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Tytuł :
H19 in Endocrine System Tumours.
Autorzy :
Rolla M; Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland .
Jawiarczyk-PrzybyŁowska A; Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland.
KolaČkov K; Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland.
Bolanowski M; Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland.
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 557-565.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Transformation, Neoplastic/*metabolism
Endocrine System/*metabolism
Endocrine System Diseases/*metabolism
Neoplasms/*metabolism
RNA, Long Noncoding/*metabolism
Animals ; Cell Differentiation ; Cell Proliferation ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Endocrine System/pathology ; Endocrine System Diseases/genetics ; Endocrine System Diseases/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; RNA, Long Noncoding/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver.
Autorzy :
Lin H; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Huang YS; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Fustin JM; Laboratory of Molecular Metabology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, 606-8501, Japan.; The University of Manchester, Faculty of Biology, Medicine and Health, Oxford Road, Manchester, M13 9PL, UK.
Doi M; Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto, 606-8501, Japan.
Chen H; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Lai HH; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
Lin SH; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Lee YL; Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
King PC; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Hou HS; Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Chen HW; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Young PY; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Chao HW; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan. .; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 28; Vol. 12 (1), pp. 645. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polyploidy*
Carcinoma, Hepatocellular/*genetics
Cell Transformation, Neoplastic/*genetics
Hepatocytes/*metabolism
Liver/*metabolism
Liver Neoplasms/*genetics
Precancerous Conditions/*genetics
Animals ; Carcinoma, Hepatocellular/chemically induced ; Carcinoma, Hepatocellular/metabolism ; Cell Transformation, Neoplastic/chemically induced ; Cell Transformation, Neoplastic/metabolism ; Cells, Cultured ; Diethylnitrosamine/toxicity ; Female ; Hepatocytes/drug effects ; Humans ; Liver/drug effects ; Liver/pathology ; Liver Neoplasms/chemically induced ; Liver Neoplasms/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Microscopy, Confocal ; Precancerous Conditions/chemically induced ; Precancerous Conditions/metabolism
Czasopismo naukowe
Tytuł :
Potential pathways of zinc deficiency-promoted tumorigenesis.
Autorzy :
Zhang Y; Department of Histology and Embryology, Medical College of Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Tian Y; Department of Histology and Embryology, Medical College of Nanchang University, Nanchang, Jiangxi, 330006, PR China; Queen Mary School, Medical Department, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Zhang H; Department of Histology and Embryology, Medical College of Nanchang University, Nanchang, Jiangxi, 330006, PR China; Queen Mary School, Medical Department, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Xu B; Department of Experimental Animals, Medical College of Nanchang University, Nanchang, Jiangxi, 330006, PR China; Jiangxi Key Laboratory of Experimental Animals, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Chen H; Department of Histology and Embryology, Medical College of Nanchang University, Nanchang, Jiangxi, 330006, PR China; Jiangxi Key Laboratory of Experimental Animals, Nanchang University, Nanchang, Jiangxi, 330006, PR China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jan; Vol. 133, pp. 110983. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Transformation, Neoplastic*/genetics
Cell Transformation, Neoplastic*/metabolism
Cell Transformation, Neoplastic*/pathology
Deficiency Diseases/*complications
Neoplasms/*etiology
Zinc/*deficiency
Animals ; Apoptosis ; Cell Proliferation ; DNA Damage ; DNA Repair ; Deficiency Diseases/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Inflammation Mediators/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Oxidative Stress ; Signal Transduction
Czasopismo naukowe
Tytuł :
Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway.
Autorzy :
Dai E; Department of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130031, China.
Han L; Department of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130031, China.
Liu J; Protein Modification and Degradation Lab, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, China.
Xie Y; Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zeh HJ; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Kang R; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Bai L; Department of Pediatric Hematology, First Hospital of Jilin University, Changchun, Jilin, 130021, China. .
Tang D; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 11; Vol. 11 (1), pp. 6339. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis/*metabolism
Cell Transformation, Neoplastic/*metabolism
Ferroptosis/*physiology
Membrane Proteins/*metabolism
Pancreas/*metabolism
Animals ; Biomarkers, Tumor ; Carcinogenesis/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Death/physiology ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; DNA ; Diet ; Disease Models, Animal ; Female ; Ferroptosis/drug effects ; Humans ; Iron/metabolism ; Macrophages ; Male ; Membrane Proteins/genetics ; Mice ; Mice, Knockout ; Pancreas/pathology ; Pancreatitis/genetics ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Proto-Oncogene Proteins p21(ras)/metabolism ; Quinoxalines/pharmacology ; Spiro Compounds/pharmacology ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
ALK-transformed mature T lymphocytes restore early thymus progenitor features.
Autorzy :
Congras A; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Equipe Labellisée LIGUE 2017, Toulouse, France.
Hoareau-Aveilla C; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Equipe Labellisée LIGUE 2017, Toulouse, France.
Caillet N; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Equipe Labellisée LIGUE 2017, Toulouse, France.
Tosolini M; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Pôle Technologique du CRCT, Plateau Bioinformatique, Toulouse, France.
Villarese P; Hematology and INSERM1151, Institut Necker-Enfants Malades, University Sorbonne Paris Cité at Descartes and Assistance Publique-Hopitaux de Paris, Paris, France.
Cieslak A; Hematology and INSERM1151, Institut Necker-Enfants Malades, University Sorbonne Paris Cité at Descartes and Assistance Publique-Hopitaux de Paris, Paris, France.
Rodriguez L; Etablissement Français du Sang, Nouvelle Aquitaine, INSERM U1035, Université de Bordeaux, Bordeaux, France.
Asnafi V; Hematology and INSERM1151, Institut Necker-Enfants Malades, University Sorbonne Paris Cité at Descartes and Assistance Publique-Hopitaux de Paris, Paris, France.
Macintyre E; Hematology and INSERM1151, Institut Necker-Enfants Malades, University Sorbonne Paris Cité at Descartes and Assistance Publique-Hopitaux de Paris, Paris, France.
Egger G; Department of Pathology, Medical University Vienna, Vienna, Austria.; Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria.
Brousset P; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Equipe Labellisée LIGUE 2017, Toulouse, France.; Institut Carnot Lymphome, Toulouse, France.; Laboratoire d'Excellence Toulouse Cancer and after Cancer (Labex TOUCAN), Toulouse, France.
Lamant L; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Equipe Labellisée LIGUE 2017, Toulouse, France.; Institut Carnot Lymphome, Toulouse, France.; Laboratoire d'Excellence Toulouse Cancer and after Cancer (Labex TOUCAN), Toulouse, France.; European Research Initiative on ALK-Related Malignancies, Cambridge, United Kingdom, Vienna, Austria, and Toulouse, France.
Meggetto F; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Equipe Labellisée LIGUE 2017, Toulouse, France.; Hematology and INSERM1151, Institut Necker-Enfants Malades, University Sorbonne Paris Cité at Descartes and Assistance Publique-Hopitaux de Paris, Paris, France.; Institut Carnot Lymphome, Toulouse, France.; Laboratoire d'Excellence Toulouse Cancer and after Cancer (Labex TOUCAN), Toulouse, France.; European Research Initiative on ALK-Related Malignancies, Cambridge, United Kingdom, Vienna, Austria, and Toulouse, France.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Dec 01; Vol. 130 (12), pp. 6395-6408.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anaplastic Lymphoma Kinase/*biosynthesis
CD4-Positive T-Lymphocytes/*enzymology
Cell Transformation, Neoplastic/*metabolism
Lymphoma, Large-Cell, Anaplastic/*enzymology
Neoplastic Stem Cells/*enzymology
Thymus Gland/*enzymology
Anaplastic Lymphoma Kinase/genetics ; Animals ; CD4-Positive T-Lymphocytes/pathology ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Female ; Humans ; Lymphoma, Large-Cell, Anaplastic/genetics ; Lymphoma, Large-Cell, Anaplastic/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplastic Stem Cells/pathology ; Thymus Gland/pathology
Czasopismo naukowe
Tytuł :
Mechanisms of long non-coding RNA function in colorectal cancer tumorigenesis.
Autorzy :
Poursheikhani A; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Abbaszadegan MR; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Kerachian MA; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Cancer Genetics Research Unit, Reza Radiotherapy, and Oncology Center, Mashhad, Iran.
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Źródło :
Asia-Pacific journal of clinical oncology [Asia Pac J Clin Oncol] 2021 Feb; Vol. 17 (1), pp. 7-23. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Transformation, Neoplastic*
Colorectal Neoplasms/*genetics
RNA, Long Noncoding/*genetics
Apoptosis ; Cell Movement ; Cell Proliferation ; Colorectal Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; Humans
Czasopismo naukowe
Tytuł :
Reversion from Methionine Addiction to Methionine Independence Results in Loss of Tumorigenic Potential of Highly-malignant Lung-cancer Cells.
Autorzy :
Yamamoto J; AntiCancer Inc, San Diego, CA, U.S.A.; .; Department of Surgery, University of California, San Diego, CA, U.S.A.; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Aoki Y; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Han Q; AntiCancer Inc, San Diego, CA, U.S.A.
Sugisawa N; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Sun YU; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Hamada K; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Nishino H; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Inubushi S; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Miyake K; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Matsuyama R; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Bouvet M; Department of Surgery, University of California, San Diego, CA, U.S.A.
Endo I; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan .
Hoffman RM; AntiCancer Inc, San Diego, CA, U.S.A.; .; Department of Surgery, University of California, San Diego, CA, U.S.A.
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 641-643.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Transformation, Neoplastic/*metabolism
Lung Neoplasms/*metabolism
Methionine/*metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation ; Cell Transformation, Neoplastic/pathology ; Humans ; Lung Neoplasms/pathology ; Mice, Nude ; Signal Transduction ; Tumor Burden
Czasopismo naukowe
Tytuł :
Progression, transformation, and unusual manifestations of myelodysplastic syndromes and myelodysplastic-myeloproliferative neoplasms: lessons learned from the XIV European Bone Marrow Working Group Course 2019.
Autorzy :
Hebeda K; Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands.
Boudova L; Bioptická laboratoř, Pilsen, Czech Republic.
Beham-Schmid C; Institute of Pathology, Medical University of Graz, Graz, Austria.
Orazi A; Department of Pathology, Texas Tech Health Sciences Center El Paso, El Paso, TX, USA.
Kvasnicka HM; Institute of Pathology, Helios University Hospital, Wuppertal, Germany.
Gianelli U; Pathology Unit, Department of Pathophysiology and Transplantation, University of Milan and Fondazione IRCCS, Ca' Granda-Maggiore Policlinico, Milan, Italy.
Tzankov A; Institute of Medical Genetics and Pathology, University Hospital of Basel, Schoenbeinstrasse 40, CH-4031, Basel, Switzerland. .
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Źródło :
Annals of hematology [Ann Hematol] 2021 Jan; Vol. 100 (1), pp. 117-133. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Disease Progression*
Bone Marrow/*pathology
Cell Transformation, Neoplastic/*pathology
Education/*methods
Myelodysplastic Syndromes/*pathology
Myelodysplastic-Myeloproliferative Diseases/*pathology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cell Transformation, Neoplastic/genetics ; Europe ; Female ; Germany ; Humans ; Male ; Middle Aged ; Myelodysplastic Syndromes/genetics ; Myelodysplastic-Myeloproliferative Diseases/genetics
Czasopismo naukowe
Tytuł :
Richter transformation in chronic lymphocytic leukemia (CLL)-a pooled analysis of German CLL Study Group (GCLLSG) front line treatment trials.
Autorzy :
Al-Sawaf O; Department I of Internal Medicine and Center of Integrated Oncology Aachen, University of Cologne, Bonn, Cologne, Duesseldorf, Cologne, Germany. .
Robrecht S; Department I of Internal Medicine and Center of Integrated Oncology Aachen, University of Cologne, Bonn, Cologne, Duesseldorf, Cologne, Germany.
Bahlo J; Department I of Internal Medicine and Center of Integrated Oncology Aachen, University of Cologne, Bonn, Cologne, Duesseldorf, Cologne, Germany.
Fink AM; Department I of Internal Medicine and Center of Integrated Oncology Aachen, University of Cologne, Bonn, Cologne, Duesseldorf, Cologne, Germany.
Cramer P; Department I of Internal Medicine and Center of Integrated Oncology Aachen, University of Cologne, Bonn, Cologne, Duesseldorf, Cologne, Germany.
V Tresckow J; Department I of Internal Medicine and Center of Integrated Oncology Aachen, University of Cologne, Bonn, Cologne, Duesseldorf, Cologne, Germany.
Lange E; Department of Hematology and Oncology, Evangelisches Krankenhaus Hamm, Hamm, Germany.
Kiehl M; Department of Internal Medicine, Frankfurt (Oder) General Hospital, Frankfurt/Oder, Germany.
Dreyling M; Department of Medicine III, University Hospital Ludwig Maximilians University, Munich, Germany.
Ritgen M; Second Medical Department, University Hospital Schleswig-Holstein, Kiel, Germany.
Dürig J; Department of Hematology, University Hospital Essen, Essen, Germany.
Tausch E; Department of Internal Medicine III, Ulm University, Ulm, Germany.
Schneider C; Department of Internal Medicine III, Ulm University, Ulm, Germany.
Stilgenbauer S; Department of Internal Medicine III, Ulm University, Ulm, Germany.; Department of Internal Medicine I, Saarland University Medical Center, Homburg, Germany.
Wendtner CM; Department of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases and Tropical Medicine, German CLL Study Group, Munich Clinic Schwabing, Munich, Germany.
Fischer K; Department I of Internal Medicine and Center of Integrated Oncology Aachen, University of Cologne, Bonn, Cologne, Duesseldorf, Cologne, Germany.
Goede 5th; Department I of Internal Medicine and Center of Integrated Oncology Aachen, University of Cologne, Bonn, Cologne, Duesseldorf, Cologne, Germany.; Oncogeriatric Unit, Department of Geriatric Medicine, St. Marienhospital, Cologne, Germany.
Hallek M; Department I of Internal Medicine and Center of Integrated Oncology Aachen, University of Cologne, Bonn, Cologne, Duesseldorf, Cologne, Germany.
Eichhorst B; Department I of Internal Medicine and Center of Integrated Oncology Aachen, University of Cologne, Bonn, Cologne, Duesseldorf, Cologne, Germany. .
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Źródło :
Leukemia [Leukemia] 2021 Jan; Vol. 35 (1), pp. 169-176. Date of Electronic Publication: 2020 Mar 17.
Typ publikacji :
Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Transformation, Neoplastic*/genetics
Leukemia, Lymphocytic, Chronic, B-Cell/*pathology
Lymphoma/*pathology
Adult ; Aged ; Aged, 80 and over ; Biopsy ; Disease Progression ; Female ; Genetic Variation ; Germany ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy ; Lymphoma/etiology ; Lymphoma/mortality ; Lymphoma/therapy ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Survival Analysis ; Time Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Role of the PI3K/Akt pathway in cadmium induced malignant transformation of normal prostate epithelial cells.
Autorzy :
Kulkarni P; Department of Urology, VA Medical Center and UCSF, San Francisco, CA, USA.
Dasgupta P; Department of Urology, VA Medical Center and UCSF, San Francisco, CA, USA.
Bhat NS; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Hashimoto Y; Department of Urology, VA Medical Center and UCSF, San Francisco, CA, USA.
Saini S; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, USA.
Shahryari V; Department of Urology, VA Medical Center and UCSF, San Francisco, CA, USA.
Yamamura S; Department of Urology, VA Medical Center and UCSF, San Francisco, CA, USA.
Shiina M; Department of Urology, VA Medical Center and UCSF, San Francisco, CA, USA.
Tanaka Y; Department of Urology, VA Medical Center and UCSF, San Francisco, CA, USA.
Dahiya R; Department of Urology, VA Medical Center and UCSF, San Francisco, CA, USA. Electronic address: .
Majid S; Department of Urology, VA Medical Center and UCSF, San Francisco, CA, USA. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Dec 15; Vol. 409, pp. 115308. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Transformation, Neoplastic/*metabolism
Epithelial Cells/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
Prostate/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Signal Transduction/*physiology
Animals ; Cadmium/adverse effects ; Carcinogenesis/drug effects ; Carcinogenesis/metabolism ; Cell Line ; Cell Line, Tumor ; Cell Transformation, Neoplastic/drug effects ; Cohort Studies ; Down-Regulation/drug effects ; Down-Regulation/physiology ; Epithelial Cells/drug effects ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Prostate/drug effects ; Prostatic Neoplasms/metabolism ; Signal Transduction/drug effects ; Up-Regulation/drug effects ; Up-Regulation/physiology
Czasopismo naukowe
Tytuł :
In-depth characterization and comparison of the N-glycosylated proteome of two-dimensional- and three-dimensional-cultured breast cancer cells and xenografted tumors.
Autorzy :
Mao Y; Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China.; Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Zhao Y; Mass Spectrometry Engineering Technology Research Center, Center for Advanced Measurement Science, National Institute of Metrology, Beijing, China.
Zhang Y; Key Lab of Transplant Engineering and Immunology, MOH, West China Hospital, Sichuan University, Chengdu, China.; Institutes for Systems Genetics, West China Hospital, Sichuan University, Chengdu, China.; Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Yang H; Key Lab of Transplant Engineering and Immunology, MOH, West China Hospital, Sichuan University, Chengdu, China.; Institutes for Systems Genetics, West China Hospital, Sichuan University, Chengdu, China.; Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
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Źródło :
PloS one [PLoS One] 2020 Dec 10; Vol. 15 (12), pp. e0243789. Date of Electronic Publication: 2020 Dec 10 (Print Publication: 2020).
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Transformation, Neoplastic*
Proteomics*
Breast Neoplasms/*pathology
Animals ; Female ; Glycosylation ; Hep G2 Cells ; Humans ; Mice
Czasopismo naukowe
Tytuł :
The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation.
Autorzy :
Dzulko M; Department of Toxicology, University Medical Center, 55131 Mainz, Germany.
Pons M; Department of Toxicology, University Medical Center, 55131 Mainz, Germany.
Henke A; Section of Experimental Virology, Institute of Medical Microbiology, Jena University Hospital, Friedrich Schiller University, 07745 Jena, Germany.
Schneider G; Klinik und Poliklinik für Innere Medizin II, Technical University of Munich, 81675 Munich, Germany.
Krämer OH; Department of Toxicology, University Medical Center, 55131 Mainz, Germany. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2020 Dec; Vol. 1874 (2), pp. 188453. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cell Transformation, Neoplastic/*metabolism
Protein Phosphatase 2/*genetics
Protein Phosphatase 2/*metabolism
Animals ; Apoptosis ; Autophagy ; Cell Proliferation ; Cell Transformation, Neoplastic/genetics ; DNA Repair ; Heart Function Tests ; Humans ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Accuracy of genotyping for HPV16 and 18 to triage women with low-grade squamous intraepithelial lesions: a pooled analysis of VALGENT studies.
Autorzy :
Xu L; a Unit of Cancer Epidemiology & Belgian Cancer Centre , Scientific Institute of Public Health , Brussels , Belgium.
Benoy I; b Department of Molecular Pathology , AML Laboratory, Sonic Healthcare , Antwerp , Belgium.
Cuschieri K; c Scottish HPV Reference Laboratory , Royal Infirmary of Edinburgh, Edinburgh , Scotland , UK.
Poljak M; d Institute of Microbiology and Immunology, Faculty of Medicine , University of Ljubljana , Ljubljana , Slovenia.
Bonde J; e Molecular Pathology Laboratory, Department of Pathology , Copenhagen University Hospital , Hvidovre , Denmark.
Arbyn M; a Unit of Cancer Epidemiology & Belgian Cancer Centre , Scientific Institute of Public Health , Brussels , Belgium.
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Źródło :
Expert review of molecular diagnostics [Expert Rev Mol Diagn] 2019 Jun; Vol. 19 (6), pp. 543-551. Date of Electronic Publication: 2019 May 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Transformation, Neoplastic*
Cervical Intraepithelial Neoplasia/*diagnosis
Cervical Intraepithelial Neoplasia/*etiology
Human papillomavirus 16/*genetics
Human papillomavirus 18/*genetics
Squamous Intraepithelial Lesions/*diagnosis
Squamous Intraepithelial Lesions/*etiology
Adolescent ; Adult ; Aged ; Cell Transformation, Viral ; Disease Susceptibility ; Early Detection of Cancer ; Female ; Genotype ; Genotyping Techniques ; Human papillomavirus 16/classification ; Human papillomavirus 18/classification ; Humans ; Middle Aged ; Molecular Diagnostic Techniques ; Pregnancy ; Reproducibility of Results ; Young Adult
Czasopismo naukowe
Tytuł :
Replication stress and FOXM1 drive radiation induced genomic instability and cell transformation.
Autorzy :
Li Z; Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Yu DS; Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Doetsch PW; Laboratory of Genomic Integrity and Structural Biology, NIH, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.
Werner E; Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Nov 30; Vol. 15 (11), pp. e0235998. Date of Electronic Publication: 2020 Nov 30 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Replication*
Stress, Physiological*
Bronchi/*pathology
Cell Transformation, Neoplastic/*pathology
Epithelial Cells/*pathology
Forkhead Box Protein M1/*metabolism
Genomic Instability/*radiation effects
Bronchi/metabolism ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cells, Cultured ; DNA Damage ; Epithelial Cells/metabolism ; Forkhead Box Protein M1/genetics ; Humans ; Radiation, Ionizing
Czasopismo naukowe
Tytuł :
Autophagy involvement in oncogenesis.
Autorzy :
Torii S; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Honda S; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Murohashi M; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Yamaguchi H; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Shimizu S; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
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Źródło :
Cancer science [Cancer Sci] 2020 Nov; Vol. 111 (11), pp. 3993-3999. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Autophagy*
Cell Transformation, Neoplastic*/genetics
Cell Transformation, Neoplastic*/metabolism
Neoplasms/*etiology
Neoplasms/*metabolism
Animals ; Biomarkers ; Centrosome/metabolism ; Disease Progression ; Disease Susceptibility ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasms/pathology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Metastatic lung adenocarcinoma mimicking Richter transformation in a patient with chronic lymphocytic leukemia.
Autorzy :
Cherng HJ; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Jain N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Thakral B; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Muzzafar T; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Miranda RN; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Tan D; Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Rashid A; Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Kalhor N; Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Hahn AW; Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Byers LA; Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Parseghian CM; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Ferrajoli A; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Pemmaraju N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address: .
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Źródło :
Leukemia research [Leuk Res] 2020 Nov; Vol. 98, pp. 106445. Date of Electronic Publication: 2020 Sep 13.
Typ publikacji :
Case Reports; Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma of Lung*/diagnostic imaging
Adenocarcinoma of Lung*/metabolism
Adenocarcinoma of Lung*/pathology
Adenocarcinoma of Lung*/secondary
Cell Transformation, Neoplastic*/metabolism
Cell Transformation, Neoplastic*/pathology
Leukemia, Lymphocytic, Chronic, B-Cell*/diagnostic imaging
Leukemia, Lymphocytic, Chronic, B-Cell*/metabolism
Lung Neoplasms*/diagnostic imaging
Lung Neoplasms*/metabolism
Lung Neoplasms*/pathology
Lung Neoplasms*/secondary
Positron Emission Tomography Computed Tomography*
Biomarkers, Tumor/*metabolism
Aged ; Humans ; Male ; Neoplasm Metastasis
Raport
Tytuł :
APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development.
Autorzy :
Zhang T; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.; Thomas Jefferson University, Philadelphia, PA, United States of America.
Ahn K; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.; Thomas Jefferson University, Philadelphia, PA, United States of America.
Emerick B; Center for Applications of Mathematics in Medicine, Department of Mathematical Sciences, University of Delaware, Newark, DE, United States of America.
Modarai SR; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.
Opdenaker LM; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.
Palazzo J; Thomas Jefferson University, Philadelphia, PA, United States of America.
Schleiniger G; Center for Applications of Mathematics in Medicine, Department of Mathematical Sciences, University of Delaware, Newark, DE, United States of America.
Fields JZ; CATX, Inc., Princeton, NJ, United States of America.
Boman BM; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.; Thomas Jefferson University, Philadelphia, PA, United States of America.; Center for Applications of Mathematics in Medicine, Department of Mathematical Sciences, University of Delaware, Newark, DE, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Oct 28; Vol. 15 (10), pp. e0239601. Date of Electronic Publication: 2020 Oct 28 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, APC*
Mutation*
Cell Transformation, Neoplastic/*genetics
Colon/*cytology
Colon/*metabolism
Colorectal Neoplasms/*genetics
Glucagon-Like Peptide 2/*metabolism
Somatostatin/*metabolism
Adenomatous Polyposis Coli/genetics ; Adenomatous Polyposis Coli/metabolism ; Adenomatous Polyposis Coli/pathology ; Adult Stem Cells/cytology ; Adult Stem Cells/metabolism ; Aldehyde Dehydrogenase 1 Family/metabolism ; Animals ; Biomarkers/metabolism ; Cell Differentiation/genetics ; Cell Line ; Cell Line, Tumor ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Chromogranin A/metabolism ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Feedback, Physiological ; Glucagon-Like Peptide-2 Receptor/metabolism ; HCT116 Cells ; HT29 Cells ; Humans ; Mice ; Models, Genetic ; Neuroendocrine Cells/cytology ; Neuroendocrine Cells/metabolism ; Receptors, Somatostatin/metabolism ; Signal Transduction ; Stem Cell Niche ; Tretinoin/metabolism ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł :
Novel Imidazo[2,1-b]oxazole Derivatives Inhibit Epithelial Cell Transformation and Triple Negative Breast Cancer Tumorigenesis.
Autorzy :
Bhattarai PY; College of Pharmacy, Chosun University, Gwangju, Republic of Korea.
Oh CH; Department Centre for Biomaterials, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Kim G; College of Pharmacy, Chosun University, Gwangju, Republic of Korea.
Kim MS; College of Pharmacy, Chosun University, Gwangju, Republic of Korea.
Lee BS; CTCScience Inc., Hwaseong, Republic of Korea.
Choi HS; College of Pharmacy, Chosun University, Gwangju, Republic of Korea .
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Źródło :
Anticancer research [Anticancer Res] 2020 Sep; Vol. 40 (9), pp. 5081-5090.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Cell Transformation, Neoplastic/*drug effects
Epithelial-Mesenchymal Transition/*drug effects
Imidazoles/*pharmacology
Triple Negative Breast Neoplasms/*etiology
Triple Negative Breast Neoplasms/*metabolism
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Disease Models, Animal ; Epithelial-Mesenchymal Transition/genetics ; Female ; Genes, Reporter ; Humans ; Imidazoles/chemistry ; Mice ; Molecular Structure ; Signal Transduction/drug effects ; Triple Negative Breast Neoplasms/pathology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Lithium promotes malignant transformation of nontumorigenic cells in vitro.
Autorzy :
Sudo M; Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hashimoto K; Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Voluntary Body, International Health Care in Universities, Nagoya, Japan.
Yoshinaga M; Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Azimi MD; Department of Human Resources, Ministry of Public Health, Kabul, Afghanistan.
Fayaz SH; Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Administrative Office of the President, Deputy Public Relations and Outreach, Kabul, Afghanistan.
Hamajima N; Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kondo-Ida L; Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Molecular and Cancer Medicine, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Yanagisawa K; Department of Molecular and Cancer Medicine, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Kato M; Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Voluntary Body, International Health Care in Universities, Nagoya, Japan; Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan. Electronic address: .
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Źródło :
The Science of the total environment [Sci Total Environ] 2020 Nov 20; Vol. 744, pp. 140830. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Transformation, Neoplastic*
Lithium*
Afghanistan ; Cell Line ; Humans ; Keratinocytes
Czasopismo naukowe
Tytuł :
Metabolic rivalry: circadian homeostasis and tumorigenesis.
Autorzy :
Kinouchi K; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA, USA. .; Department of Endocrinology, Metabolism, and Nephrology, School of Medicine, Keio University, Tokyo, Japan. .
Sassone-Corsi P; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA, USA. .
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Źródło :
Nature reviews. Cancer [Nat Rev Cancer] 2020 Nov; Vol. 20 (11), pp. 645-661. Date of Electronic Publication: 2020 Sep 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Carcinogenesis/*metabolism
Cell Transformation, Neoplastic/*metabolism
Circadian Clocks/*physiology
Circadian Rhythm/*physiology
Homeostasis/*physiology
Neoplasms/*physiopathology
Animals ; Carcinogenesis/genetics ; Cell Transformation, Neoplastic/genetics ; Circadian Clocks/genetics ; Circadian Rhythm/genetics ; Disease Models, Animal ; Disease Progression ; Homeostasis/genetics ; Humans ; Mice ; Neoplasms/etiology ; Neoplasms/genetics ; Neoplasms/metabolism
Czasopismo naukowe

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