, Philadelphia, PA, USA.
Choi H; The Wistar Institute, Philadelphia, PA, USA.
Samarkina A; The Wistar Institute, Philadelphia, PA, USA.
Li L; The Wistar Institute, Philadelphia, PA, USA.
Gregorio E; The Wistar Institute, Philadelphia, PA, USA.
Chen Y; The Wistar Institute, Philadelphia, PA, USA.
Thakur R; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Abdel-Mohsen M; The Wistar Institute, Philadelphia, PA, USA.
Beqiri M; The Wistar Institute, Philadelphia, PA, USA.
Kiernan M; The Wistar Institute, Philadelphia, PA, USA.
Perego M; The Wistar Institute, Philadelphia, PA, USA.
Wang F; The Wistar Institute, Philadelphia, PA, USA.
Xiao M; The Wistar Institute, Philadelphia, PA, USA.
Brafford P; The Wistar Institute, Philadelphia, PA, USA.
Yang X; The Wistar Institute, Philadelphia, PA, USA.
Xu X; Department of Pathology and Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Secreto A; Department of Medicine, Stem Cell and Xenograft Core, University of Pennsylvania, Philadelphia, PA, USA.
Danet-Desnoyers G; Department of Medicine, Stem Cell and Xenograft Core, University of Pennsylvania, Philadelphia, PA, USA.
Traum D; Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kaestner KH; Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Huang AC; Department of Pathology and Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hristova D; The Wistar Institute, Philadelphia, PA, USA.
Wang J; The Wistar Institute, Philadelphia, PA, USA.
Fukunaga-Kalabis M; The Wistar Institute, Philadelphia, PA, USA.
Krepler C; The Wistar Institute, Philadelphia, PA, USA.
Ping-Chen F; The Wistar Institute, Philadelphia, PA, USA.
Zhou X; The Wistar Institute, Philadelphia, PA, USA.
Gutierrez A; The Wistar Institute, Philadelphia, PA, USA.
Rebecca VW; The Wistar Institute, Philadelphia, PA, USA.
Vonteddu P; The Wistar Institute, Philadelphia, PA, USA.
Dotiwala F; The Wistar Institute, Philadelphia, PA, USA.
Bala S; The Wistar Institute, Philadelphia, PA, USA.
Majumdar S; The Wistar Institute, Philadelphia, PA, USA.
Dweep H; The Wistar Institute, Philadelphia, PA, USA.
Wickramasinghe J; The Wistar Institute, Philadelphia, PA, USA.
Kossenkov AV; The Wistar Institute, Philadelphia, PA, USA.
Reyes-Arbujas J; The Wistar Institute, Philadelphia, PA, USA.
Santiago K; The Wistar Institute, Philadelphia, PA, USA.
Nguyen T; The Wistar Institute, Philadelphia, PA, USA.
Griss J; Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Keeney F; The Wistar Institute, Philadelphia, PA, USA.
Hayden J; The Wistar Institute, Philadelphia, PA, USA.
Gavin BJ; The Wistar Institute, Philadelphia, PA, USA.
Weiner D; The Wistar Institute, Philadelphia, PA, USA.
Montaner LJ; The Wistar Institute, Philadelphia, PA, USA.
Liu Q; The Wistar Institute, Philadelphia, PA, USA.
Peiffer L; University of Duisburg-Essen, Essen, Germany.
Becker J; University of Duisburg-Essen, Essen, Germany.
Burton EM; Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Davies MA; Department of Melanoma Medical Oncology, University of California, San Francisco, CA, USA.
Tetzlaff MT; Department of Pathology and Dermatology, University of California, San Francisco, CA, USA.
Muthumani K; The Wistar Institute, Philadelphia, PA, USA.; GeneOne Life Science Inc., Fort Washington, PA, USA.
Wargo JA; Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Gabrilovich D; AstraZeneca, Gaithersburg, MD, USA.
Herlyn M; The Wistar Institute, Philadelphia, PA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 12; Vol. 12 (1), pp. 346. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Drug Resistance, Neoplasm*/drug effects
Lymphocytes, Tumor-Infiltrating/*immunology
Mast Cells/*immunology
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Animals ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Lymphocytes, Tumor-Infiltrating/drug effects ; Mast Cells/drug effects ; Melanoma/immunology ; Melanoma/pathology ; Melanoma/therapy ; Mice, Transgenic ; Programmed Cell Death 1 Receptor/metabolism ; Sunitinib/pharmacology ; Sunitinib/therapeutic use ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
The spliceosome inhibitors isoginkgetin and pladienolide B induce ATF3-dependent cell death.
Autorzy :
Vanzyl EJ; Department of Biology, Carleton University, Ottawa, ON, Canada.
Sayed H; Department of Biology, Carleton University, Ottawa, ON, Canada.
Blackmore AB; Department of Biology, Carleton University, Ottawa, ON, Canada.
Rick KRC; Department of Biology, Carleton University, Ottawa, ON, Canada.
Fernando P; Department of Biology, Carleton University, Ottawa, ON, Canada.
McKay BC; Department of Biology, Carleton University, Ottawa, ON, Canada.; Institute of Biochemistry, Carleton University, Ottawa, ON, Canada.
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Źródło :
PloS one [PLoS One] 2020 Dec 28; Vol. 15 (12), pp. e0224953. Date of Electronic Publication: 2020 Dec 28 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Activating Transcription Factor 3/*metabolism
Biflavonoids/*pharmacology
Cell Death/*drug effects
Epoxy Compounds/*pharmacology
Fibroblasts/*drug effects
Macrolides/*pharmacology
Spliceosomes/*metabolism
Activating Transcription Factor 3/genetics ; Animals ; Apoptosis/drug effects ; Apoptosis/physiology ; Cell Death/physiology ; Fibroblasts/metabolism ; Gene Expression/drug effects ; Gene Knockdown Techniques ; HeLa Cells ; Humans ; Mice ; RNA, Small Interfering
Czasopismo naukowe
Tytuł :
Cytocidal macrophages in symbiosis with CD4 and CD8 T cells cause acute diabetes following checkpoint blockade of PD-1 in NOD mice.
Autorzy :
Hu H; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Zakharov PN; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Peterson OJ; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Unanue ER; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110 .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 08; Vol. 117 (49), pp. 31319-31330. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Symbiosis*
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Diabetes Mellitus, Experimental/*immunology
Macrophages/*immunology
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Acute Disease ; Animals ; Cell Line, Tumor ; Diabetes Mellitus, Experimental/pathology ; Female ; Immune Checkpoint Inhibitors/pharmacology ; Insulin-Secreting Cells/pathology ; Macrophages/pathology ; Mice, Inbred NOD ; Programmed Cell Death 1 Receptor/metabolism
Czasopismo naukowe
Tytuł :
CXCL13-producing PD-1 helper T cells in chronic inflammation.
Autorzy :
Yoshitomi H; Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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Źródło :
Immunological medicine [Immunol Med] 2020 Dec; Vol. 43 (4), pp. 156-160. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Programmed Cell Death 1 Receptor*
Receptors, CXCR5*
Arthritis, Rheumatoid/*immunology
Chemokine CXCL13/*metabolism
Lupus Erythematosus, Systemic/*immunology
T-Lymphocytes, Helper-Inducer/*immunology
CD4-Positive T-Lymphocytes ; Chronic Disease ; Diabetes Mellitus, Type 1/immunology ; Humans ; Immunoglobulin G4-Related Disease/immunology ; Inflammation ; Neoplasms/immunology ; Synovial Membrane/immunology ; T-Lymphocytes, Helper-Inducer/metabolism
Czasopismo naukowe
Tytuł :
PD-1 blockade in extranodal NK/T-cell lymphoma: who is in charge?
Autorzy :
Wang L; Department of Hematology, Beijing Tongren Hospital, Capital Medical University, 100730, Beijing, China.
Wang JW; Department of Hematology, Beijing Tongren Hospital, Capital Medical University, 100730, Beijing, China. .
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Źródło :
Leukemia [Leukemia] 2020 Dec; Vol. 34 (12), pp. 3432-3433. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Letter; Comment
MeSH Terms :
Lymphoma, Extranodal NK-T-Cell*/drug therapy
Programmed Cell Death 1 Receptor*
Antibodies, Monoclonal, Humanized ; Humans ; Neoplasm Recurrence, Local
Opinia redakcyjna
Tytuł :
Oral commensal bacteria differentially modulate epithelial cell death.
Autorzy :
White T; Division of Periodontics, College of Dentistry, University of Kentucky, 800 Rose St, Lexington, KY, 40536-7001, United States.
Alimova Y; Center for Oral Health Research, College of Dentistry, University of Kentucky, 1095 VA Drive, HSRB 414, Lexington, KY, 40536-0305, United States.
Alves VTE; Center for Oral Health Research, College of Dentistry, University of Kentucky, 1095 VA Drive, HSRB 414, Lexington, KY, 40536-0305, United States.
Emecen-Huja P; Division of Periodontics, College of Dentistry, University of Kentucky, 800 Rose St, Lexington, KY, 40536-7001, United States.
Al-Sabbagh M; Division of Periodontics, College of Dentistry, University of Kentucky, 800 Rose St, Lexington, KY, 40536-7001, United States.
Villasante A; Department of Statistics, College of Arts and Sciences, University of Kentucky, 725 Rose Street, Lexington, KY, 40536-0082, United States.
Ebersole JL; Center for Oral Health Research, College of Dentistry, University of Kentucky, 1095 VA Drive, HSRB 414, Lexington, KY, 40536-0305, United States.
Gonzalez OA; Division of Periodontics, College of Dentistry, University of Kentucky, 800 Rose St, Lexington, KY, 40536-7001, United States; Center for Oral Health Research, College of Dentistry, University of Kentucky, 1095 VA Drive, HSRB 414, Lexington, KY, 40536-0305, United States. Electronic address: .
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Źródło :
Archives of oral biology [Arch Oral Biol] 2020 Dec; Vol. 120, pp. 104926. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Death*
Epithelial Cells/*microbiology
Mouth/*microbiology
Apoptosis ; Cells, Cultured ; Epithelial Cells/cytology ; Fusobacterium nucleatum ; Humans ; Porphyromonas gingivalis ; Pyroptosis ; Streptococcus ; Tannerella forsythia ; Veillonella
SCR Organism :
Veillonella parvula
Czasopismo naukowe
Tytuł :
High Expression of Programmed Death Ligand 1 and Programmed Death Ligand 2 in Ophthalmic Sebaceous Carcinoma: The Case for a Clinical Trial of Checkpoint Inhibitors.
Autorzy :
Wolkow N; David G. Cogan Ophthalmic Pathology Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA; Ophthalmic Plastic and Reconstructive Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
Jakobiec FA; David G. Cogan Ophthalmic Pathology Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: .
Afrogheh AH; Department of Oral and Maxillofacial Pathology, National Health Laboratory Service, University of the Western Cape, Cape Town, South Africa.
Pai SI; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Faquin WC; Division of Head and Neck Pathology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
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Źródło :
American journal of ophthalmology [Am J Ophthalmol] 2020 Dec; Vol. 220, pp. 128-139. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Adenocarcinoma, Sebaceous/*genetics
B7-H1 Antigen/*genetics
Eye Neoplasms/*genetics
Programmed Cell Death 1 Ligand 2 Protein/*genetics
RNA, Neoplasm/*genetics
Sebaceous Gland Neoplasms/*genetics
Adenocarcinoma, Sebaceous/metabolism ; Adenocarcinoma, Sebaceous/pathology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen/biosynthesis ; Biomarkers, Tumor/biosynthesis ; Biomarkers, Tumor/genetics ; Child ; Child, Preschool ; Eye Neoplasms/metabolism ; Eye Neoplasms/pathology ; Female ; Humans ; Male ; Middle Aged ; Programmed Cell Death 1 Ligand 2 Protein/biosynthesis ; Retrospective Studies ; Sebaceous Gland Neoplasms/diagnosis ; Sebaceous Gland Neoplasms/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Programmed cell death pathways in hearing loss: A review of apoptosis, autophagy and programmed necrosis.
Autorzy :
Wu J; Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Ye J; College of Biomedical Engineering, Sichuan University, Chengdu, China.
Kong W; Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Zhang S; School of Life Sciences, Tsinghua University, Beijing, China.
Zheng Y; Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
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Źródło :
Cell proliferation [Cell Prolif] 2020 Nov; Vol. 53 (11), pp. e12915. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Apoptosis*/drug effects
Autophagic Cell Death*/drug effects
Necroptosis*/drug effects
Hair Cells, Auditory/*pathology
Hearing Loss/*pathology
Aging ; Animals ; Hair Cells, Auditory/drug effects ; Hair Cells, Auditory/metabolism ; Hearing Loss/etiology ; Hearing Loss/genetics ; Hearing Loss/metabolism ; Humans ; Mutation ; Noise/adverse effects
Czasopismo naukowe
Tytuł :
Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
Autorzy :
Färkkilä A; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.; Research Program in Systems Oncology, University of Helsinki, Haartmaninkatu 8, 00014, Helsinki, Finland.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, 200 Longwood Avenue, MA, 02115, USA.
Gulhan DC; Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
Casado J; Research Program in Systems Oncology, University of Helsinki, Haartmaninkatu 8, 00014, Helsinki, Finland.
Jacobson CA; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, 200 Longwood Avenue, MA, 02115, USA.
Nguyen H; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.
Kochupurakkal B; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.
Maliga Z; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, 200 Longwood Avenue, MA, 02115, USA.
Yapp C; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, 200 Longwood Avenue, MA, 02115, USA.
Chen YA; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, 200 Longwood Avenue, MA, 02115, USA.
Schapiro D; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, 200 Longwood Avenue, MA, 02115, USA.
Zhou Y; TESARO: A GSK company, 1000 Winter Street, Waltham, MA, 02451, USA.
Graham JR; TESARO: A GSK company, 1000 Winter Street, Waltham, MA, 02451, USA.
Dezube BJ; TESARO: A GSK company, 1000 Winter Street, Waltham, MA, 02451, USA.
Munster P; Helen Diller Family Comprehensive Cancer Center, 1450 3rd Street, San Francisco, CA, 94158, USA.
Santagata S; Brigham and Women's Hospital, Laboratory for Systems Pharmacology, 75 Francis Street, Boston, MA, 02115, USA.
Garcia E; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Rodig S; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Lako A; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Chowdhury D; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.
Shapiro GI; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.
Matulonis UA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.
Park PJ; Department of Biomedical Informatics, Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
Hautaniemi S; Research Program in Systems Oncology, University of Helsinki, Haartmaninkatu 8, 00014, Helsinki, Finland.
Sorger PK; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, 200 Longwood Avenue, MA, 02115, USA.
Swisher EM; University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
D'Andrea AD; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA. .
Konstantinopoulos PA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Mar 19; Vol. 11 (1), pp. 1459. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
B7-H1 Antigen/*genetics
Neoplasm Recurrence, Local/*drug therapy
Ovarian Neoplasms/*drug therapy
Poly(ADP-ribose) Polymerase Inhibitors/*therapeutic use
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; DNA Mutational Analysis ; Drug Monitoring/methods ; Female ; Gene Amplification ; Humans ; Indazoles/pharmacology ; Indazoles/therapeutic use ; Interferons/immunology ; Interferons/metabolism ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Middle Aged ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/immunology ; Neoplasm Recurrence, Local/pathology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/immunology ; Ovarian Neoplasms/pathology ; Ovary/pathology ; Piperidines/pharmacology ; Piperidines/therapeutic use ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Programmed Cell Death 1 Ligand 2 Protein/genetics ; Programmed Cell Death 1 Ligand 2 Protein/metabolism ; Recombinational DNA Repair/genetics ; Single-Cell Analysis ; Treatment Outcome ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
PD-L2 wound zone macrophage-like cells display M1/M2-mixed activation and restrain the effector Th1 responses.
Autorzy :
Tavukcuoglu E; Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
Horzum U; Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
Yilmaz KB; Department of Medical and Surgical Research, Institute of Health Sciences, Hacettepe University, Ankara, Turkey.; Department of General Surgery, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Esendagli G; Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.; Department of Medical and Surgical Research, Institute of Health Sciences, Hacettepe University, Ankara, Turkey.
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Źródło :
Immunology and cell biology [Immunol Cell Biol] 2020 Feb; Vol. 98 (2), pp. 152-164. Date of Electronic Publication: 2020 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation/*immunology
Inflammation/*metabolism
Macrophages/*metabolism
Programmed Cell Death 1 Ligand 2 Protein/*metabolism
Th1 Cells/*immunology
Wound Healing/*physiology
Adult ; Apoptosis/drug effects ; Apoptosis/immunology ; Arginase/metabolism ; B7-H1 Antigen/metabolism ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Female ; Humans ; Interferon-gamma/pharmacology ; Interleukin-2/metabolism ; Lectins, C-Type/metabolism ; Macrophages/cytology ; Macrophages/drug effects ; Male ; Mannose-Binding Lectins/metabolism ; Middle Aged ; Programmed Cell Death 1 Receptor/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Reactive Oxygen Species/metabolism ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptors, Cell Surface/metabolism ; Th1 Cells/drug effects ; Tumor Necrosis Factor-alpha/metabolism ; Wound Healing/drug effects ; c-Mer Tyrosine Kinase/genetics ; c-Mer Tyrosine Kinase/metabolism
Czasopismo naukowe
Tytuł :
Cell Death in the Lung: The Apoptosis-Necroptosis Axis.
Autorzy :
Sauler M; Department of Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA; email: .
Bazan IS; Department of Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA; email: .
Lee PJ; Department of Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA; email: .
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Źródło :
Annual review of physiology [Annu Rev Physiol] 2019 Feb 10; Vol. 81, pp. 375-402. Date of Electronic Publication: 2018 Nov 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Regulated Cell Death*
Lung Diseases/*physiopathology
Animals ; Apoptosis ; Asthma/physiopathology ; Autophagic Cell Death ; Humans ; Idiopathic Pulmonary Fibrosis/physiopathology ; Necroptosis ; Pulmonary Arterial Hypertension/physiopathology ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pyroptosis ; Respiratory Distress Syndrome/physiopathology
Czasopismo naukowe

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